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Select item 103302991.

Ubiquitin ligases Siah1a/2 control alveolar macrophage functions to limit carcinogen-induced lung adenocarcinoma

Marzia Scortegagna, Yuanning Du, Linda M. Bradley, Kun Wang, Alfredo Molinolo, Eytan Ruppin, Rabi Murad, Ze’ev A. Ronai

Cancer Res. Author manuscript; available in PMC 2023 Dec 15.

Published in final edited form as: Cancer Res. 2023 Jun 15; 83(12): 2016–2033. doi: 10.1158/0008-5472.CAN-23-0258

PMCID:: PMC10330299

Abstract Article PDF–2.6M

Select item 97415052.

SIAH proteins regulate the degradation and intra‐mitochondrial aggregation of PINK1: Implications for mitochondrial pathology in Parkinson's disease

Fatimah Abd Elghani, Hazem Safory, Haya Hamza, Mor Savyon, Malik Farhoud, Michal Toren‐Hershoviz, Zagorka Vitic, Kirsten Ebanks, Vered Shani, Sleman Bisharat, Lihi Shaulov, Claude Brodski, Zhiyin Song, Rina Bandopadhyay, Simone Engelender

Aging Cell. 2022 Dec; 21(12): e13731. Published online 2022 Oct 28. doi: 10.1111/acel.13731

PMCID:: PMC9741505

Abstract Article PDF–5.1M

Select item 95612743.

SIAH2 regulates DNA end resection and replication fork recovery by promoting CtIP ubiquitination

Seo-Yeon Jeong, Gurusamy Hariharasudhan, Min-Ji Kim, Ji-Yeon Lim, Sung Mi Jung, Eun-Ji Choi, In-Youb Chang, Younghoon Kee, Ho Jin You, Jung-Hee Lee

Nucleic Acids Res. 2022 Oct 14; 50(18): 10469–10486. Published online 2022 Sep 26. doi: 10.1093/nar/gkac808

PMCID:: PMC9561274

Abstract Article PDF–5.7M

Select item 93777974.

Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression

Qiangqiang Liu, Qian Luo, Jianyu Feng, Yanping Zhao, Biao Ma, Hongcheng Cheng, Tian Zhao, Hong Lei, Chenglong Mu, Linbo Chen, Yuanyuan Meng, Jiaojiao Zhang, Yijia Long, Jingyi Su, Guo Chen, Yanjun Li, Gang Hu, Xudong Liao, Quan Chen, Yushan Zhu

eLife. 2022; 11: e81247. Published online 2022 Aug 1. doi: 10.7554/eLife.81247

PMCID:: PMC9377797

Abstract Article PDF–4.9M

Select item 92626145.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 91225296.

P-TEFb is degraded by Siah1/2 in quiescent cells

Fang Huang, Yongmei Feng, B Matija Peterlin, Koh Fujinaga

Nucleic Acids Res. 2022 May 20; 50(9): 5000–5013. Published online 2022 May 7. doi: 10.1093/nar/gkac291

PMCID:: PMC9122529

Abstract Article PDF–6.1M

Select item 88286557.

Decreased Expression of Programmed Death Ligand-L1 by Seven in Absentia Homolog 2 in Cholangiocarcinoma Enhances T-Cell–Mediated Antitumor Activity

Hao Zheng, Wen-juan Zheng, Zhen-guang Wang, Yuan-ping Tao, Zhi-ping Huang, Le Yang, Liu Ouyang, Zhi-qing Duan, Yi-nuo Zhang, Bo-ning Chen, Dai-min Xiang, Gang Jin, Lu Fang, Fan Zhou, Bo Liang

Front Immunol. 2022; 13: 845193. Published online 2022 Jan 27. doi: 10.3389/fimmu.2022.845193

Correction in:: Front Immunol. 2022; 13: 1093403.

PMCID:: PMC8828655

Abstract Article PDF–18M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80854309.

Targeting ADT-Induced Activation of the E3 Ubiquitin Ligase Siah2 to Delay the Occurrence of Castration-Resistant Prostate Cancer

Tingmang Yan, Dapeng Zhou, Youwei Shi, Di Cui, Juntao Jiang, Bangmin Han, Shujie Xia, Zhou Wang, Haitao Liu, Wenhuan Guo, Yifeng Jing

Front Oncol. 2021; 11: 637040. Published online 2021 Apr 16. doi: 10.3389/fonc.2021.637040

PMCID:: PMC8085430

Abstract Article PDF–1.8M

Select item 801772010.

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Ukhyun Jo, Yasuhisa Murai, Sirisha Chakka, Lu Chen, Ken Cheng, Junko Murai, Liton Kumar Saha, Lisa M. Miller Jenkins, Yves Pommier

Proc Natl Acad Sci U S A. 2021 Feb 9; 118(6): e2015654118. Published online 2021 Feb 3. doi: 10.1073/pnas.2015654118

PMCID:: PMC8017720

Abstract Article PDF–1.9M

Select item 785673811.

Helicobacter pylori-induced gastric cancer is orchestrated by MRCKβ-mediated Siah2 phosphorylation

Pragyesh Dixit, Shrikant B. Kokate, Indrajit Poirah, Debashish Chakraborty, Duane T. Smoot, Hassan Ashktorab, Niranjan Rout, Shivaram P. Singh, Asima Bhattacharyya

J Biomed Sci. 2021; 28: 12. Published online 2021 Feb 3. doi: 10.1186/s12929-021-00710-0

PMCID:: PMC7856738

Abstract Article PDF–2.7M

Select item 757618312.

