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Select item 110991251.

Shared and distinct mechanisms of UBA1 inactivation across different diseases

Jason C Collins, Samuel J Magaziner, Maya English, Bakar Hassan, Xiang Chen, Nicholas Balanda, Meghan Anderson, Athena Lam, Sebastian Fernandez-Pol, Bernice Kwong, Peter L Greenberg, Benjamin Terrier, Mary E Likhite, Olivier Kosmider, Yan Wang, Nadine L Samara, Kylie J Walters, David B Beck, Achim Werner

EMBO J. 2024 May; 43(10): 1919–1946. Published online 2024 Feb 15. doi: 10.1038/s44318-024-00046-z

PMCID:: PMC11099125

Abstract Article PDF–7.3M

Select item 108369982.

Clonal haematopoiesis and UBA1 mutations in individuals with biopsy-proven giant cell arteritis and population-based controls

Jonas B Salzbrunn, Isabelle A van Zeventer, Aniek O de Graaf, Priscilla Kamphuis, Maaike G J M van Bergen, Yannick van Sleen, Bert A van der Reijden, Jan Jacob Schuringa, Elisabeth Brouwer, Arjan Diepstra, Joop H Jansen, Gerwin Huls

Rheumatology (Oxford) 2024 Feb; 63(2): e45–e47. Published online 2023 Aug 26. doi: 10.1093/rheumatology/kead435

PMCID:: PMC10836998

Article PDF–389K

Select item 107628063.

Dynamic monitoring of UBA1 somatic mutations in patients with relapsing polychondritis

Suying Duan, Haiyang Luo, Yunchao Wang, Dongbin Jiang, Jiajia Liu, Jiaqi Li, Honglin Zheng, Taiqi Zhao, Chenyang Liu, Hang Zhang, Chengyuan Mao, Lei Zhang, Yuming Xu

Orphanet J Rare Dis. 2024; 19: 1. Published online 2024 Jan 2. doi: 10.1186/s13023-023-03003-x

PMCID:: PMC10762806

Abstract Article PDF–1.3M

Select item 102374224.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101390835.

Novel Isoform DTX3c Associates with UBE2N-UBA1 and Cdc48/p97 as Part of the EphB4 Degradation Complex Regulated by the Autocrine IGF-II/IR^A Signal in Malignant Mesothelioma

Pierluigi Scalia, Carmen Merali, Carlos Barrero, Antonio Suma, Vincenzo Carnevale, Salim Merali, Stephen J. Williams

Int J Mol Sci. 2023 Apr; 24(8): 7380. Published online 2023 Apr 17. doi: 10.3390/ijms24087380

PMCID:: PMC10139083

Abstract Article PDF–4.7M

Select item 101389316.

Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage

Sanna Abbasi, Laila Bayat, Caroline Schild-Poulter

Int J Mol Sci. 2023 Apr; 24(8): 7041. Published online 2023 Apr 11. doi: 10.3390/ijms24087041

PMCID:: PMC10138931

Abstract Article PDF–4.0M

Select item 99504477.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 99436488.

A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma

Xianli Du, Jing Pang, Bin Gu, Tian Si, Yan Chang, Tianqi Li, Min Wu, Zicheng Wang, Yuxia Wang, Jiannan Feng, Ning Wu, Jianghong Man, Huiyan Li, Ailing Li, Tong Zhang, Bo Wang, Xiaotao Duan

Nucleic Acids Res. 2023 Feb 22; 51(3): 1050–1066. Published online 2023 Jan 20. doi: 10.1093/nar/gkad002

PMCID:: PMC9943648

Abstract Article PDF–5.3M

Select item 98604969.

Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid–liquid phase separation–based method

Ryota Hayashida, Reika Kikuchi, Kenichiro Imai, Waka Kojima, Tatsuya Yamada, Miho Iijima, Hiromi Sesaki, Keiji Tanaka, Noriyuki Matsuda, Koji Yamano

J Biol Chem. 2023 Feb; 299(2): 102822. Published online 2022 Dec 21. doi: 10.1016/j.jbc.2022.102822

PMCID:: PMC9860496

Abstract Article PDF–6.6M

Select item 982624110.

Systematic search for the UBA1 mutation in men after a first episode of venous thromboembolism: A monocentric study

Lina Khider, Marie Templé, Cécile Bally, Agathe Spaeth, Luc Darnige, Olivier Sanchez, Benjamin Planquette, Hélène Mortelette, Emmanuel Messas, David M. Smadja, Joseph Emmerich, Tristan Mirault, Olivier Kosmider, Nicolas Gendron

J Thromb Haemost. 2022 Nov; 20(11): 2697–2699. Published online 2022 Sep 13. doi: 10.1111/jth.15858

PMCID:: PMC9826241

Article PDF–431K

Select item 963497711.

A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase

Jingjing Ruan, Dongdong Liang, Wenjing Yan, Yongwang Zhong, Daniel C. Talley, Ganesha Rai, Dingyin Tao, Christopher A. LeClair, Anton Simeonov, Yinghua Zhang, Feihu Chen, Nancy L. Quinney, Susan E. Boyles, Deborah M. Cholon, Martina Gentzsch, Mark J. Henderson, Fengtian Xue, Shengyun Fang

Mol Biol Cell. 2022 Nov 1; 33(13): ar120. Published online 2022 Nov 1. doi: 10.1091/mbc.E22-06-0233

PMCID:: PMC9634977

Abstract Article PDF–5.8M

Select item 963079212.

Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability

Prakash K. Shukla, Dhiraj Sinha, Andrew M. Leng, Jesse E. Bissell, Shravya Thatipamula, Rajarshi Ganguly, Kaitlin S. Radmall, Jack J. Skalicky, Dennis C. Shrieve, Mahesh B. Chandrasekharan

J Biol Chem. 2022 Nov; 298(11): 102524. Published online 2022 Sep 23. doi: 10.1016/j.jbc.2022.102524

PMCID:: PMC9630792

Abstract Article PDF–4.0M

Select item 959735213.

RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes

Shalini Rawat, Dhruba Chatterjee, Rituraj Marwaha, Gitanjali Charak, Gaurav Kumar, Shrestha Shaw, Divya Khatter, Sheetal Sharma, Cecilia de Heus, Nalan Liv, Judith Klumperman, Amit Tuli, Mahak Sharma

J Cell Biol. 2023 Jan 2; 222(1): e202108001. Published online 2022 Oct 25. doi: 10.1083/jcb.202108001