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Select item 114632451.

Clinical implications of activation of the LIMD1-VHL-HIF1α pathway during head-&-neck squamous cell carcinoma development

Debalina Mukhopadhyay, Balarko Chakraborty, Shreya Sarkar, Neyaz Alam, Chinmay Kumar Panda

Indian J Med Res. 2024 May; 159(5): 479–493. Published online 2024 Aug 3. doi: 10.25259/ijmr_1262_22

PMCID:: PMC11463245

Abstract Article PDF–2.5M

Select item 114499102.

Network modeling links kidney developmental programs and the cancer type-specificity of VHL mutations

Xiaobao Dong, Donglei Zhang, Xian Zhang, Yun Liu, Yuanyuan Liu

NPJ Syst Biol Appl. 2024; 10: 114. Published online 2024 Oct 3. doi: 10.1038/s41540-024-00445-2

PMCID:: PMC11449910

Abstract Article PDF–6.6M

Select item 111965973.

VHL suppresses UBE3B-mediated breast tumor growth and metastasis

Shuo Wang, Huiyan Li, Xiong Liu, Tingting Yin, Tingru Li, Miaomiao Zheng, Min Liu, Xiaoqian Meng, Jun Zhou, Yijie Wang, Yan Chen

Cell Death Dis. 2024 Jun; 15(6): 446. Published online 2024 Jun 24. doi: 10.1038/s41419-024-06844-x

PMCID:: PMC11196597

Abstract Article PDF–5.9M

Select item 111694714.

REST-dependent downregulation of von Hippel-Lindau tumor suppressor promotes autophagy in SHH-medulloblastoma

Ashutosh Singh, Donghang Cheng, Jyothishmathi Swaminathan, Yanwen Yang, Yan Zheng, Nancy Gordon, Vidya Gopalakrishnan

Sci Rep. 2024; 14: 13596. Published online 2024 Jun 12. doi: 10.1038/s41598-024-63371-7

PMCID:: PMC11169471

Abstract Article PDF–16M

Select item 111158525.

15-Deoxy-Δ^12,14-prostaglandin-J₂ reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1α degradation

Gemma Olmos, María I. Arenas, Raquel Bienes, María Jose Calzada, Julián Aragonés, Maria Laura Garcia-Bermejo, Manuel O. Landazuri, Javier Lucio-Cazaña

Cell Mol Life Sci. 2009 Jul; 66(13): 2167–2180. Published online 2009 May 21. doi: 10.1007/s00018-009-0039-x

PMCID:: PMC11115852

Abstract Article PDF–657K

Select item 110146726.

VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis

Melissa M. Wolf, Matthew Z. Madden, Emily N. Arner, Jackie E. Bader, Xiang Ye, Logan Vlach, Megan L. Tigue, Madelyn D. Landis, Patrick B. Jonker, Zaid Hatem, KayLee K. Steiner, Dakim K. Gaines, Bradley I. Reinfeld, Emma S. Hathaway, Fuxue Xin, M. Noor Tantawy, Scott M. Haake, Eric Jonasch, Alexander Muir, Vivian L. Weiss, Kathryn E. Beckermann, W. Kimryn Rathmell, Jeffrey C. Rathmell

J Clin Invest. 2024 Apr 15; 134(8): e173934. Published online 2024 Apr 15. doi: 10.1172/JCI173934

PMCID:: PMC11014672

Abstract Article PDF–9.8M

Select item 110146687.

Von Hippel Lindau tumor suppressor controls m6A-dependent gene expression in renal tumorigenesis

Cheng Zhang, Miaomiao Yu, Austin J. Hepperla, Zhao Zhang, Rishi Raj, Hua Zhong, Jin Zhou, Lianxin Hu, Jun Fang, Hongyi Liu, Qian Liang, Liwei Jia, Chengheng Liao, Sichuan Xi, Jeremy M. Simon, Kexin Xu, Zhijie Liu, Yunsun Nam, Payal Kapur, Qing Zhang

J Clin Invest. 2024 Apr 15; 134(8): e175703. Published online 2024 Apr 15. doi: 10.1172/JCI175703

PMCID:: PMC11014668

Abstract Article PDF–16M

Select item 110146648.

VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas

Hyemin Lee, Li Zhuang, Boyi Gan

J Clin Invest. 2024 Apr 15; 134(8): e179560. Published online 2024 Apr 15. doi: 10.1172/JCI179560

PMCID:: PMC11014664

Abstract Article PDF–606K

Select item 109996589.

VHL mutation drives human clear cell renal cell carcinoma progression through PI3K/AKT-dependent cholesteryl ester accumulation

Shuo Zhang, Tinghe Fang, Yexuan He, Weichen Feng, Zhuoyang Yu, Yaoyao Zheng, Chi Zhang, Shuai Hu, Zhuojun Liu, Jia Liu, Jian Yu, Han Zhang, Anbang He, Yanqing Gong, Zhisong He, Kaiwei Yang, Zhijun Xi, Wei Yu, Liqun Zhou, Lin Yao, Shuhua Yue

eBioMedicine. 2024 May; 103: 105070. Published online 2024 Apr 1. doi: 10.1016/j.ebiom.2024.105070

PMCID:: PMC10999658

Abstract Article PDF–4.4M

Select item 1094302010.

VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation

Zheng Wang, Meisi Yan, Leiguang Ye, Qimin Zhou, Yuran Duan, Hongfei Jiang, Lei Wang, Yuan Ouyang, Huahe Zhang, Yuli Shen, Guimei Ji, Xiaohan Chen, Qi Tian, Liwei Xiao, Qingang Wu, Ying Meng, Guijun Liu, Leina Ma, Bo Lei, Zhimin Lu, Daqian Xu

EMBO J. 2024 Mar; 43(6): 931–955. Published online 2024 Feb 15. doi: 10.1038/s44318-024-00051-2

PMCID:: PMC10943020

Abstract Article PDF–7.2M

Select item 1072764411.

Does the VHL polymorphisms rs779805 and rs1642742 affect renal cell carcinoma susceptibility, prognosis and survival in Central European population?

Magdalena Chrabańska, Nikola Szweda-Gandor, Bogna Drozdzowska

Medicine (Baltimore) 2023 Dec 15; 102(50): e36540. Published online 2023 Dec 15. doi: 10.1097/MD.0000000000036540

PMCID:: PMC10727644

Abstract Article PDF–573K

Select item 1046073212.

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4

Wenhu Chen, Liqiang Hu, Xuemei Lu, Xiaofei Wang, Changan Zhao, Chen Guo, Xiaoyan Li, Yuqin Ding, Hongguang Zhao, Dongdong Tong, Lifang Wang, Chen Huang

Breast Cancer Res Treat. 2023; 201(3): 353–366. Published online 2023 Jul 11. doi: 10.1007/s10549-023-07028-5

PMCID:: PMC10460732

Abstract Article PDF–5.6M

Select item 1018193513.

Hypoxia switches TET1 from being tumor-suppressive to oncogenic

Qi Yang, Hui Dang, Jiaxin Liu, Xingye Wang, Jingyuan Wang, Xinhui Lan, Meiju Ji, Mingzhao Xing, Peng Hou

Oncogene. 2023; 42(20): 1634–1648. Published online 2023 Apr 5. doi: 10.1038/s41388-023-02659-w

PMCID:: PMC10181935

Abstract Article PDF–5.3M

Select item 1010482414.

Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism

Jie Shen, Qian Zha, Qian-hua Yang, Yue-qian Zhou, Xiao Liang, Ying-jie Chen, Gui-xia Qi, Xiao-jin Zhang, Wen-bing Yao, Xiang-dong Gao, Song Chen

Acta Pharmacol Sin. 2023 May; 44(5): 940–953. Published online 2022 Nov 10. doi: 10.1038/s41401-022-01014-1

PMCID:: PMC10104824

Abstract Article PDF–6.3M

Select item 1007034415.

PIN1 and CDK1 cooperatively govern pVHL stability and suppressive functions

Jiayi Chen, Mei Li, Yeqing Liu, Tangming Guan, Xiao Yang, Yalei Wen, Yingjie Zhu, Zeyu Xiao, Xiangchun Shen, Haoxing Zhang, Hui Tang, Tongzheng Liu

Cell Death Differ. 2023 Apr; 30(4): 1082–1095. Published online 2023 Feb 23. doi: 10.1038/s41418-023-01128-x

PMCID:: PMC10070344

Abstract Article PDF–5.0M

Select item 1003818616.

Suppressive effects of iron chelation in clear cell renal cell carcinoma and their dependency on VHL inactivation

Christopher J. Greene, Nitika J. Sharma, Peter N. Fiorica, Emily Forrester, Gary J. Smith, Kenneth W. Gross, Eric C. Kauffman

Free Radic Biol Med. Author manuscript; available in PMC 2023 Mar 24.

Published in final edited form as: Free Radic Biol Med. 2019 Mar; 133: 295–309. Published online 2018 Dec 13. doi: 10.1016/j.freeradbiomed.2018.12.013

PMCID:: PMC10038186

Abstract Article PDF–2.2M

Select item 1001715817.

Positive Feedback Regulation of Circular RNA Hsa_circ_0000566 and HIF-1α promotes Osteosarcoma Progression and Glycolysis Metabolism

Shuying Shen, Yining Xu, Zhe Gong, Teng Yao, Di Qiao, Yizhen Huang, Zhenlei Zhang, Jun Gao, Haonan Ni, Zhanping Jin, Yingchun Zhu, Hongfei Wu, Qingxin Wang, Xiangqian Fang, Kangmao Huang, Jianjun Ma

Aging Dis. 2023 Apr 1; 14(2): 529–547. Published online 2023 Apr 1. doi: 10.14336/AD.2022.0826