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Items: 1 to 20 of 113

1.
KDM6A/UTX promotes spermatogenic gene expression across generations and is not required for male fertility
Benjamin W Walters, Shannon R Rainsford, Rachel A Heuer, Nicolas Dias, Xiaofang Huang, Dirk de Rooij, Bluma J Lesch
Biol Reprod. 2024 Feb; 110(2): 391–407. Published online 2023 Oct 20. doi: 10.1093/biolre/ioad141
PMCID:
PMC11484508
AbstractArticlePDF–2.5M
2.
Growth deficiency in a mouse model of Kabuki syndrome 2 bears mechanistic similarities to Kabuki syndrome 1
Christine W. Gao, WanYing Lin, Ryan C. Riddle, Sheetal Chopra, Jiyoung Kim, Leandros Boukas, Kasper D. Hansen, Hans T. Björnsson, Jill A. Fahrner
PLoS Genet. 2024 Jun; 20(6): e1011310. Published online 2024 Jun 10. doi: 10.1371/journal.pgen.1011310
PMCID:
PMC11192384
AbstractArticlePDF–2.5M
3.
Inactivation of KDM6A promotes the progression of colorectal cancer by enhancing the glycolysis
Dexiang Zhang, Xiaohong Zhao, Yu Gao, Meixing Wang, Mi Xiao, Kaihua Zhu, Wei Niu, Yuedi Dai
Eur J Med Res. 2024; 29: 310. Published online 2024 Jun 6. doi: 10.1186/s40001-024-01828-1
PMCID:
PMC11155098
AbstractArticlePDF–7.5M
4.
Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair
Chengjun Li, Tian Qin, Jinyun Zhao, Yuxin Jin, Yiming Qin, Rundong He, Tianding Wu, Chunyue Duan, Liyuan Jiang, Feifei Yuan, Hongbin Lu, Yong Cao, Jianzhong Hu
Bone Res. 2024; 12: 19. Published online 2024 Mar 25. doi: 10.1038/s41413-024-00323-x
PMCID:
PMC10963366
AbstractArticlePDF–11M
5.
Extracellular vesicles from UTX-knockout endothelial cells boost neural stem cell differentiation in spinal cord injury
Yudong Liu, Zixiang Luo, Yong Xie, Yi Sun, Feifei Yuan, Liyuan Jiang, Hongbin Lu, Jianzhong Hu
Cell Commun Signal. 2024; 22: 155. Published online 2024 Feb 29. doi: 10.1186/s12964-023-01434-4
PMCID:
PMC10903014
AbstractArticlePDF–4.0M
6.
Inhibition of UTX/KDM6A improves recovery of spinal cord injury by attenuating BSCB permeability and macrophage infiltration through the MLCK/p-MLC pathway
Yong Xie, Zixiang Luo, Wei Peng, Yudong Liu, Feifei Yuan, Jiaqi Xu, Yi Sun, Hongbin Lu, Tianding Wu, Liyuan Jiang, Jianzhong Hu
J Neuroinflammation. 2023; 20: 259. Published online 2023 Nov 11. doi: 10.1186/s12974-023-02936-1
PMCID:
PMC10638785
AbstractArticlePDF–21M
7.
KDM6A Epigenetically Regulates Subtype Plasticity in Small Cell Lung Cancer
Leslie Duplaquet, Yixiang Li, Matthew A. Booker, Yingtian Xie, Sarah Naomi Olsen, Radhika A. Patel, Deli Hong, Charlie Hatton, Thomas Denize, Emily Walton, Yasmin N. Laimon, Rong Li, Yijia Jiang, Roderick T. Bronson, Jackson Southard, Shuqiang Li, Sabina Signoretti, Xintao Qiu, Paloma Cejas, Scott A. Armstrong, Henry W. Long, Michael Y. Tolstorukov, Michael C. Haffner, Matthew G. Oser
Nat Cell Biol. Author manuscript; available in PMC 2024 Sep 1.
Published in final edited form as: Nat Cell Biol. 2023 Sep; 25(9): 1346–1358. Published online 2023 Aug 17. doi: 10.1038/s41556-023-01210-z
PMCID:
PMC10546329
AbstractArticlePDF–6.5M
8.
