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Select item 114164111.

TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition

Pascual Torres, Santiago Rico-Rios, Miriam Ceron-Codorniu, Marta Santacreu-Vilaseca, David Seoane-Miraz, Yahya Jad, Victòria Ayala, Guillermo Mariño, Maria Beltran, Maria P. Miralles, Pol Andrés-Benito, Joaquin Fernandez-Irigoyen, Enrique Santamaria, Carlos López-Otín, Rosa M. Soler, Monica Povedano, Isidro Ferrer, Reinald Pamplona, Matthew J. A. Wood, Miguel A. Varela, Manuel Portero-Otin

Acta Neuropathol. 2024; 148(1): 45. Published online 2024 Sep 21. doi: 10.1007/s00401-024-02780-4

PMCID:: PMC11416411

Abstract Article PDF–5.1M

Select item 111637242.

Elevated nuclear TDP-43 induces constitutive exon skipping

Rogger P. Carmen-Orozco, William Tsao, Yingzhi Ye, Irika R. Sinha, Koping Chang, Vickie T. Trinh, William Chung, Kyra Bowden, Juan C. Troncoso, Seth Blackshaw, Lindsey R. Hayes, Shuying Sun, Philip C. Wong, Jonathan P. Ling

Mol Neurodegener. 2024; 19: 45. Published online 2024 Jun 9. doi: 10.1186/s13024-024-00732-w

PMCID:: PMC11163724

Abstract Article PDF–8.3M

Select item 111439333.

Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammation

Víctor Arribas, Yara Onetti, Marina Ramiro-Pareta, Pilar Villacampa, Heike Beck, Mariona Alberola, Anna Esteve-Codina, Angelika Merkel, Markus Sperandio, Ofelia M. Martínez-Estrada, Bettina Schmid, Eloi Montanez

JCI Insight. 2024 Mar 8; 9(5): e177819. Published online 2024 Feb 1. doi: 10.1172/jci.insight.177819

PMCID:: PMC11143933

Abstract Article PDF–31M

Select item 110325484.

Gene replacement‐Alzheimer's disease (GR‐AD): Modeling the genetics of human dementias in mice

Kellie Benzow, Kul Karanjeet, Adrian L. Oblak, Gregory W. Carter, Michael Sasner, Michael D. Koob

Alzheimers Dement. 2024 Apr; 20(4): 3080–3087. Published online 2024 Feb 11. doi: 10.1002/alz.13730

PMCID:: PMC11032548

Abstract Article PDF–463K

Select item 110160665.

Plasminogen degrades α-synuclein, Tau and TDP-43 and decreases dopaminergic neurodegeneration in mouse models of Parkinson’s disease

Chunying Guo, Ting Wang, Haiyan Huang, Xiaolu Wang, Yugui Jiang, Jinan Li

Sci Rep. 2024; 14: 8581. Published online 2024 Apr 13. doi: 10.1038/s41598-024-59090-8

PMCID:: PMC11016066

Abstract Article PDF–4.1M

Select item 109958866.

TDP-43 deficiency in suprachiasmatic nucleus perturbs rhythmicity of neuroactivity in prefrontal cortex

Hongxia Zhang, Chen Chen, Eric Erquan Zhang, Xiaotian Huang

iScience. 2024 Apr 19; 27(4): 109522. Published online 2024 Mar 16. doi: 10.1016/j.isci.2024.109522

PMCID:: PMC10995886

Abstract Article PDF–5.9M

Select item 109882187.

TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43

Juan M. Godoy-Corchuelo, Zeinab Ali, Jose M. Brito Armas, Aurea B. Martins-Bach, Irene García-Toledo, Luis C. Fernández-Beltrán, Juan I. López-Carbonero, Pablo Bascuñana, Shoshana Spring, Irene Jimenez-Coca, Ramón A. Muñoz de Bustillo Alfaro, Maria J. Sánchez-Barrena, Remya R. Nair, Brian J. Nieman, Jason P. Lerch, Karla L. Miller, Hande P. Ozdinler, Elizabeth M.C. Fisher, Thomas J. Cunningham, Abraham Acevedo-Arozena, Silvia Corrochano

Neurobiol Dis. 2024 Apr; 193: 106437. doi: 10.1016/j.nbd.2024.106437

Correction in:: Neurobiol Dis. 2024 Nov; 202: 106708.

