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Select item 114472561.

Cell fixation improves performance of in situ crosslinking mass spectrometry while preserving cellular ultrastructure

Andrew R. M. Michael, Bruno C. Amaral, Kallie L. Ball, Kristen H. Eiriksson, David C. Schriemer

Nat Commun. 2024; 15: 8537. Published online 2024 Oct 2. doi: 10.1038/s41467-024-52844-y

PMCID:: PMC11447256

Abstract Article PDF–2.8M

Select item 113456482.

MLL-AF9 regulates transcriptional initiation in mixed lineage leukemic cells

Zimei Yang, Ge Zhang, Ruoyu Zhao, Tian Tian, Junhong Zhi, Gang Wei, Robert G. Roeder, Lili Jing, Ming Yu

J Biol Chem. 2024 Aug; 300(8): 107566. Published online 2024 Jul 11. doi: 10.1016/j.jbc.2024.107566

PMCID:: PMC11345648

Abstract Article PDF–4.3M

Select item 112467433.

The ENL YEATS epigenetic reader domain critically links MLL-ENL to leukemic stem cell frequency in t(11;19) Leukemia

Hsiangyu Hu, Nirmalya Saha, Yuting Yang, Ejaz Ahmad, Lauren Lachowski, Uttar Shrestha, Vidhya Premkumar, James Ropa, Lili Chen, Blaine Teahan, Sierrah Grigsby, Rolf Marschalek, Zaneta Nikolovska-Coleska, Andrew G. Muntean

Leukemia. Author manuscript; available in PMC 2024 Jul 14.

Published in final edited form as: Leukemia. 2023 Jan; 37(1): 190–201. Published online 2022 Nov 26. doi: 10.1038/s41375-022-01765-0

PMCID:: PMC11246743

Abstract Article PDF–2.2M

Select item 112379304.

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein

Xiao Tang, Yang Liu, Jinhui Wang, Teng Long, Bobo Wing Yee Mok, Yan Huang, Ziqing Peng, Qinyu Jia, Chengxi Liu, Pui-Kin So, Sirius Pui-Kam Tse, Cheuk Hei NG, Shiyi Liu, Fei Sun, Shaojun Tang, Zhong-Ping Yao, Honglin Chen, Yusong Guo

J Biol Chem. 2024 Jun; 300(6): 107390. Published online 2024 May 21. doi: 10.1016/j.jbc.2024.107390

PMCID:: PMC11237930

Abstract Article PDF–3.8M

Select item 112099355.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111851276.

KMT2A and chronic inflammation as potential drivers of sporadic parathyroid adenoma

Qin Xu, Ting La, Kaihong Ye, Li Wang, Shasha Wang, Yifeng Hu, Liu Teng, Lei Yan, Jinming Li, Zhenhua Zhang, Zehua Shao, Yuan Yuan Zhang, Xiao Hong Zhao, Yu Chen Feng, Lei Jin, Mark Baker, Rick F. Thorne, Xu Dong Zhang, Feng‐Min Shao, Huixia Cao

Clin Transl Med. 2024 Jun; 14(6): e1734. Published online 2024 Jun 18. doi: 10.1002/ctm2.1734

PMCID:: PMC11185127

Abstract Article PDF–10M

Select item 111732737.

Distinct Responses to Menin Inhibition and Synergy with DOT1L Inhibition in KMT2A-Rearranged Acute Lymphoblastic and Myeloid Leukemia

Fabienne R. S. Adriaanse, Pauline Schneider, Susan T. C. J. M. Arentsen-Peters, Ana M. Neves da Fonseca, Janine Stutterheim, Rob Pieters, C. Michel Zwaan, Ronald W. Stam

Int J Mol Sci. 2024 Jun; 25(11): 6020. Published online 2024 May 30. doi: 10.3390/ijms25116020

PMCID:: PMC11173273

Abstract Article PDF–4.5M

Select item 110789788.

Regulation of cytokine and chemokine expression by histone lysine methyltransferase MLL1 in rheumatoid arthritis synovial fibroblasts

Keita Okamoto, Yasuto Araki, Yoshimi Aizaki, Shinya Tanaka, Yuho Kadono, Toshihide Mimura

Sci Rep. 2024; 14: 10610. Published online 2024 May 9. doi: 10.1038/s41598-024-60860-7

PMCID:: PMC11078978

Abstract Article PDF–1.1M

Select item 110732449.

RhoC in association with TET2/WDR5 regulates cancer stem cells by epigenetically modifying the expression of pluripotency genes

Pavana Thomas, Sweta Srivastava, Avinash H. Udayashankara, Samyuktha Damodaran, Lokendra Yadav, Boby Mathew, Srinag Bangalore Suresh, Amit Kumar Mandal, Nirmala Srikantia

Cell Mol Life Sci. 2023 Jan; 80(1): 1. Published online 2022 Dec 5. doi: 10.1007/s00018-022-04645-z

PMCID:: PMC11073244

Abstract Article PDF–12M

Select item 1093326710.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 1091849311.

Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion

Caterina Tretti Parenzan, Anna Dal Molin, Giorgia Longo, Enrico Gaffo, Alessia Buratin, Alice Cani, Elena Boldrin, Valentina Serafin, Paola Guglielmelli, Alessandro M. Vannucchi, Giovanni Cazzaniga, Andrea Biondi, Franco Locatelli, Lueder H. Meyer, Barbara Buldini, Geertruij te Kronnie, Silvia Bresolin, Stefania Bortoluzzi

Blood Adv. 2024 Mar 12; 8(5): 1305–1319. Published online 2023 Dec 1. doi: 10.1182/bloodadvances.2023011291

PMCID:: PMC10918493

Abstract Article PDF–2.3M

Select item 1084576412.

Epigenetic drug screening for trophoblast syncytialization reveals a novel role for MLL1 in regulating fetoplacental growth

Jiayi Wu, Chuanmei Qin, Fuju Tian, Xueqing Liu, Jianing Hu, Fan Wu, Cailian Chen, Yi Lin

BMC Med. 2024; 22: 57. Published online 2024 Feb 5. doi: 10.1186/s12916-024-03264-8

PMCID:: PMC10845764

Abstract Article PDF–17M

Select item 1068032713.

Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer

Xiang Lin, Ji-Dong Chen, Chen-Yu Wang, Zhen Cai, Rui Zhan, Chen Yang, La-Ying Zhang, Lian-Yun Li, Yong Xiao, Ming-Kai Chen, Min Wu

Genome Biol. 2023; 24: 268. Published online 2023 Nov 27. doi: 10.1186/s13059-023-03108-3

PMCID:: PMC10680327

Abstract Article PDF–6.7M

Select item 1067098614.

Dependency of B-Cell Acute Lymphoblastic Leukemia and Multiple Myeloma Cell Lines on MEN1 Extends beyond MEN1–KMT2A Interaction

Tatjana Magdalena Wolffhardt, Franz Ketzer, Stefano Telese, Thomas Wirth, Alexey Ushmorov

Int J Mol Sci. 2023 Nov; 24(22): 16472. Published online 2023 Nov 17. doi: 10.3390/ijms242216472

PMCID:: PMC10670986

Abstract Article PDF–6.1M

Select item 1065246415.

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival

Ezgi Ozyerli-Goknar, Ezgi Yagmur Kala, Ali Cenk Aksu, Ipek Bulut, Ahmet Cingöz, Sheikh Nizamuddin, Martin Biniossek, Fidan Seker-Polat, Tunc Morova, Can Aztekin, Sonia H. Y. Kung, Hamzah Syed, Nurcan Tuncbag, Mehmet Gönen, Martin Philpott, Adam P. Cribbs, Ceyda Acilan, Nathan A. Lack, Tamer T. Onder, H. T. Marc Timmers, Tugba Bagci-Onder

Cell Commun Signal. 2023; 21: 328. Published online 2023 Nov 16. doi: 10.1186/s12964-023-01335-6

PMCID:: PMC10652464

Abstract Article PDF–8.0M

Select item 1059185516.

Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement

Zach H. Gray, Damayanti Chakraborty, Reuben R. Duttweiler, Gulnaz D. Alekbaeva, Sedona E. Murphy, Kashish Chetal, Fei Ji, Benjamin I. Ferman, Madison A. Honer, Zhentian Wang, Cynthia Myers, Renhong Sun, H. Ümit Kaniskan, Monika Maria Toma, Elena A. Bondarenko, John N. Santoro, Christopher Miranda, Megan E. Dillingham, Ran Tang, Or Gozani, Jian Jin, Tomasz Skorski, Cihangir Duy, Hayan Lee, Ruslan I. Sadreyev, Johnathan R. Whetstine

Cell. Author manuscript; available in PMC 2024 Oct 12.

Published in final edited form as: Cell. 2023 Oct 12; 186(21): 4528–4545.e18. Published online 2023 Oct 2. doi: 10.1016/j.cell.2023.09.009

PMCID:: PMC10591855

Abstract Article PDF–2.6M

Select item 1058490417.

MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1

Chen Zhang, Weilong Ye, Mengyao Zhao, Lujue Long, Dengsheng Xia, Zhipeng Fan

Int J Oral Sci. 2023; 15: 48. Published online 2023 Oct 18. doi: 10.1038/s41368-023-00253-0

PMCID:: PMC10584904

Abstract Article PDF–7.9M

Select item 1056587618.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 1033567719.

MLL methyltransferases regulate H3K4 methylation to ensure CENP-A assembly at human centromeres

Kausika Kumar Malik, Sreerama Chaitanya Sridhara, Kaisar Ahmad Lone, Payal Deepakbhai Katariya, Deepshika Pulimamidi, Shweta Tyagi

PLoS Biol. 2023 Jun; 21(6): e3002161. Published online 2023 Jun 28. doi: 10.1371/journal.pbio.3002161

PMCID:: PMC10335677

Abstract Article PDF–3.5M

Select item 1028094020.

CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability

Feifei Yang, Qiang Ma, Bo Huang, Xiaolin Wang, Xiaojuan Pan, Ting Yu, Lingyu Ran, Shan Jiang, Haiping Li, Ye Chen, Yuying Liu, Ce Liang, Junwu Ren, Yuying Zhang, Shimin Wang, Wei Li, Bin Xiao

J Transl Med. 2023; 21: 402. Published online 2023 Jun 20. doi: 10.1186/s12967-023-04235-y

PMCID:: PMC10280940

Abstract Article PDF–11M

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