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Items: 1 to 20 of 83

1.
MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis
Shuzhen Liu, Preston Perez, Xue Sun, Ken Chen, Rojin Fatirkhorani, Jamila Mammadova, Zhigao Wang
Cell Death Differ. 2024 Jan; 31(1): 40–52. Published online 2023 Nov 23. doi: 10.1038/s41418-023-01237-7
PMCID:
PMC10782024
AbstractArticlePDF–11M
2.
MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease
Lu Geng, Wenqing Gao, Hexige Saiyin, Yuanyuan Li, Yu Zeng, Zhifei Zhang, Xue Li, Zuolong Liu, Qiang Gao, Ping An, Ning Jiang, Xiaofei Yu, Xiangjun Chen, Suhua Li, Lei Chen, Boxun Lu, Aiqun Li, Guoyuan Chen, Yidong Shen, Haibing Zhang, Mei Tian, Zhuohua Zhang, Jixi Li
Mol Neurodegener. 2023; 18: 94. Published online 2023 Dec 1. doi: 10.1186/s13024-023-00686-5
PMCID:
PMC10693130
AbstractArticlePDF–8.9M
3.
MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction
Yanyan Tang, Quanhong Chu, Guanfeng Xie, Yafu Tan, Ziming Ye, Chao Qin
Mol Brain. 2023; 16: 74. Published online 2023 Oct 30. doi: 10.1186/s13041-023-01064-4
PMCID:
PMC10617209
AbstractArticlePDF–6.5M
4.
Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization
Yanxiang Meng, Sarah E. Garnish, Katherine A. Davies, Katrina A. Black, Andrew P. Leis, Christopher R. Horne, Joanne M. Hildebrand, Hanadi Hoblos, Cheree Fitzgibbon, Samuel N. Young, Toby Dite, Laura F. Dagley, Aarya Venkat, Natarajan Kannan, Akiko Koide, Shohei Koide, Alisa Glukhova, Peter E. Czabotar, James M. Murphy
Nat Commun. 2023; 14: 6804. Published online 2023 Oct 26. doi: 10.1038/s41467-023-42255-w
PMCID:
PMC10603135
AbstractArticlePDF–3.2M
5.
A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation
Sarah E. Garnish, Katherine R. Martin, Maria Kauppi, Victoria E. Jackson, Rebecca Ambrose, Vik Ven Eng, Shene Chiou, Yanxiang Meng, Daniel Frank, Emma C. Tovey Crutchfield, Komal M. Patel, Annette V. Jacobsen, Georgia K. Atkin-Smith, Ladina Di Rago, Marcel Doerflinger, Christopher R. Horne, Cathrine Hall, Samuel N. Young, Matthew Cook, Vicki Athanasopoulos, Carola G. Vinuesa, Kate E. Lawlor, Ian P. Wicks, Gregor Ebert, Ashley P. Ng, Charlotte A. Slade, Jaclyn S. Pearson, André L. Samson, John Silke, James M. Murphy, Joanne M. Hildebrand
Nat Commun. 2023; 14: 6046. Published online 2023 Sep 28. doi: 10.1038/s41467-023-41724-6
PMCID:
PMC10539340
AbstractArticlePDF–2.6M
6.
Necroptosis executioner MLKL plays pivotal roles in agonist-induced platelet prothrombotic responses and lytic cell death in a temporal order
Mohammad Ekhlak, Paresh P. Kulkarni, Vipin Singh, Susheel N. Chaurasia, Saroj Kant Mohapatra, Rameshwar Nath Chaurasia, Debabrata Dash
Cell Death Differ. 2023 Aug; 30(8): 1886–1899. Published online 2023 Jun 10. doi: 10.1038/s41418-023-01181-6
PMCID:
PMC10406901
AbstractArticlePDF–4.6M
7.
Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells
Huiling Zhou, Li Zhou, Qing Guan, Xuyang Hou, Cong Wang, Lijun Liu, Jian Wang, Xinfang Yu, Wei Li, Haidan Liu
Commun Biol. 2023; 6: 805. Published online 2023 Aug 2. doi: 10.1038/s42003-023-05166-6
PMCID:
PMC10397346
AbstractArticlePDF–3.5M
8.
IKK-mediated TRAF6 and RIPK1 interaction stifles cell death complex assembly leading to the suppression of TNF-α-induced cell death
Choong-Sil Lee, Gyuho Hwang, Young Woo Nam, Chi Hyun Hwang, Jaewhan Song
Cell Death Differ. 2023 Jun; 30(6): 1575–1584. Published online 2023 Apr 21. doi: 10.1038/s41418-023-01161-w
PMCID:
PMC10244383
AbstractArticlePDF–2.8M
9.
