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Select item 113210671.

Orai1 and Orai3 act through distinct signalling axes to promote stemness and tumorigenicity of breast cancer stem cells

Duan Zhuo, Zhenchuan Lei, Lin Dong, Andrew Man Lok Chan, Jiacheng Lin, Liwen Jiang, Beibei Qiu, Xiaohua Jiang, Youhua Tan, Xiaoqiang Yao

Stem Cell Res Ther. 2024; 15: 256. Published online 2024 Aug 13. doi: 10.1186/s13287-024-03875-1

PMCID:: PMC11321067

Abstract Article PDF–2.5M

Select item 107170672.

Physiological functions of calcium signaling via Orai1 in cancer

Masanari Umemura, Rina Nakakaji, Yoshihiro Ishikawa

J Physiol Sci. 2023; 73: 21. Published online 2023 Sep 27. doi: 10.1186/s12576-023-00878-0

PMCID:: PMC10717067

Abstract Article PDF–784K

Select item 106666723.

Neutrophil-specific ORAI1 Calcium Channel Inhibition Reduces Pancreatitis-associated Acute Lung Injury

Mengya Niu, Xiuli Zhang, Zengkai Wu, Bin Li, Jingpiao Bao, Juanjuan Dai, Zihan Yang, Yue Zeng, Liang Li, Stephen Pandol, Robert Sutton, Li Wen

Function (Oxf) 2024; 5(1): zqad061. Published online 2023 Oct 23. doi: 10.1093/function/zqad061

PMCID:: PMC10666672

Abstract Article PDF–9.7M

Select item 103713434.

Orai1 calcium channel inhibition prevents progression of chronic pancreatitis

Viktória Szabó, Noémi Csákány-Papp, Marietta Görög, Tamara Madácsy, Árpád Varga, Aletta Kiss, Bálint Tél, Boldizsár Jójárt, Tim Crul, Krisztina Dudás, Mária Bagyánszki, Nikolett Bódi, Ferhan Ayaydin, Shyam Jee, László Tiszlavicz, Kenneth A. Stauderman, Sudarshan Hebbar, Petra Pallagi, József Maléth

JCI Insight. 2023 Jul 10; 8(13): e167645. Published online 2023 Jul 10. doi: 10.1172/jci.insight.167645

PMCID:: PMC10371343

Abstract Article PDF–28M

Select item 99910585.

A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels

Priscilla S-W Yeung, Megumi Yamashita, Murali Prakriya

eLife. 2023; 12: e82281. Published online 2023 Feb 20. doi: 10.7554/eLife.82281

PMCID:: PMC9991058

Abstract Article PDF–3.5M

Select item 99827476.

Super Resolution Microscopy Analysis Reveals Increased Orai1 Activity in Asthma and Cystic Fibrosis Lungs

Alexandra S. Goriounova, Rodney C. Gilmore, Joe A. Wrennall, Robert Tarran

J Cyst Fibros. Author manuscript; available in PMC 2024 Jan 1.

Published in final edited form as: J Cyst Fibros. 2023 Jan; 22(1): 161–171. Published online 2022 Aug 10. doi: 10.1016/j.jcf.2022.07.003

PMCID:: PMC9982747

Abstract Article PDF–2.0M

Select item 99228197.

The store-operated Ca²⁺ channel Orai1α is required for agonist-evoked NF-κB activation by a mechanism dependent on PKCβ2

Joel Nieto-Felipe, Jose Sanchez-Collado, Isaac Jardin, Gines M. Salido, Jose J. Lopez, Juan A. Rosado

J Biol Chem. 2023 Feb; 299(2): 102882. Published online 2023 Jan 7. doi: 10.1016/j.jbc.2023.102882

PMCID:: PMC9922819

Abstract Article PDF–3.0M

Select item 98902328.

STIM1 and ORAI1 form a novel cold transduction mechanism in sensory and sympathetic neurons

Tamara J Buijs, Bruno Vilar, Chun‐Hsiang Tan, Peter A McNaughton

EMBO J. 2023 Feb; 42(3): e111348. Published online 2022 Dec 16. doi: 10.15252/embj.2022111348

PMCID:: PMC9890232

Abstract Article PDF–1.5M

Select item 96882349.

Functional Role of STIM-1 and Orai1 in Human Microvascular Aging

Mariam El Assar, Esther García-Rojo, Alejandro Sevilleja-Ortiz, Alberto Sánchez-Ferrer, Argentina Fernández, Borja García-Gómez, Javier Romero-Otero, Leocadio Rodríguez-Mañas, Javier Angulo

Cells. 2022 Nov; 11(22): 3675. Published online 2022 Nov 18. doi: 10.3390/cells11223675

PMCID:: PMC9688234

Abstract Article PDF–2.0M

Select item 967089810.

