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Select item 109098581.

AMPK stimulation inhibits YAP/TAZ signaling to ameliorate hepatic fibrosis

Mahbubul H. Shihan, Sachin Sharma, Carson Cable, Vijaya Prathigudupu, Alina Chen, Aras N. Mattis, Jennifer Y. Chen

Sci Rep. 2024; 14: 5205. Published online 2024 Mar 3. doi: 10.1038/s41598-024-55764-5

PMCID:: PMC10909858

Abstract Article PDF–1.6M

Select item 107017682.

TAZ facilitates breast tumor growth by promoting an immune‐suppressive tumor microenvironment

Anat Gershoni, Ori Hassin, Nishanth Belugali Nataraj, Sivan Baruch, Adi Avioz‐Seligman, Anna Chiara Pirona, Liat Fellus‐Alyagor, Tomer Meir Salame, Saptaparna Mukherjee, Giuseppe Mallel, Yosef Yarden, Yael Aylon, Moshe Oren

Mol Oncol. 2023 Dec; 17(12): 2675–2693. Published online 2023 Oct 16. doi: 10.1002/1878-0261.13525

PMCID:: PMC10701768

Abstract Article PDF–2.0M

Select item 103872373.

DELE1 is protective for mitochondrial cardiomyopathy

Helen Huynh, Siting Zhu, Sharon Lee, Yutong Bao, Jing Pang, Anh Nguyen, Yusu Gu, Chao Chen, Kunfu Ouyang, Sylvia M. Evans, Xi Fang

J Mol Cell Cardiol. Author manuscript; available in PMC 2023 Jul 30.

Published in final edited form as: J Mol Cell Cardiol. 2023 Feb; 175: 44–48. Published online 2022 Dec 17. doi: 10.1016/j.yjmcc.2022.12.003

PMCID:: PMC10387237

Abstract Article PDF–661K

Select item 102442224.

Genetic modifiers modulate phenotypic expression of tafazzin deficiency in a mouse model of Barth syndrome

Suya Wang, Erika Yazawa, Erin M Keating, Neil Mazumdar, Alexander Hauschild, Qing Ma, Haiyan Wu, Yang Xu, Xu Shi, Douglas Strathdee, Robert E Gerszten, Michael Schlame, William T Pu

Hum Mol Genet. 2023 Jun 15; 32(12): 2055–2067. Published online 2023 Mar 14. doi: 10.1093/hmg/ddad041

PMCID:: PMC10244222

Abstract Article PDF–2.3M

Select item 101323215.

Mice Deficient in TAZ (Wwtr1) Demonstrate Clinical Features of Late-Onset Fuchs’ Endothelial Corneal Dystrophy

Brian C. Leonard, Sangwan Park, Soohyun Kim, Laura J. Young, Iman Jalilian, Krista Cosert, Xunzhi Zhang, Jessica M. Skeie, Hanna Shevalye, Nayeli Echeverria, Vanessa Rozo, Xin Gong, Chao Xing, Christopher J. Murphy, Mark A. Greiner, V. Vinod Mootha, Vijay Krishna Raghunathan, Sara M. Thomasy

Invest Ophthalmol Vis Sci. 2023 Apr; 64(4): 22. Published online 2023 Apr 19. doi: 10.1167/iovs.64.4.22

PMCID:: PMC10132321

Abstract Article PDF–1.5M

Select item 95291886.

Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal Myofibroblasts in the Developing Mouse Kidney

Keri A. Drake, Christopher Chaney, Mohita Patel, Amrita Das, Julia Bittencourt, Martin Cohn, Thomas J. Carroll

J Am Soc Nephrol. 2022 Sep; 33(9): 1694–1707. Published online 2022 Sep. doi: 10.1681/ASN.2021121559

Correction in:: J Am Soc Nephrol. 2023 Mar; 34(3): 515–516.

PMCID:: PMC9529188

Abstract Article

Select item 95234917.

Mitochondrial stress induces an HRI-eIF2α pathway protective for cardiomyopathy

Siting Zhu, Anh Nguyen, Jing Pang, Jun Zhao, Ze’e Chen, Zhengyu Liang, Yusu Gu, Helen Huynh, Yutong Bao, Sharon Lee, Yuval Kluger, Kunfu Ouyang, Sylvia M Evans, Xi Fang

Circulation. Author manuscript; available in PMC 2023 Sep 27.

