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Select item 107135731.

The ubiquitin thioesterase YOD1 ameliorates mutant Huntingtin induced pathology in Drosophila

Anita Farkas, Nóra Zsindely, Gábor Nagy, Levente Kovács, Péter Deák, László Bodai

Sci Rep. 2023; 13: 21951. Published online 2023 Dec 11. doi: 10.1038/s41598-023-49241-8

PMCID:: PMC10713573

Abstract Article PDF–2.9M

Select item 106020082.

Increase in brain glycogen levels ameliorates Huntington's disease phenotype and rescues neurodegeneration in Drosophila

Akanksha Onkar, Deepashree Sheshadri, Anupama Rai, Arjit Kant Gupta, Nitin Gupta, Subramaniam Ganesh

Dis Model Mech. 2023 Oct 1; 16(10): dmm050238. Published online 2023 Oct 19. doi: 10.1242/dmm.050238

PMCID:: PMC10602008

Abstract Article

Select item 105627063.

Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Drosophila

Jonathan R. Roth, Ruan Carlos Macedo de Moraes, Brittney P. Xu, Savannah R. Crawley, Malghalara A. Khan, Girish C. Melkani

Front Aging Neurosci. 2023; 15: 1223911. Published online 2023 Sep 26. doi: 10.3389/fnagi.2023.1223911

PMCID:: PMC10562706

Abstract Article PDF–6.4M

Select item 102327754.

Drosophila melanogaster as a model to study autophagy in neurodegenerative diseases induced by proteinopathies

Stefania Santarelli, Chiara Londero, Alessia Soldano, Carlotta Candelaresi, Leonardo Todeschini, Luisa Vernizzi, Paola Bellosta

Front Neurosci. 2023; 17: 1082047. Published online 2023 May 18. doi: 10.3389/fnins.2023.1082047

PMCID:: PMC10232775

Abstract Article PDF–2.4M

Select item 100129555.

HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury

Thomas J. Krzystek, Joseph A. White, Rasika Rathnayake, Layne Thurston, Hayley Hoffmar-Glennon, Yichen Li, Shermali Gunawardena

Autophagy. 2023; 19(4): 1199–1220. Published online 2022 Sep 9. doi: 10.1080/15548627.2022.2119351

PMCID:: PMC10012955

Abstract Article PDF–7.7M

Select item 98800766.

The making of the Drosophila mushroom body

Suewei Lin

Front Physiol. 2023; 14: 1091248. Published online 2023 Jan 13. doi: 10.3389/fphys.2023.1091248

PMCID:: PMC9880076

Abstract Article PDF–2.2M

Select item 93716707.

Chemical interference with DSIF complex formation lowers synthesis of mutant huntingtin gene products and curtails mutant phenotypes

Ning Deng, Yun-Yun Wu, Yanan Feng, Wen-Chieh Hsieh, Jen-Shin Song, Yu-Shiuan Lin, Ya-Hsien Tseng, Wan-Jhu Liao, Yi-Fan Chu, Yu-Cheng Liu, En-Cheng Chang, Chia-Rung Liu, Sheh-Yi Sheu, Ming-Tsan Su, Hung-Chih Kuo, Stanley N. Cohen, Tzu-Hao Cheng

Proc Natl Acad Sci U S A. 2022 Aug 9; 119(32): e2204779119. Published online 2022 Aug 1. doi: 10.1073/pnas.2204779119

PMCID:: PMC9371670

Abstract Article PDF–1.3M

Select item 92959568.

HAP40 is a conserved central regulator of Huntingtin and a potential modulator of Huntington’s disease pathogenesis

Shiyu Xu, Gang Li, Xin Ye, Dongsheng Chen, Zhihua Chen, Zhen Xu, Moretti Daniele, Sara Tambone, Alessandra Ceccacci, Licia Tomei, Lili Ye, Yue Yu, Amanda Solbach, Stephen M. Farmer, Erin Furr Stimming, George McAllister, Deanna M. Marchionini, Sheng Zhang

PLoS Genet. 2022 Jul; 18(7): e1010302. Published online 2022 Jul 19. doi: 10.1371/journal.pgen.1010302

PMCID:: PMC9295956

Abstract Article PDF–5.2M

Select item 89099429.

