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Select item 112772581.

Melanocortin-4 Receptor PLC Activation Is Modulated by an Interaction with the Monocarboxylate Transporter 8

Larissa Anthofer, Philipp Gmach, Zeynep Cansu Uretmen Kagiali, Gunnar Kleinau, Jonas Rotter, Robert Opitz, Patrick Scheerer, Annette G. Beck-Sickinger, Philipp Wolf, Heike Biebermann, Ingo Bechmann, Peter Kühnen, Heiko Krude, Sarah Paisdzior

Int J Mol Sci. 2024 Jul; 25(14): 7565. Published online 2024 Jul 10. doi: 10.3390/ijms25147565

PMCID:: PMC11277258

Abstract Article PDF–3.1M

Select item 109637832.

Unexpected identification of obesity-associated mutations in LEP and MC4R genes in patients with anorexia nervosa

Luisa Sophie Rajcsanyi, Yiran Zheng, Beate Herpertz-Dahlmann, Jochen Seitz, Martina de Zwaan, Wolfgang Herzog, Stefan Ehrlich, Stephan Zipfel, Katrin Giel, Karin Egberts, Roland Burghardt, Manuel Föcker, Jochen Antel, Pamela Fischer-Posovszky, Johannes Hebebrand, Anke Hinney

Sci Rep. 2024; 14: 7067. Published online 2024 Mar 25. doi: 10.1038/s41598-024-57517-w

PMCID:: PMC10963783

Abstract Article PDF–1.1M

Select item 106713283.

Predisposition of the Common MC4R rs17782313 Female Carriers to Elevated Obesity and Interaction with Eating Habits

Danyel Chermon, Ruth Birk

Genes (Basel) 2023 Nov; 14(11): 1996. Published online 2023 Oct 25. doi: 10.3390/genes14111996

PMCID:: PMC10671328

Abstract Article PDF–570K

Select item 106712624.

Functional Characterization of Novel MC4R Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar

Idris Mohammed, Senthil Selvaraj, Wesam S. Ahmed, Tara Al-Barazenji, Ayat S Hammad, Hajar Dauleh, Luis R. Saraiva, Mashael Al-Shafai, Khalid Hussain

Int J Mol Sci. 2023 Nov; 24(22): 16361. Published online 2023 Nov 15. doi: 10.3390/ijms242216361

PMCID:: PMC10671262

Abstract Article PDF–3.7M

Select item 106390175.

Sex differences in weight gain, blood pressure control, and responses to melanocortin-4 receptor antagonism in offspring from lean and obese parents

Jussara M. do Carmo, Xuemei Dai, Nikaela Aitken, Kylie M. Larson, Ana C. M. Omoto, Rodrigo R. Gulke, Zhen Wang, Xuan Li, Alan J. Mouton, John E. Hall, Alexandre A. da Silva

Am J Physiol Regul Integr Comp Physiol. 2023 Oct 1; 325(4): R401–R410. Published online 2023 Jul 31. doi: 10.1152/ajpregu.00106.2023

PMCID:: PMC10639017

Abstract Article

Select item 104457586.

The rs17782313 polymorphism near MC4R gene confers a high risk of obesity and hyperglycemia, while PGC1α rs8192678 polymorphism is weakly correlated with glucometabolic disorder: a systematic review and meta-analysis

Youjin Zhang, Shiyun Li, Haiyan Nie, Xue Wang, Xuanxuan Li, Jinhui Wen, Mengxi Li, Yongyan Song

Front Endocrinol (Lausanne) 2023; 14: 1210455. Published online 2023 Aug 9. doi: 10.3389/fendo.2023.1210455

PMCID:: PMC10445758

Abstract Article PDF–2.5M

Select item 103745467.

Investigation the interaction of dietary fat quality indices and the MC4R gene in metabolically healthy and unhealthy overweight and obese women

Niloufar Rasaei, Melika Fallah, Mohammad Nemati, Fatemeh Gholami, Rasool Ghaffarian-Ensaf, Khadijeh Mirzaei

Sci Rep. 2023; 13: 12183. Published online 2023 Jul 27. doi: 10.1038/s41598-023-38988-9

PMCID:: PMC10374546

Abstract Article PDF–1.1M

Select item 101116918.

