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Select item 109902771.

ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication

Guy J. Pearson, Harriet V. Mears, Malgorzata Broncel, Ambrosius P. Snijders, David L. V. Bauer, Jeremy G. Carlton

Sci Adv. 2024 Apr 5; 10(14): eadl5012. Published online 2024 Apr 3. doi: 10.1126/sciadv.adl5012

PMCID:: PMC10990277

Abstract Article PDF–3.9M

Select item 109168662.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 103459633.

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy

Amr El Zawily, Frederick S. Vizeacoumar, Renuka Dahiya, Sara L. Banerjee, Kalpana K. Bhanumathy, Hussain Elhasasna, Glinton Hanover, Jessica C. Sharpe, Malkon G. Sanchez, Paul Greidanus, R. Greg Stacey, Kyung-Mee Moon, Ilya Alexandrov, Juha P. Himanen, Dimitar B. Nikolov, Humphrey Fonge, Aaron P. White, Leonard J. Foster, Bingcheng Wang, Behzad M. Toosi, Nicolas Bisson, Tajib A. Mirzabekov, Franco J. Vizeacoumar, Andrew Freywald

Clin Cancer Res. 2023 Jul 14; 29(14): 2686–2701. Published online 2023 Mar 28. doi: 10.1158/1078-0432.CCR-22-2535

PMCID:: PMC10345963

Abstract Article PDF–13M

Select item 100729064.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 81755855.

Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells

Marianne Strazza, Inbar Azoulay-Alfaguter, Michael Peled, Kieran Adam, Adam Mor

Commun Biol. 2021; 4: 672. Published online 2021 Jun 3. doi: 10.1038/s42003-021-02225-8

PMCID:: PMC8175585

Abstract Article PDF–3.3M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 75507007.

PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation

Lauren Foltz, Juan Palacios-Moreno, Makenzie Mayfield, Shelby Kinch, Jordan Dillon, Jed Syrenne, Tyler Levy, Mark Grimes

Mol Biol Cell. 2020 Sep 15; 31(20): 2269–2282. doi: 10.1091/mbc.E20-02-0135

PMCID:: PMC7550700

Abstract Article PDF–4.2M

Select item 74273278.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 65318759.

SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function

Nan Cui, Tianqi Liu, Yanmin Guo, Jinzhuo Dou, Qianqian Yang, Hailong Zhang, Ran Chen, Yanli Wang, Xian Zhao, Jianxiu Yu, Jian Huang

Neoplasia. 2019 Jul; 21(7): 676–688. Published online 2019 May 21. doi: 10.1016/j.neo.2019.04.010

PMCID:: PMC6531875

Abstract Article PDF–2.8M

Select item 612890510.

Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability

Hema Adhikari, Christopher M. Counter

Nat Commun. 2018; 9: 3646. Published online 2018 Sep 7. doi: 10.1038/s41467-018-05692-6

PMCID:: PMC6128905

Abstract Article PDF–2.2M

Select item 553161111.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 502968112.

Transmembrane adaptor protein PAG1 is a novel tumor suppressor in neuroblastoma

Saurabh Agarwal, Rajib Ghosh, Zaowen Chen, Anna Lakoma, Preethi H. Gunaratne, Eugene S. Kim, Jason M. Shohet

Oncotarget. 2016 Apr 26; 7(17): 24018–24026. Published online 2016 Mar 16. doi: 10.18632/oncotarget.8116

PMCID:: PMC5029681

Abstract Article PDF–3.1M

Select item 497239713.

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

Zhenhuan Guo, Lisa J Neilson, Hang Zhong, Paul S Murray, Megha Vaman Rao, Sara Zanivan, Ronen Zaidel-Bar

Sci Signal. Author manuscript; available in PMC 2016 Aug 3.

Published in final edited form as: Sci Signal. 2014 Dec 2; 7(354): rs7. Published online 2014 Dec 2. doi: 10.1126/scisignal.2005473

PMCID:: PMC4972397

Abstract Article PDF–3.1M

Select item 461721114.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 457327515.

Long-Range Modulation of PAG1 Expression by 8q21 Allergy Risk Variants

Cristina T. Vicente, Stacey L. Edwards, Kristine M. Hillman, Susanne Kaufmann, Hayley Mitchell, Lisa Bain, Dylan M. Glubb, Jason S. Lee, Juliet D. French, Manuel A.R. Ferreira

Am J Hum Genet. 2015 Aug 6; 97(2): 329–336. doi: 10.1016/j.ajhg.2015.06.010

PMCID:: PMC4573275

Abstract Article PDF–1.1M

Select item 432345716.

Overexpression of Csk-binding protein decreases growth, invasion, and migration of esophageal carcinoma cells by controlling Src activation

Dong Zhou, Peng Dong, Yu-Min Li, Fa-Cai Guo, An-Ping Zhang, Run-Ze Song, Ya-Min Zhang, Zhi-Yong Li, Dong Yuan, Chuan Yang

World J Gastroenterol. 2015 Feb 14; 21(6): 1814–1820. Published online 2015 Feb 14. doi: 10.3748/wjg.v21.i6.1814

PMCID:: PMC4323457

Abstract Article PDF–1.5M

Select item 391900517.

