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Items: 1 to 20 of 49

1.
Dominant Negative Variants in IKZF2 Cause ICHAD Syndrome, a New Disorder Characterized by Immunodysregulation, Craniofacial Anomalies, Hearing Impairment, Athelia, and Developmental Delay
Arezoo Mohajeri, Maryam Vaseghi-Shanjani, Jill A. Rosenfeld, Gui Xiang Yang, Henry Lu, Mehul Sharma, Susan Lin, Areesha Salman, Meriam Waqas, Mahshid Sababi Azamian, Kim C. Worley, Kate L. Del Bel, Frederick K. Kozak, Ronak Rahmanian, Catherine M. Biggs, Kyla J. Hildebrand, Seema R. Lalani, Sarah K. Nicholas, Daryl A. Scott, Sara Mostafavi, Clara van Karnebeek, Erika Henkelman, Jessica Halparin, Connie L Yang, Linlea Armstrong, Undiagnosed Diseases Network, Stuart E. Turvey
J Med Genet. Author manuscript; available in PMC 2024 Nov 1.
Published in final edited form as: J Med Genet. 2023 Nov; 60(11): 1092–1104. Published online 2023 Jun 14. doi: 10.1136/jmg-2022-109127
PMCID:
PMC11206234
AbstractArticlePDF–2.2M
2.
Characterization of the short isoform of Helios overexpressed in patients with T‐cell malignancies
Takayuki Tabayashi, Fumihiko Ishimaru, Minoru Takata, Itaru Kataoka, Koichi Nakase, Teruhiko Kozuka, Mitsune Tanimoto
Cancer Sci. 2007 Feb; 98(2): 182–188. Published online 2006 Dec 15. doi: 10.1111/j.1349-7006.2006.00372.x
PMCID:
PMC11159431
AbstractArticlePDF–541K
3.
Temporal changes in regulatory T cell subsets defined by the transcription factor Helios in stroke and their potential role in stroke-associated infection: a prospective case–control study
Maria Lukasik, Magdalena Telec, Radoslaw Kazmierski, Izabela Wojtasz, Natalia Andrzejewska-Gorczyńska, Wojciech Kociemba, Grzegorz Dworacki, Wojciech P. Kozubski, Magdalena Frydrychowicz
J Neuroinflammation. 2023; 20: 275. Published online 2023 Nov 23. doi: 10.1186/s12974-023-02957-w
PMCID:
PMC10666369
AbstractArticlePDF–970K
4.
Aging-associated HELIOS deficiency in naïve CD4+ T cells alters chromatin remodeling and promotes effector cell responses
Huimin Zhang, Rohit R. Jadhav, Wenqiang Cao, Isabel N. Goronzy, Tuantuan V. Zhao, Jun Jin, Shozo Ohtsuki, Zhaolan Hu, Jose Morales, William J. Greenleaf, Cornelia M. Weyand, Jörg J. Goronzy
Nat Immunol. Author manuscript; available in PMC 2024 Jan 1.
Published in final edited form as: Nat Immunol. 2023 Jan; 24(1): 96–109. Published online 2022 Dec 12. doi: 10.1038/s41590-022-01369-x
PMCID:
PMC10118794
AbstractArticlePDF–5.2M
5.
Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL
Patrick R. Hagner, Hsiling Chiu, Vivek S. Chopra, Martino Colombo, Nisha Patel, Maria Ortiz Estevez, Michelle F. Waldman, Remco Loos, Fadi Towfic, Anita K. Gandhi
Clin Cancer Res. 2022 Aug 2; 28(15): 3367–3377. Published online 2022 May 18. doi: 10.1158/1078-0432.CCR-21-3347
PMCID:
PMC9662945
AbstractArticlePDF–1.6M
6.
Co-Expression of TIGIT and Helios Marks Immunosenescent CD8+ T Cells During Aging
Daan K. J. Pieren, Noortje A. M. Smits, Rimke J. Postel, Vinitha Kandiah, Jelle de Wit, Josine van Beek, Debbie van Baarle, Teun Guichelaar
Front Immunol. 2022; 13: 833531. Published online 2022 May 16. doi: 10.3389/fimmu.2022.833531
PMCID:
PMC9148977
AbstractArticlePDF–6.1M
7.
Identification of germline monoallelic mutations in IKZF2 in patients with immune dysregulation
Tala Shahin, Daniel Mayr, Mohamed R. Shoeb, Hye Sun Kuehn, Birgit Hoeger, Sarah Giuliani, Lisa M. Gawriyski, Özlem Yüce Petronczki, Jérôme Hadjadj, Sevgi Köstel Bal, Samaneh Zoghi, Matthias Haimel, Raul Jimenez Heredia, David Boutboul, Michael P. Triebwasser, Fanny Rialland-Battisti, Nathalie Costedoat Chalumeau, Pierre Quartier, Stuart G. Tangye, Thomas A. Fleisher, Nima Rezaei, Neil Romberg, Sylvain Latour, Markku Varjosalo, Florian Halbritter, Frédéric Rieux-Laucat, Irinka Castanon, Sergio D. Rosenzweig, Kaan Boztug
Blood Adv. 2022 Apr 12; 6(7): 2444–2451. Published online 2022 Apr 11. doi: 10.1182/bloodadvances.2021006367
PMCID:
PMC9006292
AbstractArticlePDF–1.2M
8.
CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system
Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar
Mol Syst Biol. 2022 Feb; 18(2): e10629. Published online 2022 Feb 14. doi: 10.15252/msb.202110629
PMCID:
PMC8842165
AbstractArticlePDF–3.0M
9.
