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Select item 111138701.

Coxsackievirus B4 can infect human pancreas ductal cells and persist in ductal-like cell cultures which results in inhibition of Pdx1 expression and disturbed formation of islet-like cell aggregates

Famara Sane, Delphine Caloone, Valéry Gmyr, Ilka Engelmann, Sandrine Belaich, Julie Kerr-Conte, François Pattou, Rachel Desailloud, Didier Hober

Cell Mol Life Sci. 2013 Nov; 70(21): 4169–4180. Published online 2013 Jun 18. doi: 10.1007/s00018-013-1383-4

PMCID:: PMC11113870

Abstract Article PDF–601K

Select item 110718062.

TAZ promotes PDX1-mediated insulinogenesis

Mi Gyeong Jeong, Hyo Kyeong Kim, Gibbeum Lee, Hee Yeon Won, Da Hye Yoon, Eun Sook Hwang

Cell Mol Life Sci. 2022 Mar; 79(3): 186. Published online 2022 Mar 13. doi: 10.1007/s00018-022-04216-2

PMCID:: PMC11071806

Abstract Article PDF–16M

Select item 108152833.

Novel pathogenic PDX1 gene variant in a Korean family with maturity-onset diabetes of the young

Hyunji Kim, Hwa Young Kim, Jae Hyun Kim, Soo Hyun Seo, Kyung Un Park

Cold Spring Harb Mol Case Stud. 2023 Dec; 9(4): a006305. doi: 10.1101/mcs.a006305

PMCID:: PMC10815283

Abstract Article PDF–1.0M

Select item 97416424.

STAT3 suppression and β-cell ablation enhance α-to-β reprogramming mediated by Pdx1

Yuka Wakabayashi, Takeshi Miyatsuka, Masaki Miura, Miwa Himuro, Tomomi Taguchi, Hitoshi Iida, Yuya Nishida, Yoshio Fujitani, Hirotaka Watada

Sci Rep. 2022; 12: 21419. Published online 2022 Dec 10. doi: 10.1038/s41598-022-25941-5

PMCID:: PMC9741642

Abstract Article PDF–2.3M

Select item 96919425.

Biophysical insights into glucose-dependent transcriptional regulation by PDX1

Emery T. Usher, Scott A. Showalter

J Biol Chem. 2022 Dec; 298(12): 102623. Published online 2022 Oct 20. doi: 10.1016/j.jbc.2022.102623

PMCID:: PMC9691942

Abstract Article PDF–2.3M

Select item 94621276.

Significance of pancreatic duodenal homeobox-1 (PDX-1) genetic polymorphism in insulin secretion in Japanese patients with type 2 diabetes

Tsuyoshi Okura, Risa Nakamura, Yuichi Ito, Sonoko Kitao, Mari Anno, Satomi Endo, Natsuka Taneda, Kazuhisa Matsumoto, Kyoko Shoji, Hiroko Okura, Kazuhiko Matsuzawa, Shoichiro Izawa, Etsuko Ueta, Masahiko Kato, Takeshi Imamura, Shin-ichi Taniguchi, Kazuhiro Yamamoto

BMJ Open Diabetes Res Care. 2022; 10(5): e002908. Published online 2022 Sep 7. doi: 10.1136/bmjdrc-2022-002908

PMCID:: PMC9462127

Abstract Article PDF–432K

Select item 88944257.

Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer

Yeongun Lee, So Hee Dho, Jiyeon Lee, Ji-Hyun Hwang, Minjung Kim, Won-Young Choi, Jin-Young Lee, Jongwon Lee, Woochul Chang, Min Young Lee, Jungmin Choi, Tae-You Kim, Lark Kyun Kim

Exp Mol Med. 2022 Feb; 54(2): 156–168. Published online 2022 Feb 15. doi: 10.1038/s12276-022-00731-1

PMCID:: PMC8894425

Abstract Article PDF–3.9M

Select item 88585638.

Knockdown of PDX1 enhances the osteogenic differentiation of ADSCs partly via activation of the PI3K/Akt signaling pathway

Fan Liu, Guang-Dong Chen, Long-Kun Fan

J Orthop Surg Res. 2022; 17: 107. Published online 2022 Feb 19. doi: 10.1186/s13018-021-02825-4

PMCID:: PMC8858563

Abstract Article PDF–11M

Select item 86016329.

Oxidative Stress Leads to β-Cell Dysfunction Through Loss of β-Cell Identity

Floris Leenders, Nathalie Groen, Natascha de Graaf, Marten A. Engelse, Ton J. Rabelink, Eelco J. P. de Koning, Françoise Carlotti

Front Immunol. 2021; 12: 690379. Published online 2021 Nov 4. doi: 10.3389/fimmu.2021.690379

PMCID:: PMC8601632

Abstract Article PDF–14M

Select item 854391710.

PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population

Ning Wang, Rui Tong, Jing Xu, Yanni Tian, Juan Pan, Jiaqi Cui, Huan Chen, Yanqi Peng, Sijia Fei, Shujun Yang, Lu Wang, Juanchuan Yao, Wei Cui

BMC Med Genomics. 2021; 14: 249. Published online 2021 Oct 25. doi: 10.1186/s12920-021-01037-3

PMCID:: PMC8543917

Abstract Article PDF–1.3M

Select item 818466411.

Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial–mesenchymal transition in diabetes

Daniel S. de Jesus, Tracy C.S. Mak, Yi-Fang Wang, Yorrick von Ohlen, Ying Bai, Eva Kane, Pauline Chabosseau, Catherine M. Chahrour, Walter Distaso, Victoria Salem, Alejandra Tomas, Markus Stoffel, Guy A. Rutter, Mathieu Latreille

Mol Metab. 2021 Nov; 53: 101248. Published online 2021 May 12. doi: 10.1016/j.molmet.2021.101248

PMCID:: PMC8184664

Abstract Article PDF–4.6M

Select item 816503012.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 813876713.

Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity

Emery T. Usher, Nafiseh Sabri, Roman Rohac, Amie K. Boal, Tanja Mittag, Scott A. Showalter

J Biol Chem. 2021 Jan-Jun; 296: 100693. Published online 2021 Apr 22. doi: 10.1016/j.jbc.2021.100693

PMCID:: PMC8138767

Abstract Article PDF–3.7M

Select item 800904814.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 778940215.

miR-1249-5p regulates the osteogenic differentiation of ADSCs by targeting PDX1

Xiao-Mei Yang, Ya-Qi Song, Liang Li, Dong-Ming Liu, Guang-Dong Chen

J Orthop Surg Res. 2021; 16: 10. Published online 2021 Jan 6. doi: 10.1186/s13018-020-02147-x

PMCID:: PMC7789402

Abstract Article PDF–4.5M

Select item 748991316.

Tectorigenin enhances PDX1 expression and protects pancreatic β-cells by activating ERK and reducing ER stress

Xinlei Yao, Kun Li, Chen Liang, Zilong Zhou, Jiao Wang, Shuyue Wang, Lei Liu, Chun-Lei Yu, Zhen-Bo Song, Yong-Li Bao, Li-Hua Zheng, Ying Sun, Guannan Wang, Yanxin Huang, Jingwen Yi, Luguo Sun, Yuxin Li

J Biol Chem. 2020 Sep 11; 295(37): 12975–12992. Published online 2020 Jul 20. doi: 10.1074/jbc.RA120.012849

PMCID:: PMC7489913

Abstract Article PDF–7.2M

Select item 725079317.

Alternative Lengthening of Telomeres and Differential Expression of Endocrine Transcription Factors Distinguish Metastatic and Non-metastatic Insulinomas

Wenzel M. Hackeng, Willemien Schelhaas, Folkert H. M. Morsink, Charlotte M. Heidsma, Susanne van Eeden, Gerlof D. Valk, Menno R. Vriens, Christopher M. Heaphy, Els J. M. Nieveen van Dijkum, G. Johan A. Offerhaus, Koen M. A. Dreijerink, Lodewijk A. A. Brosens

Endocr Pathol. 2020; 31(2): 108–118. Published online 2020 Feb 26. doi: 10.1007/s12022-020-09611-8

PMCID:: PMC7250793

Abstract Article PDF–866K

Select item 653184118.

Point mutations in the PDX1 transactivation domain impair human β-cell development and function

Xianming Wang, Michael Sterr, Ansarullah, Ingo Burtscher, Anika Böttcher, Julia Beckenbauer, Johanna Siehler, Thomas Meitinger, Hans-Ulrich Häring, Harald Staiger, Filippo M. Cernilogar, Gunnar Schotta, Martin Irmler, Johannes Beckers, Christopher V.E. Wright, Mostafa Bakhti, Heiko Lickert

Mol Metab. 2019 Jun; 24: 80–97. Published online 2019 Mar 20. doi: 10.1016/j.molmet.2019.03.006

PMCID:: PMC6531841

Abstract Article PDF–6.5M

Select item 617576219.

Potential involvement of heat shock proteins in pancreatic-duodenal homeobox-1-mediated effects on the genesis of gastric cancer: A 2D gel-based proteomic study

Juan Ma, Bei-Bei Wang, Xiao-Yan Ma, Wei-Ping Deng, Li-Shu Xu, Wei-Hong Sha

World J Gastroenterol. 2018 Oct 7; 24(37): 4263–4271. Published online 2018 Oct 7. doi: 10.3748/wjg.v24.i37.4263

PMCID:: PMC6175762

Abstract Article PDF–2.1M

Select item 566746720.

PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration

Yaxi Zhu, Qian Liu, Zhiguang Zhou, Yasuhiro Ikeda

Stem Cell Res Ther. 2017; 8: 240. Published online 2017 Nov 2. doi: 10.1186/s13287-017-0694-z

PMCID:: PMC5667467

Abstract Article PDF–565K

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