Genome-wide association study identifies multiple loci associated with bladder cancer risk

Jonine D. Figueroa, Yuanqing Ye, Afshan Siddiq, Montserrat Garcia-Closas, Nilanjan Chatterjee, Ludmila Prokunina-Olsson, Victoria K. Cortessis, Charles Kooperberg, Olivier Cussenot, Simone Benhamou, Jennifer Prescott, Stefano Porru, Colin P. Dinney, Núria Malats, Dalsu Baris, Mark Purdue, Eric J. Jacobs, Demetrius Albanes, Zhaoming Wang, Xiang Deng, Charles C. Chung, Wei Tang, H. Bas Bueno-de-Mesquita, Dimitrios Trichopoulos, Börje Ljungberg, Françoise Clavel-Chapelon, Elisabete Weiderpass, Vittorio Krogh, Miren Dorronsoro, Ruth Travis, Anne Tjønneland, Paul Brenan, Jenny Chang-Claude, Elio Riboli, David Conti, Manuela Gago-Dominguez, Mariana C. Stern, Malcolm C. Pike, David Van Den Berg, Jian-Min Yuan, Chancellor Hohensee, Rebecca Rodabough, Geraldine Cancel-Tassin, Morgan Roupret, Eva Comperat, Constance Chen, Immaculata De Vivo, Edward Giovannucci, David J. Hunter, Peter Kraft, Sara Lindstrom, Angela Carta, Sofia Pavanello, Cecilia Arici, Giuseppe Mastrangelo, Ashish M. Kamat, Seth P. Lerner, H. Barton Grossman, Jie Lin, Jian Gu, Xia Pu, Amy Hutchinson, Laurie Burdette, William Wheeler, Manolis Kogevinas, Adonina Tardón, Consol Serra, Alfredo Carrato, Reina García-Closas, Josep Lloreta, Molly Schwenn, Margaret R. Karagas, Alison Johnson, Alan Schned, Karla R. Armenti, G.M. Hosain, Gerald Andriole, Jr, Robert Grubb, III, Amanda Black, W. Ryan Diver, Susan M. Gapstur, Stephanie J. Weinstein, Jarmo Virtamo, Chris A. Haiman, Maria T. Landi, Neil Caporaso, Joseph F. Fraumeni, Jr, Paolo Vineis, Xifeng Wu, Debra T. Silverman, Stephen Chanock, Nathaniel Rothman

Hum Mol Genet. 2014 Mar 1; 23(5): 1387–1398. Published online 2013 Oct 24. doi: 10.1093/hmg/ddt519

PMCID:: PMC3919005

Abstract Article PDF–580K

Select item 372517518.

Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells

Parnetta Sutton, Jeffrey A Borgia, Philip Bonomi, Janet MD Plate

Mol Cancer. 2013; 12: 76. Published online 2013 Jul 16. doi: 10.1186/1476-4598-12-76

PMCID:: PMC3725175

Abstract Article PDF–3.2M

Select item 364601419.

A Novel Function of Novobiocin: Disrupting the Interaction of HIF 1α and p300/CBP through Direct Binding to the HIF1α C-Terminal Activation Domain

Donglu Wu, Rui Zhang, Rui Zhao, Guang Chen, Yong Cai, Jingji Jin

PLoS One. 2013; 8(5): e62014. Published online 2013 May 6. doi: 10.1371/journal.pone.0062014

PMCID:: PMC3646014

Abstract Article PDF–1.9M

Select item 348464820.

Discovery and Fine Mapping of Serum Protein Loci through Transethnic Meta-analysis

Nora Franceschini, Frank J.A. van Rooij, Bram P. Prins, Mary F. Feitosa, Mahir Karakas, John H. Eckfeldt, Aaron R. Folsom, Jeffrey Kopp, Ahmad Vaez, Jeanette S. Andrews, Jens Baumert, Vesna Boraska, Linda Broer, Caroline Hayward, Julius S. Ngwa, Yukinori Okada, Ozren Polasek, Harm-Jan Westra, Ying A. Wang, Fabiola Del Greco M., Nicole L. Glazer, Karen Kapur, Ido P. Kema, Lorna M. Lopez, Arne Schillert, Albert V. Smith, Cheryl A. Winkler, Lina Zgaga, The LifeLines Cohort Study, Stefania Bandinelli, Sven Bergmann, Mladen Boban, Murielle Bochud, Y.D. Chen, Gail Davies, Abbas Dehghan, Jingzhong Ding, Angela Doering, J. Peter Durda, Luigi Ferrucci, Oscar H. Franco, Lude Franke, Grog Gunjaca, Albert Hofman, Fang-Chi Hsu, Ivana Kolcic, Aldi Kraja, Michiaki Kubo, Karl J. Lackner, Lenore Launer, Laura R. Loehr, Guo Li, Christa Meisinger, Yusuke Nakamura, Christine Schwienbacher, John M. Starr, Atsushi Takahashi, Vesela Torlak, André G. Uitterlinden, Veronique Vitart, Melanie Waldenberger, Philipp S. Wild, Mirna Kirin, Tanja Zeller, Tatijana Zemunik, Qunyuan Zhang, Andreas Ziegler, Stefan Blankenberg, Eric Boerwinkle, Ingrid B. Borecki, Harry Campbell, Ian J. Deary, Timothy M. Frayling, Christian Gieger, Tamara B. Harris, Andrew A. Hicks, Wolfgang Koenig, Christopher J. O’Donnell, Caroline S. Fox, Peter P. Pramstaller, Bruce M. Psaty, Alex P. Reiner, Jerome I. Rotter, Igor Rudan, Harold Snieder, Toshihiro Tanaka, Cornelia M. van Duijn, Peter Vollenweider, Gerard Waeber, James F. Wilson, Jacqueline C.M. Witteman, Bruce H.R. Wolffenbuttel, Alan F. Wright, Qingyu Wu, Yongmei Liu, Nancy S. Jenny, Kari E. North, Janine F. Felix, Behrooz Z. Alizadeh, L. Adrienne Cupples, John R.B. Perry, Andrew P. Morris

Am J Hum Genet. 2012 Oct 5; 91(4): 744–753. doi: 10.1016/j.ajhg.2012.08.021

PMCID:: PMC3484648

Abstract Article PDF–788K

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