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Select item 107874791.

Activation of γ-globin expression by LncRNA-mediated ERF promoter hypermethylation in β-thalassemia

Xiuqin Bao, Yuanyi Gao, Zhongju Wang, Yuhua Ye, Diyu Chen, Yangjin Zuo, Cunyou Zhao, Xiangmin Xu

Clin Epigenetics. 2024; 16: 12. Published online 2024 Jan 13. doi: 10.1186/s13148-023-01614-6

PMCID:: PMC10787479

Abstract Article PDF–2.1M

Select item 95239972.

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer

Natsumi Tsuboyama, Aileen Patricia Szczepanski, Zibo Zhao, Lu Wang

Genome Biol. 2022; 23: 206. Published online 2022 Sep 30. doi: 10.1186/s13059-022-02776-x

PMCID:: PMC9523997

Abstract Article PDF–6.9M

Select item 89809473.

Joint efficacy of the three biomarkers SNCA, GYPB and HBG1 for atrial fibrillation and stroke: Analysis via the support vector machine neural network

Xiang Wang, Xuyang Meng, Lingbing Meng, Ying Guo, Yi Li, Chenguang Yang, Zuowei Pei, Jiahan Li, Fang Wang

J Cell Mol Med. 2022 Apr; 26(7): 2010–2022. Published online 2022 Feb 9. doi: 10.1111/jcmm.17224

PMCID:: PMC8980947

Abstract Article PDF–2.2M

Select item 86101734.

Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin

Phillip A. Doerfler, Ruopeng Feng, Yichao Li, Lance E. Palmer, Shaina N. Porter, Henry W. Bell, Merlin Crossley, Shondra M. Pruett-Miller, Yong Cheng, Mitchell J. Weiss

Nat Genet. Author manuscript; available in PMC 2022 Feb 2.

Published in final edited form as: Nat Genet. 2021 Aug; 53(8): 1177–1186. Published online 2021 Aug 2. doi: 10.1038/s41588-021-00904-0

PMCID:: PMC8610173

Abstract Article PDF–5.3M

Select item 84488625.

Novel variants in Krueppel like factor 1 that cause persistence of fetal hemoglobin in In(Lu) individuals

Jesse Eernstman, Barbera Veldhuisen, Peter Ligthart, Marieke von Lindern, C. Ellen van der Schoot, Emile van den Akker

Sci Rep. 2021; 11: 18557. Published online 2021 Sep 17. doi: 10.1038/s41598-021-97149-y

PMCID:: PMC8448862

Abstract Article PDF–2.9M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80389717.

Transcription factor competition at the γ-globin promoters controls hemoglobin switching

Nan Liu, Shuqian Xu, Qiuming Yao, Qian Zhu, Yan Kai, Jonathan Y. Hsu, Phraew Sakon, Luca Pinello, Guo-Cheng Yuan, Daniel E. Bauer, Stuart H. Orkin

Nat Genet. Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: Nat Genet. 2021 Apr; 53(4): 511–520. Published online 2021 Mar 1. doi: 10.1038/s41588-021-00798-y

Correction in:: Nat Genet. 2021 Apr; 53(4): 586.

PMCID:: PMC8038971

Abstract Article PDF–3.9M

Select item 73114558.

Comparative targeting analysis of KLF1, BCL11A, and HBG1/2 in CD34⁺ HSPCs by CRISPR/Cas9 for the induction of fetal hemoglobin

Andrés Lamsfus-Calle, Alberto Daniel-Moreno, Justin S. Antony, Thomas Epting, Lukas Heumos, Praveen Baskaran, Jakob Admard, Nicolas Casadei, Ngadhnjim Latifi, Darina M. Siegmund, Michael S. D. Kormann, Rupert Handgretinger, Markus Mezger

Sci Rep. 2020; 10: 10133. Published online 2020 Jun 23. doi: 10.1038/s41598-020-66309-x

PMCID:: PMC7311455

Abstract Article PDF–3.4M

Select item 73073369.

Association of polymorphisms in the HBG1‐HBD intergenic region with HbF levels

Li Hu, Ling Huang, Yuanyuan Han, Tingting Jin, Juan Liu, Minmin Jiang, Xingmei Liu, Yuanyuan Li, Wenping Han, Bangquan An, Shengwen Huang

J Clin Lab Anal. 2020 Jun; 34(6): e23243. Published online 2020 Feb 18. doi: 10.1002/jcla.23243

PMCID:: PMC7307336

Abstract Article PDF–787K

Select item 638658810.

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Joanna R. Kovalski, Aparna Bhaduri, Ashley M. Zehnder, Poornima H. Neela, Yonglu Che, Glenn G. Wozniak, Paul A. Khavari

Mol Cell. Author manuscript; available in PMC 2020 Feb 21.

Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 830–844.e12. Published online 2019 Jan 10. doi: 10.1016/j.molcel.2018.12.001

PMCID:: PMC6386588

Abstract Article PDF–1.7M

Select item 621331611.

