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Items: 1 to 20 of 44

1.
Human NLRC4 expression promotes cancer survival and associates with type I interferon signaling and immune infiltration
Charlotte Domblides, Steven Crampton, Hong Liu, Juliet M. Bartleson, Annie Nguyen, Claudia Champagne, Emily E. Landy, Lindsey Spiker, Christopher Proffitt, Sunil Bhattarai, Anissa P. Grawe, Matias Fuentealba Valenzuela, Lydia Lartigue, Isabelle Mahouche, Jeremy Dupaul-Chicoine, Kazuho Nishimura, Félix Lefort, Marie Decraecker, Valérie Velasco, Sonia Netzer, Vincent Pitard, Christian Roy, Isabelle Soubeyran, Victor Racine, Patrick Blanco, Julie Déchanet-Merville, Maya Saleh, Scott W. Canna, David Furman, Benjamin Faustin
J Clin Invest. 2024 Jun 3; 134(11): e166085. Published online 2024 Apr 23. doi: 10.1172/JCI166085
PMCID:
PMC11142746
AbstractArticlePDF–12M
2.
NFκB and NLRP3/NLRC4 inflammasomes regulate differentiation, activation and functional properties of monocytes in response to distinct SARS-CoV-2 proteins
Ilya Tsukalov, Ildefonso Sánchez-Cerrillo, Olga Rajas, Elena Avalos, Gorane Iturricastillo, Laura Esparcia, María José Buzón, Meritxell Genescà, Camila Scagnetti, Olga Popova, Noa Martin-Cófreces, Marta Calvet-Mirabent, Ana Marcos-Jimenez, Pedro Martínez-Fleta, Cristina Delgado-Arévalo, Ignacio de los Santos, Cecilia Muñoz-Calleja, María José Calzada, Isidoro González Álvaro, José Palacios-Calvo, Arantzazu Alfranca, Julio Ancochea, Francisco Sánchez-Madrid, Enrique Martin-Gayo
Nat Commun. 2024; 15: 2100. Published online 2024 Mar 7. doi: 10.1038/s41467-024-46322-8
PMCID:
PMC10920883
AbstractArticlePDF–2.7M
3.
Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis
Yaping An, Zihan Zhai, Xin Wang, Yiyun Ding, Linlin He, Lingfeng Li, Qi Mo, Chenlu Mu, Runxiang Xie, Tianyu Liu, Weilong Zhong, Bangmao Wang, Hailong Cao
J Adv Res. 2023 Oct; 52: 219–232. Published online 2023 Aug 15. doi: 10.1016/j.jare.2023.08.008
PMCID:
PMC10555950
AbstractArticlePDF–6.3M
4.
LNCGM1082-mediated NLRC4 activation drives resistance to bacterial infection
Yunhuan Gao, Yazheng Yang, Jianmei Wei, Jianmei Yue, Ya Wang, Qianjing Zhang, Mengli Jin, Rong Wang, Xiaorong Yang, Junqi Zhang, Xinqi Liu, Lin Liu, Yuan Zhang, Rongcun Yang
Cell Mol Immunol. 2023 May; 20(5): 475–488. Published online 2023 Mar 20. doi: 10.1038/s41423-023-00995-1
PMCID:
PMC10203293
AbstractArticlePDF–6.2M
5.
NLRC4-mediated activation of CD1c+ DC contributes to perpetuation of synovitis in rheumatoid arthritis
Cristina Delgado-Arévalo, Marta Calvet-Mirabent, Ana Triguero-Martínez, Enrique Vázquez de Luis, Alberto Benguría-Filippini, Raquel Largo, Diego Calzada-Fraile, Olga Popova, Ildefonso Sánchez-Cerrillo, Ilya Tsukalov, Roberto Moreno-Vellisca, Hortensia de la Fuente, Gabriel Herrero-Beaumont, Almudena Ramiro, Francisco Sánchez-Madrid, Santos Castañeda, Ana Dopazo, Isidoro González Álvaro, Enrique Martin-Gayo
JCI Insight. 2022 Nov 22; 7(22): e152886. Published online 2022 Nov 22. doi: 10.1172/jci.insight.152886
PMCID:
PMC9746818
AbstractArticlePDF–3.0M
6.
Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells
Nawar Naseer, Jenna Zhang, Renate Bauer, David A. Constant, Timothy J. Nice, Igor E. Brodsky, Isabella Rauch, Sunny Shin
Infect Immun. 2022 Jul; 90(7): e00663-21. Published online 2022 Jun 9. doi: 10.1128/iai.00663-21
PMCID:
PMC9302179
AbstractArticlePDF–2.0M
7.
Association of Tim-3/Gal-9 Axis with NLRC4 Inflammasome in Glioma Malignancy: Tim-3/Gal-9 Induce the NLRC4 Inflammasome
JeongMin Sim, JeongMan Park, Suwan Kim, Sojung Hwang, KyoungSu Sung, Jung-Eun Lee, SeungHo Yang, Kyunggi Cho, SungHwan Lee, Jong-Seok Moon, JuWon Ahn, Jaejoon Lim
Int J Mol Sci. 2022 Feb; 23(4): 2028. Published online 2022 Feb 12. doi: 10.3390/ijms23042028
PMCID:
PMC8878774
AbstractArticlePDF–7.1M
8.
The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3
Tiantian Tang, Ping Li, Xinhui Zhou, Rui Wang, Xiuqin Fan, Mengyi Yang, Kemin Qi
Front Immunol. 2021; 12: 741839. Published online 2021 Aug 26. doi: 10.3389/fimmu.2021.741839
PMCID:
PMC8427430
AbstractArticlePDF–2.1M
9.
Inflammasome Genetic Variants, Macrophage Function, and Clinical Outcomes in Cystic Fibrosis
Andrew D. Graustein, William R. Berrington, Kati J. Buckingham, Felicia K. Nguyen, Lara L. Joudeh, Margaret Rosenfeld, Michael J. Bamshad, Ronald L. Gibson, Thomas R. Hawn, Mary J. Emond
Am J Respir Cell Mol Biol. 2021 Aug; 65(2): 157–166. Published online 2021 Mar 30. doi: 10.1165/rcmb.2020-0257OC
PMCID:
PMC8399576
AbstractArticlePDF–993K
10.
Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry
Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang
Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118
PMCID:
PMC8364181
AbstractArticlePDF–3.0M
11.
Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers
Pilar Samperio Ventayol, Petra Geiser, Maria Letizia Di Martino, Alexandra Florbrant, Stefan A. Fattinger, Naemi Walder, Eduardo Sima, Feng Shao, Nelson O. Gekara, Magnus Sundbom, Wolf-Dietrich Hardt, Dominic-Luc Webb, Per M. Hellström, Jens Eriksson, Mikael E. Sellin
Proc Natl Acad Sci U S A. 2021 Apr 20; 118(16): e2013963118. Published online 2021 Apr 12. doi: 10.1073/pnas.2013963118
PMCID:
PMC8072224
AbstractArticlePDF–4.7M
12.
A role for the NLRC4 inflammasome in premature rupture of membrane
Jinming Zhu, Chunling Ma, Lina Zhu, Juan Li, Fengyun Peng, Lei Huang, Xiaomei Luan
PLoS One. 2020; 15(8): e0237847. Published online 2020 Aug 24. doi: 10.1371/journal.pone.0237847
PMCID:
PMC7446792
AbstractArticlePDF–1.8M
13.
