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Select item 113440801.

Prefrontal cortex molecular clock modulates development of depression-like phenotype and rapid antidepressant response in mice

David H. Sarrazin, Wilf Gardner, Carole Marchese, Martin Balzinger, Chockalingam Ramanathan, Marion Schott, Stanislav Rozov, Maxime Veleanu, Stefan Vestring, Claus Normann, Tomi Rantamäki, Benedicte Antoine, Michel Barrot, Etienne Challet, Patrice Bourgin, Tsvetan Serchov

Nat Commun. 2024; 15: 7257. Published online 2024 Aug 23. doi: 10.1038/s41467-024-51716-9

PMCID:: PMC11344080

Abstract Article PDF–4.4M

Select item 113273532.

Role of the circadian nuclear receptor REV-ERBα in dorsal raphe serotonin synthesis in mood regulation

Inah Park, Mijung Choi, Jeongah Kim, Sangwon Jang, Doyeon Kim, Jihoon Kim, Youngshik Choe, Dongho Geum, Seong-Woon Yu, Ji-Woong Choi, Cheil Moon, Han Kyoung Choe, Gi Hoon Son, Kyungjin Kim

Commun Biol. 2024; 7: 998. Published online 2024 Aug 15. doi: 10.1038/s42003-024-06647-y

PMCID:: PMC11327353

Abstract Article PDF–2.4M

Select item 112962393.

Nuclear receptor Rev-erbα role in fine-tuning erythropoietin gene expression

Sumit Kumar, Rashmi Arora, Shalini Gupta, Nancy Ahuja, Ella Bhagyaraj, Ravikanth Nanduri, Rashi Kalra, Asheesh Kumar Khare, Saumyata Kumawat, Vipashu Kaushal, Mahathi Sharma, Pawan Gupta

Blood Adv. 2024 Jul 23; 8(14): 3705–3717. Published online 2024 May 17. doi: 10.1182/bloodadvances.2023012228

PMCID:: PMC11296239

Abstract Article PDF–2.4M

Select item 110730704.

Nuclear receptor Nr1d1 alleviates asthma by abating GATA3 gene expression and Th2 cell differentiation

Drishti Tiwari, Nancy Ahuja, Sumit Kumar, Rashi Kalra, Ravikanth Nanduri, Shalini Gupta, Asheesh Kumar Khare, Ella Bhagyaraj, Rashmi Arora, Pawan Gupta

Cell Mol Life Sci. 2022 Jun; 79(6): 308. Published online 2022 May 21. doi: 10.1007/s00018-022-04323-0

PMCID:: PMC11073070

Abstract Article PDF–18M

Select item 110533145.

Time of day and circadian disruption influence host response and parasite growth in a mouse model of cerebral malaria

Priscilla Carvalho Cabral, Joelle Weinerman, Martin Olivier, Nicolas Cermakian

iScience. 2024 May 17; 27(5): 109684. Published online 2024 Apr 8. doi: 10.1016/j.isci.2024.109684

PMCID:: PMC11053314

Abstract Article PDF–3.8M

Select item 109176606.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107927617.

Hindbrain REV-ERB nuclear receptors regulate sensitivity to diet-induced obesity and brown adipose tissue pathophysiology

Lauren N. Woodie, Lily C. Melink, Ahren J. Alberto, Michelle Burrows, Samantha M. Fortin, Calvin C. Chan, Matthew R. Hayes, Mitchell A. Lazar

Mol Metab. 2024 Jan; 79: 101861. Published online 2023 Dec 23. doi: 10.1016/j.molmet.2023.101861

PMCID:: PMC10792761

Abstract Article PDF–1.5M

Select item 107881808.

Microglia depletion ameliorates neuroinflammation, anxiety-like behavior, and cognitive deficits in a sex-specific manner in Rev-erbα knockout mice

Ruizhuo Chen, Brandy N. Routh, Jillian E. Straetker, Cecily R. Gibson, Aidan S. Weitzner, Kiersten S. Bell, Andrew D. Gaudet, Laura K. Fonken

Brain Behav Immun. Author manuscript; available in PMC 2024 Nov 1.

Published in final edited form as: Brain Behav Immun. 2023 Nov; 114: 287–298. Published online 2023 Aug 28. doi: 10.1016/j.bbi.2023.08.029

PMCID:: PMC10788180

Abstract Article PDF–2.0M

Select item 105383679.

NR1D1 Stimulates Antitumor Immune Responses in Breast Cancer by Activating cGAS-STING Signaling

Na-Lee Ka, Mi Kyung Park, Seung-Su Kim, Yoon Jeon, Sewon Hwang, Sun Mi Kim, Ga Young Lim, Ho Lee, Mi-Ock Lee

Cancer Res. 2023 Sep 15; 83(18): 3045–3058. Published online 2023 Jul 3. doi: 10.1158/0008-5472.CAN-23-0329

PMCID:: PMC10538367

Abstract Article PDF–16M

Select item 1053168610.

Uncovering the Novel Role of NR1D1 in Regulating BNIP3-Mediated Mitophagy in Ulcerative Colitis

Yidong Chen, Junrong Li, Shuang Li, Yiyu Cheng, Xiaoyu Fu, Jiamin Li, Liangru Zhu

Int J Mol Sci. 2023 Sep; 24(18): 14222. Published online 2023 Sep 18. doi: 10.3390/ijms241814222

PMCID:: PMC10531686

Abstract Article PDF–12M

Select item 1047401311.

