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Select item 113274371.

TrxR1 is involved in the activation of Caspase-11 by regulating the oxidative-reductive status of Trx-1

Dongsheng Bai, Chen Zhou, Jiaying Du, Jiawei Zhao, Chunyang Gu, YuXiang Wang, Lulu Zhang, Na Lu, Yue Zhao

Redox Biol. 2024 Sep; 75: 103277. Published online 2024 Jul 20. doi: 10.1016/j.redox.2024.103277

PMCID:: PMC11327437

Abstract Article PDF–18M

Select item 109159782.

The cold‐inducible RNA‐binding protein—Thioredoxin 1 pathway ameliorates mitochondrial dysfunction and mitochondrial dynamin‐related protein 1 level in the hippocampus of aged mice with perioperative neurocognitive dysfunction

Jingyao Huang, Yongliang Zhu, Yongxin Liu, Rui Zhang, Zhenjiang Zhang, Jie Liu, Zhihao Zhang, Yingxia Liang, Baoyu Ma

CNS Neurosci Ther. 2024 Mar; 30(3): e14433. Published online 2023 Aug 29. doi: 10.1111/cns.14433

PMCID:: PMC10915978

Abstract Article PDF–28M

Select item 105266693.

Nuclear translocation of thioredoxin-1 promotes colorectal cancer development via modulation of the IL-6/STAT3 signaling axis through interaction with STAT3

Aihua Wu, Daoquan Fang, Yangyang Liu, Xiaomeng Shi, Zuyue Zhong, Baojian Zhou, Lechi Ye, Xuecheng Sun, Lei Jiang

Theranostics. 2023; 13(14): 4730–4744. Published online 2023 Aug 28. doi: 10.7150/thno.85460

PMCID:: PMC10526669

Abstract Article PDF–19M

Select item 103078524.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 98883895.

Thioredoxin 1 promotes autophagy through transnitrosylation of Atg7 during myocardial ischemia

Narayani Nagarajan, Shin-ichi Oka, Jihoon Nah, Changgong Wu, Peiyong Zhai, Risa Mukai, Xiaoyong Xu, Sanchita Kashyap, Chun-Yang Huang, Eun-Ah Sung, Wataru Mizushima, Allen Sam Titus, Koichiro Takayama, Youssef Mourad, Jamie Francisco, Tong Liu, Tong Chen, Hong Li, Junichi Sadoshima

J Clin Invest. 2023 Feb 1; 133(3): e162326. Published online 2023 Feb 1. doi: 10.1172/JCI162326

PMCID:: PMC9888389

Abstract Article PDF–7.2M

Select item 94819336.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 93911427.

Downregulation of Inflammatory Response via Nrf2/Trx1/TXNIP Axis in Oxidative Stress-Induced ARPE-19 Cells and Mouse Model of AMD

Qian Yang, Wenting Cai, Huizi Jin, Tianyi Shen, Jing Yu

Oxid Med Cell Longev. 2022; 2022: 1497813. Published online 2022 Aug 12. doi: 10.1155/2022/1497813

PMCID:: PMC9391142

Abstract Article PDF–4.1M

Select item 89372458.

Thioredoxin Prevents Loss of UCP2 in Hyperoxia via MKK4–p38 MAPK–PGC1α Signaling and Limits Oxygen Toxicity

Somasundaram Raghavan, Venkatesh Kundumani-Sridharan, Sudhir Kumar, Carl W. White, Kumuda C. Das

Am J Respir Cell Mol Biol. 2022 Mar; 66(3): 323–336. Published online 2021 Dec 10. doi: 10.1165/rcmb.2021-0219OC

PMCID:: PMC8937245

Abstract Article PDF–2.2M

Select item 86175899.

Selenoprotein M Promotes Hypothalamic Leptin Signaling and Thioredoxin Antioxidant Activity

Ting Gong, Ann C. Hashimoto, Alexandru R. Sasuclark, Vedbar S. Khadka, Alexandra Gurary, Matthew W. Pitts

Antioxid Redox Signal. October 2021; 35(10): 775–787. Published online 2021 Sep 13. doi: 10.1089/ars.2018.7594

PMCID:: PMC8617589

Abstract Article PDF–1013K

Select item 826661710.

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins

Benjamin Lang, Jae-Seong Yang, Mireia Garriga-Canut, Silvia Speroni, Moritz Aschern, Maria Gili, Tobias Hoffmann, Gian Gaetano Tartaglia, Sebastian P Maurer

Nucleic Acids Res. 2021 Jul 9; 49(12): 6702–6721. Published online 2021 Jun 16. doi: 10.1093/nar/gkab490

PMCID:: PMC8266617

Abstract Article PDF–4.0M

Select item 793877011.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 782550112.

Thioredoxin-1 maintains mitochondrial function via mechanistic target of rapamycin signalling in the heart

Shin-Ichi Oka, Adave Chin, Ji Yeon Park, Shohei Ikeda, Wataru Mizushima, Guersom Ralda, Peiyong Zhai, Mingming Tong, Jaemin Byun, Fan Tang, Yudai Einaga, Chun-Yang Huang, Toshihide Kashihara, Mengyuan Zhao, Jihoon Nah, Bin Tian, Yoko Hirabayashi, Junji Yodoi, Junichi Sadoshima

Cardiovasc Res. 2020 Aug 1; 116(10): 1742–1755. Published online 2019 Oct 4. doi: 10.1093/cvr/cvz251

PMCID:: PMC7825501

Abstract Article PDF–1.7M

Select item 729503313.

