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Select item 114113391.

In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells

Ioannis Oikonomakos, Melina Tedesco, Fariba Jian Motamedi, Mirko Peitzsch, Serge Nef, Stefan R. Bornstein, Andreas Schedl, Charlotte Steenblock, Yasmine Neirijnck

Stem Cell Reports. 2024 Sep 10; 19(9): 1289–1303. Published online 2024 Aug 22. doi: 10.1016/j.stemcr.2024.07.010

PMCID:: PMC11411339

Abstract Article PDF–5.7M

Select item 110765932.

Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster

Alicia Hurtado, Irene Mota-Gómez, Miguel Lao, Francisca M. Real, Johanna Jedamzick, Miguel Burgos, Darío G. Lupiáñez, Rafael Jiménez, Francisco J. Barrionuevo

Nat Commun. 2024; 15: 3809. Published online 2024 May 7. doi: 10.1038/s41467-024-47658-x

PMCID:: PMC11076593

Abstract Article PDF–4.4M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 105057324.

Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure

Penny A. F. Whiley, Michael C. M. Luu, Liza O’Donnell, David J. Handelsman, Kate L. Loveland

Front Endocrinol (Lausanne) 2023; 14: 1234712. Published online 2023 Sep 1. doi: 10.3389/fendo.2023.1234712

PMCID:: PMC10505732

Abstract Article PDF–9.9M

Select item 104875155.

FXR Maintains the Intestinal Barrier and Stemness by Regulating CYP11A1-Mediated Corticosterone Synthesis in Biliary Obstruction Diseases

Zequn Li, Haijiang Dong, Suchen Bian, Hao Wu, Wenfeng Song, Xing Jia, Jian Chen, Xingxin Zhu, Long Zhao, Zefeng Xuan, Cheng Jin, Mengqiao Zhou, Shusen Zheng, Penghong Song

Int J Mol Sci. 2023 Sep; 24(17): 13494. Published online 2023 Aug 30. doi: 10.3390/ijms241713494

PMCID:: PMC10487515

Abstract Article PDF–4.4M

Select item 104107176.

Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve

Camilla H. K. Hughes, Olivia E. Smith, Marie-Charlotte Meinsohn, Mylène Brunelle, Nicolas Gévry, Bruce D. Murphy

Proc Natl Acad Sci U S A. 2023 Aug 8; 120(32): e2220849120. Published online 2023 Jul 26. doi: 10.1073/pnas.2220849120

PMCID:: PMC10410717

Abstract Article PDF–3.9M

Select item 100177037.

Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions

Xiaowei Gu, Anna Heinrich, Shu-Yun Li, Tony DeFalco

Nat Commun. 2023; 14: 1439. Published online 2023 Mar 15. doi: 10.1038/s41467-023-37199-0

PMCID:: PMC10017703

Abstract Article PDF–16M

Select item 99505158.

Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age

Jorge Lopez-Tello, Amanda N. Sferruzzi-Perri

Front Endocrinol (Lausanne) 2023; 14: 1116770. Published online 2023 Feb 10. doi: 10.3389/fendo.2023.1116770

PMCID:: PMC9950515

Abstract Article PDF–4.2M

Select item 93380409.

TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway

Moïra Rossitto, Stephanie Déjardin, Chris M. Rands, Stephanie Le Gras, Roberta Migale, Mahmoud-Reza Rafiee, Yasmine Neirijnck, Alain Pruvost, Anvi Laetitia Nguyen, Guillaume Bossis, Florence Cammas, Lionel Le Gallic, Dagmar Wilhelm, Robin Lovell-Badge, Brigitte Boizet-Bonhoure, Serge Nef, Francis Poulat

Nat Commun. 2022; 13: 4412. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32061-1

PMCID:: PMC9338040

Abstract Article PDF–11M

Select item 932773710.

Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice

Esteban Salazar-Petres, Daniela Pereira-Carvalho, Jorge Lopez-Tello, Amanda Nancy Sferruzzi-Perri

Biol Reprod. 2022 Jun; 106(6): 1292–1311. Published online 2022 Mar 16. doi: 10.1093/biolre/ioac056

PMCID:: PMC9327737

Abstract Article PDF–3.0M

Select item 920030711.

Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice

Alejo Torres-Cano, Rosa Portella-Fortuny, Claudia Müller-Sánchez, Sonia Porras-Marfil, Marina Ramiro-Pareta, You-Ying Chau, Manuel Reina, Francesc X. Soriano, Ofelia M. Martínez-Estrada

PLoS Genet. 2022 Jun; 18(6): e1010240. Published online 2022 Jun 15. doi: 10.1371/journal.pgen.1010240

PMCID:: PMC9200307

Abstract Article PDF–4.3M

Select item 886401612.

Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling

Mengying Liu, Wenbo Deng, Lu Tang, Meng Liu, Haili Bao, Chuanhui Guo, Changxian Zhang, Jinhua Lu, Haibin Wang, Zhongxian Lu, Shuangbo Kong

Nat Commun. 2022; 13: 1006. Published online 2022 Feb 22. doi: 10.1038/s41467-022-28657-2

PMCID:: PMC8864016

Abstract Article PDF–9.7M

Select item 884375313.

Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse

Vijay K. Yadav, Julian M. Berger, Parminder Singh, Perumal Nagarajan, Gerard Karsenty

J Clin Invest. 2022 Feb 15; 132(4): e153752. Published online 2022 Feb 15. doi: 10.1172/JCI153752

PMCID:: PMC8843753

Abstract Article PDF–4.9M

Select item 878692914.

Loss of NEDD4 causes complete XY gonadal sex reversal in mice

Simon P. Windley, Chloé Mayère, Alice E. McGovern, Natasha L. Harvey, Serge Nef, Quenten Schwarz, Sharad Kumar, Dagmar Wilhelm

Cell Death Dis. 2022 Jan; 13(1): 75. Published online 2022 Jan 24. doi: 10.1038/s41419-022-04519-z

PMCID:: PMC8786929

Abstract Article PDF–16M

Select item 857083115.

Sexually Dimorphic Neurosteroid Synthesis Regulates Neuronal Activity in the Murine Brain

Philipp Wartenberg, Imre Farkas, Veronika Csillag, William H. Colledge, Erik Hrabovszky, Ulrich Boehm

J Neurosci. 2021 Nov 3; 41(44): 9177–9191. doi: 10.1523/JNEUROSCI.0885-21.2021

PMCID:: PMC8570831

Abstract Article PDF–9.6M

Select item 829986616.

Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility and metabolic homeostasis in female mice

Emmi Rotgers, Barbara Nicol, Karina Rodriguez, Saniya Rattan, Jodi A. Flaws, Humphrey Hung-Chang Yao

FASEB J. Author manuscript; available in PMC 2022 Aug 1.

Published in final edited form as: FASEB J. 2021 Aug; 35(8): e21770. doi: 10.1096/fj.202100304R

PMCID:: PMC8299866

Abstract Article PDF–2.6M

Select item 820637717.

Fatty acids suppress the steroidogenesis of the MA-10 mouse Leydig cell line by downregulating CYP11A1 and inhibiting late-stage autophagy

Chien Huang, Hsiu-Ju Hsu, Mu-En Wang, Meng-Chieh Hsu, Leang-Shin Wu, De-Shien Jong, Yi-Fan Jiang, Chih-Hsien Chiu

Sci Rep. 2021; 11: 12561. Published online 2021 Jun 15. doi: 10.1038/s41598-021-92008-2

PMCID:: PMC8206377

Abstract Article PDF–1.9M

Select item 790485818.

The conditional deletion of steroidogenic factor 1 (Nr5a1) in Sox9-Cre mice compromises testis differentiation

Yayoi Ikeda, Ayako Tagami, Mamiko Maekawa, Akiko Nagai

Sci Rep. 2021; 11: 4486. Published online 2021 Feb 24. doi: 10.1038/s41598-021-84095-y

PMCID:: PMC7904858

Abstract Article PDF–5.1M

Select item 787391719.

Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity

Anne-Louise Gannon, Laura O’Hara, Ian J. Mason, Anne Jørgensen, Hanne Frederiksen, Michael Curley, Laura Milne, Sarah Smith, Rod T. Mitchell, Lee B. Smith

Front Endocrinol (Lausanne) 2020; 11: 599869. Published online 2021 Jan 21. doi: 10.3389/fendo.2020.599869

PMCID:: PMC7873917

Abstract Article PDF–9.8M

Select item 771707220.

Antifibrogenic Activities of CYP11A1-derived Vitamin D3-hydroxyderivatives Are Dependent on RORγ

Zorica Janjetovic, Arnold Postlethwaite, Hong Soon Kang, Tae-Kang Kim, Robert C Tuckey, David K Crossman, Shariq Qayyum, Anton M Jetten, Andrzej T Slominski

Endocrinology. 2021 Jan; 162(1): bqaa198. Published online 2020 Oct 27. doi: 10.1210/endocr/bqaa198

PMCID:: PMC7717072

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