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Select item 112510821.

Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis

Aaron L Moye, Antonella FM Dost, Robert Ietswaart, Shreoshi Sengupta, VanNashlee Ya, Chrystal Aluya, Caroline G Fahey, Sharon M Louie, Margherita Paschini, Carla F Kim

EMBO J. 2024 Jul; 43(14): 2843–2861. Published online 2024 May 16. doi: 10.1038/s44318-024-00113-5

PMCID:: PMC11251082

Abstract Article PDF–4.3M

Select item 108217202.

Integrin α3 promotes Th17 cell polarization and extravasation during autoimmune neuroinflammation.

Eunchong Park, William E. Barclay, Alejandro Barrera, Tzu-Chieh Liao, Harmony R. Salzler, Timothy E. Reddy, Mari L. Shinohara, Maria Ciofani

Sci Immunol. Author manuscript; available in PMC 2024 Jan 27.

Published in final edited form as: Sci Immunol. 2023 Oct 20; 8(88): eadg7597. Published online 2023 Oct 13. doi: 10.1126/sciimmunol.adg7597

PMCID:: PMC10821720

Abstract Article PDF–3.2M

Select item 107999033.

Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly

Emilie Murigneux, Laurent Softic, Corentin Aubé, Carmen Grandi, Delphine Judith, Johanna Bruce, Morgane Le Gall, François Guillonneau, Alain Schmitt, Vincent Parissi, Clarisse Berlioz-Torrent, Laurent Meertens, Maike M. K. Hansen, Sarah Gallois-Montbrun

Nat Commun. 2024; 15: 640. Published online 2024 Jan 20. doi: 10.1038/s41467-024-44958-0

PMCID:: PMC10799903

Abstract Article PDF–25M

Select item 102374224.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 97589495.

A novel lncRNA MDHDH suppresses glioblastoma multiforme by acting as a scaffold for MDH2 and PSMA1 to regulate NAD+ metabolism and autophagy

Dong He, Tao Xin, Bo Pang, Jun Sun, Zi Hao Liu, Zhen Qin, Xiao Shuai Ji, Fan Yang, Yan Bang Wei, Zi Xiao Wang, Jia Jia Gao, Qi Pang, Qian Liu

J Exp Clin Cancer Res. 2022; 41: 349. Published online 2022 Dec 17. doi: 10.1186/s13046-022-02543-7

PMCID:: PMC9758949

Abstract Article PDF–18M

Select item 92626146.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 92316237.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 86877688.

miRNA-144-5p/ITGA3 Suppressed the Tumor-Promoting Behaviors of Thyroid Cancer Cells by Downregulating ITGA3

Jizong Zhang, Yan Zhong, Yiming Sang, Guanghui Ren

Comput Math Methods Med. 2021; 2021: 9181941. Published online 2021 Dec 13. doi: 10.1155/2021/9181941

PMCID:: PMC8687768

Abstract Article PDF–1.9M

Select item 83529649.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 765653711.

Identification of integrin α3 as a molecular marker of cells undergoing epithelial–mesenchymal transition and of cancer cells with aggressive phenotypes

Takuya Shirakihara, Tomonori Kawasaki, Akihiko Fukagawa, Kentaro Semba, Ryuichi Sakai, Kohei Miyazono, Keiji Miyazawa, Masao Saitoh

Cancer Sci. 2013 Sep; 104(9): 1189–1197. Published online 2013 Jul 20. doi: 10.1111/cas.12220

PMCID:: PMC7656537

Abstract Article PDF–1.4M

Select item 765581912.

Paracoccidioides brasiliensis downmodulates α3 integrin levels in human lung epithelial cells in a TLR2-dependent manner

Bianca Carla Silva Campitelli de Barros, Bruna Rocha Almeida, Erika Suzuki

Sci Rep. 2020; 10: 19483. Published online 2020 Nov 10. doi: 10.1038/s41598-020-76557-6

PMCID:: PMC7655819

Abstract Article PDF–1.3M

Select item 759458613.