PMCID:: PMC10988218

Abstract Article PDF–13M

Select item 109467068.

TDP‐43 pathology and functional deficits in wild‐type and ALS/FTD mutant cyclin F mouse models

Annika van Hummel, Miheer Sabale, Magdalena Przybyla, Julia van der Hoven, Gabriella Chan, Astrid F. Feiten, Roger S. Chung, Lars M. Ittner, Yazi D. Ke

Neuropathol Appl Neurobiol. 2023 Apr; 49(2): e12902. Published online 2023 Apr 10. doi: 10.1111/nan.12902

PMCID:: PMC10946706

Abstract Article PDF–6.7M

Select item 109176609.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 1087664510.

A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration

Rebecca San Gil, Dana Pascovici, Juliana Venturato, Heledd Brown-Wright, Prachi Mehta, Lidia Madrid San Martin, Jemma Wu, Wei Luan, Yi Kit Chui, Adekunle T. Bademosi, Shilpa Swaminathan, Serey Naidoo, Britt A. Berning, Amanda L. Wright, Sean S. Keating, Maurice A. Curtis, Richard L. M. Faull, John D. Lee, Shyuan T. Ngo, Albert Lee, Marco Morsch, Roger S. Chung, Emma Scotter, Leszek Lisowski, Mehdi Mirzaei, Adam K. Walker

Nat Commun. 2024; 15: 1508. Published online 2024 Feb 19. doi: 10.1038/s41467-024-45646-9

PMCID:: PMC10876645

Abstract Article PDF–13M

Select item 1082475911.

RNA polymerase II pausing is essential during spermatogenesis for appropriate gene expression and completion of meiosis

Emily G. Kaye, Kavyashree Basavaraju, Geoffrey M. Nelson, Helena D. Zomer, Debarun Roy, Irene Infancy Joseph, Reza Rajabi-Toustani, Huanyu Qiao, Karen Adelman, Prabhakara P. Reddi

Nat Commun. 2024; 15: 848. Published online 2024 Jan 29. doi: 10.1038/s41467-024-45177-3

PMCID:: PMC10824759

Abstract Article PDF–2.6M

Select item 1076986012.

Excessive nucleic acid R-loops induce mitochondria-dependent epithelial cell necroptosis and drive spontaneous intestinal inflammation

Xu Yang, Guilin Li, Pengbo Lou, Mingxin Zhang, Kai Yao, Jintao Xiao, Yiqian Chen, Jiuzhi Xu, Shengyuan Tian, Min Deng, Yuwei Pan, Mengzhen Li, Xi Wu, Ruiqi Liu, Xiaojing Shi, Yuhua Tian, Lu Yu, Hao Ke, Baowei Jiao, Yingzi Cong, Maksim V. Plikus, Xiaowei Liu, Zhengquan Yu, Cong Lv

Proc Natl Acad Sci U S A. 2024 Jan 2; 121(1): e2307395120. Published online 2023 Dec 29. doi: 10.1073/pnas.2307395120

PMCID:: PMC10769860

Abstract Article PDF–6.6M

Select item 1073179413.

Genetic ablation of Sarm1 attenuates expression and mislocalization of phosphorylated TDP-43 after mouse repetitive traumatic brain injury

Elif O. Dogan, James Bouley, Jianjun Zhong, Ashley L. Harkins, Allison M. Keeler, Daryl A. Bosco, Robert H. Brown, Jr., Nils Henninger

Acta Neuropathol Commun. 2023; 11: 206. Published online 2023 Dec 20. doi: 10.1186/s40478-023-01709-4

PMCID:: PMC10731794

Abstract Article PDF–14M

Select item 1056711514.

