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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 104494132.

Mouse Testicular Mkrn3 Expression Is Primarily Interstitial, Increases Peripubertally, and Is Responsive to LH/hCG

Sidney A Pereira, Fernanda C B Oliveira, Lydie Naulé, Carine Royer, Francisco A R Neves, Ana Paula Abreu, Rona S Carroll, Ursula B Kaiser, Michella S Coelho, Adriana Lofrano-Porto

Endocrinology. 2023 Sep; 164(9): bqad123. Published online 2023 Aug 16. doi: 10.1210/endocr/bqad123

PMCID:: PMC10449413

Abstract Article

Select item 102438073.

MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity

Lydie Naulé, Alessandra Mancini, Sidney A. Pereira, Brandon M. Gassaway, John R. Lydeard, John C. Magnotto, Han Kyeol Kim, Joy Liang, Cynara Matos, Steven P. Gygi, Florian T. Merkle, Rona S. Carroll, Ana Paula Abreu, Ursula B. Kaiser

JCI Insight. 2023 Apr 24; 8(8): e164178. Published online 2023 Apr 24. doi: 10.1172/jci.insight.164178

PMCID:: PMC10243807

Abstract Article PDF–9.5M

Select item 102332974.

Hypothalamic Overexpression of Makorin Ring Finger Protein 3 Results in Delayed Puberty in Female Mice

Stephanie A Roberts, Lydie Naulé, Soukayna Chouman, Tatyana Johnson, Marciana Johnson, Rona S Carroll, Victor M Navarro, Ursula B Kaiser

Endocrinology. 2022 Nov; 163(11): bqac132. Published online 2022 Aug 17. doi: 10.1210/endocr/bqac132

PMCID:: PMC10233297

Abstract Article

Select item 98801545.

Methylation status of hypothalamic Mkrn3 promoter across puberty

Pavlos Fanis, Maria Morrou, Marios Tomazou, Kyriaki Michailidou, George M. Spyrou, Meropi Toumba, Nicos Skordis, Vassos Neocleous, Leonidas A. Phylactou

Front Endocrinol (Lausanne) 2022; 13: 1075341. Published online 2023 Jan 13. doi: 10.3389/fendo.2022.1075341

PMCID:: PMC9880154

Abstract Article PDF–4.9M

Select item 82888666.

MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3

Chuanyin Li, Wenli Lu, Liguang Yang, Zhengwei Li, Xiaoyi Zhou, Rong Guo, Junqi Wang, Zhebao Wu, Zhiya Dong, Guang Ning, Yujiang Shi, Yinmin Gu, Peng Chen, Zijian Hao, Tianting Han, Meiqiang Yang, Wei Wang, Xuehui Huang, Yixue Li, Shan Gao, Ronggui Hu

Natl Sci Rev. 2020 Mar; 7(3): 671–685. Published online 2020 Feb 14. doi: 10.1093/nsr/nwaa023

PMCID:: PMC8288866

Abstract Article PDF–2.2M

Select item 82179677.

E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non–small cell lung cancer

Ke Li, Xufen Zheng, Hua Tang, Yuan-Sheng Zang, Chunling Zeng, Xiaoxiao Liu, Yanying Shen, Yuzhi Pang, Simin Wang, Feifei Xie, Xiaojing Lu, Yuxiang Luo, Zhang Li, Wenbo Bi, Xiaona Jia, Tao Huang, Rongqiang Wei, Kenan Huang, Zihao Chen, Qingchen Zhu, Yi He, Miaoying Zhang, Zhizhan Gu, Yichuan Xiao, Xiaoyang Zhang, Jonathan A. Fletcher, Yuexiang Wang

J Exp Med. 2021 Aug 2; 218(8): e20210151. Published online 2021 Jun 18. doi: 10.1084/jem.20210151

PMCID:: PMC8217967

Abstract Article PDF–6.6M

Select item 80531118.