Coexpression of Helios in Foxp3+ Regulatory T Cells and Its Role in Human Disease
Wen-qing Yu, Ning-fei Ji, Cheng-jing Gu, Yan-li Wang, Mao Huang, Ming-shun Zhang
Dis Markers. 2021; 2021: 5574472. Published online 2021 Jun 22. doi: 10.1155/2021/5574472
PMCID:
PMC8245237
AbstractArticlePDF–419K
10.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
11.
Differences in Maturation Status and Immune Phenotypes of Circulating Helios+ and Helios− Tregs and Their Disrupted Correlations With Monocyte Subsets in Autoantibody-Positive T1D Individuals
Yuyue Zhang, Jie Zhang, Yun Shi, Min Shen, Hui Lv, Shu Chen, Yingjie Feng, Heng Chen, Xinyu Xu, Tao Yang, Kuanfeng Xu
Front Immunol. 2021; 12: 628504. Published online 2021 May 12. doi: 10.3389/fimmu.2021.628504
PMCID:
PMC8149963
AbstractArticlePDF–2.4M
12.
Potential therapeutic effects of interleukin-35 on the differentiation of naïve T cells into Helios+Foxp3+ Tregs in clinical and experimental acute respiratory distress syndrome
Chuanjiang Wang, Ke Xie, Kefeng Li, Shihui Lin, Fang Xu
Mol Immunol. 2021 Apr; 132: 236–249. Published online 2021 Jan 16. doi: 10.1016/j.molimm.2021.01.009
PMCID:
PMC8058740
AbstractArticlePDF–5.3M
13.
Adult T‐cell leukemia cells are characterized by abnormalities of Helios expression that promote T cell growth
Satomi Asanuma, Makoto Yamagishi, Katsuaki Kawanami, Kazumi Nakano, Aiko Sato‐Otsubo, Satsuki Muto, Masashi Sanada, Tadanori Yamochi, Seiichiro Kobayashi, Atae Utsunomiya, Masako Iwanaga, Kazunari Yamaguchi, Kaoru Uchimaru, Seishi Ogawa, Toshiki Watanabe
Cancer Sci. 2013 Aug; 104(8): 1097–1106. Published online 2013 May 19. doi: 10.1111/cas.12181
PMCID:
PMC7657222
AbstractArticlePDF–1.6M
14.
Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity
Tala Shahin, Hye Sun Kuehn, Mohamed R. Shoeb, Lisa Gawriyski, Sarah Giuliani, Peter Repiscak, Birgit Hoeger, Özlem Yüce Petronczki, Sevgi Köstel Bal, Samaneh Zoghi, Jasmin Dmytrus, Davide Seruggia, Irinka Castanon, Nima Rezaei, Markku Varjosalo, Florian Halbritter, Sergio D. Rosenzweig, Kaan Boztug
Sci Immunol. Author manuscript; available in PMC 2022 Jul 5.
Published in final edited form as: Sci Immunol. 2021 Nov 26; 6(65): eabe3981. Published online 2021 Nov 26. doi: 10.1126/sciimmunol.abe3981
PMCID:
PMC7612971
AbstractArticlePDF–2.7M
15.
Helios enhances the preferential differentiation of human fetal CD4+ naïve T cells into regulatory T cells.
Melissa S. F. Ng, Theodore L. Roth, Ventura F. Mendoza, Alexander Marson, Trevor D. Burt
Sci Immunol. Author manuscript; available in PMC 2020 Jul 7.
Published in final edited form as: Sci Immunol. 2019 Nov 22; 4(41): eaav5947. doi: 10.1126/sciimmunol.aav5947
PMCID:
PMC7340007
AbstractArticlePDF–3.6M
16.
RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells
Sohei Makita, Hiroaki Takatori, Arifumi Iwata, Shigeru Tanaka, Shunsuke Furuta, Kei Ikeda, Akira Suto, Kotaro Suzuki, Silvia B. V. Ramos, Hiroshi Nakajima
Front Immunol. 2020; 11: 1291. Published online 2020 Jun 23. doi: 10.3389/fimmu.2020.01291
PMCID:
PMC7324482
AbstractArticlePDF–1.9M
17.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
18.
Coexpression of FOXP3 and a Helios isoform enhances the effectiveness of human engineered regulatory T cells
Amara Seng, Kelsey L. Krausz, Dong Pei, Devin C. Koestler, Ryan T. Fischer, Thomas M. Yankee, Mary A. Markiewicz
Blood Adv. 2020 Apr 14; 4(7): 1325–1339. Published online 2020 Apr 7. doi: 10.1182/bloodadvances.2019000965
PMCID:
PMC7160257
AbstractArticlePDF–2.3M
19.
ARIH2 is a Vif-dependent regulator of CUL5-mediated APOBEC3G degradation in HIV infection
Ruth Hüttenhain, Jiewei Xu, Lily A. Burton, David E. Gordon, Judd F. Hultquist, Jeffrey R. Johnson, Laura Satkamp, Joseph Hiatt, David Y. Rhee, Kheewoong Baek, David C. Crosby, Alan D. Frankel, Alexander Marson, J. Wade Harper, Arno F. Alpi, Brenda A. Schulman, John D. Gross, Nevan J. Krogan
Cell Host Microbe. Author manuscript; available in PMC 2020 Jul 10.
Published in final edited form as: Cell Host Microbe. 2019 Jul 10; 26(1): 86–99.e7. Published online 2019 Jun 25. doi: 10.1016/j.chom.2019.05.008
PMCID:
PMC7153695
AbstractArticlePDF–2.6M
20.
Helios: still behind the clouds
Angela M. Thornton, Ethan M. Shevach
Immunology. 2019 Nov; 158(3): 161–170. Published online 2019 Oct 13. doi: 10.1111/imm.13115
PMCID:
PMC6797934
AbstractArticlePDF–721K

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