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Select item 106578221.

The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization

Meiwan Cao, Peiyu Chen, Baoling Peng, Yang Cheng, Jing Xie, Ziang Hou, Huan Chen, Liping Ye, Huiwen Li, Hongli Wang, Lu Ren, Liya Xiong, Lanlan Geng, Sitang Gong

Front Immunol. 2023; 14: 1270411. Published online 2023 Nov 6. doi: 10.3389/fimmu.2023.1270411

PMCID:: PMC10657822

Abstract Article PDF–10M

Select item 103603272.

Knockdown of ELF4 aggravates renal injury in ischemia/reperfusion mice through promotion of pyroptosis, inflammation, oxidative stress, and endoplasmic reticulum stress

Li Li, Shunying Wang, Wenming Wang

BMC Mol Cell Biol. 2023; 24: 22. Published online 2023 Jul 20. doi: 10.1186/s12860-023-00485-2

PMCID:: PMC10360327

Abstract Article PDF–5.5M

Select item 97469173.

An ELF4 hypomorphic variant results in NK cell deficiency

Sandra Andrea Salinas, Emily M. Mace, Matilde I. Conte, Chun Shik Park, Yu Li, Joshua I. Rosario-Sepulveda, Sanjana Mahapatra, Emily K. Moore, Evelyn R. Hernandez, Ivan K. Chinn, Abigail E. Reed, Barclay J. Lee, Alexander Frumovitz, Richard A. Gibbs, Jennifer E. Posey, Lisa R. Forbes Satter, Akaluck Thatayatikom, Eric J. Allenspach, Theodore G. Wensel, James R. Lupski, H. Daniel Lacorazza, Jordan S. Orange

JCI Insight. 2022 Dec 8; 7(23): e155481. Published online 2022 Dec 8. doi: 10.1172/jci.insight.155481

PMCID:: PMC9746917

Abstract Article PDF–7.0M

Select item 89858514.

Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation

Paul M. Tyler, Molly L. Bucklin, Mengting Zhao, Timothy J. Maher, Andrew J. Rice, Weizhen Ji, Neil Warner, Jie Pan, Raffaella Morotti, Paul McCarthy, Anne Griffiths, Annemarie M.C. van Rossum, Iris H.I.M. Hollink, Virgil A.S.H. Dalm, Jason Catanzaro, Saquib A. Lakhani, Aleixo M. Muise, Carrie L. Lucas

Nat Immunol. Author manuscript; available in PMC 2022 Apr 6.

Published in final edited form as: Nat Immunol. 2021 Sep; 22(9): 1118–1126. Published online 2021 Jul 29. doi: 10.1038/s41590-021-00984-4

PMCID:: PMC8985851

Abstract Article PDF–3.7M

Select item 79074805.

Suppression of ELF4 in ulcerative colitis predisposes host to colorectal cancer

Hongqiang Du, Huawei Xia, Tongtong Liu, Yingjie Li, Jilong Liu, Bingteng Xie, Jingxuan Chen, Tong Liu, Lili Cao, Shengde Liu, Siji Li, Peiyan Wang, Dandan Wang, Zeming Zhang, Yunfei Li, Xiaohuan Guo, Aiwen Wu, Mo Li, Fuping You

iScience. 2021 Mar 19; 24(3): 102169. Published online 2021 Feb 9. doi: 10.1016/j.isci.2021.102169

PMCID:: PMC7907480

Abstract Article PDF–7.8M

Select item 65146186.

ELF4 facilitates innate host defenses against Plasmodium by activating transcription of Pf4 and Ppbp

Dandan Wang, Zeming Zhang, Shuang Cui, Yingchi Zhao, Samuel Craft, Erol Fikrig, Fuping You

J Biol Chem. 2019 May 10; 294(19): 7787–7796. Published online 2019 Mar 21. doi: 10.1074/jbc.RA118.006321

PMCID:: PMC6514618

Abstract Article PDF–2.1M

Select item 60825027.

MiR-221 negatively regulates innate anti-viral response

Hongqiang Du, Shuang Cui, Yunfei Li, Guang Yang, Peiyan Wang, Erol Fikrig, Fuping You

PLoS One. 2018; 13(8): e0200385. Published online 2018 Aug 8. doi: 10.1371/journal.pone.0200385

PMCID:: PMC6082502

Abstract Article PDF–2.8M

Select item 55680748.

Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg

Yoichi Ohta, Takahiro Okabe, Colleen Larmour, Agnese Di Rocco, Marijke Maijenburg, Amanda Phillips, Nancy A. Speck, Shigeyuki Wakitani, Takashi Nakamura, Yoshihiko Yamada, Motomi Enomoto-Iwamoto, Maurizio Pacifici, Masahiro Iwamoto

Arthritis Rheumatol. Author manuscript; available in PMC 2017 Aug 23.

Published in final edited form as: Arthritis Rheumatol. 2015 Oct; 67(10): 2679–2690. doi: 10.1002/art.39243

PMCID:: PMC5568074

Abstract Article PDF–2.6M

Select item 47853519.

Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms

Takashi Asai, Megan A. Hatlen, Chen Lossos, Delphine Ndiaye-Lobry, Anthony Deblasio, Kazunori Murata, Martin Fleisher, Elena M. Cortizas, Ramiro E. Verdun, John Petrini, Stephen D. Nimer

Sci Rep. 2016; 6: 22760. Published online 2016 Mar 10. doi: 10.1038/srep22760

PMCID:: PMC4785351

Abstract Article PDF–2.3M

Select item 431955910.

A high resolution spatiotemporal atlas of gene expression of the developing mouse brain

Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones

Neuron. Author manuscript; available in PMC 2015 Jul 16.

Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033

PMCID:: PMC4319559

Abstract Article PDF–3.0M

Select item 407367711.

The Mef/Elf4 transcription factor fine tunes the DNA damage response

Goro Sashida, Narae Bae, Silvana Di Giandomenico, Takashi Asai, Nadia Gurvich, Elena Bazzoli, Yan Liu, Gang Huang, Xinyang Zhao, Silvia Menendez, Stephen D Nimer

Cancer Res. Author manuscript; available in PMC 2014 Jun 27.

Published in final edited form as: Cancer Res. 2011 Jul 15; 71(14): 4857–4865. Published online 2011 May 26. doi: 10.1158/0008-5472.CAN-11-0455

PMCID:: PMC4073677

Abstract Article PDF–1.9M

Select item 393985512.

ELF4 is critical for induction of type I interferon and the host antiviral response

Fuping You, Penghua Wang, Long Yang, Guang Yang, Yang O Zhao, Feng Qian, Wendy Walker, Richard Sutton, Ruth Montgomery, Rongtuan Lin, Akiko Iwasaki, Erol Fikrig

Nat Immunol. Author manuscript; available in PMC 2014 Mar 3.

Published in final edited form as: Nat Immunol. 2013 Dec; 14(12): 1237–1246. Published online 2013 Nov 3. doi: 10.1038/ni.2756

PMCID:: PMC3939855

Abstract Article PDF–3.4M

Select item 387225013.

The Transcription Factor ELF4 Suppresses Differentiation of Proliferating CD4⁺ T Cells to the Th17 Lineage

Ping-Hsien Lee, Monica Puppi, Kimberly S. Schluns, Li-Yuan Yu-Lee, Chen Dong, H. Daniel Lacorazza

J Immunol. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: J Immunol. 2014 Jan 1; 192(1): 10.4049/jimmunol.1301372. Published online 2013 Nov 20. doi: 10.4049/jimmunol.1301372

PMCID:: PMC3872250

Abstract Article PDF–2.8M

Select item 381292414.

MEF promotes stemness in the pathogenesis of gliomas

Elena Bazzoli, Teodoro Pulvirenti, Moritz C. Oberstadt, Fabiana Perna, Boyoung Wee, Nikolaus Schultz, Jason T. Huse, Elena I. Fomchenko, Francesca Voza, Viviane Tabar, Cameron W. Brennan, Lisa M. DeAngelis, Stephen D. Nimer, Eric C. Holland, Massimo Squatrito

Cell Stem Cell. Author manuscript; available in PMC 2013 Dec 7.

Published in final edited form as: Cell Stem Cell. 2012 Dec 7; 11(6): 10.1016/j.stem.2012.09.012. doi: 10.1016/j.stem.2012.09.012

PMCID:: PMC3812924

Abstract Article PDF–642K

Select item 357241015.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 344801216.

Transcription factor Foxp3 and its protein partners form a complex regulatory network

Dipayan Rudra, Paul deRoos, Ashutosh Chaudhry, Rachel Niec, Aaron Arvey, Robert M. Samstein, Christina Leslie, Scott A. Shaffer, David R. Goodlett, Alexander Y. Rudensky

Nat Immunol. Author manuscript; available in PMC 2013 Apr 1.

Published in final edited form as: Nat Immunol. 2012 Oct; 13(10): 1010–1019. Published online 2012 Aug 26. doi: 10.1038/ni.2402

PMCID:: PMC3448012

Abstract Article PDF–2.6M

Select item 327297917.

Integration of Elf-4 into Stem/Progenitor and Erythroid Regulatory Networks through Locus-Wide Chromatin Studies Coupled with InVivo Functional Validation

Aileen M. Smith, Fernando J. Calero-Nieto, Judith Schütte, Sarah Kinston, Richard T. Timms, Nicola K. Wilson, Rebecca L. Hannah, Josette-Renee Landry, Berthold Göttgens

Mol Cell Biol. 2012 Feb; 32(4): 763–773. doi: 10.1128/MCB.05745-11

PMCID:: PMC3272979

Abstract Article PDF–1.7M

Select item 324656518.

ETS-Dependent Regulation of a Distal Gata4 Cardiac Enhancer

William Schachterle, Anabel Rojas, Shan-Mei Xu, Brian L. Black

Dev Biol. Author manuscript; available in PMC 2013 Jan 15.

Published in final edited form as: Dev Biol. 2012 Jan 15; 361(2): 439–449. Published online 2011 Oct 26. doi: 10.1016/j.ydbio.2011.10.023

PMCID:: PMC3246565

Abstract Article PDF–4.4M

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 311015120.

A Systems Approach Reveals that the Myogenesis Genome Network Is Regulated by the Transcriptional Repressor RP58

Shigetoshi Yokoyama, Yoshiaki Ito, Hiroe Ueno-Kudoh, Hirohito Shimizu, Kenta Uchibe, Sonia Albini, Kazuhiko Mitsuoka, Shigeru Miyaki, Minako Kiso, Akane Nagai, Tomohiro Hikata, Tadahiro Osada, Noritsugu Fukuda, Satoshi Yamashita, Daisuke Harada, Valeria Mezzano, Masataka Kasai, Pier Lorenzo Puri, Yoshihide Hayashizaki, Haruo Okado, Megumi Hashimoto, Hiroshi Asahara

Dev Cell. Author manuscript; available in PMC 2011 Jun 7.

Published in final edited form as: Dev Cell. 2009 Dec; 17(6): 836–848. doi: 10.1016/j.devcel.2009.10.011

PMCID:: PMC3110151

Abstract Article PDF–2.0M

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