Altered expression, but small contribution, of the histone demethylase KDM6A in obstructive uropathy in mice
Lisa Y. Q. Hong, Emily S. H. Yeung, Duc Tin Tran, Veera Ganesh Yerra, Harmandeep Kaur, M. D. Golam Kabir, Suzanne L. Advani, Youan Liu, Sri Nagarjun Batchu, Andrew Advani
Dis Model Mech. 2023 Sep 1; 16(9): dmm049991. Published online 2023 Sep 1. doi: 10.1242/dmm.049991
PMCID:
PMC10482012
AbstractArticle
9.
UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease
Ola Rizq, Naoya Mimura, Motohiko Oshima, Shuji Momose, Naoya Takayama, Naoki Itokawa, Shuhei Koide, Asuka Shibamiya, Yurie Miyamoto-Nagai, Mohamed Rizk, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Changshan Wang, Atsunori Saraya, Ryoji Ito, Masanori Seimiya, Mariko Watanabe, Satoshi Yamasaki, Tatsuhiro Shibata, Kiyoshi Yamaguchi, Yoichi Furukawa, Tetsuhiro Chiba, Emiko Sakaida, Chiaki Nakaseko, Jun-ichi Tamaru, Yu-Tzu Tai, Kenneth C. Anderson, Hiroaki Honda, Atsushi Iwama
Leukemia. 2023; 37(9): 1895–1907. Published online 2023 May 17. doi: 10.1038/s41375-023-01928-7
Correction in:
Leukemia. 2023; 37(9): 1952.
PMCID:
PMC10457198
AbstractArticlePDF–4.0M
10.
Silencing of UTX Mitigates Aging-Associated Cardiac Fibrosis via Blocking Cardiac Fibroblasts-to-Myofibroblasts Trans-Differentiation
Chao Li, Tiantian Lin, Delin Li, Daoyuan Si, Huan Sun, Sibao Yang, Zhongfan Zhang, Qian Zhang, Kaiyao Shi
Anatol J Cardiol. 2023 Jul; 27(7): 398–407. Published online 2023 Jul 1. doi: 10.14744/AnatolJCardiol.2023.2777
PMCID:
PMC10339143
AbstractArticlePDF–9.1M
11.
Combined Kdm6a and Trp53 deficiency drives the development of squamous cell skin cancer in mice
Lauren K. Shea, Neal S. Akhave, Leslie A. Sutton, Leigh A. Compton, Conner York, Sai Mukund Ramakrishnan, Christopher A. Miller, Lukas D. Wartman, David Y. Chen
J Invest Dermatol. Author manuscript; available in PMC 2024 Feb 1.
Published in final edited form as: J Invest Dermatol. 2023 Feb; 143(2): 232–241.e6. Published online 2022 Aug 31. doi: 10.1016/j.jid.2022.08.037
PMCID:
PMC10334302
AbstractArticlePDF–2.6M
12.
The histone demethylase Utx controls CD8+ T‐cell‐dependent antitumor immunity via epigenetic regulation of the effector function
Haruna Noda, Junpei Suzuki, Yuko Matsuoka, Akira Matsumoto, Makoto Kuwahara, Yoshiaki Kamei, Yasutsugu Takada, Masakatsu Yamashita
Cancer Sci. 2023 Jul; 114(7): 2787–2797. Published online 2023 Apr 17. doi: 10.1111/cas.15814
PMCID:
PMC10323087
AbstractArticlePDF–6.8M
13.
X Chromosome Factor Kdm6a Enhances Cognition Independent of Its Demethylase Function in the Aging XY Male Brain
Cayce K Shaw, Samira Abdulai-Saiku, Francesca Marino, Dan Wang, Emily J Davis, Barbara Panning, Dena B Dubal
J Gerontol A Biol Sci Med Sci. 2023 Jun; 78(6): 938–943. Published online 2023 Jan 9. doi: 10.1093/gerona/glad007
PMCID:
PMC10235195
AbstractArticlePDF–317K
14.
Inhibition of H3K27me3 demethylases promotes plasmablast formation
Anna K. Kania, Muyao Guo, Christopher D. Scharer, Jeremy M. Boss
Immunohorizons. Author manuscript; available in PMC 2023 May 19.