Siah2 integrates mitogenic and extracellular matrix signals linking neuronal progenitor ciliogenesis with germinal zone occupancy

Taren Ong, Niraj Trivedi, Randall Wakefield, Sharon Frase, David J. Solecki

Nat Commun. 2020; 11: 5312. Published online 2020 Oct 20. doi: 10.1038/s41467-020-19063-7

PMCID:: PMC7576183

Abstract Article PDF–5.6M

Select item 706909213.

Targeting GRP78-dependent AR-V7 protein degradation overcomes castration-resistance in prostate cancer therapy

Yuning Liao, Yuan Liu, Xiaohong Xia, Zhenlong Shao, Chuyi Huang, Jinchan He, Lili Jiang, Daolin Tang, Jinbao Liu, Hongbiao Huang

Theranostics. 2020; 10(8): 3366–3381. Published online 2020 Feb 10. doi: 10.7150/thno.41849

PMCID:: PMC7069092

Abstract Article PDF–2.9M

Select item 701073114.

SIAH2-mediated and organ-specific restriction of HO-1 expression by a dual mechanism

Shashipavan Chillappagari, Ratnal Belapurkar, Andreas Möller, Nicole Molenda, Michael Kracht, Susanne Rohrbach, M. Lienhard Schmitz

Sci Rep. 2020; 10: 2268. Published online 2020 Feb 10. doi: 10.1038/s41598-020-59005-3

PMCID:: PMC7010731

Abstract Article PDF–3.7M

Select item 694668415.

Siah2 control of T-regulatory cells limits anti-tumor immunity

Marzia Scortegagna, Kathryn Hockemeyer, Igor Dolgalev, Joanna Poźniak, Florian Rambow, Yan Li, Yongmei Feng, Roberto Tinoco, Dennis C. Otero, Tongwu Zhang, Kevin Brown, Marcus Bosenberg, Linda M. Bradley, Jean-Christophe Marine, Ioannis Aifantis, Ze’ev A. Ronai

Nat Commun. 2020; 11: 99. Published online 2020 Jan 7. doi: 10.1038/s41467-019-13826-7

PMCID:: PMC6946684

Abstract Article PDF–3.8M

Select item 641144716.

Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells

Yongmei Feng, E. Hampton Sessions, Fan Zhang, Fuqiang Ban, Veronica Placencio-Hickok, Chen-Ting Ma, Fu-Yue Zeng, Ian Pass, David B. Terry, Gregory Cadwell, Laurie A. Bankston, Robert C. Liddington, Thomas D.Y. Chung, Anthony B. Pinkerton, Eduard Sergienko, Martin Gleave, Neil Bhowmick, Michael R. Jackson, Artem Cherkasov, Ze’ev A. Ronai

Cancer Lett. Author manuscript; available in PMC 2020 May 1.

Published in final edited form as: Cancer Lett. 2019 May 1; 449: 145–162. Published online 2019 Feb 14. doi: 10.1016/j.canlet.2019.02.012

PMCID:: PMC6411447

Abstract Article PDF–1.5M

Select item 639932017.

The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression

Biao Ma, Hongcheng Cheng, Chenglong Mu, Guangfeng Geng, Tian Zhao, Qian Luo, Kaili Ma, Rui Chang, Qiangqiang Liu, Ruize Gao, Junli Nie, Jiaying Xie, Jinxue Han, Linbo Chen, Gui Ma, Yushan Zhu, Quan Chen

Nat Commun. 2019; 10: 1034. Published online 2019 Mar 4. doi: 10.1038/s41467-019-08618-y

PMCID:: PMC6399320

Abstract Article PDF–3.7M

Select item 585918818.

PIWIL2 suppresses Siah2-mediated degradation of HDAC3 and facilitates CK2α-mediated HDAC3 phosphorylation

Yingying Zhang, Xulei Zheng, Hao Tan, Yilu Lu, Dachang Tao, Yunqiang Liu, Yongxin Ma

Cell Death Dis. 2018 Apr; 9(4): 423. Published online 2018 Mar 19. doi: 10.1038/s41419-018-0462-8

PMCID:: PMC5859188

Abstract Article PDF–4.7M

Select item 581036819.

Inhibition of Siah2 Ubiquitin Ligase by Vitamin K3 Attenuates Chronic Myeloid Leukemia Chemo-Resistance in Hypoxic Microenvironment

Jixian Huang, Ziyuan Lu, Yajuan Xiao, Bolin He, Chengyun Pan, Xuan Zhou, Na Xu, Xiaoli Liu

Med Sci Monit. 2018; 24: 727–735. Published online 2018 Feb 5. doi: 10.12659/MSM.908553

PMCID:: PMC5810368

Abstract Article PDF–668K

Select item 579452320.

DHX15 promotes prostate cancer progression by stimulating Siah2-mediated ubiquitination of androgen receptor

Yifeng Jing, Minh M. Nguyen, Dan Wang, Laura E. Pascal, Wenhuan Guo, Yadong Xu, Junkui Ai, Fang-Ming Deng, Khalid Z. Masoodi, Xinpei Yu, Jian Zhang, Joel B. Nelson, Shujie Xia, Zhou Wang

Oncogene. Author manuscript; available in PMC 2018 Apr 9.

Published in final edited form as: Oncogene. 2018 Feb 1; 37(5): 638–650. Published online 2017 Oct 9. doi: 10.1038/onc.2017.371

PMCID:: PMC5794523

Abstract Article PDF–1.1M

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