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Select item 108298711.

Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors

Yiting Wang, Yufan Sun, Shouyan Deng, Jiayang Liu, Jianghong Yu, Hao Chi, Xue Han, Yuan Zhang, Jiawei Shi, Yungang Wang, Yingfei Quan, Hai Li, Jie Xu

Cell Rep Med. 2024 Jan 16; 5(1): 101374. Published online 2024 Jan 16. doi: 10.1016/j.xcrm.2023.101374

PMCID:: PMC10829871

Abstract Article PDF–8.2M

Select item 103250922.

Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens

Huntly M. Morrison, Julia Craft, Rafael Rivera-Lugo, Jeffery R. Johnson, Guillaume R. Golovkine, Samantha L. Bell, Claire E. Dodd, Erik Van Dis, Wandy L. Beatty, Shally R. Margolis, Teresa Repasy, Isaac Shaker, Angus Y. Lee, Russell E. Vance, Sarah A. Stanley, Robert O. Watson, Nevan J. Krogan, Daniel A. Portnoy, Bennett H. Penn, Jeffery S. Cox

PLoS Pathog. 2023 Jun; 19(6): e1011088. Published online 2023 Jun 23. doi: 10.1371/journal.ppat.1011088

PMCID:: PMC10325092

Abstract Article PDF–1.6M

Select item 98981643.

Galectin-8 downmodulates TLR4 activation and impairs bacterial clearance in a mouse model of Pseudomonas keratitis

Abdulraouf Ramadan, Zhiyi Cao, Mujtaba Hassan, Fredrik Zetterberg, Ulf J. Nilsson, Mihaela Gadjeva, Vijay Rathinam, Noorjahan Panjwani

J Immunol. Author manuscript; available in PMC 2024 Feb 15.

Published in final edited form as: J Immunol. 2023 Feb 15; 210(4): 398–407. doi: 10.4049/jimmunol.2200706

PMCID:: PMC9898164

Abstract Article PDF–890K

Select item 85284284.

Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension

Vinny Negi, Jimin Yang, Gil Speyer, Andres Pulgarin, Adam Handen, Jingsi Zhao, Yi Yin Tai, Ying Tang, Miranda K. Culley, Qiujun Yu, Patricia Forsythe, Anastasia Gorelova, Annie M. Watson, Yassmin Al Aaraj, Taijyu Satoh, Maryam Sharifi-Sanjani, Arun Rajaratnam, John Sembrat, Steeve Provencher, Xianglin Yin, Sara O. Vargas, Mauricio Rojas, Sébastien Bonnet, Stephanie Torrino, Bridget K. Wagner, Stuart L. Schreiber, Mingji Dai, Thomas Bertero, Imad Al Ghouleh, Seungchan Kim, Stephen Y. Chan

Sci Adv. 2021 Oct; 7(43): eabh3794. Published online 2021 Oct 20. doi: 10.1126/sciadv.abh3794

PMCID:: PMC8528428

Abstract Article PDF–2.1M

Select item 84063265.

Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages

Samantha L. Bell, Kayla L. Lopez, Jeffery S. Cox, Kristin L. Patrick, Robert O. Watson

mBio. 2021 Jul-Aug; 12(4): e01871-20. Published online 2021 Jul 6. doi: 10.1128/mBio.01871-20

PMCID:: PMC8406326

Abstract Article PDF–8.5M

Select item 76166306.

Podoplanin-expressing macrophages promote lymphangiogenesis and lymphoinvasion via Galectin 8-mediated adhesion to tumor lymphatics

Paweł Bieniasz-Krzywiec, Rosa Martín-Pérez, Manuel Ehling, Melissa García-Caballero, Sotiria Pinioti, Samantha Pretto, Roel Kroes, Chiara Aldeni, Mario Di Matteo, Hans Prenen, María Virginia Tribulatti, Oscar Campetella, Ann Smeets, Agnes Noel, Giuseppe Floris, Jo A. Van Ginderachter, Massimiliano Mazzone

Cell Metab. Author manuscript; available in PMC 2024 Sep 24.

Published in final edited form as: Cell Metab. 2019 Nov 5; 30(5): 917–936.e10. Published online 2019 Aug 22. doi: 10.1016/j.cmet.2019.07.015

PMCID:: PMC7616630

Abstract Article PDF–3.4M

Select item 74159917.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 73438498.

Anti-inflammatory Role of Galectin-8 During Trypanosoma cruzi Chronic Infection

Adriano Bertelli, Liliana M. Sanmarco, Carla A. Pascuale, Miriam Postan, Maria P. Aoki, María S. Leguizamón

Front Cell Infect Microbiol. 2020; 10: 285. Published online 2020 Jul 2. doi: 10.3389/fcimb.2020.00285

PMCID:: PMC7343849

Abstract Article PDF–3.7M

Select item 73343769.

Galectin-8 Enhances T cell Response by Promotion of Antigen Internalization and Processing

Cecilia Arahí Prato, Julieta Carabelli, Oscar Campetella, María Virginia Tribulatti

iScience. 2020 Jul 24; 23(7): 101278. Published online 2020 Jun 17. doi: 10.1016/j.isci.2020.101278

PMCID:: PMC7334376

Abstract Article PDF–7.1M

Select item 719359410.

The Animal Lectin Galectin-8 Promotes Cytokine Expression and Metastatic Tumor Growth in Mice

Hadas Shatz-Azoulay, Yaron Vinik, Roi Isaac, Ulrike Kohler, Sima Lev, Yehiel Zick

Sci Rep. 2020; 10: 7375. Published online 2020 Apr 30. doi: 10.1038/s41598-020-64371-z

PMCID:: PMC7193594

Abstract Article PDF–3.9M

Select item 630254711.

