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Select item 109402941.

Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2

Jingjing Zhang, Mario Ruiz, Per-Olof Bergh, Marcus Henricsson, Nena Stojanović, Ranjan Devkota, Marius Henn, Mohammad Bohlooly-Y, Abrahan Hernández-Hernández, Manfred Alsheimer, Jan Borén, Marc Pilon, Hiroki Shibuya

Nat Commun. 2024; 15: 2315. Published online 2024 Mar 14. doi: 10.1038/s41467-024-46718-6

PMCID:: PMC10940294

Abstract Article PDF–6.0M

Select item 106845602.

CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice

Philipp Hammerschmidt, Sophie M. Steculorum, Cécile L. Bandet, Almudena Del Río-Martín, Lukas Steuernagel, Vivien Kohlhaas, Marvin Feldmann, Luis Varela, Adam Majcher, Marta Quatorze Correia, Rhena F. U. Klar, Corinna A. Bauder, Ecem Kaya, Marta Porniece, Nasim Biglari, Anna Sieben, Tamas L. Horvath, Thorsten Hornemann, Susanne Brodesser, Jens C. Brüning

Nat Commun. 2023; 14: 7824. Published online 2023 Nov 29. doi: 10.1038/s41467-023-42595-7

PMCID:: PMC10684560

Abstract Article PDF–5.2M

Select item 105611213.

Ceramide synthase 6 (CerS6) is upregulated in alcohol-associated liver disease and exhibits sex-based differences in the regulation of energy homeostasis and lipid droplet accumulation

Sookyoung Jeon, Eleonora Scorletti, Joseph Dempsey, Delfin Buyco, Chelsea Lin, Yedidya Saiman, Susovon Bayen, Julia Harkin, Jasmin Martin, Royce Hooks, Besim Ogretmen, Josepmaria Argemi, Luma Melo, Ramon Bataller, Rotonya M. Carr

Mol Metab. 2023 Dec; 78: 101804. Published online 2023 Sep 14. doi: 10.1016/j.molmet.2023.101804

PMCID:: PMC10561121

Abstract Article PDF–3.3M

Select item 105111794.

CERS6-derived ceramides aggravate kidney fibrosis by inhibiting PINK1-mediated mitophagy in diabetic kidney disease

Xiangyu Wang, Minkai Song, Xiaomin Li, Cailin Su, Yanlin Yang, Kai Wang, Cuiting Liu, Zongji Zheng, Yijie Jia, Shijing Ren, Wenhui Dong, Jiaqi Chen, Ting Wang, Lerong Liu, Meiping Guan, Chao Zhang, Yaoming Xue

Am J Physiol Cell Physiol. 2023 Aug 1; 325(2): C538–C549. Published online 2023 Jul 17. doi: 10.1152/ajpcell.00144.2023

PMCID:: PMC10511179

Abstract Article

Select item 98597575.

Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis

Kerstin Griess, Michael Rieck, Nadine Müller, Gergely Karsai, Sonja Hartwig, Angela Pelligra, Robert Hardt, Caroline Schlegel, Jennifer Kuboth, Celina Uhlemeyer, Sandra Trenkamp, Kay Jeruschke, Jürgen Weiss, Leon Peifer-Weiss, Weiwei Xu, Sandra Cames, Xiaoyan Yi, Miriam Cnop, Mathias Beller, Holger Stark, Arun Kumar Kondadi, Andreas S. Reichert, Daniel Markgraf, Marianne Wammers, Dieter Häussinger, Oliver Kuss, Stefan Lehr, Decio Eizirik, Heiko Lickert, Eckhard Lammert, Michael Roden, Dominic Winter, Hadi Al-Hasani, Doris Höglinger, Thorsten Hornemann, Jens C. Brüning, Bengt-Frederik Belgardt

Nat Cell Biol. 2023; 25(1): 20–29. Published online 2022 Dec 21. doi: 10.1038/s41556-022-01027-2

PMCID:: PMC9859757

Abstract Article PDF–11M

Select item 92920916.

Generation of a ceramide synthase 6 mouse lacking the DDRSDIE C-terminal motif

Jiyoon Kim, Yael Pewzner-Jung, Tammar Joseph, Shifra Ben-Dor, Anthony H. Futerman

PLoS One. 2022; 17(7): e0271675. Published online 2022 Jul 18. doi: 10.1371/journal.pone.0271675

PMCID:: PMC9292091

Abstract Article PDF–1.2M

Select item 92567687.

Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK Pathway

M.Hanief Sofi, Linlu Tian, Steven Schutt, Imran Khan, Hee-Jin Choi, Yongxia Wu, David Bastian, Taylor Ticer, Mohamed Faisal Kassir, Firdevs Cansu Atilgan, Jisun Kim, Xiaohui Sui, Aleksandra Zivkovic, Shikhar Mehrotra, John P. O’Bryan, Holger Stark, Paul J. Martin, Besim Ogretmen, Xue-Zhong Yu

Leukemia. Author manuscript; available in PMC 2022 Nov 5.

Published in final edited form as: Leukemia. 2022 Jul; 36(7): 1907–1915. Published online 2022 May 5. doi: 10.1038/s41375-022-01581-6

PMCID:: PMC9256768

Abstract Article PDF–1.4M

Select item 74159918.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 57860689.

Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis

Kristi Helke, Peggi Angel, Ping Lu, Elizabeth Garrett-Mayer, Besim Ogretmen, Richard Drake, Christina Voelkel-Johnson

Sci Rep. 2018; 8: 1627. Published online 2018 Jan 26. doi: 10.1038/s41598-018-20102-z

PMCID:: PMC5786068

Abstract Article PDF–2.2M

Select item 573179310.