A Common NLRC4 Gene Variant Associates With Inflammation and Pulmonary Function in Human Immunodeficiency Virus and Tuberculosis
Shruthi Ravimohan, Pholo Maenetje, Sara C Auld, Itai Ncube, Mandla Mlotshwa, William Chase, Caroline T Tiemessen, Mboyo-Di-Tamba Vangu, Robert S Wallis, Gavin Churchyard, Drew Weissman, Hardy Kornfeld, Gregory P Bisson
Clin Infect Dis. 2020 Aug 15; 71(4): 924–932. Published online 2019 Nov 22. doi: 10.1093/cid/ciz898
PMCID:
PMC7428399
AbstractArticlePDF–2.7M
14.
Associations between NLRC4 Gene Polymorphisms and Autoimmune Thyroid Disease
Xuerong Liu, Xiaogang Bai, Jing Zhao, Chaoqun Gao, Peng Du, Jin-an Zhang, Sheli Li
Biomed Res Int. 2020; 2020: 1378427. Published online 2020 Aug 4. doi: 10.1155/2020/1378427
PMCID:
PMC7424365
AbstractArticlePDF–383K
15.
NLRC4, ASC and Caspase-1 Are Inflammasome Components That Are Mediated by P2Y2R Activation in Breast Cancer Cells
Hana Jin, Hye Jung Kim
Int J Mol Sci. 2020 May; 21(9): 3337. Published online 2020 May 8. doi: 10.3390/ijms21093337
PMCID:
PMC7246622
AbstractArticlePDF–2.5M
16.
HSC70 regulates cold-induced caspase-1 hyperactivation by an autoinflammation-causing mutant of cytoplasmic immune receptor NLRC4
Akhouri Kishore Raghawan, Rajashree Ramaswamy, Vegesna Radha, Ghanshyam Swarup
Proc Natl Acad Sci U S A. 2019 Oct 22; 116(43): 21694–21703. Published online 2019 Oct 9. doi: 10.1073/pnas.1905261116
PMCID:
PMC6815140
AbstractArticlePDF–1.8M
17.
Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression
Shouhua Wang, Yongjie Zhang, Qiang Cai, Mingzhe Ma, Long Yang Jin, Mingzhe Weng, Di Zhou, Zhaohui Tang, Jian Dong Wang, Zhiwei Quan
Mol Cancer. 2019; 18: 145. Published online 2019 Oct 17. doi: 10.1186/s12943-019-1078-z
PMCID:
PMC6796492
AbstractArticlePDF–4.1M
18.
Flagellin/NLRC4 Pathway Rescues NLRP3-Inflammasome Defect in Dendritic Cells From HIV-Infected Patients: Perspective for New Adjuvant in Immunocompromised Individuals
Edione Cristina dos Reis, Vinícius Nunes Cordeiro Leal, Jaíne Lima da Silva Soares, Fernanda Pereira Fernandes, Dhêmerson Souza de Lima, Bruna Cunha de Alencar, Alessandra Pontillo
Front Immunol. 2019; 10: 1291. Published online 2019 Jun 11. doi: 10.3389/fimmu.2019.01291
PMCID:
PMC6579915
AbstractArticlePDF–3.0M
19.
Upregulation of the NLRC4 inflammasome contributes to poor prognosis in glioma patients
Jaejoon Lim, Min Jun Kim, YoungJoon Park, Ju Won Ahn, So Jung Hwang, Jong-Seok Moon, Kyung Gi Cho, KyuBum Kwack
Sci Rep. 2019; 9: 7895. Published online 2019 May 27. doi: 10.1038/s41598-019-44261-9
PMCID:
PMC6536517
AbstractArticlePDF–3.8M
20.
Cryo-EM structure of the NLRC4CARD filament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly
Mariusz Matyszewski, Weili Zheng, Jacob Lueck, Brendan Antiochos, Edward H. Egelman, Jungsan Sohn
J Biol Chem. 2018 Dec 28; 293(52): 20240–20248. Published online 2018 Nov 1. doi: 10.1074/jbc.RA118.006050
PMCID:
PMC6311515
AbstractArticlePDF–2.8M

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