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Select item 116156931.

Effects of glucokinase haploinsufficiency on the pancreatic β‐cell mass and function of long‐term high‐fat, high‐sucrose diet‐fed mice

Ikumi Shigesawa, Akinobu Nakamura, Yuki Yamauchi, Shinichiro Kawata, Asuka Miyazaki, Hiroshi Nomoto, Hiraku Kameda, Yasuo Terauchi, Tatsuya Atsumi

J Diabetes Investig. 2024 Dec; 15(12): 1732–1742. Published online 2024 Sep 21. doi: 10.1111/jdi.14307

PMCID:: PMC11615693

Abstract Article PDF–6.5M

Select item 112347652.

Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice

Ying Zhi, Kerui Fan, Shuang Liu, Kai Hu, Xinyan Zan, Ling Lin, Yongqiang Yang, Xianqiong Gong, Kun Chen, Li Tang, Longjiang Li, Jiayi Huang, Shujun Zhang, Li Zhang

Mol Med. 2024; 30: 99. Published online 2024 Jul 9. doi: 10.1186/s10020-024-00867-y

PMCID:: PMC11234765

Abstract Article PDF–13M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106341844.

Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like behavior

Mohammad Ali Mohammad Nezhady, Gael Cagnone, Jean-Sébastien Joyal, Sylvain Chemtob

Cell Commun Signal. 2023; 21: 196. Published online 2023 Nov 9. doi: 10.1186/s12964-023-01188-z

PMCID:: PMC10634184

Abstract Article PDF–3.3M

Select item 99468035.

Lactate secreted via MCT4 from bone-colonizing breast cancer excites sensory neurons via GPR81

Tatsuo Okui, Masahiro Hiasa, Kazuaki Hasegawa, Tomoya Nakamura, Kisho Ono, Soichiro Ibaragi, Takahiro Kanno, Akira Sasaki, Toshiyuki Yoneda

Int J Oncol. 2023 Mar; 62(3): 39. Published online 2023 Feb 8. doi: 10.3892/ijo.2023.5487

PMCID:: PMC9946803

Abstract Article PDF–5.2M

Select item 94417216.

Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue

Marc Briquet, Anne-Bérengère Rocher, Maxime Alessandri, Nadia Rosenberg, Haissa de Castro Abrantes, Joel Wellbourne-Wood, Céline Schmuziger, Vanessa Ginet, Julien Puyal, Etienne Pralong, Roy Thomas Daniel, Stefan Offermanns, Jean-Yves Chatton

J Cereb Blood Flow Metab. 2022 Sep; 42(9): 1650–1665. Published online 2022 Mar 3. doi: 10.1177/0271678X221080324

PMCID:: PMC9441721

Abstract Article PDF–1.3M

Select item 94237717.

Overexpressing the hydroxycarboxylic acid receptor 1 in mouse brown adipose tissue restores glucose tolerance and insulin sensitivity in diet-induced obese mice

Hyeon-Young Min, Jiyeon Hwang, Yuna Choi, Young-Hwan Jo

Am J Physiol Endocrinol Metab. 2022 Sep 1; 323(3): E231–E241. Published online 2022 Jul 13. doi: 10.1152/ajpendo.00084.2022

PMCID:: PMC9423771

Abstract Article

Select item 93631158.

Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia

Lauritz Kennedy, Emilie R Glesaaen, Vuk Palibrk, Marco Pannone, Wei Wang, Ali Al-Jabri, Rajikala Suganthan, Niklas Meyer, Marie Landa Austbø, Xiaolin Lin, Linda H Bergersen, Magnar Bjørås, Johanne E Rinholm

eLife. 2022; 11: e76451. Published online 2022 Aug 9. doi: 10.7554/eLife.76451

PMCID:: PMC9363115

Abstract Article PDF–4.3M

Select item 92074929.

Neuronal GPR81 regulates developmental brain angiogenesis and promotes brain recovery after a hypoxic ischemic insult

Prabhas Chaudhari, Ankush Madaan, José Carlos Rivera, Iness Charfi, Tiffany Habelrih, Xin Hou, Mohammad Nezhady, Gregory Lodygensky, Graciela Pineyro, Thierry Muanza, Sylvain Chemtob

J Cereb Blood Flow Metab. 2022 Jul; 42(7): 1294–1308. Published online 2022 Feb 2. doi: 10.1177/0271678X221077499

PMCID:: PMC9207492

Abstract Article PDF–1.9M

Select item 856917110.

Lactate activates hypothalamic POMC neurons by intercellular signaling

P. Órdenes, P. S. Villar, E. Tarifeño-Saldivia, M. Salgado, R. Elizondo-Vega, Ricardo C. Araneda, María A. García-Robles

Sci Rep. 2021; 11: 21644. Published online 2021 Nov 4. doi: 10.1038/s41598-021-00947-7

PMCID:: PMC8569171

Abstract Article PDF–5.2M

Select item 830316111.

Participation of L-Lactate and Its Receptor HCAR1/GPR81 in Neurovisual Development

Samuel Laroche, Aurélie Stil, Philippe Germain, Hosni Cherif, Sylvain Chemtob, Jean-François Bouchard

Cells. 2021 Jul; 10(7): 1640. Published online 2021 Jun 30. doi: 10.3390/cells10071640

PMCID:: PMC8303161

Abstract Article PDF–2.7M

Select item 736392812.

Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling

Eman Khatib-Massalha, Suditi Bhattacharya, Hassan Massalha, Adi Biram, Karin Golan, Orit Kollet, Anju Kumari, Francesca Avemaria, Ekaterina Petrovich-Kopitman, Shiri Gur-Cohen, Tomer Itkin, Isabell Brandenburger, Asaf Spiegel, Ziv Shulman, Zachary Gerhart-Hines, Shalev Itzkovitz, Matthias Gunzer, Stefan Offermanns, Ronen Alon, Amiram Ariel, Tsvee Lapidot

Nat Commun. 2020; 11: 3547. Published online 2020 Jul 15. doi: 10.1038/s41467-020-17402-2

PMCID:: PMC7363928

Abstract Article PDF–3.7M

Select item 699219713.

Hydrocarboxylic acid receptor 1 in BAT regulates glucose uptake in mice fed a high-fat diet

Eunjin Kwon, Taesik Yoo, Hye-Young Joung, Young-Hwan Jo

PLoS One. 2020; 15(1): e0228320. Published online 2020 Jan 30. doi: 10.1371/journal.pone.0228320

PMCID:: PMC6992197

Abstract Article PDF–1.2M

Select item 655463414.

The Lactate Receptor HCAR1 Modulates Neuronal Network Activity through the Activation of G_α and G_βγ Subunits

Haíssa de Castro Abrantes, Marc Briquet, Céline Schmuziger, Leonardo Restivo, Julien Puyal, Nadia Rosenberg, Anne-Bérengère Rocher, Stefan Offermanns, Jean-Yves Chatton

J Neurosci. 2019 Jun 5; 39(23): 4422–4433. doi: 10.1523/JNEUROSCI.2092-18.2019

PMCID:: PMC6554634

Abstract Article PDF–1.5M

Select item 649522415.

Inhibition of G Protein‐Coupled Receptor 81 (GPR81) Protects Against Ischemic Brain Injury

Zhe Shen, Lei Jiang, Yang Yuan, Tian Deng, Yan‐Rong Zheng, Yan‐Yan Zhao, Wen‐Lu Li, Jia‐Ying Wu, Jian‐Qing Gao, Wei‐Wei Hu, Xiang‐Nan Zhang, Zhong Chen

CNS Neurosci Ther. 2015 Mar; 21(3): 271–279. Published online 2014 Dec 11. doi: 10.1111/cns.12362

PMCID:: PMC6495224

Abstract Article PDF–1.7M

Select item 585892816.

GPR81, a cell-surface receptor for lactate, regulates intestinal homeostasis and protects mice from experimental colitis

Punithavathi Ranganathan, Arulkumaran Shanmugam, Daniel Swafford, Amol Suryawanshi, Pushpak Bhattacharjee, Mohamed S Hussein, Pandelakis A Koni, Puttur D Prasad, Zoya B Kurago, Muthusamy Thangaraju, Vadivel Ganapathy, Santhakumar Manicassamy

J Immunol. Author manuscript; available in PMC 2019 Mar 1.

Published in final edited form as: J Immunol. 2018 Mar 1; 200(5): 1781–1789. Published online 2018 Jan 31. doi: 10.4049/jimmunol.1700604

PMCID:: PMC5858928

Abstract Article PDF–948K

Select item 545751317.

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

Cecilie Morland, Krister A. Andersson, Øyvind P. Haugen, Alena Hadzic, Liv Kleppa, Andreas Gille, Johanne E. Rinholm, Vuk Palibrk, Elisabeth H. Diget, Lauritz H. Kennedy, Tomas Stølen, Eivind Hennestad, Olve Moldestad, Yiqing Cai, Maja Puchades, Stefan Offermanns, Koen Vervaeke, Magnar Bjørås, Ulrik Wisløff, Jon Storm-Mathisen, Linda H. Bergersen

Nat Commun. 2017; 8: 15557. Published online 2017 May 23. doi: 10.1038/ncomms15557

PMCID:: PMC5457513

Abstract Article PDF–1.5M

Select item 511284918.

Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner

Agustina Errea, Delphine Cayet, Philippe Marchetti, Cong Tang, Jerome Kluza, Stefan Offermanns, Jean-Claude Sirard, Martin Rumbo

PLoS One. 2016; 11(11): e0163694. Published online 2016 Nov 15. doi: 10.1371/journal.pone.0163694

PMCID:: PMC5112849

Abstract Article PDF–1.7M

Select item 410430519.

Lactate Reduces Organ Injury in Toll-like Receptor- and Inflammasome-Mediated Inflammation via GPR81-mediated Suppression of Innate Immunity

Rafaz Hoque, Ahmad Farooq, Ayaz Ghani, Fred Gorelick, Wajahat Zafar Mehal

Gastroenterology. Author manuscript; available in PMC 2015 Jun 1.

Published in final edited form as: Gastroenterology. 2014 Jun; 146(7): 1763–1774. Published online 2014 Mar 20. doi: 10.1053/j.gastro.2014.03.014

PMCID:: PMC4104305

Abstract Article PDF–1.1M

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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