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Items: 1 to 20 of 40

1.
Beyond Allergies—Updates on The Role of Mas-Related G-Protein-Coupled Receptor X2 in Chronic Urticaria and Atopic Dermatitis
Liron Lerner, Magda Babina, Torsten Zuberbier, Katarina Stevanovic
Cells. 2024 Feb; 13(3): 220. Published online 2024 Jan 25. doi: 10.3390/cells13030220
PMCID:
PMC10854933
AbstractArticlePDF–1.0M
2.
Proinflammatory chemokine CXCL14 activates MAS-related G protein-coupled receptor MRGPRX2 and its putative mouse ortholog MRGPRB2
Ghazl Al Hamwi, Vigneshwaran Namasivayam, Beatriz Büschbell, Robin Gedschold, Stefan Golz, Christa E. Müller
Commun Biol. 2024; 7: 52. Published online 2024 Jan 6. doi: 10.1038/s42003-023-05739-5
PMCID:
PMC10771525
AbstractArticlePDF–3.0M
3.
PACAP activates MRGPRX2 on meningeal mast cells to drive migraine-like pain
Sami Sbei, Taylor Moncrief, Nathachit Limjunyawong, Yaping Zeng, Dustin P. Green
Sci Rep. 2023; 13: 12302. Published online 2023 Jul 29. doi: 10.1038/s41598-023-39571-y
Correction in:
Sci Rep. 2023; 13: 13298.
PMCID:
PMC10387048
AbstractArticlePDF–2.8M
4.
Substance P analogs devoid of key residues fail to activate human mast cells via MRGPRX2
Shammy Raj, Stepan Hlushak, Narcy Arizmendi, Andriy Kovalenko, Marianna Kulka
Front Immunol. 2023; 14: 1155740. Published online 2023 May 9. doi: 10.3389/fimmu.2023.1155740
PMCID:
PMC10203606
AbstractArticlePDF–6.2M
5.
Itch receptor MRGPRX4 interacts with the receptor activity–modifying proteins
Ilana B. Kotliar, Emilie Ceraudo, Kevin Kemelmakher-Liben, Deena A. Oren, Emily Lorenzen, Tea Dodig-Crnković, Mizuho Horioka-Duplix, Thomas Huber, Jochen M. Schwenk, Thomas P. Sakmar
J Biol Chem. 2023 May; 299(5): 104664. Published online 2023 Mar 30. doi: 10.1016/j.jbc.2023.104664
PMCID:
PMC10165273
AbstractArticlePDF–3.6M
6.
Mas-related G protein-coupled receptor MRGPRX2 in human basophils: Expression and functional studies
Alessandro Toscano, Jessy Elst, Athina L. Van Gasse, Michiel Beyens, Marie-Line van der Poorten, Chris H. Bridts, Christel Mertens, Michel Van Houdt, Margo M. Hagendorens, Samuel Van Remoortel, Jean-Pierre Timmermans, Didier G. Ebo, Vito Sabato
Front Immunol. 2022; 13: 1026304. Published online 2023 Jan 16. doi: 10.3389/fimmu.2022.1026304
PMCID:
PMC9885256
AbstractArticlePDF–5.4M
7.
MRGPRX2 and Its Role in Non-IgE-mediated Drug Hypersensitivity
Chalatip Chompunud Na Ayudhya, Hydar Ali
Immunol Allergy Clin North Am. Author manuscript; available in PMC 2023 May 1.
Published in final edited form as: Immunol Allergy Clin North Am. 2022 May; 42(2): 269–284. Published online 2022 Mar 31. doi: 10.1016/j.iac.2021.12.003
PMCID:
PMC9674431
ArticlePDF–519K
8.
Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma
Andrea Seldeslachts, Steve Peigneur, Dietrich Mebs, Jan Tytgat
Front Immunol. 2022; 13: 972442. Published online 2022 Aug 24. doi: 10.3389/fimmu.2022.972442
PMCID:
PMC9448982
AbstractArticlePDF–2.0M
9.
The effect of substance P and its common in vivo‐formed metabolites on MRGPRX2 and human mast cell activation
Lin Hsin, Nithya A. Fernandopulle, Jie Ding, Chris Lumb, Nicholas Veldhuis, John A. Karas, Susan E. Northfield, Graham A. Mackay
Pharmacol Res Perspect. 2022 Aug; 10(4): e00990. Published online 2022 Jul 29. doi: 10.1002/prp2.990
PMCID:
PMC9337217
AbstractArticlePDF–2.0M
10.
STRUCTURE, FUNCTION AND PHARMACOLOGY OF HUMAN ITCH GPCRs
Can Cao, Hye Jin Kang, Isha Singh, He Chen, Chengwei Zhang, Wenlei Ye, Byron W. Hayes, Jing Liu, Ryan H. Gumpper, Brian J. Bender, Samuel T. Slocum, Brian E. Krumm, Katherine Lansu, John D. McCorvy, Wesley K. Kroeze, Justin G. English, Jeffrey F. DiBerto, Reid H. J. Olsen, Xi-Ping. Huang, Shicheng Zhang, Yongfeng Liu, Kuglae Kim, Joel Karpiak, Lily Y. Jan, Soman N. Abraham, Jian Jin, Brian K. Shoichet, Jonathan F. Fay, Bryan L. Roth
Nature. Author manuscript; available in PMC 2022 Jun 1.
Published in final edited form as: Nature. 2021 Dec; 600(7887): 170–175. Published online 2021 Nov 17. doi: 10.1038/s41586-021-04126-6
PMCID:
PMC9150435
AbstractArticlePDF–2.5M
11.
