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Items: 1 to 20 of 38

1.
OTU deubiquitinase, ubiquitin aldehyde binding 2  (OTUB2) modulates the stemness feature, chemoresistance, and epithelial-mesenchymal transition of colon cancer via regulating GINS complex subunit 1 (GINS1) expression
Wenjie Zhu, Changlei Wu, Zitao Liu, ShiMin Zhao, Jun Huang
Cell Commun Signal. 2024; 22: 420. Published online 2024 Aug 29. doi: 10.1186/s12964-024-01789-2
PMCID:
PMC11361113
AbstractArticlePDF–9.0M
2.
OTUB2 silencing promotes ovarian cancer via mitochondrial metabolic reprogramming and can be synthetically targeted by CA9 inhibition
Yabing Nan, Xiaowei Wu, Qingyu Luo, Wan Chang, Pengfei Zhao, Lingqiang Zhang, Zhihua Liu
Proc Natl Acad Sci U S A. 2024 May 7; 121(19): e2315348121. Published online 2024 May 3. doi: 10.1073/pnas.2315348121
PMCID:
PMC11087800
AbstractArticlePDF–10M
3.
Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1
Wenfeng Ren, Zilong Xu, Yating Chang, Fei Ju, Hongning Wu, Zhiqi Liang, Min Zhao, Naizhen Wang, Yanhua Lin, Chenhang Xu, Shengming Chen, Yipeng Rao, Chaolong Lin, Jianxin Yang, Pingguo Liu, Jun Zhang, Chenghao Huang, Ningshao Xia
Nat Commun. 2024; 15: 9. Published online 2024 Jan 2. doi: 10.1038/s41467-023-44466-7
PMCID:
PMC10761827
AbstractArticlePDF–3.5M
4.
Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2
Ken Ikeuchi, Nives Ivic, Robert Buschauer, Jingdong Cheng, Thomas Fröhlich, Yoshitaka Matsuo, Otto Berninghausen, Toshifumi Inada, Thomas Becker, Roland Beckmann
Nat Commun. 2023; 14: 2730. Published online 2023 May 12. doi: 10.1038/s41467-023-38161-w
PMCID:
PMC10175282
AbstractArticlePDF–7.5M
5.
Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc
Yunhua Peng, Jing Liu, Zhen Wang, Chunping Cui, Tiantian Zhang, Shuangxi Zhang, Peipei Gao, Zhanwu Hou, Huadong Liu, Jianping Guo, Jinfang Zhang, Yurong Wen, Wenyi Wei, Lingqiang Zhang, Jiankang Liu, Jiangang Long
Cell Death Differ. 2022 Sep; 29(9): 1730–1743. Published online 2022 Feb 25. doi: 10.1038/s41418-022-00960-x
Correction in:
Cell Death Differ. 2023 Jan; 30(1): 224–225.
PMCID:
PMC9433443
AbstractArticlePDF–6.8M
6.
HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis
Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai
Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4
PMCID:
PMC9338313
AbstractArticlePDF–2.8M
7.
OTUB2 Promotes Proliferation and Migration of Hepatocellular Carcinoma Cells by PJA1 Deubiquitylation
Gang Hu, Jianwu Yang, Hongwen Zhang, Zhen Huang, Heming Yang
Cell Mol Bioeng. 2022 Jun; 15(3): 281–292. Published online 2022 Feb 1. doi: 10.1007/s12195-022-00720-4
PMCID:
PMC9124278
AbstractArticlePDF–3.2M
8.
Structural and functional consequences of NEDD8 phosphorylation
Katrin Stuber, Tobias Schneider, Jill Werner, Michael Kovermann, Andreas Marx, Martin Scheffner
Nat Commun. 2021; 12: 5939. Published online 2021 Oct 12. doi: 10.1038/s41467-021-26189-9
PMCID:
PMC9020517
AbstractArticlePDF–2.8M
9.
Human transcription factor protein interaction networks
Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo
Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5
PMCID:
PMC8828895
AbstractArticlePDF–1.7M
10.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
11.
Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases
Dakshinamurthy Sivakumar, Vikash Kumar, Michael Naumann, Matthias Stein
J Biol Chem. 2020 May 15; 295(20): 6972–6982. Published online 2020 Apr 7. doi: 10.1074/jbc.RA120.013073
PMCID:
PMC7242701
AbstractArticlePDF–3.1M
12.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
13.
USP1 deubiquitinates Akt to inhibit PI3K‐Akt‐FoxO signaling in muscle during prolonged starvation
Dana Goldbraikh, Danielle Neufeld, Yara Eid‐Mutlak, Inbal Lasry, Jennifer E Gilda, Anna Parnis, Shenhav Cohen
EMBO Rep. 2020 Apr 3; 21(4): e48791. Published online 2020 Mar 5. doi: 10.15252/embr.201948791
PMCID:
PMC7132338
AbstractArticlePDF–1.6M
14.
A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate
Christian M. Loch, James E. Strickler
Biochim Biophys Acta Mol Cell Res. 2012 Nov; 1823(11): 2069–2078. Published online 2012 May 21. doi: 10.1016/j.bbamcr.2012.05.006
PMCID:
PMC7113913
AbstractArticlePDF–1.5M
15.
USP37 is a SNAI1 deubiquitinase
Zhenna Xiao, Liang Chang, Jongchan Kim, Peijing Zhang, Qinglei Hang, Shannon Yap, Youming Guo, Zhicheng Zhou, Liyong Zeng, Xiaoyu Hu, Ashley Siverly, Yutong Sun, Li Ma
Am J Cancer Res. 2019; 9(12): 2749–2759. Published online 2019 Dec 1.
PMCID:
PMC6943346
AbstractArticlePDF–1.2M
16.
Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis
Weicheng Zang, Chuanzhen Yang, Tingting Li, Liming Liao, Xiaofeng Zheng
Proc Natl Acad Sci U S A. 2019 Dec 17; 116(51): 25624–25633. Published online 2019 Dec 3. doi: 10.1073/pnas.1910250116
PMCID:
PMC6926050
AbstractArticlePDF–1.4M
17.
Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions
Weili Kong, Tsuyoshi Hayashi, Guillaume Fiches, Qikai Xu, Mamie Z. Li, Jianwen Que, Shuai Liu, Wei Zhang, Jun Qi, Netty Santoso, Stephen J. Elledge, Jian Zhu
Genomics Proteomics Bioinformatics. 2019 Jun; 17(3): 319–331. Published online 2019 Sep 5. doi: 10.1016/j.gpb.2018.12.010
PMCID:
PMC6818353
AbstractArticlePDF–2.5M
18.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu
Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3
PMCID:
PMC6742646
AbstractArticlePDF–1.2M
19.
OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer
Jing Li, Dongdong Cheng, Miaoxin Zhu, Huajian Yu, Zhen Pan, Lei Liu, Qin Geng, Hongyu Pan, Mingxia Yan, Ming Yao
Theranostics. 2019; 9(1): 179–195. Published online 2019 Jan 1. doi: 10.7150/thno.29545
PMCID:
PMC6332791
AbstractArticlePDF–3.3M
20.
Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin
Jongchan Kim, Fatemeh Alavi Naini, Yutong Sun, Li Ma
Am J Cancer Res. 2018; 8(9): 1823–1836. Published online 2018 Sep 1.
PMCID:
PMC6176183
AbstractArticlePDF–3.1M

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