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Select item 110146571.

A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis

Jingwen Yang, Lingxin Zhu, Haichun Pan, Hiroki Ueharu, Masako Toda, Qian Yang, Shawn A. Hallett, Lorin E. Olson, Yuji Mishina

J Clin Invest. 2024 Apr 15; 134(8): e165787. Published online 2024 Mar 11. doi: 10.1172/JCI165787

PMCID:: PMC11014657

Abstract Article PDF–16M

Select item 110017232.

Kinesin KIF3A regulates meiotic progression and spindle assembly in oocyte meiosis

Jing-Cai Liu, Zhen-Nan Pan, Jia-Qian Ju, Yuan-Jing Zou, Meng-Hao Pan, Yue Wang, Xin Wu, Shao-Chen Sun

Cell Mol Life Sci. 2024 Dec; 81(1): 168. Published online 2024 Apr 8. doi: 10.1007/s00018-024-05213-3

PMCID:: PMC11001723

Abstract Article PDF–7.8M

Select item 97246743.

Loss of primary cilia promotes inflammation and carcinogenesis

Conception Paul, Ruizhi Tang, Ciro Longobardi, Rossano Lattanzio, Thibaut Eguether, Hulya Turali, Julie Bremond, Chloé Maurizy, Monica Gabola, Sophie Poupeau, Andrei Turtoi, Emilie Denicolai, Maria Concetta Cufaro, Magali Svrcek, Philippe Seksik, Vincent Castronovo, Philippe Delvenne, Vincenzo de Laurenzi, Quentin Da Costa, François Bertucci, Bénédicte Lemmers, Damiana Pieragostino, Emilie Mamessier, Carsten Janke, Valérie Pinet, Michael Hahne

EMBO Rep. 2022 Dec; 23(12): e55687. Published online 2022 Oct 25. doi: 10.15252/embr.202255687

PMCID:: PMC9724674

Abstract Article PDF–4.2M

Select item 91226344.

Skin depletion of Kif3a resembles the pediatric atopic dermatitis transcriptome profile

Mariana L Stevens, Tesfaye B Mersha, Zhonghua Zhang, Arjun Kothari, Gurjit K Khurana Hershey

Hum Mol Genet. 2022 May 15; 31(10): 1588–1598. Published online 2021 Nov 23. doi: 10.1093/hmg/ddab342

PMCID:: PMC9122634

Abstract Article PDF–2.0M

Select item 84601525.

Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function

Casey D. Gailey, Eric J. Wang, Li Jin, Sean Ahmadi, David L. Brautigan, Xudong Li, Wenhao Xu, Michael M. Scott, Zheng Fu

Dev Dyn. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Dev Dyn. 2021 Feb; 250(2): 263–273. Published online 2020 Oct 7. doi: 10.1002/dvdy.252

PMCID:: PMC8460152

Abstract Article PDF–1.2M

Select item 83487156.

Photoreceptor Compartment-Specific TULP1 Interactomes

Lindsey A. Ebke, Satyabrata Sinha, Gayle J. T. Pauer, Stephanie A. Hagstrom

Int J Mol Sci. 2021 Aug; 22(15): 8066. Published online 2021 Jul 28. doi: 10.3390/ijms22158066

PMCID:: PMC8348715

Abstract Article PDF–3.5M

Select item 83132397.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 82666178.

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins

Benjamin Lang, Jae-Seong Yang, Mireia Garriga-Canut, Silvia Speroni, Moritz Aschern, Maria Gili, Tobias Hoffmann, Gian Gaetano Tartaglia, Sebastian P Maurer

Nucleic Acids Res. 2021 Jul 9; 49(12): 6702–6721. Published online 2021 Jun 16. doi: 10.1093/nar/gkab490

PMCID:: PMC8266617

Abstract Article PDF–4.0M

Select item 79862219.

Kif3a deletion prevents primary cilia assembly on oligodendrocyte progenitor cells, reduces oligodendrogenesis and impairs fine motor function

Carlie L. Cullen, Megan O'Rourke, Shannon J. Beasley, Loic Auderset, Yilan Zhen, Renee E. Pepper, Robert Gasperini, Kaylene M. Young

Glia. 2021 May; 69(5): 1184–1203. Published online 2020 Dec 24. doi: 10.1002/glia.23957

PMCID:: PMC7986221

Abstract Article PDF–7.1M

Select item 794897610.

KIF3A accelerates KIF3C within the kinesin-2 heterodimer to generate symmetrical phosphate release rates for each processive step

Sean M. Quinn, Troy Vargason, Nilisha Pokhrel, Edwin Antony, Juergen Hahn, Susan P. Gilbert

J Biol Chem. 2021 Jan-Jun; 296: 100020. Published online 2020 Nov 22. doi: 10.1074/jbc.RA120.015272

PMCID:: PMC7948976

Abstract Article PDF–1.7M

Select item 793877011.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 789465412.