Published in final edited form as: Immunohorizons. 2021 Dec 8; 5(12): 918–930. Published online 2021 Dec 8. doi: 10.4049/immunohorizons.2000087
PMCID:
PMC10197425
AbstractArticlePDF–1.7M
15.
USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities
Chao Liu, Lingang Sun, Yijun Tan, Qi Wang, Tao Luo, Chenlu Li, Nan Yao, Yuting Xie, Xiao Yi, Yi Zhu, Tiannan Guo, Junfeng Ji
Sci Adv. 2023 May; 9(20): eade3888. Published online 2023 May 17. doi: 10.1126/sciadv.ade3888
PMCID:
PMC10191441
AbstractArticlePDF–2.4M
16.
UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation
Mingyu Pan, Yue Yin, Tongyu Hu, Xinxia Wang, Tian Jia, Jing Sun, Quanyi Wang, Wei Meng, Juanjuan Zhu, Chunsun Dai, Haiyang Hu, Chen Wang
Autophagy. 2023; 19(2): 440–456. Published online 2022 May 30. doi: 10.1080/15548627.2022.2076192
PMCID:
PMC9851252
AbstractArticlePDF–3.3M
17.
Loss of epigenetic regulation disrupts lineage integrity, induces aberrant alveogenesis and promotes breast cancer
Ellen Langille, Khalid N. Al-Zahrani, Zhibo Ma, Minggao Liang, Liis Uuskula-Reimand, Roderic Espin, Katie Teng, Ahmad Malik, Helga Bergholtz, Samah El Ghamrasni, Somaieh Afiuni-Zadeh, Ricky Tsai, Sana Alvi, Andrew Elia, YiQing Lü, Robin H. Oh, Katelyn J. Kozma, Daniel Trcka, Masahiro Narimatsu, Jeff C. Liu, Thomas Nguyen, Seda Barutcu, Sampath K. Loganathan, Rod Bremner, Gary D. Bader, Sean E. Egan, David W. Cescon, Therese Sørlie, Jeffrey L. Wrana, Hartland W. Jackson, Michael D. Wilson, Agnieszka K. Witkiewicz, Erik S. Knudsen, Miguel Angel Pujana, Geoffrey M. Wahl, Daniel Schramek
Cancer Discov. Author manuscript; available in PMC 2023 Jun 2.
Published in final edited form as: Cancer Discov. 2022 Dec 2; 12(12): 2930–2953. doi: 10.1158/2159-8290.CD-21-0865
PMCID:
PMC9812400
AbstractArticlePDF–4.5M
18.
Sex-biased and parental allele-specific gene regulation by KDM6A
Wenxiu Ma, He Fang, Nicolas Pease, Galina N. Filippova, Christine M. Disteche, Joel B. Berletch
Biol Sex Differ. 2022; 13: 40. Published online 2022 Jul 23. doi: 10.1186/s13293-022-00452-0
PMCID:
PMC9308343
AbstractArticlePDF–3.2M
19.
Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signalling in cancer
Steffie Revia, Agnieszka Seretny, Lena Wendler, Ana Banito, Christoph Eckert, Kersten Breuer, Anand Mayakonda, Pavlo Lutsik, Matthias Evert, Silvia Ribback, Suchira Gallage, Ismaiel Chikh Bakri, Kai Breuhahn, Peter Schirmacher, Stefan Heinrich, Matthias M Gaida, Mathias Heikenwälder, Diego F Calvisi, Christoph Plass, Scott W Lowe, Darjus F Tschaharganeh
Gut. 2022 Aug; 71(8): 1613–1628. Published online 2021 Sep 11. doi: 10.1136/gutjnl-2021-325405
PMCID:
PMC9279849
AbstractArticlePDF–7.5M
20.
Kdm6b Haploinsufficiency Causes ASD/ADHD-Like Behavioral Deficits in Mice
Yuen Gao, Mohammad B. Aljazi, Jin He
Front Behav Neurosci. 2022; 16: 905783. Published online 2022 May 31. doi: 10.3389/fnbeh.2022.905783
PMCID:
PMC9194811
AbstractArticlePDF–3.1M

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