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy

Julie C Necarsulmer, Jeremy M Simon, Baggio A Evangelista, Youjun Chen, Xu Tian, Sara Nafees, Ariana B Marquez, Huijun Jiang, Ping Wang, Deepa Ajit, Viktoriya D Nikolova, Kathryn M Harper, J Ashley Ezzell, Feng-Chang Lin, Adriana S Beltran, Sheryl S Moy, Todd J Cohen

eLife. 2023; 12: RP85921. Published online 2023 Oct 11. doi: 10.7554/eLife.85921

PMCID:: PMC10567115

Abstract Article PDF–13M

Select item 1046388415.

Traumatic brain injury induces TDP-43 mislocalization and neurodegenerative effects in tissue distal to the primary injury site in a non-transgenic mouse

George R. Bjorklund, Jennifer Wong, David Brafman, Robert Bowser, Sarah E. Stabenfeldt

Acta Neuropathol Commun. 2023; 11: 137. Published online 2023 Aug 22. doi: 10.1186/s40478-023-01625-7

PMCID:: PMC10463884

Abstract Article PDF–3.7M

Select item 1035229416.

Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation

Xiaoqing Nie, Qianhua Xu, Chengpeng Xu, Fengling Chen, Qizhi Wang, Dandan Qin, Rui Wang, Zheng Gao, Xukun Lu, Xinai Yang, Yu Wu, Chen Gu, Wei Xie, Lei Li

Nat Commun. 2023; 14: 4275. Published online 2023 Jul 17. doi: 10.1038/s41467-023-39924-1

PMCID:: PMC10352294

Abstract Article PDF–3.5M

Select item 1033036217.

Polycomb group protein CBX7 represses cardiomyocyte proliferation via modulation of the TARDBP/RBM38 axis

Kyu-Won Cho, Mark Andrade, Seongho Bae, Sangsung Kim, Jin Eyun Kim, Er Yearn Jang, Sangho Lee, Ahsan Husain, Roy L. Sutliff, John W. Calvert, Changwon Park, Young-sup Yoon

Circulation. Author manuscript; available in PMC 2024 Jun 13.

Published in final edited form as: Circulation. 2023 Jun 13; 147(24): 1823–1842. Published online 2023 May 9. doi: 10.1161/CIRCULATIONAHA.122.061131

PMCID:: PMC10330362

Abstract Article PDF–1.6M

Select item 1018373518.

TDP-43 knockdown in mouse model of ALS leads to dsRNA deposition, gliosis, and neurodegeneration in the spinal cord

Ryan A Milstead, Christopher D Link, Zuoshang Xu, Charles A Hoeffer

Cereb Cortex. 2023 May 15; 33(10): 5808–5816. Published online 2022 Nov 28. doi: 10.1093/cercor/bhac461

PMCID:: PMC10183735

Abstract Article PDF–2.0M

Select item 1014275219.

Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain

Molly E. V. Swanson, Miran Mrkela, Helen C. Murray, Maize C. Cao, Clinton Turner, Maurice A. Curtis, Richard L. M. Faull, Adam K. Walker, Emma L. Scotter

Acta Neuropathol Commun. 2023; 11: 69. Published online 2023 Apr 28. doi: 10.1186/s40478-023-01561-6

PMCID:: PMC10142752

Abstract Article PDF–12M

Select item 994532520.

TDP-43 drives synaptic and cognitive deterioration following traumatic brain injury

Fei Gao, Mei Hu, Jian Zhang, Jack Hashem, Chu Chen

Acta Neuropathol. Author manuscript; available in PMC 2023 Aug 1.

Published in final edited form as: Acta Neuropathol. 2022 Aug; 144(2): 187–210. Published online 2022 Jun 17. doi: 10.1007/s00401-022-02449-w

PMCID:: PMC9945325

Abstract Article PDF–3.8M

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