MKRN3-mediated ubiquitination of Poly(A)-binding proteins modulates the stability and translation of GNRH1 mRNA in mammalian puberty

Chuanyin Li, Tianting Han, Qingrun Li, Menghuan Zhang, Rong Guo, Yun Yang, Wenli Lu, Zhengwei Li, Chao Peng, Ping Wu, Xiaoxu Tian, Qinqin Wang, Yuexiang Wang, Vincent Zhou, Ziyan Han, Hecheng Li, Feng Wang, Ronggui Hu

Nucleic Acids Res. 2021 Apr 19; 49(7): 3796–3813. Published online 2021 Mar 21. doi: 10.1093/nar/gkab155

PMCID:: PMC8053111

Abstract Article PDF–3.8M

Select item 74100469.

MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons

Ana Paula Abreu, Carlos A. Toro, Yong Bhum Song, Victor M. Navarro, Martha A. Bosch, Aysegul Eren, Joy N. Liang, Rona S. Carroll, Ana Claudia Latronico, Oline K. Rønnekleiv, Carlos F. Aylwin, Alejandro Lomniczi, Sergio Ojeda, Ursula B. Kaiser

J Clin Invest. 2020 Aug 3; 130(8): 4486–4500. Published online 2020 Jul 20. doi: 10.1172/JCI136564

PMCID:: PMC7410046

Abstract Article PDF–7.1M

Select item 636209510.

Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development

Katarína Tiklová, Åsa K. Björklund, Laura Lahti, Alessandro Fiorenzano, Sara Nolbrant, Linda Gillberg, Nikolaos Volakakis, Chika Yokota, Markus M. Hilscher, Thomas Hauling, Fredrik Holmström, Eliza Joodmardi, Mats Nilsson, Malin Parmar, Thomas Perlmann

Nat Commun. 2019; 10: 581. Published online 2019 Feb 4. doi: 10.1038/s41467-019-08453-1

PMCID:: PMC6362095

Abstract Article PDF–4.6M

Select item 598857911.

Imprinted gene Zinc finger protein 127 is a novel regulator of master pluripotency transcription factor, Oct4

Yoo-Wook Kwon, Hyo-Suk Ahn, Joo-Young Park, Han-Mo Yang, Hyun-Jai Cho, Hyo-Soo Kim

BMB Rep. 2018 May; 51(5): 242–248. Published online 2018 May 31. doi: 10.5483/BMBRep.2018.51.5.196

PMCID:: PMC5988579

Abstract Article PDF–5.5M

Select item 568959612.

Mkrn3 functions as a novel ubiquitin E3 ligase to inhibit Nptx1 during puberty initiation

Huifang Liu, Xiangxin Kong, Fengling Chen

Oncotarget. 2017 Oct 17; 8(49): 85102–85109. Published online 2017 Jul 18. doi: 10.18632/oncotarget.19347

PMCID:: PMC5689596

Abstract Article PDF–3.0M

Select item 375390813.

Epigenetic Functions of Smchd1 Repress Gene Clusters on the Inactive X Chromosome and on Autosomes

Anne-Valerie Gendrel, Y. Amy Tang, Masako Suzuki, Jonathan Godwin, Tatyana B. Nesterova, John M. Greally, Edith Heard, Neil Brockdorff

Mol Cell Biol. 2013 Aug; 33(16): 3150–3165. doi: 10.1128/MCB.00145-13

PMCID:: PMC3753908

Abstract Article PDF–3.9M

Select item 370782214.

Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation

Arne W Mould, Zhenyi Pang, Miha Pakusch, Ian D Tonks, Mitchell Stark, Dianne Carrie, Pamela Mukhopadhyay, Annica Seidel, Jonathan J Ellis, Janine Deakin, Matthew J Wakefield, Lutz Krause, Marnie E Blewitt, Graham F Kay

Epigenetics Chromatin. 2013; 6: 19. Published online 2013 Jul 2. doi: 10.1186/1756-8935-6-19

PMCID:: PMC3707822

Abstract Article PDF–3.7M

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 309397316.

Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome

Mihaela Stefan, Rebecca A. Simmons, Suzanne Bertera, Massimo Trucco, Farzad Esni, Peter Drain, Robert D. Nicholls

Am J Physiol Endocrinol Metab. 2011 May; 300(5): E909–E922. Published online 2011 Feb 22. doi: 10.1152/ajpendo.00185.2010

PMCID:: PMC3093973

Abstract Article

Select item 302253417.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582