Galectin-8 Favors the Presentation of Surface-Tethered Antigens by Stabilizing the B Cell Immune Synapse

Dorian Obino, Luc Fetler, Andrea Soza, Odile Malbec, Juan José Saez, Mariana Labarca, Claudia Oyanadel, Felipe Del Valle Batalla, Nicolas Goles, Aleksandra Chikina, Danielle Lankar, Fabián Segovia-Miranda, Camille Garcia, Thibaut Léger, Alfonso Gonzalez, Marion Espéli, Ana-Maria Lennon-Duménil, Maria-Isabel Yuseff

Cell Rep. 2018 Dec 11; 25(11): 3110–3122.e6. Published online 2018 Dec 11. doi: 10.1016/j.celrep.2018.11.052

PMCID:: PMC6302547

Abstract Article

Select item 591193512.

Galectins control mTOR in response to endomembrane damage

Jingyue Jia, Yakubu Princely Abudu, Aurore Claude-Taupin, Yuexi Gu, Suresh Kumar, Seong Won Choi, Ryan Peters, Michal Mudd, Lee Allers, Michelle Salemi, Brett Phinney, Terje Johansen, Vojo Deretic

Mol Cell. Author manuscript; available in PMC 2019 Apr 5.

Published in final edited form as: Mol Cell. 2018 Apr 5; 70(1): 120–135.e8. doi: 10.1016/j.molcel.2018.03.009

PMCID:: PMC5911935

Abstract Article PDF–965K

Select item 548446613.

Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis

Evelyn Pardo, Claudia Cárcamo, Reinaldo Uribe-San Martín, Ethel Ciampi, Fabián Segovia-Miranda, Cristobal Curkovic-Peña, Fabián Montecino, Christopher Holmes, Juan Enrique Tichauer, Eric Acuña, Francisco Osorio-Barrios, Marjorie Castro, Priscilla Cortes, Claudia Oyanadel, David M. Valenzuela, Rodrigo Pacheco, Rodrigo Naves, Andrea Soza, Alfonso González

PLoS One. 2017; 12(6): e0177472. Published online 2017 Jun 26. doi: 10.1371/journal.pone.0177472

PMCID:: PMC5484466

Abstract Article PDF–8.6M

Select item 521015414.

Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy

Tomonori Kimura, Jingyue Jia, Suresh Kumar, Seong Won Choi, Yuexi Gu, Michal Mudd, Nicolas Dupont, Shanya Jiang, Ryan Peters, Farzin Farzam, Ashish Jain, Keith A Lidke, Christopher M Adams, Terje Johansen, Vojo Deretic

EMBO J. 2017 Jan 4; 36(1): 42–60. Published online 2016 Dec 8. doi: 10.15252/embj.201695081

PMCID:: PMC5210154

Abstract Article PDF–3.7M

Select item 483207715.

Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3

Wei-Sheng Chen, Zhiyi Cao, Satoshi Sugaya, Maria J. Lopez, Victor G. Sendra, Nora Laver, Hakon Leffler, Ulf J. Nilsson, Jianxin Fu, Jianhua Song, Lijun Xia, Pedram Hamrah, Noorjahan Panjwani

Nat Commun. 2016; 7: 11302. Published online 2016 Apr 12. doi: 10.1038/ncomms11302

Correction in:: Nat Commun. 2016; 7: 12063.

PMCID:: PMC4832077

Abstract Article PDF–8.2M

Select item 474782216.

Galectin-8 promotes regulatory T cell differentiation by modulating IL-2 and TGFß signaling

James F. Sampson, Amol Suryawanshi, Wei-Sheng Chen, Gabriel A. Rabinovich, Noorjahan Panjwani

Immunol Cell Biol. Author manuscript; available in PMC 2016 May 18.

Published in final edited form as: Immunol Cell Biol. 2016 Feb; 94(2): 213–219. Published online 2015 Aug 18. doi: 10.1038/icb.2015.72

Correction in:: Immunol Cell Biol. 2016 Feb; 94(2): 220.

PMCID:: PMC4747822

Abstract Article PDF–1.1M

Select item 448833917.

Galectin-8 Ameliorates Murine Autoimmune Ocular Pathology and Promotes a Regulatory T Cell Response

James F. Sampson, Eiichi Hasegawa, Lama Mulki, Amol Suryawanshi, Shuhong Jiang, Wei-Sheng Chen, Gabriel A. Rabinovich, Kip M. Connor, Noorjahan Panjwani

PLoS One. 2015; 10(6): e0130772. Published online 2015 Jun 30. doi: 10.1371/journal.pone.0130772

PMCID:: PMC4488339

Abstract Article PDF–7.3M

Select item 442449318.

The mammalian lectin galectin-8 induces RANKL expression, osteoclastogenesis, and bone mass reduction in mice

Yaron Vinik, Hadas Shatz-Azoulay, Alessia Vivanti, Navit Hever, Yifat Levy, Rotem Karmona, Vlad Brumfeld, Saja Baraghithy, Malka Attar-Lamdar, Sigalit Boura-Halfon, Itai Bab, Yehiel Zick

eLife. 2015; 4: e05914. Published online 2015 May 8. doi: 10.7554/eLife.05914

PMCID:: PMC4424493

Abstract Article PDF–2.3M

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 255627020.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

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