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Select item 103458551.

EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts

Ji Wu, Kenta Moriwaki, Tatsuya Asuka, Ritsuko Nakai, Satoshi Kanda, Manabu Taniguchi, Tatsuki Sugiyama, Shin-ichiro Yoshimura, Masataka Kunii, Takashi Nagasawa, Naoki Hosen, Eiji Miyoshi, Akihiro Harada

Blood Adv. 2023 Jul 25; 7(14): 3382–3394. Published online 2023 Apr 14. doi: 10.1182/bloodadvances.2022008930

Correction in:: Blood Adv. 2024 Mar 12; 8(5): 1151.

PMCID:: PMC10345855

Abstract Article PDF–5.8M

Select item 99363062.

Regulation of iron homeostasis by hepatocyte TfR1 requires HFE and contributes to hepcidin suppression in β-thalassemia

Xia Xiao, Gillian A. Moschetta, Yang Xu, Allison L. Fisher, Víctor M. Alfaro-Magallanes, Som Dev, Chia-Yu Wang, Jodie L. Babitt

Blood. 2023 Jan 26; 141(4): 422–432. Published online 2022 Nov 4. doi: 10.1182/blood.2022017811

PMCID:: PMC9936306

Abstract Article

Select item 96038603.

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3

Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany

Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527

PMCID:: PMC9603860

Abstract Article PDF–3.4M

Select item 91402864.

High phosphate intake induces bone loss in nephrectomized thalassemic mice

Sasithorn Wanna-udom, Chainarong Luesiripong, Nithidol Sakunrangsit, Piyanuch Metheepakornchai, Sitthichai Intharamonthian, Saovaros Svasti, Matthew B. Greenblatt, Asada Leelahavanichkul, Sutada Lotinun

PLoS One. 2022; 17(5): e0268732. Published online 2022 May 27. doi: 10.1371/journal.pone.0268732

PMCID:: PMC9140286

Abstract Article PDF–3.5M

Select item 90626595.

Interactome and Ubiquitinome Analyses Identify Functional Targets of Herpes Simplex Virus 1 Infected Cell Protein 0

Fujun Hou, Zeyu Sun, Yue Deng, Siyu Chen, Xiyuan Yang, Feiyang Ji, Menghao Zhou, Keyi Ren, Dongli Pan

Front Microbiol. 2022; 13: 856471. Published online 2022 Apr 18. doi: 10.3389/fmicb.2022.856471

PMCID:: PMC9062659

Abstract Article PDF–3.5M

Select item 89938756.

Mild-intensity physical activity prevents cardiac and osseous iron deposition without affecting bone mechanical property or porosity in thalassemic mice

Narattaphol Charoenphandhu, Supagarn Sooksawanwit, Ratchaneevan Aeimlapa, Natchayaporn Thonapan, Pornpailin Upanan, Punyanuch Adulyaritthikul, Saowalak Krungchanuchat, Nattapon Panupinthu, Jarinthorn Teerapornpuntakit, Catleya Rojviriya, Kornkamon Lertsuwan, Saovaros Svasti, Kannikar Wongdee

Sci Rep. 2022; 12: 5959. Published online 2022 Apr 8. doi: 10.1038/s41598-022-09997-x

PMCID:: PMC8993875

Abstract Article PDF–1.9M

Select item 83479367.

A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis

Chun-Hao Hung, Tung-Liang Lee, Anna Yu-Szu Huang, Kang-Chung Yang, Yu-Chiau Shyu, Shau-Ching Wen, Mu-Jie Lu, Shinsheng Yuan, Che-Kun James Shen

Int J Mol Sci. 2021 Aug; 22(15): 8024. Published online 2021 Jul 27. doi: 10.3390/ijms22158024

PMCID:: PMC8347936

Abstract Article PDF–4.4M

Select item 83425518.

Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity

Alexander Mattebo, Taha Sen, Maria Jassinskaja, Kristýna Pimková, Isabel Prieto González-Albo, Abdul Ghani Alattar, Ramprasad Ramakrishnan, Stefan Lang, Marcus Järås, Jenny Hansson, Shamit Soneji, Sofie Singbrant, Emile van den Akker, Johan Flygare

Sci Rep. 2021; 11: 15898. Published online 2021 Aug 5. doi: 10.1038/s41598-021-95291-1

PMCID:: PMC8342551

Abstract Article PDF–2.5M

Select item 82054829.

The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry

Melanie Castro-Mollo, Sakshi Gera, Marc Ruiz-Martinez, Maria Feola, Anisa Gumerova, Marina Planoutene, Cara Clementelli, Veena Sangkhae, Carla Casu, Se-Min Kim, Vaughn Ostland, Huiling Han, Elizabeta Nemeth, Robert Fleming, Stefano Rivella, Daria Lizneva, Tony Yuen, Mone Zaidi, Yelena Ginzburg

eLife. 2021; 10: e68217. Published online 2021 May 18. doi: 10.7554/eLife.68217

PMCID:: PMC8205482

Abstract Article PDF–3.3M

Select item 818038010.

ZNF410 represses fetal globin by singular control of CHD4

Divya S. Vinjamur, Qiuming Yao, Mitchel A. Cole, Connor McGuckin, Chunyan Ren, Jing Zeng, Mir Hossain, Kevin Luk, Scot A. Wolfe, Luca Pinello, Daniel E. Bauer

Nat Genet. Author manuscript; available in PMC 2022 May 1.

Published in final edited form as: Nat Genet. 2021 May; 53(5): 719–728. Published online 2021 Apr 15. doi: 10.1038/s41588-021-00843-w

PMCID:: PMC8180380

Abstract Article PDF–2.1M

Select item 812152611.

The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model

Alessandro Matte, Enrica Federti, Charles Kung, Penelope A. Kosinski, Rohini Narayanaswamy, Roberta Russo, Giorgia Federico, Francesca Carlomagno, Maria Andrea Desbats, Leonardo Salviati, Christophe Leboeuf, Maria Teresa Valenti, Francesco Turrini, Anne Janin, Shaoxia Yu, Elisabetta Beneduce, Sebastien Ronseaux, Iana Iatcenko, Lenny Dang, Tomas Ganz, Chun-Ling Jung, Achille Iolascon, Carlo Brugnara, Lucia De Franceschi

J Clin Invest. 2021 May 17; 131(10): e144206. Published online 2021 May 17. doi: 10.1172/JCI144206

PMCID:: PMC8121526

Abstract Article PDF–6.3M

Select item 809321212.

Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation

Maria Feola, Andrea Zamperone, Daniel Moskop, Huiyong Chen, Carla Casu, Dechen Lama, Julie Di Martino, Mansour Djedaini, Luena Papa, Marc Ruiz Martinez, Tenzin Choesang, Jose Javier Bravo-Cordero, Matthew MacKay, Paul Zumbo, Nathan Brinkman, Charles S. Abrams, Stefano Rivella, Shilpa Hattangadi, Christopher E. Mason, Ronald Hoffman, Peng Ji, Antonia Follenzi, Yelena Z. Ginzburg

Commun Biol. 2021; 4: 517. Published online 2021 May 3. doi: 10.1038/s42003-021-02046-9

PMCID:: PMC8093212

Abstract Article PDF–3.3M

Select item 803442913.

Crystal structure of hemoglobin from mouse (Mus musculus) compared with those from other small animals and humans

Selvarajan Sigamani Sundaresan, Pandian Ramesh, Nagaraj Shobana, Thangaraj Vinuchakkaravarthy, Sayed Yasien, Mondikalipudur Nanjappa Gounder Ponnuswamy

Acta Crystallogr F Struct Biol Commun. 2021 Apr 1; 77(Pt 4): 113–120. Published online 2021 Apr 1. doi: 10.1107/S2053230X2100306X

PMCID:: PMC8034429

Abstract Article PDF–2.4M

Select item 792801514.

NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice

Antonella Nai, Maria Rosa Lidonnici, Giorgia Federico, Mariateresa Pettinato, Violante Olivari, Federica Carrillo, Simonetta Geninatti Crich, Giuliana Ferrari, Clara Camaschella, Laura Silvestri, Francesca Carlomagno

Haematologica. 2021 Mar 1; 106(3): 795–805. Published online 2020 Feb 27. doi: 10.3324/haematol.2019.241232

PMCID:: PMC7928015

Abstract Article PDF–2.1M

Select item 754753315.

Hematopoietic stem cell function in β-thalassemia is impaired and is rescued by targeting the bone marrow niche

Annamaria Aprile, Alessandro Gulino, Mariangela Storto, Isabella Villa, Stefano Beretta, Ivan Merelli, Alessandro Rubinacci, Maurilio Ponzoni, Sarah Marktel, Claudio Tripodo, Maria Rosa Lidonnici, Giuliana Ferrari

Blood. 2020 Jul 30; 136(5): 610–622. Prepublished online 2020 Apr 28. doi: 10.1182/blood.2019002721

PMCID:: PMC7547533

Abstract Article

Select item 752066316.

Heparanase Level and Procoagulant Activity Are Increased in Thalassemia and Attenuated by Janus Kinase 2 Inhibition

Hussam Ghoti, Shanny Ackerman, Stefano Rivella, Carla Casu, Yona Nadir

Am J Pathol. 2020 Oct; 190(10): 2146–2154. doi: 10.1016/j.ajpath.2020.07.011

PMCID:: PMC7520663

Abstract Article PDF–1.5M

Select item 730196617.

POGZ Is Required for Silencing Mouse Embryonic β-like Hemoglobin and Human Fetal Hemoglobin Expression

Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Kimberly D. Klarmann, Satyendra K. Singh, Lei Sun, Shweta Singh, Yang Du, Vincenzo Coppola, Luke Stockwin, Nhu Nguyen, Lino Tessarollo, Leifur Thorsteinsson, Olafur E. Sigurjonsson, Sveinn Gudmundsson, Thorunn Rafnar, John F. Tisdale, Jonathan R. Keller

Cell Rep. Author manuscript; available in PMC 2020 Jun 18.

Published in final edited form as: Cell Rep. 2018 Jun 12; 23(11): 3236–3248. doi: 10.1016/j.celrep.2018.05.043

PMCID:: PMC7301966

Abstract Article PDF–2.2M

Select item 729503318.

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant

Meagan A. Quinlan, Matthew J. Robson, Ran Ye, Kristie L. Rose, Kevin L. Schey, Randy D. Blakely

Front Mol Neurosci. 2020; 13: 89. Published online 2020 Jun 8. doi: 10.3389/fnmol.2020.00089

PMCID:: PMC7295033

Abstract Article PDF–2.7M

Select item 721095419.

Nephrectomy Does not Exacerbate Cancellous Bone loss in Thalassemic Mice

Sutada Lotinun, Korakot Atjanasuppat, Jutatip Limsuvech, Asada Leelahavanichkul, Saovaros Svasti, Nateetip Krishnamra

Sci Rep. 2020; 10: 7786. Published online 2020 May 8. doi: 10.1038/s41598-020-64681-2

PMCID:: PMC7210954

Abstract Article PDF–4.6M

Select item 704659820.

Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia

João Arezes, Niall Foy, Kirsty McHugh, Doris Quinkert, Susan Benard, Anagha Sawant, Joe N. Frost, Andrew E. Armitage, Sant-Rayn Pasricha, Pei Jin Lim, May S. Tam, Edward Lavallie, Debra D. Pittman, Orla Cunningham, Matthew Lambert, John E. Murphy, Simon J. Draper, Reema Jasuja, Hal Drakesmith

Blood. 2020 Feb 20; 135(8): 547–557. Prepublished online 2020 Jan 3. doi: 10.1182/blood.2019003140

PMCID:: PMC7046598

Abstract Article

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