Upregulation of necroptosis markers RIPK3/MLKL and their crosstalk with autophagy-related protein Beclin-1 in primary immune thrombocytopenia
Amany M. Kamal, Nermeen A. Nabih, Nahed M. Rakha, Eman F. Sanad
Clin Exp Med. 2023; 23(2): 447–456. Published online 2022 Jun 14. doi: 10.1007/s10238-022-00839-8
PMCID:
PMC10224853
AbstractArticlePDF–1.1M
10.
MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection
Xuqiu Lei, Yongzhi Chen, Egil Lien, Katherine A. Fitzgerald
mBio. 2023 Mar-Apr; 14(2): e00110-23. Published online 2023 Feb 28. doi: 10.1128/mbio.00110-23
PMCID:
PMC10127685
AbstractArticlePDF–1.2M
11.
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong
Mol Cell. Author manuscript; available in PMC 2023 Apr 4.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015
PMCID:
PMC10072906
AbstractArticlePDF–4.2M
12.
SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses
Shufen Li, Yulan Zhang, Zhenqiong Guan, Meidi Ye, Huiling Li, Miaomiao You, Zhenxing Zhou, Chongtao Zhang, Fan Zhang, Ben Lu, Peng Zhou, Ke Peng
Cell Res. 2023 Mar; 33(3): 201–214. Published online 2023 Jan 17. doi: 10.1038/s41422-022-00775-y
PMCID:
PMC9844202
AbstractArticlePDF–6.5M
13.
Enhanced nuclear localization of phosphorylated MLKL predicts adverse events in patients with dilated cardiomyopathy
Yugo Fujita, Toshiyuki Yano, Hiromitsu Kanamori, Daigo Nagahara, Atsuko Muranaka, Hidemichi Kouzu, Atsushi Mochizuki, Masayuki Koyama, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Naoyuki Kamiyama, Marenao Tanaka, Atsushi Kuno, Masaya Tanno, Tetsuji Miura
ESC Heart Fail. 2022 Oct; 9(5): 3435–3451. Published online 2022 Jul 18. doi: 10.1002/ehf2.14059
PMCID:
PMC9715765
AbstractArticlePDF–44M
14.
Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL
Ashish Sethi, Christopher R. Horne, Cheree Fitzgibbon, Karyn Wilde, Katherine A. Davies, Sarah E. Garnish, Annette V. Jacobsen, André L. Samson, Joanne M. Hildebrand, Ahmad Wardak, Peter E. Czabotar, Emma J. Petrie, Paul R. Gooley, James M. Murphy
Cell Death Differ. 2022 Sep; 29(9): 1804–1815. Published online 2022 Mar 9. doi: 10.1038/s41418-022-00965-6
PMCID:
PMC9433430
AbstractArticlePDF–3.6M
15.
Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling
Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser
Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151
PMCID:
PMC9105235
AbstractArticlePDF–5.8M
16.
Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway
Sarah E. Garnish, Joanne M. Hildebrand
Biochem Soc Trans. 2022 Feb 28; 50(1): 529–539. Published online 2022 Feb 15. doi: 10.1042/BST20210517
PMCID:
PMC9022980
AbstractArticlePDF–4.3M
17.
Necroptosis-driving genes RIPK1, RIPK3 and MLKL-p are associated with intratumoral CD3+ and CD8+ T cell density and predict prognosis in hepatocellular carcinoma
Lorenzo Nicolè, Tiziana Sanavia, Rocco Cappellesso, Valeria Maffeis, Jun Akiba, Akihiko Kawahara, Yoshiki Naito, Claudia Maria Radu, Paolo Simioni, Davide Serafin, Giuliana Cortese, Maria Guido, Giacomo Zanus, Hirohisa Yano, Ambrogio Fassina
J Immunother Cancer. 2022; 10(3): e004031. Published online 2022 Mar 8. doi: 10.1136/jitc-2021-004031
PMCID:
PMC8915343
AbstractArticlePDF–5.0M
18.
Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes
Seongmin Yoon, Konstantin Bogdanov, David Wallach
Cell Death Differ. 2022 Feb; 29(2): 306–322. Published online 2022 Jan 9. doi: 10.1038/s41418-021-00924-7
PMCID:
PMC8816944
AbstractArticlePDF–5.4M
19.
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
Yanxiang Meng, Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Christopher R. Horne, Cindy Luo, Jean-Marc Garnier, Lung-Yu Liang, Angus D. Cowan, Andre L. Samson, Guillaume Lessene, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy
Nat Commun. 2021; 12: 6783. Published online 2021 Nov 22. doi: 10.1038/s41467-021-27032-x
PMCID:
PMC8608796
AbstractArticlePDF–6.8M
20.
Positive Charges in the Brace Region Facilitate the Membrane Disruption of MLKL-NTR in Necroptosis
Yaqing Yang, Encheng Xie, Lingyu Du, Yu Yang, Bin Wu, Liming Sun, Shuqing Wang, Bo OuYang
Molecules. 2021 Sep; 26(17): 5194. Published online 2021 Aug 27. doi: 10.3390/molecules26175194
PMCID:
PMC8433767
AbstractArticlePDF–2.7M

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