Impact of the circadian nuclear receptor REV-ERBα in dorsal raphe 5-HT neurons on social interaction behavior, especially social preference

Sangwon Jang, Inah Park, Mijung Choi, Jihoon Kim, Seungeun Yeo, Sung-Oh Huh, Ji-Woong Choi, Cheil Moon, Han Kyoung Choe, Youngshik Choe, Kyungjin Kim

Exp Mol Med. 2023 Aug; 55(8): 1806–1819. Published online 2023 Aug 3. doi: 10.1038/s12276-023-01052-7

PMCID:: PMC10474013

Abstract Article PDF–2.9M

Select item 1045731912.

Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice

Jiyeon Lee, Julie M. Dimitry, Jong Hee Song, Minsoo Son, Patrick W. Sheehan, Melvin W. King, G. Travis Tabor, Young Ah Goo, Mitchell A. Lazar, Leonard Petrucelli, Erik S. Musiek

Nat Commun. 2023; 14: 5197. Published online 2023 Aug 25. doi: 10.1038/s41467-023-40927-1

Correction in:: Nat Commun. 2023; 14: 7760.

PMCID:: PMC10457319

Abstract Article PDF–5.9M

Select item 1015455513.

REV-ERB activation as a novel pharmacological approach for treating inflammatory pain

Sangeet Makhija, Joshua D. Griffett, Giri Babu Veerakanellore, Thomas P. Burris, Bahaa Elgendy, Kristine Griffett

Front Pharmacol. 2023; 14: 1171931. Published online 2023 Apr 19. doi: 10.3389/fphar.2023.1171931

PMCID:: PMC10154555

Abstract Article PDF–1.7M

Select item 1010489314.

Hepatocyte SREBP signaling mediates clock communication within the liver

Dongyin Guan, Hosung Bae, Dishu Zhou, Ying Chen, Chunjie Jiang, Cam Mong La, Yang Xiao, Kun Zhu, Wenxiang Hu, Trang Minh Trinh, Panpan Liu, Ying Xiong, Bishuang Cai, Cholsoon Jang, Mitchell A. Lazar

J Clin Invest. 2023 Apr 17; 133(8): e163018. Published online 2023 Apr 17. doi: 10.1172/JCI163018

PMCID:: PMC10104893

Abstract Article PDF–1.6M

Select item 999659815.

Circadian clock molecule REV-ERBα regulates lung fibrotic progression through collagen stabilization

Qixin Wang, Isaac Kirubakaran Sundar, Joseph H. Lucas, Jun-Gyu Park, Aitor Nogales, Luis Martinez-Sobrido, Irfan Rahman

Nat Commun. 2023; 14: 1295. Published online 2023 Mar 9. doi: 10.1038/s41467-023-36896-0

PMCID:: PMC9996598

Abstract Article PDF–8.3M

Select item 997447416.

The circadian demethylation of a unique intronic deoxymethylCpG-rich island boosts the transcription of its cognate circadian clock output gene

Nisha Misra, Manohar Damara, Tao Ye, Pierre Chambon

Proc Natl Acad Sci U S A. 2023 Feb 21; 120(8): e2214062120. Published online 2023 Feb 15. doi: 10.1073/pnas.2214062120

PMCID:: PMC9974474

Abstract Article PDF–1.1M

Select item 981344417.

Puerariae lobatae radix protects against UVB-induced skin aging via antagonism of REV-ERBα in mice

Luyao Ma, Meiping Huang, Guanghui Sun, Yanke Lin, Danyi Lu, Baojian Wu

Front Pharmacol. 2022; 13: 1088294. Published online 2022 Dec 22. doi: 10.3389/fphar.2022.1088294

PMCID:: PMC9813444

Abstract Article PDF–3.0M

Select item 968587218.

Circadian gene Rev-erbα influenced by sleep conduces to pregnancy by promoting endometrial decidualization via IL-6-PR-C/EBPβ axis

Liyuan Cui, Feng Xu, Chunfang Xu, Yan Ding, Songcun Wang, Meirong Du

J Biomed Sci. 2022; 29: 101. Published online 2022 Nov 24. doi: 10.1186/s12929-022-00884-1

PMCID:: PMC9685872

Abstract Article PDF–5.6M

Select item 967444819.

Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2

Ling-Yue Sun, Yu-Yan Lyu, Heng-Yuan Zhang, Zhi Shen, Guan-Qiao Lin, Na Geng, Yu-Li Wang, Lin Huang, Ze-Hao Feng, Xiao Guo, Nan Lin, Song Ding, An-Cai Yuan, Lan Zhang, Kun Qian, Jun Pu

Circulation. 2022 Nov 22; 146(21): 1591–1609. Published online 2022 Jul 26. doi: 10.1161/CIRCULATIONAHA.121.057623

PMCID:: PMC9674448

Abstract Article PDF–7.1M

Select item 960863920.

IL-6 deletion decreased REV-ERBα protein and influenced autophagy and mitochondrial markers in the skeletal muscle after acute exercise

Ana P. Pinto, Vitor R. Muñoz, Alisson L. da Rocha, Rafael L. Rovina, Gustavo D. Ferrari, Luciane C. Alberici, Fernando M. Simabuco, Giovana R. Teixeira, José R. Pauli, Leandro P. de Moura, Dennys E. Cintra, Eduardo R. Ropelle, Ellen C. Freitas, Donato A. Rivas, Adelino S. R. da Silva

Front Immunol. 2022; 13: 953272. Published online 2022 Oct 13. doi: 10.3389/fimmu.2022.953272

PMCID:: PMC9608639

Abstract Article PDF–4.3M

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