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Select item 109473901.

Bsep/Abcb11 knockout ameliorates Schistosoma mansoni liver pathology by reducing parasite fecundity

Tomáš Macháček, Claudia D. Fuchs, Franziska Winkelmann, Marcus Frank, Hubert Scharnagl, Tatjana Stojakovic, Martina Sombetzki, Michael Trauner

Liver Int. 2023 Nov; 43(11): 2469–2478. Published online 2023 Aug 29. doi: 10.1111/liv.15710

PMCID:: PMC10947390

Abstract Article PDF–14M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108447193.

Cav‐1 regulates the bile salt export pump on the canalicular membrane of hepatocytes by PKCα‐associated signalling under cholesterol stimulation

Liwei Pang, Meiying Cui, Shuodong Wu, Jing Kong

J Cell Mol Med. 2024 Feb; 28(3): e18110. Published online 2024 Jan 1. doi: 10.1111/jcmm.18110

PMCID:: PMC10844719

Abstract Article PDF–34M

Select item 105882754.

An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets

Mark P. Keller, Emily M. Hawes, Kathryn L. Schueler, Donnie S. Stapleton, Kelly A. Mitok, Shane P. Simonett, James K. Oeser, Leesa L. Sampson, Alan D. Attie, Mark A. Magnuson, Richard M. O’Brien

Diabetes. 2023 Nov; 72(11): 1621–1628. Published online 2023 Aug 8. doi: 10.2337/db23-0215

PMCID:: PMC10588275

Abstract Article PDF–9.5M

Select item 94263985.

Tetrahydroxylated bile acids improve cholestatic liver and bile duct injury in the Mdr2^−/− mouse model of sclerosing cholangitis via immunomodulatory effects

Claudia D. Fuchs, Emmanuel D. Dixon, Tim Hendrikx, Veronika Mlitz, Annika Wahlström, Marcus Ståhlman, Hubert Scharnagl, Tatjana Stojakovic, Christoph J. Binder, Hanns‐Ulrich Marschall, Michael Trauner

Hepatol Commun. 2022 Sep; 6(9): 2368–2378. Published online 2022 Jun 12. doi: 10.1002/hep4.1998

PMCID:: PMC9426398

Abstract Article PDF–1.5M

Select item 93066296.

Loss of bile salt export pump aggravates lipopolysaccharide‐induced liver injury in mice due to impaired hepatic endotoxin clearance

Jelena Remetic, Ahmed Ghallab, Zaynab Hobloss, Lisa Brackhagen, Reham Hassan, Maiju Myllys, Richard Radun, Veronika Mlitz, Ci Zhu, Maximilian Baumgartner, Waltraud C. Schrottmaier, Marion Mussbacher, Gerald Timelthaler, Hubert Scharnagl, Tatjana Stojakovic, Alice Assinger, Claudia D. Fuchs, Jan G. Hengstler, Michael Trauner

Hepatology. 2022 May; 75(5): 1095–1109. Published online 2022 Jan 19. doi: 10.1002/hep.32289

PMCID:: PMC9306629

Abstract Article PDF–5.1M

Select item 86653607.

miR-199a-5p inhibits the expression of ABCB11 in obstructive cholestasis

Natarajan Balasubramaniyan, Michael W. Devereaux, David J. Orlicky, Ronald J. Sokol, Frederick J. Suchy

J Biol Chem. 2021 Dec; 297(6): 101400. Published online 2021 Nov 12. doi: 10.1016/j.jbc.2021.101400

PMCID:: PMC8665360

Abstract Article PDF–2.3M

Select item 74231428.

Heterozygous knockout of Bile salt export pump ameliorates liver steatosis in mice fed a high-fat diet

Kazuya Okushin, Takeya Tsutsumi, Kazuhiko Ikeuchi, Akira Kado, Kenichiro Enooku, Hidetaka Fujinaga, Naoko Yamauchi, Tetsuo Ushiku, Kyoji Moriya, Hiroshi Yotsuyanagi, Kazuhiko Koike

PLoS One. 2020; 15(8): e0234750. Published online 2020 Aug 12. doi: 10.1371/journal.pone.0234750

PMCID:: PMC7423142

Abstract Article PDF–2.2M

Select item 73175339.