The interaction between MC4R gene variant (rs17782313) and dominant dietary patterns on depression in obese and overweight women: a cross sectional study

Mahya Mehri Hajmir, Atieh Mirzababaei, Cain C. T. Clark, Rasool Ghaffarian-Ensaf, Khadijeh Mirzaei

BMC Endocr Disord. 2023; 23: 83. Published online 2023 Apr 18. doi: 10.1186/s12902-023-01335-0

PMCID:: PMC10111691

Abstract Article PDF–1.3M

Select item 100062469.

Genetic association of the rs17782313 polymorphism with antipsychotic-induced weight gain

Korbinian Felix Schreyer, Stefan Leucht, Stephan Heres, Werner Steimer

Psychopharmacology (Berl) 2023; 240(4): 899–908. Published online 2023 Feb 9. doi: 10.1007/s00213-023-06331-9

PMCID:: PMC10006246

Abstract Article PDF–623K

Select item 994706710.

Increased constraints on MC4R during primate and human evolution

David A. Hughes, Anke Hinney, Harald Brumm, Anne-Kathrin Wermter, Heike Biebermann, Johannes Hebebrand, Mark Stoneking

Hum Genet. 2009; 124(6): 633–647. Published online 2008 Nov 15. doi: 10.1007/s00439-008-0591-8

PMCID:: PMC9947067

Abstract Article PDF–590K

Select item 977860011.

Effect of the Melanocortin 4-Receptor Ile269Asn Mutation on Weight Loss Response to Dietary, Phentermine and Bariatric Surgery Interventions

Itzel G. Salazar-Valencia, Hugo Villamil-Ramírez, Francisco Barajas-Olmos, Martha Guevara-Cruz, Luis R. Macias-Kauffer, Humberto García-Ortiz, Omar Hernández-Vergara, David Alberto Díaz de Sandy-Galán, Paola León-Mimila, Federico Centeno-Cruz, Luis E. González-Salazar, Rocío Guizar-Heredia, Edgar Pichardo-Ontiveros, Leonor Jacobo-Albavera, Rosalinda Posadas-Sánchez, Gilberto Vargas-Alarcón, Rafael Velazquez-Cruz, Ruth Gutiérrez-Aguilar, Carlos Zerrweck, Héctor Isaac Rocha-González, Juan Gerardo Reyes-García, Miriam del C. Carrasco-Portugal, Francisco Javier Flores-Murrieta, Armando R. Tovar, Lorena Orozco, Teresa Villarreal-Molina, Samuel Canizales-Quinteros

Genes (Basel) 2022 Dec; 13(12): 2267. Published online 2022 Dec 1. doi: 10.3390/genes13122267

PMCID:: PMC9778600

Abstract Article PDF–966K

Select item 968396712.

The Role of Dietary Glycemic Index and Glycemic Load in Mediating Genetic Susceptibility via MC4R s17782313 Genotypes to Affect Cardiometabolic Risk Factors among Apparently Healthy Obese Individuals

Mahdieh Khodarahmi, Goli Siri, Mohaddeseh Mohammadi, Mahdieh Abbasalizad Farhangi, Samira Aleseidi

Biomed Res Int. 2022; 2022: 3044545. Published online 2022 Nov 16. doi: 10.1155/2022/3044545

PMCID:: PMC9683967

Abstract Article PDF–465K

Select item 943496713.

Are there any interactions between modified Nordic-style diet score and MC4R polymorphism on cardiovascular risk factors among overweight and obese women? A cross-sectional study

Dorsa Hosseininasab, Atieh Mirzababaei, Faezeh Abaj, Roya Firoozi, Cain C. T. Clark, Khadijeh Mirzaei

BMC Endocr Disord. 2022; 22: 221. Published online 2022 Sep 1. doi: 10.1186/s12902-022-01132-1

PMCID:: PMC9434967

Abstract Article PDF–877K

Select item 926821014.