MRGPRX2-Mediated Degranulation of Human Skin Mast Cells Requires the Operation of Gαi, Gαq, Ca++ Channels, ERK1/2 and PI3K—Interconnection between Early and Late Signaling
Zhao Wang, Kristin Franke, Gürkan Bal, Zhuoran Li, Torsten Zuberbier, Magda Babina
Cells. 2022 Mar; 11(6): 953. Published online 2022 Mar 10. doi: 10.3390/cells11060953
PMCID:
PMC8946553
AbstractArticlePDF–3.5M
12.
Antibody or Anybody? Considering the Role of MRGPRX2 in Acute Drug-Induced Anaphylaxis and as a Therapeutic Target
Graham A. Mackay, Nithya A. Fernandopulle, Jie Ding, Jeremy McComish, Paul F. Soeding
Front Immunol. 2021; 12: 688930. Published online 2021 Nov 19. doi: 10.3389/fimmu.2021.688930
PMCID:
PMC8639860
AbstractArticlePDF–991K
13.
Expression of MRGPRX2 in skin mast cells of patients with maculopapular cutaneous mastocytosis
Vishwa Deepak, Hirsh D. Komarow, Abdulaziz A Alblaihess, Melody C. Carter, Dean D. Metcalfe, Hydar Ali
J Allergy Clin Immunol Pract. Author manuscript; available in PMC 2022 Oct 1.
Published in final edited form as: J Allergy Clin Immunol Pract. 2021 Oct; 9(10): 3841–3843.e1. Published online 2021 Jun 25. doi: 10.1016/j.jaip.2021.05.042
PMCID:
PMC8511159
ArticlePDF–466K
14.
Inflamed ulcerative colitis regions associated to MRGPRX2-mediated mast cell degranulation and cell activation modules, defining a new therapeutic target
Ernie Chen, Ling-shiang Chuang, Mamta Giri, Nicole Villaverde, Nai-yun Hsu, Ksenija Sabic, Sari Joshowitz, Kyle Gettler, Shikha Nayar, Zhi Chai, Isaac L. Alter, Colleen C. Chasteau, Ujunwa M. Korie, Siarhei Dzedzik, Tin Htwe Thin, Aayushee Jain, Arden Moscati, Gerardus Bongers, Richard H. Duerr, Mark S. Silverberg, Steven R. Brant, John D. Rioux, Inga Peter, L. Philip Schumm, Talin Haritunians, Dermot P. McGovern, Yuval Itan, Judy H. Cho
Gastroenterology. Author manuscript; available in PMC 2022 Apr 1.
Published in final edited form as: Gastroenterology. 2021 Apr; 160(5): 1709–1724. Published online 2021 Jan 6. doi: 10.1053/j.gastro.2020.12.076
PMCID:
PMC8494017
AbstractArticlePDF–2.1M
15.
Multifaceted MRGPRX2: New Insight into the Role of Mast Cells in Health and Disease
Saptarshi Roy, Chalatip Chompunud Na Ayudhya, Monica Thapaliya, Vishwa Deepak, Hydar Ali
J Allergy Clin Immunol. Author manuscript; available in PMC 2022 Aug 1.
Published in final edited form as: J Allergy Clin Immunol. 2021 Aug; 148(2): 293–308. Published online 2021 May 4. doi: 10.1016/j.jaci.2021.03.049
PMCID:
PMC8355064
AbstractArticlePDF–2.3M
16.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
17.
Substance P Serves as a Balanced Agonist for MRGPRX2 and a Single Tyrosine Residue Is Required for β-Arrestin Recruitment and Receptor Internalization
Chalatip Chompunud Na Ayudhya, Aetas Amponnawarat, Hydar Ali
Int J Mol Sci. 2021 May; 22(10): 5318. Published online 2021 May 18. doi: 10.3390/ijms22105318
PMCID:
PMC8158387
AbstractArticlePDF–2.2M
18.
MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway
Magda Babina, Zhao Wang, Saptarshi Roy, Sven Guhl, Kristin Franke, Metin Artuc, Hydar Ali, Torsten Zuberbier
J Invest Dermatol. Author manuscript; available in PMC 2022 May 1.
Published in final edited form as: J Invest Dermatol. 2021 May; 141(5): 1286–1296.e4. Published online 2020 Oct 13. doi: 10.1016/j.jid.2020.09.017
PMCID:
PMC8041898
AbstractArticlePDF–1.5M
19.
Cytokines Stimulated by IL-33 in Human Skin Mast Cells: Involvement of NF-κB and p38 at Distinct Levels and Potent Co-Operation with FcεRI and MRGPRX2
Kristin Franke, Zhao Wang, Torsten Zuberbier, Magda Babina
Int J Mol Sci. 2021 Apr; 22(7): 3580. Published online 2021 Mar 30. doi: 10.3390/ijms22073580
PMCID:
PMC8036466
AbstractArticlePDF–2.7M
20.
Human Mast Cell Line HMC1 Expresses Functional Mas-Related G-Protein Coupled Receptor 2
Maud A. W. Hermans, Astrid C. van Stigt, Sanne van de Meerendonk, Benjamin Schrijver, Paul L. A. van Daele, Petrus M. van Hagen, Marloes van Splunter, Willem A. Dik
Front Immunol. 2021; 12: 625284. Published online 2021 Mar 15. doi: 10.3389/fimmu.2021.625284
PMCID:
PMC8006456
AbstractArticlePDF–3.2M

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