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Select item 113644181.

RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis

Zhenqiong Guan, Huiling Li, Chongtao Zhang, Ziyan Huang, Meidi Ye, Yulan Zhang, Shufen Li, Ke Peng

PLoS Pathog. 2024 Aug; 20(8): e1012387. Published online 2024 Aug 30. doi: 10.1371/journal.ppat.1012387

PMCID:: PMC11364418

Abstract Article PDF–3.7M

Select item 111481842.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 111480363.

Lipid unsaturation promotes BAX and BAK pore activity during apoptosis

Shashank Dadsena, Rodrigo Cuevas Arenas, Gonçalo Vieira, Susanne Brodesser, Manuel N. Melo, Ana J. García-Sáez

Nat Commun. 2024; 15: 4700. Published online 2024 Jun 3. doi: 10.1038/s41467-024-49067-6

PMCID:: PMC11148036

Abstract Article PDF–4.8M

Select item 110434124.

Endogenous BAX and BAK form mosaic rings of variable size and composition on apoptotic mitochondria

Sarah V. Schweighofer, Daniel C. Jans, Jan Keller-Findeisen, Anne Folmeg, Peter Ilgen, Mark Bates, Stefan Jakobs

Cell Death Differ. 2024 Apr; 31(4): 469–478. Published online 2024 Mar 19. doi: 10.1038/s41418-024-01273-x

PMCID:: PMC11043412

Abstract Article PDF–2.0M

Select item 103756375.

Hsa_circ_0002348 regulates trophoblast proliferation and apoptosis through miR-126-3p/BAK1 axis in preeclampsia

Jizi Zhou, Ying Zhao, Ping An, Huanqiang Zhao, Xiaotian Li, Yu Xiong

J Transl Med. 2023; 21: 509. Published online 2023 Jul 28. doi: 10.1186/s12967-023-04240-1

PMCID:: PMC10375637

Abstract Article PDF–9.6M

Select item 103126746.

AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor

Philipp Trepte, Christopher Secker, Simona Kostova, Sibusiso B. Maseko, Soon Gang Choi, Jeremy Blavier, Igor Minia, Eduardo Silva Ramos, Patricia Cassonnet, Sabrina Golusik, Martina Zenkner, Stephanie Beetz, Mara J. Liebich, Nadine Scharek, Anja Schütz, Marcel Sperling, Michael Lisurek, Yang Wang, Kerstin Spirohn, Tong Hao, Michael A. Calderwood, David E. Hill, Markus Landthaler, Julien Olivet, Jean-Claude Twizere, Marc Vidal, Erich E. Wanker

Version 1. bioRxiv. Preprint. 2023 Jun 14. doi: 10.1101/2023.06.14.544560

Published in:: Mol Syst Biol. 2024 Apr; 20(4): 428–457.

PMCID:: PMC10312674

Abstract Article PDF–9.6M

Select item 98522247.

Mechanisms of MCL-1 protein stability induced by MCL-1 antagonists in B-cell malignancies

Shady I. Tantawy, Aloke Sarkar, Stefan Hubner, Zhi Tan, William G. Wierda, Abdelraouf Eldeib, Shuxing Zhang, Steven Kornblau, Varsha Gandhi

Clin Cancer Res. Author manuscript; available in PMC 2023 Jul 17.

Published in final edited form as: Clin Cancer Res. 2023 Jan 17; 29(2): 446–457. doi: 10.1158/1078-0432.CCR-22-2088

PMCID:: PMC9852224

Abstract Article PDF–2.1M

Select item 95619608.

NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived Vesicles

Md Imam Faizan, Rituparna Chaudhuri, Shakti Sagar, Sarah Albogami, Nisha Chaudhary, Iqbal Azmi, Areej Akhtar, Syed Mansoor Ali, Rohit Kumar, Jawed Iqbal, Mohan C. Joshi, Gaurav Kharya, Pankaj Seth, Soumya Sinha Roy, Tanveer Ahmad

Cells. 2022 Oct; 11(19): 2969. Published online 2022 Sep 23. doi: 10.3390/cells11192969

PMCID:: PMC9561960

Abstract Article PDF–52M

Select item 93461289.

A common deletion at BAK1 reduces enhancer activity and confers risk of intracranial germ cell tumors

Kyuto Sonehara, Yui Kimura, Yoshiko Nakano, Tatsuya Ozawa, Meiko Takahashi, Ken Suzuki, Takashi Fujii, Yuko Matsushita, Arata Tomiyama, Toshihiro Kishikawa, Kenichi Yamamoto, Tatsuhiko Naito, Tomonari Suzuki, Shigeru Yamaguchi, Tomoru Miwa, Hikaru Sasaki, Masashi Kitagawa, Naoyuki Ohe, Junya Fukai, Hideki Ogiwara, Atsufumi Kawamura, Satoru Miyawaki, Fumihiko Matsuda, Nobutaka Kiyokawa, Koichi Ichimura, Ryo Nishikawa, Yukinori Okada, Keita Terashima

Nat Commun. 2022; 13: 4478. Published online 2022 Aug 2. doi: 10.1038/s41467-022-32005-9

PMCID:: PMC9346128

Abstract Article PDF–2.7M

Select item 930837410.

