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Select item 108173981.

ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis

Mingkui Shen, Kuankuan Li, Lulu Wang, Li Feng, Xinyu Zhang, Haoping Zhang, Honggang Zhou, Guoxian Pei

Aging (Albany NY) 2024 Jan 15; 16(1): 685–700. Published online 2024 Jan 12. doi: 10.18632/aging.205412

PMCID:: PMC10817398

Abstract Article PDF–2.6M

Select item 104985572.

GREM1, LRPPRC and SLC39A4 as potential biomarkers of intervertebral disc degeneration: a bioinformatics analysis based on multiple microarray and single-cell sequencing data

ZhaoLiang Zhang, JianZhong Huo, XingHua Ji, LinDong Wei, Jinfeng Zhang

BMC Musculoskelet Disord. 2023; 24: 729. Published online 2023 Sep 12. doi: 10.1186/s12891-023-06854-4

PMCID:: PMC10498557

Abstract Article PDF–9.2M

Select item 97271573.

The transmembrane domains mediate oligomerization of the human ZIP4 transporter in vivo

Yuting Liu, Elizabeth M. Bafaro, Ann E. Cowan, Robert E. Dempski

Sci Rep. 2022; 12: 21083. Published online 2022 Dec 6. doi: 10.1038/s41598-022-24782-6

PMCID:: PMC9727157

Abstract Article PDF–2.9M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78374545.

ZIP4 Increases Expression of Transcription Factor ZEB1 to Promote Integrin α3β1 Signaling and Inhibit Expression of the Gemcitabine Transporter ENT1 in Pancreatic Cancer Cells

Mingyang Liu, Yuqing Zhang, Jingxuan Yang, Xiaobo Cui, Zhijun Zhou, Hanxiang Zhan, Kai Ding, Xiang Tian, Zhibo Yang, Kar-Ming A. Fung, Barish H. Edil, Russell G. Postier, Michael S. Bronze, Martin E. Fernandez-Zapico, Marc P. Stemmler, Thomas Brabletz, Yi-Ping Li, Courtney W. Houchen, Min Li

Gastroenterology. Author manuscript; available in PMC 2021 Feb 1.

Published in final edited form as: Gastroenterology. 2020 Feb; 158(3): 679–692.e1. Published online 2019 Nov 9. doi: 10.1053/j.gastro.2019.10.038

PMCID:: PMC7837454

Abstract Article PDF–1.7M

Select item 76612186.

The histidine-rich loop in the extracellular domain of ZIP4 binds zinc and plays a role in zinc transport

Tuo Zhang, Eziz Kuliyev, Dexin Sui, Jian Hu

Biochem J. Author manuscript; available in PMC 2020 Nov 12.

Published in final edited form as: Biochem J. 2019 Jun 28; 476(12): 1791–1803. Published online 2019 Jun 28. doi: 10.1042/BCJ20190108

PMCID:: PMC7661218

Abstract Article PDF–1.4M

Select item 76611027.

Molecular Basis of Zinc-Dependent Endocytosis of Human ZIP4 Transceptor

Chi Zhang, Dexin Sui, Tuo Zhang, Jian Hu

Cell Rep. Author manuscript; available in PMC 2020 Nov 12.

Published in final edited form as: Cell Rep. 2020 Apr 28; 31(4): 107582. doi: 10.1016/j.celrep.2020.107582

PMCID:: PMC7661102

Abstract Article PDF–1.4M

Select item 71638008.

Quantifying the Oligomeric State of hZIP4 on the Surface of Cells

Meghan E. Ahern, Elizabeth M. Bafaro, Ann Cowan, Robert E. Dempski

Biochemistry. Author manuscript; available in PMC 2020 Apr 17.

Published in final edited form as: Biochemistry. 2019 Apr 2; 58(13): 1705–1708. Published online 2019 Mar 20. doi: 10.1021/acs.biochem.9b00131

PMCID:: PMC7163800

Abstract Article PDF–991K

Select item 70378709.

Elucidating the H⁺ Coupled Zn²⁺ Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica

Eitan Hoch, Moshe Levy, Michal Hershfinkel, Israel Sekler

Int J Mol Sci. 2020 Feb; 21(3): 734. Published online 2020 Jan 22. doi: 10.3390/ijms21030734

PMCID:: PMC7037870

Abstract Article PDF–2.1M

Select item 700604810.

ZIP4 Promotes Pancreatic Cancer Progression by Repressing ZO-1 and claudin-1 through a ZEB1-Dependent Transcriptional Mechanism

Mingyang Liu, Jingxuan Yang, Yuqing Zhang, Zhijun Zhou, Xiaobo Cui, Liyang Zhang, Kar-Ming Fung, Wei Zheng, Felicia D. Allard, Eric U. Yee, Kai Ding, Huanwen Wu, Zhiyong Liang, Lei Zheng, Martin E. Fernandez-Zapico, Yi-Ping Li, Michael S. Bronze, Katherine T. Morris, Russell G. Postier, Courtney W. Houchen, Jing Yang, Min Li

Clin Cancer Res. Author manuscript; available in PMC 2020 Feb 7.