Absence of Bsep/Abcb11 attenuates MCD diet‐induced hepatic steatosis but aggravates inflammation in mice

Claudia D. Fuchs, Sebastian Krivanec, Daniel Steinacher, Veronika Mlitz, Annika Wahlström, Marcus Stahlman, Thierry Claudel, Hubert Scharnagl, Tatjana Stojakovic, Hanns‐Ulrich Marschall, Michael Trauner

Liver Int. 2020 Jun; 40(6): 1366–1377. Published online 2020 Mar 18. doi: 10.1111/liv.14423

PMCID:: PMC7317533

Abstract Article PDF–1.3M

Select item 726384310.

Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis

Kang Ho Kim, Jong Min Choi, Feng Li, Armando Arizpe, Clavia Ruth Wooton-Kee, Sayeepriyadarshini Anakk, Sung Yun Jung, Milton J Finegold, David D Moore

Endocrinology. 2018 Jun; 159(6): 2435–2446. Published online 2018 Apr 26. doi: 10.1210/en.2018-00110

PMCID:: PMC7263843

Abstract Article

Select item 631426511.

Hydrophilic bile acids prevent liver damage caused by lack of biliary phospholipid in Mdr2^−/− mice

Renxue Wang, Jonathan A. Sheps, Lin Liu, Jun Han, Patrick S. K. Chen, Jason Lamontagne, Peter D. Wilson, Ian Welch, Christoph H. Borchers, Victor Ling

J Lipid Res. 2019 Jan; 60(1): 85–97. Published online 2018 Nov 11. doi: 10.1194/jlr.M088070

PMCID:: PMC6314265

Abstract Article PDF–2.2M

Select item 593761512.

De Novo Endotoxin-Induced Production of Antibodies against the Bile Salt Export Pump Associated with Bacterial Infection following Major Hepatectomy

Kun-Ming Chan, Chih-Hsien Cheng, Tsung-Han Wu, Chen-Fang Lee, Ting-Jung Wu, Hong-Shiue Chou, Wei-Chen Lee

Biomed Res Int. 2018; 2018: 6197152. Published online 2018 Apr 23. doi: 10.1155/2018/6197152

PMCID:: PMC5937615

Abstract Article PDF–5.2M

Select item 529582113.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 459835614.

Maternal bile acid transporter deficiency promotes neonatal demise

Yuanyuan Zhang, Fei Li, Yao Wang, Aaron Pitre, Zhong-ze Fang, Matthew W. Frank, Christopher Calabrese, Kristopher W. Krausz, Geoffrey Neale, Sharon Frase, Peter Vogel, Charles O. Rock, Frank J. Gonzalez, John D. Schuetz

Nat Commun. 2015; 6: 8186. Published online 2015 Sep 29. doi: 10.1038/ncomms9186

PMCID:: PMC4598356

Abstract Article PDF–1.5M

Select item 419418815.

Transcriptional Dynamics of Bile Salt Export Pump during Pregnancy: Mechanisms and Implications in Intrahepatic Cholestasis of Pregnancy

Xiulong Song, Alexander Vasilenko, Yuan Chen, Leila Valanejad, Ruchi Verma, Bingfang Yan, Ruitang Deng

Hepatology. Author manuscript; available in PMC 2015 Dec 1.

Published in final edited form as: Hepatology. 2014 Dec; 60(6): 1993–2007. Published online 2014 May 19. doi: 10.1002/hep.27171

PMCID:: PMC4194188

Abstract Article PDF–8.8M

Select item 395843316.

LKB1/AMPK and PKA Control ABCB11 Trafficking and Polarization in Hepatocytes

László Homolya, Dong Fu, Prabuddha Sengupta, Michal Jarnik, Jean-Pierre Gillet, Lynn Vitale-Cross, J. Silvio Gutkind, Jennifer Lippincott-Schwartz, Irwin M. Arias

PLoS One. 2014; 9(3): e91921. Published online 2014 Mar 18. doi: 10.1371/journal.pone.0091921