Nuanced Interactions between AKAP79 and STIM1 with Orai1 Ca²⁺ Channels at Endoplasmic Reticulum-Plasma Membrane Junctions Sustain NFAT Activation

Yu-Ping Lin, Erica Scappini, Carlos Landaverde, Frederick Parekh-Glitsch, Charles J. Tucker, Gary R. Mirams, Anant B. Parekh

Mol Cell Biol. 2022 Nov; 42(11): e00175-22. Published online 2022 Nov 1. doi: 10.1128/mcb.00175-22

PMCID:: PMC9670898

Abstract Article PDF–3.7M

Select item 926617711.

PKC-Mediated Orai1 Channel Phosphorylation Modulates Ca²⁺ Signaling in HeLa Cells

Ericka Martínez-Martínez, Víctor Hugo Sánchez-Vázquez, Daniel León-Aparicio, Jose Sanchez-Collado, Martín-Leonardo Gallegos-Gómez, Juan A. Rosado, Juan M. Arias, Agustin Guerrero-Hernández

Cells. 2022 Jul; 11(13): 2037. Published online 2022 Jun 27. doi: 10.3390/cells11132037

PMCID:: PMC9266177

Abstract Article PDF–3.2M

Select item 926261412.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 918018613.

ORAI1-Regulated Gene Expression in Breast Cancer Cells: Roles for STIM1 Binding, Calcium Influx and Transcription Factor Translocation

Mélanie Robitaille, Shao Ming Chan, Amelia A. Peters, Limin Dai, Choon Leng So, Alice H. L. Bong, Francisco Sadras, Sarah J. Roberts-Thomson, Gregory R. Monteith

Int J Mol Sci. 2022 Jun; 23(11): 5867. Published online 2022 May 24. doi: 10.3390/ijms23115867

PMCID:: PMC9180186

Abstract Article PDF–1.9M

Select item 913612814.

Enhanced Orai1-mediated store-operated Ca²⁺ channel/calpain signaling contributes to high glucose-induced podocyte injury

Yu Tao, Sarika Chaudhari, Parisa Yazdizadeh Shotorbani, Yanfeng Ding, Zhenglan Chen, Ramesh Kasetti, Gulab Zode, Rong Ma

J Biol Chem. 2022 Jun; 298(6): 101990. Published online 2022 Apr 29. doi: 10.1016/j.jbc.2022.101990

PMCID:: PMC9136128

Abstract Article PDF–2.0M

Select item 911973615.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 911465316.

SPLUNC1 is a negative regulator of the Orai1 Ca²⁺ channel

Tongde Wu, Alexandra S. Goriounova, Erin N. Worthington, Joe A. Wrennall, Arunava Ghosh, Saira Ahmad, M. Flori Sassano, Robert Tarran

Physiol Rep. 2022 May; 10(10): e15306. Published online 2022 May 17. doi: 10.14814/phy2.15306

PMCID:: PMC9114653

Abstract Article PDF–2.0M

Select item 911374917.

Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

Tiantian Wei, Jue Wang, Ruqi Liang, Wendong Chen, Yilan Chen, Mingzhe Ma, An He, Yifei Du, Wenjing Zhou, Zhiying Zhang, Xin Zeng, Chu Wang, Jin Lu, Xing Guo, Xiao-Wei Chen, Youjun Wang, Ruijun Tian, Junyu Xiao, Xiaoguang Lei

eLife. 2022; 11: e77696. Published online 2022 Apr 19. doi: 10.7554/eLife.77696

PMCID:: PMC9113749

Abstract Article PDF–7.6M

Select item 901197618.

ORAI1 and STIM1 deficiency in human and mice: roles of store-operated Ca²⁺ entry in the immune system and beyond

Stefan Feske

Immunol Rev. Author manuscript; available in PMC 2022 Apr 15.

Published in final edited form as: Immunol Rev. 2009 Sep; 231(1): 189–209. doi: 10.1111/j.1600-065X.2009.00818.x

PMCID:: PMC9011976

Abstract Article PDF–1.3M

Select item 881289619.

Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality

Heba Shawer, Chew W. Cheng, Marc A. Bailey

PLoS One. 2022; 17(2): e0263303. Published online 2022 Feb 3. doi: 10.1371/journal.pone.0263303

PMCID:: PMC8812896

Abstract Article PDF–1.2M

Select item 873281320.

Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells

Jose Sanchez-Collado, Jose J. Lopez, Isaac Jardin, Alejandro Berna-Erro, Pedro J. Camello, Carlos Cantonero, Tarik Smani, Gines M. Salido, Juan A. Rosado

Cell Mol Life Sci. 2022 Jan; 79(1): 33. Published online 2022 Jan 6. doi: 10.1007/s00018-021-04098-w

PMCID:: PMC8732813

Abstract Article PDF–3.4M

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