Molecular Analysis and Conformational Dynamics of Human MC4R Disease-Causing Mutations

Munazza Tamkeen Fatima, Zeyaul Islam, Prasanna R. Kolatkar, Ammira Sarah Al-Shabeeb Akil

Molecules. 2022 Jul; 27(13): 4037. Published online 2022 Jun 23. doi: 10.3390/molecules27134037

PMCID:: PMC9268210

Abstract Article PDF–3.7M

Select item 909284615.

Interaction of MC4R rs17782313 variants and dietary carbohydrate quantity and quality on basal metabolic rate and general and central obesity in overweight/obese women: a cross-sectional study

Shahab Alizadeh, Sara Pooyan, Atieh Mirzababaei, Hana Arghavani, Hossein Hasani, Khadijeh Mirzaei

BMC Endocr Disord. 2022; 22: 121. Published online 2022 May 10. doi: 10.1186/s12902-022-01023-5

PMCID:: PMC9092846

Abstract Article PDF–1.2M

Select item 871721616.

Characterization of MC4R Regulation of the Kir7.1 Channel Using the Tl⁺ Flux Assay

Michael J. Litt, Roger D. Cone, Masoud Ghamari-Langroudi

Methods Mol Biol. Author manuscript; available in PMC 2021 Dec 30.

Published in final edited form as: Methods Mol Biol. 2018; 1684: 211–222. doi: 10.1007/978-1-4939-7362-0_16

PMCID:: PMC8717216

Abstract Article PDF–1005K

Select item 858459217.

An Association between Diet and MC4R Genetic Polymorphism, in Relation to Obesity and Metabolic Parameters—A Cross Sectional Population-Based Study

Edyta Adamska-Patruno, Witold Bauer, Dorota Bielska, Joanna Fiedorczuk, Monika Moroz, Urszula Krasowska, Przemyslaw Czajkowski, Marta Wielogorska, Katarzyna Maliszewska, Sylwia Puckowska, Lukasz Szczerbinski, Danuta Lipinska, Maria Gorska, Adam Kretowski

Int J Mol Sci. 2021 Nov; 22(21): 12044. Published online 2021 Nov 7. doi: 10.3390/ijms222112044

PMCID:: PMC8584592

Abstract Article PDF–2.8M

Select item 856396518.

Structural insights into ligand recognition and activation of the melanocortin-4 receptor

Huibing Zhang, Li-Nan Chen, Dehua Yang, Chunyou Mao, Qingya Shen, Wenbo Feng, Dan-Dan Shen, Antao Dai, Shanshan Xie, Yan Zhou, Jiao Qin, Jin-Peng Sun, Daniel H. Scharf, Tingjun Hou, Tianhua Zhou, Ming-Wei Wang, Yan Zhang

Cell Res. 2021 Nov; 31(11): 1163–1175. Published online 2021 Aug 25. doi: 10.1038/s41422-021-00552-3

PMCID:: PMC8563965

Abstract Article PDF–5.9M

Select item 854391719.

PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population

Ning Wang, Rui Tong, Jing Xu, Yanni Tian, Juan Pan, Jiaqi Cui, Huan Chen, Yanqi Peng, Sijia Fei, Shujun Yang, Lu Wang, Juanchuan Yao, Wei Cui

BMC Med Genomics. 2021; 14: 249. Published online 2021 Oct 25. doi: 10.1186/s12920-021-01037-3

PMCID:: PMC8543917

Abstract Article PDF–1.3M

Select item 838191620.

Obesity, dyslipidaemia and candidate gene polymorphisms: a cross-sectional study among the Liangmai and Mizo tribes of Manipur, India

Somorjit Singh Ningombam, Masan Kambo Newmei, Varhlun Chhungi, Prakash Ranjan Mondal, Naorem Kiranmala Devi, Kallur Nava Saraswathy

Ann Med. 2021; 53(1): 1439–1447. Published online 2021 Aug 20. doi: 10.1080/07853890.2021.1969034

PMCID:: PMC8381916

Abstract Article PDF–1004K

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