Cyclin-Dependent Kinase 1 Activity Is a Driver of Cyst Growth in Polycystic Kidney Disease

Chao Zhang, Bruno Balbo, Ming Ma, Jun Zhao, Xin Tian, Yuval Kluger, Stefan Somlo

J Am Soc Nephrol. 2021 Jan; 32(1): 41–51. Published online 2020 Oct 12. doi: 10.1681/ASN.2020040511

PMCID:: PMC7894654

Abstract Article

Select item 766621613.

Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus

Chan Hee Lee, Do Kyeong Song, Chae Beom Park, Jeewon Choi, Gil Myoung Kang, Sung Hoon Shin, Ijoo Kwon, Soyoung Park, Seongjun Kim, Ji Ye Kim, Hong Dugu, Jae Woo Park, Jong Han Choi, Se Hee Min, Jong-Woo Sohn, Min-Seon Kim

Nat Commun. 2020; 11: 5772. Published online 2020 Nov 13. doi: 10.1038/s41467-020-19638-4

PMCID:: PMC7666216

Abstract Article PDF–13M

Select item 747814214.

Inhibition of Ciliogenesis Promotes Hedgehog Signaling, Tumorigenesis, and Metastasis in Breast Cancer

Nadia B. Hassounah, Martha Nunez, Colleen Fordyce, Denise Roe, Ray Nagle, Thomas Bunch, Kimberly M. McDermott

Mol Cancer Res. Author manuscript; available in PMC 2020 Sep 8.

Published in final edited form as: Mol Cancer Res. 2017 Oct; 15(10): 1421–1430. Published online 2017 Jun 13. doi: 10.1158/1541-7786.MCR-17-0034

PMCID:: PMC7478142

Abstract Article PDF–1.5M

Select item 742798915.

Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk

Mariana L. Stevens, Zhonghua Zhang, Elisabet Johansson, Samriddha Ray, Amrita Jagpal, Brandy P. Ruff, Arjun Kothari, Hua He, Lisa J. Martin, Hong Ji, Kathryn Wikenheiser-Brokamp, Matthew T. Weirauch, Dorothy M. Supp, Jocelyn M. Biagini Myers, Gurjit K. Khurana Hershey

Nat Commun. 2020; 11: 4092. Published online 2020 Aug 14. doi: 10.1038/s41467-020-17895-x

PMCID:: PMC7427989

Abstract Article PDF–1.9M

Select item 741005616.

Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling

Catherine R. Cochrane, Vijesh Vaghjiani, Anette Szczepny, W. Samantha N. Jayasekara, Alvaro Gonzalez-Rajal, Kazu Kikuchi, Geoffrey W. McCaughan, Andrew Burgess, Daniel J. Gough, D. Neil Watkins, Jason E. Cain

J Clin Invest. 2020 Aug 3; 130(8): 4006–4018. Published online 2020 Jun 22. doi: 10.1172/JCI132513

PMCID:: PMC7410056

Abstract Article PDF–11M

Select item 737583217.

Role of Ca²⁺ transients at the node of the mouse embryo in breaking of left-right symmetry

Katsutoshi Mizuno, Kei Shiozawa, Takanobu A. Katoh, Katsura Minegishi, Takahiro Ide, Yayoi Ikawa, Hiromi Nishimura, Katsuyoshi Takaoka, Takeshi Itabashi, Atsuko H. Iwane, Junichi Nakai, Hidetaka Shiratori, Hiroshi Hamada

Sci Adv. 2020 Jul; 6(30): eaba1195. Published online 2020 Jul 22. doi: 10.1126/sciadv.aba1195

PMCID:: PMC7375832

Abstract Article PDF–1.0M

Select item 735492818.

The mechanochemistry of the kinesin-2 KIF3AC heterodimer is related to strain-dependent kinetic properties of KIF3A and KIF3C

Brandon M. Bensel, Michael S. Woody, Serapion Pyrpassopoulos, Yale E. Goldman, Susan P. Gilbert, E. Michael Ostap

Proc Natl Acad Sci U S A. 2020 Jul 7; 117(27): 15632–15641. Published online 2020 Jun 22. doi: 10.1073/pnas.1916343117

PMCID:: PMC7354928

Abstract Article PDF–4.4M

Select item 722702819.

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss

Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F. Hyde, Lisa Stone, Jürgen K. Naggert, Patsy M. Nishina, Mark P. Krebs

Cells. 2020 Apr; 9(4): 931. Published online 2020 Apr 10. doi: 10.3390/cells9040931

PMCID:: PMC7227028

Abstract Article PDF–5.4M

Select item 721741920.

Tubular STAT3 Limits Renal Inflammation in Autosomal Dominant Polycystic Kidney Disease

Amandine Viau, Maroua Baaziz, Amandine Aka, Manal Mazloum, Clément Nguyen, E. Wolfgang Kuehn, Fabiola Terzi, Frank Bienaimé

J Am Soc Nephrol. 2020 May; 31(5): 1035–1049. Published online 2020 Apr 1. doi: 10.1681/ASN.2019090959

PMCID:: PMC7217419

Abstract Article

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