A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis

Bianca Williams, Jason Correnti, Amanke Oranu, Annie Lin, Victoria Scott, Maxine Annoh, James Beck, Emma Furth, Victoria Mitchell, Can E. Senkal, Lina Obeid, Rotonya M. Carr

FASEB J. 2018 Jan; 32(1): 130–142. Published online 2017 Sep 1. doi: 10.1096/fj.201601142R

PMCID:: PMC5731793

Abstract Article

Select item 568618611.

Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis

Matthew J. Scheffel, Kristi Helke, Ping Lu, Jacob S. Bowers, Besim Ogretmen, Elizabeth Garrett-Mayer, Chrystal M. Paulos, Christina Voelkel-Johnson

Sci Rep. 2017; 7: 15552. Published online 2017 Nov 14. doi: 10.1038/s41598-017-15791-x

PMCID:: PMC5686186

Abstract Article PDF–2.5M

Select item 564738912.

Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development

Shan Li, Amy Teegarden, Emily M. Bauer, Jaewoo Choi, Nadia Messaddeq, David A. Hendrix, Gitali Ganguli-Indra, Mark Leid, Arup K. Indra

Sci Rep. 2017; 7: 13427. Published online 2017 Oct 18. doi: 10.1038/s41598-017-13347-7

PMCID:: PMC5647389

Abstract Article PDF–5.2M

Select item 543654413.

Ceramide synthesis regulates T cell activity and GVHD development

M. Hanief Sofi, Jessica Heinrichs, Mohammed Dany, Hung Nguyen, Min Dai, David Bastian, Steven Schutt, Yongxia Wu, Anusara Daenthanasanmak, Salih Gencer, Aleksandra Zivkovic, Zdzislaw Szulc, Holger Stark, Chen Liu, Ying-Jun Chang, Besim Ogretmen, Xue-Zhong Yu

JCI Insight. 2017 May 18; 2(10): e91701. Published online 2017 May 18. doi: 10.1172/jci.insight.91701

PMCID:: PMC5436544

Abstract Article PDF–2.4M

Select item 481717814.

Enzyme Activities of the Ceramide Synthases CERS2–6 Are Regulated by Phosphorylation in the C-terminal Region

Takayuki Sassa, Taisuke Hirayama, Akio Kihara

J Biol Chem. 2016 Apr 1; 291(14): 7477–7487. Published online 2016 Feb 17. doi: 10.1074/jbc.M115.695858

PMCID:: PMC4817178

Abstract Article PDF–1.8M

Select item 472247115.

SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY

Sergei A. Novgorodov, Christopher L. Riley, Jarryd A. Keffler, Jin Yu, Mark S. Kindy, Wendy B. Macklin, David B. Lombard, Tatyana I. Gudz

J Biol Chem. 2016 Jan 22; 291(4): 1957–1973. Published online 2015 Nov 30. doi: 10.1074/jbc.M115.668228

PMCID:: PMC4722471

Abstract Article PDF–2.0M

Select item 455249316.

Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages

Jens-Erik Dietrich, Laura Panavaite, Stefan Gunther, Sebastian Wennekamp, Anna C Groner, Anton Pigge, Stefanie Salvenmoser, Didier Trono, Lars Hufnagel, Takashi Hiiragi

EMBO Rep. 2015 Aug; 16(8): 1005–1021. Published online 2015 Jul 3. doi: 10.15252/embr.201540162

PMCID:: PMC4552493

Abstract Article PDF–2.7M

Select item 377441017.

Inactivation of Ceramide Synthase 6 in Mice Results in an Altered Sphingolipid Metabolism and Behavioral Abnormalities

Philipp Ebel, Katharina vom Dorp, Elisabeth Petrasch-Parwez, Armin Zlomuzica, Kiyoka Kinugawa, Jean Mariani, David Minich, Christina Ginkel, Jochen Welcker, Joachim Degen, Matthias Eckhardt, Ekrem Dere, Peter Dörmann, Klaus Willecke

J Biol Chem. 2013 Jul 19; 288(29): 21433–21447. Published online 2013 Jun 12. doi: 10.1074/jbc.M113.479907

PMCID:: PMC3774410

Abstract Article PDF–3.3M

Select item 372946518.

Oxidized Phospholipids Induce Ceramide Accumulation in RAW 264.7 Macrophages: Role of Ceramide Synthases

Lingaraju M. Halasiddappa, Harald Koefeler, Anthony H. Futerman, Albin Hermetter

PLoS One. 2013; 8(7): e70002. Published online 2013 Jul 31. doi: 10.1371/journal.pone.0070002

PMCID:: PMC3729465

Abstract Article PDF–729K

Select item 355634319.

Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development

Zhixing Wang, Jay S. Kirkwood, Alan W. Taylor, Jan F. Stevens, Mark Leid, Gitali Ganguli-Indra, Arup K. Indra

J Invest Dermatol. Author manuscript; available in PMC 2013 Sep 1.

Published in final edited form as: J Invest Dermatol. 2013 Mar; 133(3): 668–676. Published online 2012 Oct 25. doi: 10.1038/jid.2012.358

PMCID:: PMC3556343

Abstract Article PDF–608K

Select item 323495920.

Alteration of Ceramide Synthase 6/C₁₆-Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of Cellular Ca²⁺ and ER/Golgi Membrane Network

Can E. Senkal, Suriyan Ponnusamy, Yefim Manevich, Marisa Meyers-Needham, Sahar A. Saddoughi, Archana Mukhopadyay, Paul Dent, Jacek Bielawski, Besim Ogretmen

J Biol Chem. 2011 Dec 9; 286(49): 42446–42458. Published online 2011 Oct 19. doi: 10.1074/jbc.M111.287383

PMCID:: PMC3234959

Abstract Article PDF–3.9M

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