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Select item 112099351.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111396552.

GNAQ/GNA11 Mosaicism Is Associated with Abnormal Serum Calcium Indices and Microvascular Neurocalcification

Nicole Knöpfel, Davide Zecchin, Hanna Richardson, Satyamaanasa Polubothu, Sara Barberan-Martin, Thomas Cullup, Karolina Gholam, Simon Heales, Steve Krywawych, Pablo López-Balboa, Noreen Muwanga-Nanyonjo, Olumide Ogunbiyi, Clinda Puvirajasinghe, Lea Solman, Katherine Swarbrick, Samira B. Syed, Zubair Tahir, Martin M. Tisdall, Jeremy Allgrove, Alexander D. Chesover, Sarah E. Aylett, Thomas S. Jacques, Fadil M. Hannan, Ulrike Löbel, Robert K. Semple, Rajesh V. Thakker, Veronica A. Kinsler

J Invest Dermatol. 2024 Apr; 144(4): 820–832.e9. doi: 10.1016/j.jid.2023.09.008

PMCID:: PMC11139655

Abstract Article PDF–3.1M

Select item 108940043.

Developmental expression of the Sturge–Weber syndrome-associated genetic mutation in Gnaq: a formal test of Happle's paradominant inheritance hypothesis

Sarah E Wetzel-Strong, Francesca Galeffi, Christian Benavides, Mary Patrucco, Jessica L Bullock, Carol J Gallione, Han Kyu Lee, Douglas A Marchuk

Genetics. 2023 Aug; 224(4): iyad077. Published online 2023 Apr 25. doi: 10.1093/genetics/iyad077

PMCID:: PMC10894004

Abstract Article PDF–6.8M

Select item 106912444.

The mechanism of Gα_q regulation of PLCβ3-catalyzed PIP2 hydrolysis

Maria E. Falzone, Roderick MacKinnon

Proc Natl Acad Sci U S A. 2023 Nov 28; 120(48): e2315011120. Published online 2023 Nov 22. doi: 10.1073/pnas.2315011120

PMCID:: PMC10691244

Abstract Article PDF–3.6M

Select item 105072895.

Gαq Signaling Activates β-Catenin-Dependent Gene Transcription

Sara Ansari, Sedighe Kolivand, Sara Salmanian, Marie Saghaeian Jazi, S Mahmoud A Najafi

Iran Biomed J. 2023 Jul; 27(4): 183–190. Published online 2023 May 31. doi: 10.61186/ibj.3890

PMCID:: PMC10507289

Abstract Article PDF–692K

Select item 102374226.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100879267.

Early‐onset hypertension associated with extensive cutaneous capillary malformations harboring postzygotic variants in GNAQ and GNA11

Olivia M. T. Davies, Ashley T. Ng, Jennifer Tran, Shoshana Blumenthal, Lisa M. Arkin, Amy J. Nopper, Catherine E. Cottrell, Maria Garzon, Dawn H. Siegel, Ilona J. Frieden, Beth A. Drolet

Pediatr Dermatol. 2022 Nov-Dec; 39(6): 914–919. Published online 2022 Aug 10. doi: 10.1111/pde.15103

PMCID:: PMC10087926

Abstract Article PDF–1.0M

Select item 95297928.

A novel somatic mutation in GNAQ in a capillary malformation provides insight into molecular pathogenesis

F. Galeffi, D. A. Snellings, S. E. Wetzel-Strong, N. Kastelic, J. Bullock, C. J. Gallione, P. E. North, D. A. Marchuk

Angiogenesis. Author manuscript; available in PMC 2022 Nov 1.

Published in final edited form as: Angiogenesis. 2022 Nov; 25(4): 493–502. Published online 2022 May 30. doi: 10.1007/s10456-022-09841-w

PMCID:: PMC9529792

Abstract Article PDF–905K

Select item 92344089.

Somatic GNAQ R183Q mutation is located within the sclera and episclera in patients with Sturge-Weber syndrome

Yue Wu, Cheng Peng, Lulu Huang, Li Xu, Xuming Ding, Yixin Liu, Changjuan Zeng, Hao Sun, Wenyi Guo

Br J Ophthalmol. 2022 Jul; 106(7): 1006–1011. Published online 2021 Mar 11. doi: 10.1136/bjophthalmol-2020-317287

PMCID:: PMC9234408

Abstract Article PDF–1.0M

Select item 917548210.

LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression

Xuexue Xu, Pengsheng Ding, Lan Shi, Gang Wu, Xiaoling Ma

BMC Cancer. 2022; 22: 630. Published online 2022 Jun 8. doi: 10.1186/s12885-022-09680-4

PMCID:: PMC9175482

Abstract Article PDF–15M

Select item 911973611.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 889562712.