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant

Meagan A. Quinlan, Matthew J. Robson, Ran Ye, Kristie L. Rose, Kevin L. Schey, Randy D. Blakely

Front Mol Neurosci. 2020; 13: 89. Published online 2020 Jun 8. doi: 10.3389/fnmol.2020.00089

PMCID:: PMC7295033

Abstract Article PDF–2.7M

Select item 706247214.

Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip

Jonathan Muri, Helen Thut, Qian Feng, Manfred Kopf

eLife. 2020; 9: e53627. Published online 2020 Feb 25. doi: 10.7554/eLife.53627

PMCID:: PMC7062472

Abstract Article PDF–1.7M

Select item 699392515.

Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers

Chao Wang, Bin Zhang, Anna C. Ratliff, Justine Arrington, Jingjuan Chen, Yan Xiong, Feng Yue, Yaohui Nie, Keping Hu, Wen Jin, W. Andy Tao, Christine A. Hrycyna, Xiaobo Sun, Shihuan Kuang

FASEB J. 2019 Aug; 33(8): 9672–9684. Published online 2019 Jun 4. doi: 10.1096/fj.201900582R

PMCID:: PMC6993925

Abstract Article

Select item 693870116.

Control of protein function through oxidation and reduction of persulfidated states

É. Dóka, T. Ida, M. Dagnell, Y. Abiko, N. C. Luong, N. Balog, T. Takata, B. Espinosa, A. Nishimura, Q. Cheng, Y. Funato, H. Miki, J. M. Fukuto, J. R. Prigge, E. E. Schmidt, E. S. J. Arnér, Y. Kumagai, T. Akaike, P. Nagy

Sci Adv. 2020 Jan; 6(1): eaax8358. Published online 2020 Jan 1. doi: 10.1126/sciadv.aax8358

PMCID:: PMC6938701

Abstract Article PDF–3.2M

Select item 665555117.

WDFY4 is required for cross-presentation in response to viral and tumor antigens

Derek J. Theisen, Jesse T. Davidson, IV, Carlos G. Briseño, Marco Gargaro, Elvin J. Lauron, Qiuling Wang, Pritesh Desai, Vivek Durai, Prachi Bagadia, Joshua R. Brickner, Wandy L. Beatty, Herbert W. Virgin, William E. Gillanders, Nima Mosammaparast, Michael S. Diamond, L. David Sibley, Wayne Yokoyama, Robert D. Schreiber, Theresa L. Murphy, Kenneth M. Murphy

Science. Author manuscript; available in PMC 2019 Jul 24.

Published in final edited form as: Science. 2018 Nov 9; 362(6415): 694–699. doi: 10.1126/science.aat5030

PMCID:: PMC6655551

Abstract Article PDF–1020K

Select item 661201118.

Extracellular vesicle-mediated macrophage activation: An insight into the mechanism of thioredoxin-mediated immune activation

Chontida Yarana, Hannah Thompson, Luksana Chaiswing, D. Allan Butterfield, Heidi Weiss, Subbarao Bondada, Sara Alhakeem, Suriyan Sukati, Daret K. St. Clair

Redox Biol. 2019 Sep; 26: 101237. Published online 2019 Jun 5. doi: 10.1016/j.redox.2019.101237

PMCID:: PMC6612011

Abstract Article PDF–8.0M

Select item 659721119.

Thioredoxin-1 confines T cell alloresponse and pathogenicity in graft-versus-host disease

M. Hanief Sofi, Yongxia Wu, Steven D. Schutt, Min Dai, Anusara Daenthanasanmak, Jessica Heinrichs Voss, Hung Nguyen, David Bastian, Supinya Iamsawat, Shanmugam Panneer Selvam, Chen Liu, Nilanjana Maulik, Besim Ogretmen, Junfei Jin, Shikhar Mehrotra, Xue-Zhong Yu

J Clin Invest. 2019 Jul 1; 129(7): 2760–2774. Published online 2019 Jun 10. doi: 10.1172/JCI122899

PMCID:: PMC6597211

Abstract Article PDF–7.4M

Select item 655657520.

Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells

Paramita Chakraborty, Shilpak Chatterjee, Pravin Kesarwani, Krishnamurthy Thyagarajan, Supinya Iamsawat, Annika Dalheim, Hung Nguyen, Shanmugam P. Selvam, Patrick Nasarre, Gina Scurti, Gary Hardiman, Nilanjana Maulik, Lauren Ball, Vamsi Gangaraju, Mark P. Rubinstein, Nancy Klauber-DeMore, Elizabeth G. Hill, Besim Ogretmen, Xue-Zhong Yu, Michael I. Nishimura, Shikhar Mehrotra

J Biol Chem. 2019 Jun 7; 294(23): 9198–9212. Published online 2019 Apr 10. doi: 10.1074/jbc.RA118.006753

PMCID:: PMC6556575

Abstract Article PDF–4.1M

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