Inter-Species Rescue of Mutant Phenotype—The Standard for Genetic Analysis of Human Genetic Disorders in Drosophila melanogaster Model

Alexandru Al. Ecovoiu, Attila Cristian Ratiu, Miruna Mihaela Micheu, Mariana Carmen Chifiriuc

Int J Mol Sci. 2022 Mar; 23(5): 2613. Published online 2022 Feb 27. doi: 10.3390/ijms23052613

PMCID:: PMC8909942

Abstract Article PDF–1.3M

Select item 866448610.

Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes

Ana López-Varea, Patricia Vega-Cuesta, Ana Ruiz-Gómez, Cristina M Ostalé, Cristina Molnar, Covadonga F Hevia, Mercedes Martín, Maria F Organista, Jesus de Celis, Joaquín Culí, Nuria Esteban, Jose F de Celis

G3 (Bethesda) 2021 Dec; 11(12): jkab349. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab349

PMCID:: PMC8664486

Abstract Article PDF–3.1M

Select item 846882711.

Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders

Stefano Sechi, Angela Karimpour-Ghahnavieh, Anna Frappaolo, Laura Di Francesco, Roberto Piergentili, Eugenia Schininà, Pier Paolo D’Avino, Maria Grazia Giansanti

Cells. 2021 Sep; 10(9): 2336. Published online 2021 Sep 6. doi: 10.3390/cells10092336

PMCID:: PMC8468827

Abstract Article PDF–4.1M

Select item 820506312.

Sunday Driver Mediates Multi-Compartment Golgi Outposts Defects Induced by Amyloid Precursor Protein

Qianqian Du, Jin Chang, Guo Cheng, Yinyin Zhao, Wei Zhou

Front Neurosci. 2021; 15: 673684. Published online 2021 Jun 1. doi: 10.3389/fnins.2021.673684

PMCID:: PMC8205063

Abstract Article PDF–4.4M

Select item 807278113.

Study on the Sleep-Improvement Effects of Hemerocallis citrina Baroni in Drosophila melanogaster and Targeted Screening to Identify Its Active Components and Mechanism

Yuxuan Liang, Riming Huang, Yongchun Chen, Jing Zhong, Jie Deng, Ziyi Wang, Zhuojun Wu, Meiying Li, Hong Wang, Yuanming Sun

Foods. 2021 Apr; 10(4): 883. Published online 2021 Apr 17. doi: 10.3390/foods10040883

PMCID:: PMC8072781

Abstract Article PDF–2.9M

Select item 784596914.

Htt is a repressor of Abl activity required for APP-induced axonal growth

Claire Marquilly, Germain U. Busto, Brittany S. Leger, Ana Boulanger, Edward Giniger, James A. Walker, Lee G. Fradkin, Jean-Maurice Dura

PLoS Genet. 2021 Jan; 17(1): e1009287. Published online 2021 Jan 19. doi: 10.1371/journal.pgen.1009287

PMCID:: PMC7845969

Abstract Article PDF–3.3M

Select item 740232115.

Drosophila Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders

Taejoon Kim, Bokyeong Song, Im-Soon Lee

Int J Mol Sci. 2020 Jul; 21(14): 4859. Published online 2020 Jul 9. doi: 10.3390/ijms21144859

PMCID:: PMC7402321

Abstract Article PDF–834K

Select item 733128016.

Excess Rab4 rescues synaptic and behavioral dysfunction caused by defective HTT-Rab4 axonal transport in Huntington’s disease

Joseph A. White, II, Thomas J. Krzystek, Hayley Hoffmar-Glennon, Claire Thant, Katherine Zimmerman, Gary Iacobucci, Julia Vail, Layne Thurston, Saad Rahman, Shermali Gunawardena

Acta Neuropathol Commun. 2020; 8: 97. Published online 2020 Jul 1. doi: 10.1186/s40478-020-00964-z