Synthetic Lethal Screens Reveal Co-Targeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma

Justine S. Paradis, Monica Acosta, Robert Saddawi-Konefka, Ayush Kishore, Frederico Gomes, Nadia Arang, Manoela Tiago, Silvia Coma, Simone Lubrano, Xingyu Wu, Kyle Ford, Chi-Ping Day, Glenn Merlino, Prashant Mali, Jonathan A. Pachter, Takami Sato, Andrew E. Aplin, J. Silvio Gutkind

Clin Cancer Res. Author manuscript; available in PMC 2022 Mar 4.

Published in final edited form as: Clin Cancer Res. 2021 Jun 1; 27(11): 3190–3200. Published online 2021 Feb 10. doi: 10.1158/1078-0432.CCR-20-3363

PMCID:: PMC8895627

Abstract Article PDF–2.6M

Select item 884218513.

Assessing Gq-GPCR–induced human astrocyte reactivity using bioengineered neural organoids

Caroline Cvetkovic, Rajan Patel, Arya Shetty, Matthew K. Hogan, Morgan Anderson, Nupur Basu, Samira Aghlara-Fotovat, Srivathsan Ramesh, Debosmita Sardar, Omid Veiseh, Michael E. Ward, Benjamin Deneen, Philip J. Horner, Robert Krencik

J Cell Biol. 2022 Apr 4; 221(4): e202107135. Published online 2022 Feb 9. doi: 10.1083/jcb.202107135

PMCID:: PMC8842185

Abstract Article PDF–5.6M

Select item 882155814.

Cryo-EM structures of human bradykinin receptor-G_q proteins complexes

Jinkang Shen, Dongqi Zhang, Yao Fu, Anqi Chen, Xiaoli Yang, Haitao Zhang

Nat Commun. 2022; 13: 714. Published online 2022 Feb 7. doi: 10.1038/s41467-022-28399-1

PMCID:: PMC8821558

Abstract Article PDF–5.6M

Select item 870248715.

Endothelial GNAQ p.R183Q increases angiopoietin-2 and drives formation of enlarged blood vessels

Lan Huang, Colette Bichsel, Alexis Norris, Jeremy Thorpe, Jonathan Pevsner, Sanda Alexandrescu, Anna Pinto, David Zurakowski, Robin J. Kleiman, Mustafa Sahin, Arin K. Greene, Joyce Bischoff

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2022 Jan; 42(1): e27–e43. Published online 2021 Oct 21. doi: 10.1161/ATVBAHA.121.316651

PMCID:: PMC8702487

Abstract Article PDF–2.0M

Select item 864180416.

Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling

Pawan Sharma, Santosh K. Yadav, Sushrut D. Shah, Elham Javed, John M. Lim, Shi Pan, Ajay P. Nayak, Reynold A. Panettieri, Jr., Raymond B. Penn, Taku Kambayashi, Deepak A. Deshpande

Am J Respir Cell Mol Biol. 2021 Dec; 65(6): 658–671. Published online 2021 Mar 30. doi: 10.1165/rcmb.2021-0106OC

PMCID:: PMC8641804

Abstract Article PDF–1.5M

Select item 855290717.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 842550118.

GNAQ Mutations in Diffuse and Solitary Choroidal Hemangiomas

JH Francis, T Milman, H Grossniklaus, DM Albert, R Folberg, GM Levitin, SE Coupland, F Catalanotti, D Rabady, C Kandoth, KJ Busam, DH Abramson

Ophthalmology. Author manuscript; available in PMC 2021 Sep 8.

Published in final edited form as: Ophthalmology. 2019 May; 126(5): 759–763. Published online 2018 Dec 8. doi: 10.1016/j.ophtha.2018.12.011

Correction in:: Ophthalmology. 2021 Aug; 128(8): 1245.

PMCID:: PMC8425501

Abstract Article PDF–310K

Select item 821874619.

A novel role of ADGRF1 (GPR110) in promoting cellular quiescence and chemoresistance in human epidermal growth factor receptor 2-positive breast cancer

Noor Mazin Abdulkareem, Raksha Bhat, Lanfang Qin, Suhas Vasaikar, Ambily Gopinathan, Tamika Mitchell, Martin J. Shea, Sarmistha Nanda, Hariprasad Thangavel, Bing Zhang, Carmine De Angelis, Rachel Schiff, Meghana V. Trivedi

FASEB J. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: FASEB J. 2021 Jul; 35(7): e21719. doi: 10.1096/fj.202100070R

PMCID:: PMC8218746

Abstract Article PDF–2.5M

Select item 820856920.

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

Jesse I. Mobbs, Matthew J. Belousoff, Kaleeckal G. Harikumar, Sarah J. Piper, Xiaomeng Xu, Sebastian G. B. Furness, Hari Venugopal, Arthur Christopoulos, Radostin Danev, Denise Wootten, David M. Thal, Laurence J. Miller, Patrick M. Sexton

PLoS Biol. 2021 Jun; 19(6): e3001295. Published online 2021 Jun 4. doi: 10.1371/journal.pbio.3001295

Update in:: PLoS Biol. 2024 Jul; 22(7): e3002673.

PMCID:: PMC8208569

Abstract Article PDF–4.0M

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