Expression and Prognostic Analyses of ITGA3, ITGA5, and ITGA6 in Head and Neck Squamous Cell Carcinoma

Chen Feng, Xiaoxue Jin, Yingying Han, Ruixiang Guo, Juanjuan Zou, Yanzhong Li, Yan Wang

Med Sci Monit. 2020; 26: e926800-1–e926800-18. Prepublished online 2020 Sep 3. Published online 2020 Oct 25. doi: 10.12659/MSM.926800

PMCID:: PMC7594586

Abstract Article PDF–5.3M

Select item 744146014.

TMT-Based Quantitative Proteomic Analysis Identification of Integrin Alpha 3 and Integrin Alpha 5 as Novel Biomarkers in Pathogenesis of Acute Aortic Dissection

Lingyu Xing, Yuan Xue, Yilin Yang, Ping Wu, Catherine C. L. Wong, Haojun Wang, Zhenju Song, Dongwei Shi, Chaoyang Tong, Chenling Yao, Guorong Gu

Biomed Res Int. 2020; 2020: 1068402. Published online 2020 Jul 2. doi: 10.1155/2020/1068402

PMCID:: PMC7441460

Abstract Article PDF–1.9M

Select item 741141115.

MicroRNA-199a-5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer

Lijun Tian, Mingtong Chen, Qiang He, Qiuliang Yan, Chunbao Zhai

Mol Med Rep. 2020 Sep; 22(3): 2307–2317. Published online 2020 Jul 10. doi: 10.3892/mmr.2020.11323

PMCID:: PMC7411411

Abstract Article PDF–1.6M

Select item 739249116.

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination

Gangliang Wang, Shuai Chen, Ziang Xie, Shuying Shen, Wenbin Xu, Wenxiang Chen, Xiang Li, Yizheng Wu, Liangping Li, Bin Liu, Xianjun Ding, An Qin, Shunwu Fan

Ann Rheum Dis. 2020 Aug; 79(8): 1111–1120. Published online 2020 May 14. doi: 10.1136/annrheumdis-2019-216911

PMCID:: PMC7392491

Abstract Article PDF–14M

Select item 732206717.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 711512818.

Targeting RICTOR sensitizes SMAD4-negative colon cancer to irinotecan

Chen Khuan Wong, Arthur William Lambert, Sait Ozturk, Panagiotis Papageorgis, Delia Lopez, Ning Shen, Zaina Sen, Hamid Mostafavi Abdolmaleky, Balázs Győrffy, Hui Feng, Sam Thiagalingam

Mol Cancer Res. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Mol Cancer Res. 2020 Mar; 18(3): 414–423. Published online 2020 Jan 13. doi: 10.1158/1541-7786.MCR-19-0525

PMCID:: PMC7115128

Abstract Article PDF–1.6M

Select item 709346219.

Anatomy of a viral entry platform differentially functionalized by integrins α3 and α6

Jérôme Finke, Snježana Mikuličić, Anna-Lena Loster, Alexander Gawlitza, Luise Florin, Thorsten Lang

Sci Rep. 2020; 10: 5356. Published online 2020 Mar 24. doi: 10.1038/s41598-020-62202-9

PMCID:: PMC7093462

Abstract Article PDF–12M

Select item 707979120.

Overexpression of HAb18G/CD147 promotes invasion and metastasis via α3β1 integrin mediated FAK-paxillin and FAK-PI3K-Ca²⁺ pathways

J. Tang, Y.-M. Wu, P. Zhao, X.-M. Yang, J.-L. Jiang, Z.-N. Chen

Cell Mol Life Sci. 2008 Sep; 65(18): 2933–2942. Published online 2008 Aug 11. doi: 10.1007/s00018-008-8315-8

PMCID:: PMC7079791

Abstract Article PDF–1.6M

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