Published in final edited form as: Clin Cancer Res. 2018 Jul 1; 24(13): 3186–3196. Published online 2018 Apr 3. doi: 10.1158/1078-0432.CCR-18-0263

PMCID:: PMC7006048

Abstract Article PDF–2.1M

Select item 698397111.

Analysis of the relationship between the mutation site of the SLC39A4 gene and acrodermatitis enteropathica by reporting a rare Chinese twin: a case report and review of the literature

Wei Zhong, Chao Yang, Lei Zhu, Yu-Qi Huang, Yong-Feng Chen

BMC Pediatr. 2020; 20: 34. Published online 2020 Jan 27. doi: 10.1186/s12887-020-1942-4

PMCID:: PMC6983971

Abstract Article PDF–1.1M

Select item 695673012.

Asymmetric functions of a binuclear metal center within the transport pathway of a human zinc transporter ZIP4

Tuo Zhang, Dexin Sui, Chi Zhang, Logan Cole, Jian Hu

FASEB J. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: FASEB J. 2020 Jan; 34(1): 237–247. Published online 2019 Nov 21. doi: 10.1096/fj.201902043R

PMCID:: PMC6956730

Abstract Article PDF–2.4M

Select item 668315413.

Inhibition of ZIP4 reverses epithelial-to-mesenchymal transition and enhances the radiosensitivity in human nasopharyngeal carcinoma cells

Qi Zeng, Yi-min Liu, Jun Liu, Jian Han, Jian-xin Guo, Shun Lu, Xue-mei Huang, Ping Yi, Jin-yi Lang, Peng Zhang, Chun-ting Wang

Cell Death Dis. 2019 Aug; 10(8): 588. Published online 2019 Aug 5. doi: 10.1038/s41419-019-1807-7

PMCID:: PMC6683154

Abstract Article PDF–2.8M

Select item 645999514.

Concomitant disorder and high‐affinity zinc binding in the human zinc‐ and iron‐regulated transport protein 4 intracellular loop

Elizabeth M. Bafaro, Mark W. Maciejewski, Jeffrey C. Hoch, Robert E. Dempski

Protein Sci. 2019 May; 28(5): 868–880. Published online 2019 Mar 12. doi: 10.1002/pro.3591

PMCID:: PMC6459995

Abstract Article PDF–1.5M

Select item 612544415.

Exosomal zinc transporter ZIP4 promotes cancer growth and is a novel diagnostic biomarker for pancreatic cancer

Haoyi Jin, Peng Liu, Yunhao Wu, Xiangli Meng, Mengwei Wu, Jiahong Han, Xiaodong Tan

Cancer Sci. 2018 Sep; 109(9): 2946–2956. Published online 2018 Sep 5. doi: 10.1111/cas.13737

Correction in:: Cancer Sci. 2023 Feb; 114(2): 712–714.

PMCID:: PMC6125444

Abstract Article PDF–2.1M

Select item 554314916.

SLC39A4 expression is associated with enhanced cell migration, cisplatin resistance, and poor survival in non-small cell lung cancer

Dong-ming Wu, Teng Liu, Shi-hua Deng, Rong Han, Ying Xu

Sci Rep. 2017; 7: 7211. Published online 2017 Aug 3. doi: 10.1038/s41598-017-07830-4

PMCID:: PMC5543149

Abstract Article PDF–4.0M

Select item 553161117.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 537173018.

Systematic protein–protein interaction mapping for clinically relevant human GPCRs

Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

Mol Syst Biol. 2017 Mar; 13(3): 918. Published online 2017 Mar 15. doi: 10.15252/msb.20167430

PMCID:: PMC5371730

Abstract Article PDF–4.1M

Select item 536695019.

Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3

Stefanie Pfaender, Ann Katrin Sauer, Simone Hagmeyer, Katharina Mangus, Leonhard Linta, Stefan Liebau, Juergen Bockmann, Guillaume Huguet, Thomas Bourgeron, Tobias M. Boeckers, Andreas M. Grabrucker

Sci Rep. 2017; 7: 45190. Published online 2017 Mar 27. doi: 10.1038/srep45190

PMCID:: PMC5366950

Abstract Article PDF–2.2M

Select item 491513220.

Structural insights of ZIP4 extracellular domain critical for optimal zinc transport

Tuo Zhang, Dexin Sui, Jian Hu

Nat Commun. 2016; 7: 11979. Published online 2016 Jun 20. doi: 10.1038/ncomms11979

PMCID:: PMC4915132

Abstract Article PDF–2.9M

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