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Items: 1 to 20 of 63

1.
A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy
Amr El Zawily, Frederick S. Vizeacoumar, Renuka Dahiya, Sara L. Banerjee, Kalpana K. Bhanumathy, Hussain Elhasasna, Glinton Hanover, Jessica C. Sharpe, Malkon G. Sanchez, Paul Greidanus, R. Greg Stacey, Kyung-Mee Moon, Ilya Alexandrov, Juha P. Himanen, Dimitar B. Nikolov, Humphrey Fonge, Aaron P. White, Leonard J. Foster, Bingcheng Wang, Behzad M. Toosi, Nicolas Bisson, Tajib A. Mirzabekov, Franco J. Vizeacoumar, Andrew Freywald
Clin Cancer Res. 2023 Jul 14; 29(14): 2686–2701. Published online 2023 Mar 28. doi: 10.1158/1078-0432.CCR-22-2535
PMCID:
PMC10345963
AbstractArticlePDF–13M
2.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
3.
Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease
Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel
Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205
PMCID:
PMC9348576
AbstractArticlePDF–3.0M
4.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
5.
Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates
Hanjie Jiang, Claire Y. Chiang, Zan Chen, Sara Nathan, Gabriel D’Agostino, Joao A. Paulo, Guang Song, Heng Zhu, Sandra B. Gabelli, Philip A. Cole
J Biol Chem. 2022 May; 298(5): 101854. Published online 2022 Mar 21. doi: 10.1016/j.jbc.2022.101854
PMCID:
PMC9034101
AbstractArticlePDF–3.7M
6.
Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome
Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson
Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584
PMCID:
PMC8769072
AbstractArticlePDF–2.9M
7.
WBP2 promotes BTRC mRNA stability to drive migration and invasion in triple‐negative breast cancer via NF‐κB activation
Yvonne Xinyi Lim, Hexian Lin, Tinghine Chu, Yoon Pin Lim
Mol Oncol. 2022 Jan; 16(2): 422–446. Published online 2021 Aug 12. doi: 10.1002/1878-0261.13048
PMCID:
PMC8763649
AbstractArticlePDF–6.5M
8.
WBP2 inhibits microRNA biogenesis via interaction with the microprocessor complex
Hossein Tabatabaeian, Shen Kiat Lim, Tinghine Chu, Sock Hong Seah, Yoon Pin Lim
Life Sci Alliance. 2021 Jul; 4(7): e202101038. Published online 2021 Jun 11. doi: 10.26508/lsa.202101038
PMCID:
PMC8200299
AbstractArticlePDF–2.6M
9.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
10.
WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression
Qiang Han, Xuezhu Rong, Xuyong Lin, Xiupeng Zhang, Chuifeng Fan, Huanyu Zhao, Enhua Wang
Cell Death Dis. 2021 Apr; 12(4): 384. Published online 2021 Apr 9. doi: 10.1038/s41419-021-03600-3
PMCID:
PMC8035140
AbstractArticlePDF–9.7M
11.
WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKβ1
Zhe Zheng, Yue Li, Siyuan Fan, Jie An, Xi Luo, Minglu Liang, Feng Zhu, Kai Huang
Cell Death Dis. 2021 Mar; 12(3): 228. Published online 2021 Mar 3. doi: 10.1038/s41419-021-03536-8
PMCID:
PMC7930037
AbstractArticlePDF–6.0M
12.
Global proteomics of Ubqln2-based murine models of ALS
Alexandra M. Whiteley, Miguel A. Prado, Stefanie A.H. de Poot, Joao A. Paulo, Marissa Ashton, Sara Dominguez, Martin Weber, Hai Ngu, John Szpyt, Mark P. Jedrychowski, Amy Easton, Steven P. Gygi, Thimo Kurz, Mervyn J. Monteiro, Eric J. Brown, Daniel Finley
J Biol Chem. 2021 Jan-Jun; 296: 100153. Published online 2020 Dec 10. doi: 10.1074/jbc.RA120.015960
PMCID:
PMC7873701
AbstractArticlePDF–3.0M
13.
A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
Dick J. H. van den Boomen, Agata Sienkiewicz, Ilana Berlin, Marlieke L. M. Jongsma, Daphne M. van Elsland, J. Paul Luzio, Jacques J. C. Neefjes, Paul J. Lehner
Nat Commun. 2020; 11: 5559. Published online 2020 Nov 3. doi: 10.1038/s41467-020-19032-0
PMCID:
PMC7642327
AbstractArticlePDF–12M
14.
Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells
Seung W. Ryu, Rose Stewart, D. Chase Pectol, Nicolette A. Ender, Oshadi Wimalarathne, Ji-Hoon Lee, Carlos P. Zanini, Antony Harvey, Jon M. Huibregtse, Peter Mueller, Tanya T. Paull
PLoS Biol. 2020 Jul; 18(7): e3000606. Published online 2020 Jul 20. doi: 10.1371/journal.pbio.3000606
PMCID:
PMC7392334
AbstractArticlePDF–2.7M
15.
RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation
Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen
Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117
PMCID:
PMC7322067
AbstractArticlePDF–2.7M
16.
The emerging roles of WBP2 oncogene in human cancers
Hossein Tabatabaeian, Angad Rao, Alisha Ramos, Tinghine Chu, Marius Sudol, Yoon Pin Lim
Oncogene. 2020; 39(24): 4621–4635. Published online 2020 May 11. doi: 10.1038/s41388-020-1318-0
PMCID:
PMC7286818
AbstractArticlePDF–2.2M
17.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
18.
Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif
Thi Hai Yen Tran, Dae-Wook Yang, Minchul Kim, Da-Hye Lee, Marta Gai, Ferdinando Di Cunto, Kwang-Wook Choi, Dae-Sik Lim
J Mol Cell Biol. 2019 Nov; 11(11): 1006–1017. Published online 2019 Mar 13. doi: 10.1093/jmcb/mjz013
PMCID:
PMC6927243
AbstractArticlePDF–1.5M
19.
USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification
Casey P. Nielsen, Kristin K. Jernigan, Nicole L. Diggins, Donna J. Webb, Jason A. MacGurn
Cell Rep. Author manuscript; available in PMC 2019 Nov 29.
Published in final edited form as: Cell Rep. 2019 Jul 23; 28(4): 1074–1089.e5. doi: 10.1016/j.celrep.2019.06.083
PMCID:
PMC6884140
AbstractArticlePDF–2.6M
20.
Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases
Hanjie Jiang, Stefani N. Thomas, Zan Chen, Claire Y. Chiang, Philip A. Cole
J Biol Chem. 2019 Nov 15; 294(46): 17421–17436. Published online 2019 Oct 2. doi: 10.1074/jbc.RA119.009211
PMCID:
PMC6873185
AbstractArticlePDF–4.1M

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