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Select item 112199991.

Discovery of recessive effect of human polymerase δ proofreading deficiency through mutational analysis of POLD1-mutated normal and cancer cells

Maria A. Andrianova, Vladimir B. Seplyarskiy, Mariona Terradas, Ana Beatriz Sánchez-Heras, Pilar Mur, José Luis Soto, Gemma Aiza, Emma Borràs, Fyodor A. Kondrashov, Alexey S. Kondrashov, Georgii A. Bazykin, Laura Valle

Eur J Hum Genet. 2024 Jul; 32(7): 837–845. Published online 2024 Apr 24. doi: 10.1038/s41431-024-01598-8

PMCID:: PMC11219999

Abstract Article PDF–2.9M

Select item 109457072.

Comparative interactome analysis of α-arrestin families in human and Drosophila

Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam

eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328

PMCID:: PMC10945707

Abstract Article PDF–2.8M

Select item 109052723.

POLD1 Is Required for Cell Cycle Progression by Overcoming DNA Damage in Malignant Pleural Mesothelioma

DAIKI SHIMIZU, MIKU ISHIBASHI, TADAAKI YAMADA, YUKI TODA, SHIGEKUNI HOSOGI, EISHI ASHIHARA

Cancer Genomics Proteomics. 2024 Mar-Apr; 21(2): 158–165. Published online 2024 Mar 3. doi: 10.21873/cgp.20437

PMCID:: PMC10905272

Abstract Article PDF–5.2M

Select item 108308984.

DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors

Daria Ostroverkhova, Kathrin Tyryshkin, Annette K. Beach, Elizabeth A. Moore, Yosef Masoudi-Sobhanzadeh, Stephanie R. Barbari, Igor B. Rogozin, Konstantin V. Shaitan, Anna R. Panchenko, Polina V. Shcherbakova

Cell Rep. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: Cell Rep. 2024 Jan 23; 43(1): 113655. Published online 2024 Jan 13. doi: 10.1016/j.celrep.2023.113655

PMCID:: PMC10830898

Abstract Article PDF–1.8M

Select item 107949415.

Race, Prevalence of POLE and POLD1 Alterations, and Survival Among Patients With Endometrial Cancer

Shuhua Zheng, Eric D. Donnelly, Jonathan B. Strauss

JAMA Netw Open. 2024 Jan; 7(1): e2351906. Published online 2024 Jan 17. doi: 10.1001/jamanetworkopen.2023.51906

PMCID:: PMC10794941

Abstract Article

Select item 106643776.

Rare germline variants in POLE and POLD1 encoding the catalytic subunits of DNA polymerases ε and δ in glioma families

Christine A. M. Weber, Nicole Krönke, Valery Volk, Bernd Auber, Alisa Förster, Detlef Trost, Robert Geffers, Majid Esmaeilzadeh, Michael Lalk, Arya Nabavi, Amir Samii, Joachim K. Krauss, Friedrich Feuerhake, Christian Hartmann, Bettina Wiese, Frank Brand, Ruthild G. Weber

Acta Neuropathol Commun. 2023; 11: 184. Published online 2023 Nov 21. doi: 10.1186/s40478-023-01689-5

PMCID:: PMC10664377

Abstract Article PDF–10M

Select item 105658767.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 102374228.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101810959.

Functional Landscapes of POLE and POLD1 Mutations in Checkpoint Blockade-Dependent Anti-Tumor Immunity

Xiaoxiao Ma, Nadeem Riaz, Robert M. Samstein, Mark Lee, Vladimir Makarov, Cristina Valero, Diego Chowell, Fengshen Kuo, Douglas Hoen, Conall W.R. Fitzgerald, Hui Jiang, Jonathan Alektiar, Tyler J. Alban, Ivan Juric, Prerana Bangalore Parthasarathy, Yu Zhao, Erich Y. Sabio, Richa Verma, Raghvendra M. Srivastava, Lynda Vuong, Wei Yang, Xiao Zhang, Jingming Wang, Lawrence K. Chu, Stephen L. Wang, Daniel W. Kelly, Xin Pei, Jiapeng Chen, Rona Yaeger, Dmitriy Zamarin, Ahmet Zehir, Mithat Gönen, Luc GT Morris, Timothy A. Chan

Nat Genet. Author manuscript; available in PMC 2023 May 12.

Published in final edited form as: Nat Genet. 2022 Jul; 54(7): 996–1012. Published online 2022 Jul 11. doi: 10.1038/s41588-022-01108-w

PMCID:: PMC10181095

Abstract Article PDF–5.2M

Select item 1014002310.

DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC

Yejinpeng Wang, Lingao Ju, Gang Wang, Kaiyu Qian, Wan Jin, Mingxing Li, Jingtian Yu, Yiliang Shi, Yongzhi Wang, Yi Zhang, Yu Xiao, Xinghuan Wang

Nat Commun. 2023; 14: 2421. Published online 2023 Apr 27. doi: 10.1038/s41467-023-38160-x

PMCID:: PMC10140023

Abstract Article PDF–5.8M

Select item 1013790011.

DNA Polymerase Delta Exhibits Altered Catalytic Properties on Lysine Acetylation

Catherine Njeri, Sharon Pepenella, Tripthi Battapadi, Robert A. Bambara, Lata Balakrishnan

Genes (Basel) 2023 Apr; 14(4): 774. Published online 2023 Mar 23. doi: 10.3390/genes14040774

PMCID:: PMC10137900

Abstract Article PDF–2.1M

Select item 995018312.

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini

Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3

PMCID:: PMC9950183

Abstract Article PDF–2.4M

Select item 992246813.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Abstract Article PDF–4.9M

Select item 988113614.

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain

Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke

Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188

PMCID:: PMC9881136

Abstract Article PDF–4.4M

Select item 976969815.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 964281416.

DNA Polymerases Eta and Kappa Exchange with the Polymerase Delta Holoenzyme to Complete Common Fragile Site Synthesis

Ryan P. Barnes, Suzanne E. Hile, Marietta Y. Lee, Kristin A. Eckert

DNA Repair (Amst) Author manuscript; available in PMC 2022 Nov 8.

Published in final edited form as: DNA Repair (Amst). 2017 Sep; 57: 1–11. Published online 2017 Jun 3. doi: 10.1016/j.dnarep.2017.05.006

PMCID:: PMC9642814

Abstract Article PDF–1.6M

Select item 948193317.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 927928518.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 925017619.

POLE/POLD1 mutation and tumor immunotherapy

Xiaoting Ma, Lin Dong, Xiu Liu, Kai Ou, Lin Yang

J Exp Clin Cancer Res. 2022; 41: 216. Published online 2022 Jul 2. doi: 10.1186/s13046-022-02422-1

PMCID:: PMC9250176

Abstract Article PDF–1.1M

Select item 911973620.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

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