Fetal γ-globin genes are regulated by the BGLT3 long noncoding RNA locus

Maria Soledad Ivaldi, Luis Francisco Diaz, Lyubomira Chakalova, Jongjoo Lee, Ivan Krivega, Ann Dean

Blood. 2018 Nov 1; 132(18): 1963–1973. Prepublished online 2018 Aug 27. doi: 10.1182/blood-2018-07-862003

PMCID:: PMC6213316

Abstract Article

Select item 557587212.

An Aγ-globin G->A gene polymorphism associated with β⁰39 thalassemia globin gene and high fetal hemoglobin production

Giulia Breveglieri, Nicoletta Bianchi, Lucia Carmela Cosenza, Maria Rita Gamberini, Francesco Chiavilli, Cristina Zuccato, Giulia Montagner, Monica Borgatti, Ilaria Lampronti, Alessia Finotti, Roberto Gambari

BMC Med Genet. 2017; 18: 93. Published online 2017 Aug 29. doi: 10.1186/s12881-017-0450-3

PMCID:: PMC5575872

Abstract Article PDF–1.7M

Select item 550177213.

A Genetic Variant Ameliorates β-Thalassemia Severity by Epigenetic-Mediated Elevation of Human Fetal Hemoglobin Expression

Diyu Chen, Yangjin Zuo, Xinhua Zhang, Yuhua Ye, Xiuqin Bao, Haiyan Huang, Wanicha Tepakhan, Lijuan Wang, Junyi Ju, Guangfu Chen, Mincui Zheng, Dun Liu, Shuodan Huang, Lu Zong, Changgang Li, Yajun Chen, Chenguang Zheng, Lihong Shi, Quan Zhao, Qiang Wu, Supan Fucharoen, Cunyou Zhao, Xiangmin Xu

Am J Hum Genet. 2017 Jul 6; 101(1): 130–138. Published online 2017 Jun 29. doi: 10.1016/j.ajhg.2017.05.012

PMCID:: PMC5501772

Abstract Article PDF–1.5M

Select item 546865014.

Histone-binding of DPF2 mediates its repressive role in myeloid differentiation

Ferdinand M. Huber, Sarah M. Greenblatt, Andrew M. Davenport, Concepcion Martinez, Ye Xu, Ly P. Vu, Stephen D. Nimer, André Hoelz

Proc Natl Acad Sci U S A. 2017 Jun 6; 114(23): 6016–6021. Published online 2017 May 22. doi: 10.1073/pnas.1700328114

PMCID:: PMC5468650

Abstract Article PDF–1.3M

Select item 490949215.

Inactivation of HDAC1 or HDAC2 induces gamma globin expression without altering cell cycle or proliferation

Erica B. Esrick, Marie McConkey, Katherine Lin, Alyse Frisbee, Benjamin L. Ebert

Am J Hematol. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Am J Hematol. 2015 Jul; 90(7): 624–628. Published online 2015 May 28. doi: 10.1002/ajh.24019

PMCID:: PMC4909492

Abstract Article PDF–896K

Select item 473974216.

Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts

Divya S. Vinjamur, Yousef N. Alhashem, Safa F. Mohamad, Parth Amin, David C. Williams, Jr., Joyce A. Lloyd

PLoS One. 2016; 11(2): e0146802. Published online 2016 Feb 3. doi: 10.1371/journal.pone.0146802

PMCID:: PMC4739742

Abstract Article PDF–1.3M

Select item 468491217.

Evolutionary context for the association of γ-globin, serum uric acid, and hypertension in African Americans

Daniel Shriner, Chutima Kumkhaek, Ayo P. Doumatey, Guanjie Chen, Amy R. Bentley, Bashira A. Charles, Jie Zhou, Adebowale Adeyemo, Griffin P. Rodgers, Charles N. Rotimi

BMC Med Genet. 2015; 16: 103. Published online 2015 Nov 5. doi: 10.1186/s12881-015-0249-z

PMCID:: PMC4684912

Abstract Article PDF–1.4M

Select item 458732218.

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage

Romain Drissi, Marie-Line Dubois, Mélanie Douziech, François-Michel Boisvert

Mol Cell Proteomics. 2015 Jul; 14(7): 2002–2013. Published online 2015 May 11. doi: 10.1074/mcp.M115.048991

PMCID:: PMC4587322

Abstract Article PDF–3.0M

Select item 447591419.

Pharmacological Induction of Human Fetal Globin Gene in Hydroxyurea-Resistant Primary Adult Erythroid Cells

Yu-Chi Chou, Ruei-Lin Chen, Zheng-Sheng Lai, Jen-Shin Song, Yu-Sheng Chao, Che-Kun James Shen

Mol Cell Biol. 2015 Jul; 35(14): 2541–2553. Prepublished online 2015 May 18. Published online 2015 Jun 19. doi: 10.1128/MCB.00035-15

PMCID:: PMC4475914

Abstract Article PDF–2.5M

Select item 445996920.

Variation in Gamma-Globin Expression before and after Induction with Hydroxyurea Associated with BCL11A, KLF1 and TAL1

Amanda J. Grieco, Henny H. Billett, Nancy S. Green, M. Catherine Driscoll, Eric E. Bouhassira

PLoS One. 2015; 10(6): e0129431. Published online 2015 Jun 8. doi: 10.1371/journal.pone.0129431

PMCID:: PMC4459969

Abstract Article PDF–1.0M

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