CD36 and ERK5 link dyslipidemia to apoptotic-like platelet procoagulant function

Moua Yang, Roy L. Silverstein

Curr Opin Hematol. Author manuscript; available in PMC 2022 Jul 23.

Published in final edited form as: Curr Opin Hematol. 2019 Sep; 26(5): 357–365. doi: 10.1097/MOH.0000000000000522

PMCID:: PMC9308374

Abstract Article PDF–1.1M

Select item 890144111.

The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation

Katia Cosentino, Vanessa Hertlein, Andreas Jenner, Timo Dellmann, Milos Gojkovic, Aida Peña-Blanco, Shashank Dadsena, Noel Wajngarten, John S.H. Danial, Jervis Vermal Thevathasan, Markus Mund, Jonas Ries, Ana J. Garcia-Saez

Mol Cell. 2022 Mar 3; 82(5): 933–949.e9. doi: 10.1016/j.molcel.2022.01.008

PMCID:: PMC8901441

Abstract Article

Select item 875283712.

Structural basis of BAK activation in mitochondrial apoptosis initiation

Geetika Singh, Cristina D. Guibao, Jayaraman Seetharaman, Anup Aggarwal, Christy R. Grace, Dan E. McNamara, Sivaraja Vaithiyalingam, M. Brett Waddell, Tudor Moldoveanu

Nat Commun. 2022; 13: 250. Published online 2022 Jan 11. doi: 10.1038/s41467-021-27851-y

PMCID:: PMC8752837

Abstract Article PDF–6.5M

Select item 866412913.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

Marcel Morgenstern, Christian D. Peikert, Philipp Lübbert, Ida Suppanz, Cinzia Klemm, Oliver Alka, Conny Steiert, Nataliia Naumenko, Alexander Schendzielorz, Laura Melchionda, Wignand W.D. Mühlhäuser, Bettina Knapp, Jakob D. Busch, Sebastian B. Stiller, Stefan Dannenmaier, Caroline Lindau, Mariya Licheva, Christopher Eickhorst, Riccardo Galbusera, Ralf M. Zerbes, Michael T. Ryan, Claudine Kraft, Vera Kozjak-Pavlovic, Friedel Drepper, Sven Dennerlein, Silke Oeljeklaus, Nikolaus Pfanner, Nils Wiedemann, Bettina Warscheid

Cell Metab. 2021 Dec 7; 33(12): 2464–2483.e18. doi: 10.1016/j.cmet.2021.11.001

PMCID:: PMC8664129

Abstract Article

Select item 856087114.

Paradoxical implication of BAX/BAK in the persistence of tetraploid cells

Jiayin Deng, Lucía G. Gutiérrez, Gautier Stoll, Omar Motiño, Isabelle Martins, Lucía Núñez, José Manuel Bravo-San Pedro, Juliette Humeau, Chloé Bordenave, Juncheng Pan, Hélène Fohrer-Ting, Sylvie Souquere, Gerard Pierron, Claudio Hetz, Carlos Villalobos, Guido Kroemer, Laura Senovilla

Cell Death Dis. 2021 Nov; 12(11): 1039. Published online 2021 Nov 1. doi: 10.1038/s41419-021-04321-3

PMCID:: PMC8560871

Abstract Article PDF–6.0M

Select item 852130515.

High‐resolution analysis of the conformational transition of pro‐apoptotic Bak at the lipid membrane

Laura E Sperl, Florian Rührnößl, Anita Schiller, Martin Haslbeck, Franz Hagn

EMBO J. 2021 Oct 18; 40(20): e107159. Published online 2021 Sep 15. doi: 10.15252/embj.2020107159

PMCID:: PMC8521305

Abstract Article PDF–2.9M

Select item 852127516.

Dynamic reconfiguration of pro‐apoptotic BAK on membranes

Jarrod J Sandow, Iris KL Tan, Alan S Huang, Shashank Masaldan, Jonathan P Bernardini, Ahmad Z Wardak, Richard W Birkinshaw, Robert L Ninnis, Ziyan Liu, Destiny Dalseno, Daisy Lio, Giuseppi Infusini, Peter E Czabotar, Andrew I Webb, Grant Dewson

EMBO J. 2021 Oct 18; 40(20): e107237. Published online 2021 Sep 15. doi: 10.15252/embj.2020107237

PMCID:: PMC8521275

Abstract Article PDF–2.0M

Select item 816503017.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 756688118.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 733505019.

Characterization of an alternative BAK-binding site for BH3 peptides

Kaiqin Ye, Wei X. Meng, Hongbin Sun, Bo Wu, Meng Chen, Yuan-Ping Pang, Jia Gao, Hongzhi Wang, Junfeng Wang, Scott H. Kaufmann, Haiming Dai

Nat Commun. 2020; 11: 3301. Published online 2020 Jul 3. doi: 10.1038/s41467-020-17074-y

PMCID:: PMC7335050

Abstract Article PDF–3.4M

Select item 728023320.

Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1

Li Dong, David L. Vaux

Cell Death Dis. 2020 Jun; 11(6): 442. Published online 2020 Jun 8. doi: 10.1038/s41419-020-2599-5

PMCID:: PMC7280233

Abstract Article PDF–5.5M

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