Published in final edited form as: Circulation. 2022 Sep 27; 146(13): 1028–1031. Published online 2022 Sep 26. doi: 10.1161/CIRCULATIONAHA.122.059594

PMCID:: PMC9523491

Article PDF–1016K

Select item 90439418.

A new murine model of Barth syndrome neutropenia links TAFAZZIN deficiency to increased ER stress-induced apoptosis

Jihee Sohn, Jelena Milosevic, Thomas Brouse, Najihah Aziz, Jenna Elkhoury, Suya Wang, Alexander Hauschild, Nick van Gastel, Murat Cetinbas, Sara F. Tufa, Douglas R. Keene, Ruslan I. Sadreyev, William T. Pu, David B. Sykes

Blood Adv. 2022 Apr 26; 6(8): 2557–2577. Published online 2022 Apr 21. doi: 10.1182/bloodadvances.2021005720

PMCID:: PMC9043941

Abstract Article PDF–6.0M

Select item 88764279.

Myofibroblast YAP/TAZ activation is a key step in organ fibrogenesis

Xiaolin He, Monica F. Tolosa, Tianzhou Zhang, Santosh Kumar Goru, Luisa Ulloa Severino, Paraish S. Misra, Caitríona M. McEvoy, Lauren Caldwell, Stephen G. Szeto, Feng Gao, Xiaolan Chen, Cassandra Atin, Victoria Ki, Noah Vukosa, Catherine Hu, Johnny Zhang, Christopher Yip, Adriana Krizova, Jeffrey L. Wrana, Darren A. Yuen

JCI Insight. 2022 Feb 22; 7(4): e146243. Published online 2022 Feb 22. doi: 10.1172/jci.insight.146243

PMCID:: PMC8876427

Abstract Article PDF–28M

Select item 849273310.

TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway

Hai-Fan Yu, Lian-Wen Zheng, Zhan-Qing Yang, Yu-Si Wang, Ting-Ting Wang, Zhan-Peng Yue, Bin Guo

Exp Mol Med. 2021 Sep; 53(9): 1307–1318. Published online 2021 Sep 8. doi: 10.1038/s12276-021-00655-2

PMCID:: PMC8492733

Abstract Article PDF–7.4M

Select item 821045911.

Cardiolipin remodeling defects impair mitochondrial architecture and function in a murine model of Barth syndrome cardiomyopathy

Siting Zhu, Ze’e Chen, Mason Zhu, Ying Shen, Leonardo J Leon, Liguo Chi, Simone Spinozzi, Changming Tan, Yusu Gu, Anh Nguyen, Yi Zhou, Wei Feng, Frédéric M Vaz, Xiaohong Wang, Asa B Gustafsson, Sylvia M Evans, Ouyang Kunfu, Xi Fang

Circ Heart Fail. Author manuscript; available in PMC 2022 Jun 15.

Published in final edited form as: Circ Heart Fail. 2021 Jun; 14(6): e008289. Published online 2021 Jun 15. doi: 10.1161/CIRCHEARTFAILURE.121.008289

PMCID:: PMC8210459

Abstract Article PDF–2.9M

Select item 819728612.

Tafazzin Deficiency Reduces Basal Insulin Secretion and Mitochondrial Function in Pancreatic Islets From Male Mice

Laura K Cole, Prasoon Agarwal, Christine A Doucette, Mario Fonseca, Bo Xiang, Genevieve C Sparagna, Nivedita Seshadri, Marilyne Vandel, Vernon W Dolinsky, Grant M Hatch

Endocrinology. 2021 Jul; 162(7): bqab102. Published online 2021 May 21. doi: 10.1210/endocr/bqab102

PMCID:: PMC8197286

Abstract Article

Select item 789451313.

Cardiolipin deficiency in Barth syndrome is not associated with increased superoxide/H₂O₂ production in heart and skeletal muscle mitochondria

Renata L. S. Goncalves, Michael Schlame, Alexander Bartelt, Martin D. Brand, Gökhan S. Hotamışlıgil

FEBS Lett. 2021 Feb; 595(3): 415–432. Published online 2020 Nov 19. doi: 10.1002/1873-3468.13973

PMCID:: PMC7894513

Abstract Article PDF–3.6M

Select item 787151014.

YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression

Huapeng Li, Qi Li, Kyvan Dang, Shan Ma, Jennifer L. Cotton, Sun Yang, Lihua J. Zhu, April C. Deng, Y. Tony Ip, Randy L. Johnson, Xu Wu, Claudio Punzo, Junhao Mao

Cell Rep. Author manuscript; available in PMC 2021 Feb 9.

Published in final edited form as: Cell Rep. 2019 Dec 3; 29(10): 3200–3211.e4. doi: 10.1016/j.celrep.2019.03.021

PMCID:: PMC7871510

Abstract Article PDF–2.5M

Select item 778768115.

Single-cell transcriptome landscape of ovarian cells during primordial follicle assembly in mice

Jun-Jie Wang, Wei Ge, Qiu-Yue Zhai, Jing-Cai Liu, Xiao-Wen Sun, Wen-Xiang Liu, Lan Li, Chu-Zhao Lei, Paul W. Dyce, Massimo De Felici, Wei Shen

PLoS Biol. 2020 Dec; 18(12): e3001025. Published online 2020 Dec 22. doi: 10.1371/journal.pbio.3001025

PMCID:: PMC7787681

Abstract Article PDF–6.2M

Select item 775862616.

YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling

Boksik Cha, Yen-Chun Ho, Xin Geng, Md. Riaj Mahamud, Lijuan Chen, Yeunhee Kim, Dongwon Choi, Tae Hoon Kim, Gwendalyn J. Randolph, Xinwei Cao, Hong Chen, R. Sathish Srinivasan

Development. 2020 Dec 1; 147(23): dev195453. Published online 2020 Dec 13. doi: 10.1242/dev.195453

PMCID:: PMC7758626

Abstract Article

Select item 772110417.

Dynamic Cardiolipin Synthesis Is Required for CD8⁺ T Cell Immunity

Mauro Corrado, Joy Edwards-Hicks, Matteo Villa, Lea J. Flachsmann, David E. Sanin, Maaike Jacobs, Francesc Baixauli, Michal Stanczak, Eve Anderson, Mai Azuma, Andrea Quintana, Jonathan D. Curtis, Thomas Clapes, Katarzyna M. Grzes, Agnieszka M. Kabat, Ryan Kyle, Annette E. Patterson, Ramon Klein Geltink, Borko Amulic, Colin G. Steward, Douglas Strathdee, Eirini Trompouki, David O’Sullivan, Edward J. Pearce, Erika L. Pearce

Cell Metab. 2020 Dec 1; 32(6): 981–995.e7. doi: 10.1016/j.cmet.2020.11.003

PMCID:: PMC7721104

Abstract Article

Select item 760093018.

TAZ Represses the Neuronal Commitment of Neural Stem Cells

Natalia Robledinos-Antón, Maribel Escoll, Kun-Liang Guan, Antonio Cuadrado

Cells. 2020 Oct; 9(10): 2230. Published online 2020 Oct 2. doi: 10.3390/cells9102230

PMCID:: PMC7600930

Abstract Article PDF–8.8M

Select item 745880719.

Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria

Catherine H. Le, Lindsay G. Benage, Kalyn S. Specht, Lance C. Li Puma, Christopher M. Mulligan, Adam L. Heuberger, Jessica E. Prenni, Steven M. Claypool, Kathryn C. Chatfield, Genevieve C. Sparagna, Adam J. Chicco

J Biol Chem. 2020 Aug 28; 295(35): 12485–12497. Published online 2020 Jul 14. doi: 10.1074/jbc.RA119.011229

PMCID:: PMC7458807

Abstract Article PDF–2.5M

Select item 723310920.

AAV Gene Therapy Prevents and Reverses Heart Failure in A Murine Knockout Model of Barth Syndrome

Suya Wang, Yifei Li, Yang Xu, Qing Ma, Zhiqiang Lin, Michael Schlame, Vassilios Bezzerides, Douglas Strathdee, William Pu

Circ Res. Author manuscript; available in PMC 2021 Apr 10.

Published in final edited form as: Circ Res. 2020 Apr 10; 126(8): 1024–1039. Published online 2020 Mar 9. doi: 10.1161/CIRCRESAHA.119.315956

PMCID:: PMC7233109

Abstract Article PDF–1.6M

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