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Select item 104457591.

GBP2 promotes M1 macrophage polarization by activating the notch1 signaling pathway in diabetic nephropathy

Xiaohui Li, Jialu Liu, Mengru Zeng, Kexin Yang, Shumin Zhang, Yifei Liu, Xiangxiang Yin, Chanyue Zhao, Wenpeng Wang, Li Xiao

Front Immunol. 2023; 14: 1127612. Published online 2023 Aug 9. doi: 10.3389/fimmu.2023.1127612

PMCID:: PMC10445759

Abstract Article PDF–10M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101516153.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 98985134.

Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis

Jangho Lee, Ji-Hye Song, Jae-Ho Park, Min-Yu Chung, Seung-Hyun Lee, Sae-Bom Jeon, So Hee Park, Jin-Taek Hwang, Hyo-Kyoung Choi

Exp Mol Med. 2023 Jan; 55(1): 143–157. Published online 2023 Jan 6. doi: 10.1038/s12276-022-00919-5

PMCID:: PMC9898513

Abstract Article PDF–5.7M

Select item 98874635.

GBP2 promotes clear cell renal cell carcinoma progression through immune infiltration and regulation of PD‑L1 expression via STAT1 signaling

Shujiang Ye, Siyu Li, Lei Qin, Wei Zheng, Bin Liu, Xiaohui Li, Zhenhua Ren, Huaiming Zhao, Xudong Hu, Nan Ye, Guangyuan Li

Oncol Rep. 2023 Mar; 49(3): 49. Published online 2023 Jan 20. doi: 10.3892/or.2023.8486

PMCID:: PMC9887463

Abstract Article PDF–9.8M

Select item 94827466.

GBP2 acts as a member of the interferon signalling pathway in lupus nephritis

Yuan Zhang, Yinping Liao, Qing Hang, Dong Sun, Ya Liu

BMC Immunol. 2022; 23: 44. Published online 2022 Sep 17. doi: 10.1186/s12865-022-00520-5

PMCID:: PMC9482746

Abstract Article PDF–3.9M

Select item 93383137.

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai

Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4

PMCID:: PMC9338313

Abstract Article PDF–2.8M

Select item 92792858.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 89840169.

Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target

Haizhou Wang, Yabo Zhou, Yangyang Zhang, Shilin Fang, Meng Zhang, Haiou Li, Fei Xu, Lan Liu, Jing Liu, Qiu Zhao, Fan Wang

J Immunother Cancer. 2022; 10(4): e004302. Published online 2022 Apr 5. doi: 10.1136/jitc-2021-004302

PMCID:: PMC8984016

Abstract Article PDF–15M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 805402511.

Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins

Wen Cui, Elisabeth Braun, Wei Wang, Jinhong Tang, Yanyan Zheng, Benjamin Slater, Na Li, Cheng Chen, Qingxiang Liu, Bin Wang, Xiu Li, Yinkai Duan, Yunjie Xiao, Ruijiao Ti, Dominik Hotter, Xiaoyun Ji, Lei Zhang, Jun Cui, Yong Xiong, Daniel Sauter, Zefang Wang, Frank Kirchhoff, Haitao Yang

Proc Natl Acad Sci U S A. 2021 Apr 13; 118(15): e2022269118. Published online 2021 Apr 5. doi: 10.1073/pnas.2022269118

PMCID:: PMC8054025

Abstract Article PDF–2.2M

Select item 568092412.

Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion

Juan Zhang, Yu Zhang, Wenshuang Wu, Fang Wang, Xinyu Liu, Guanghou Shui, Chunlai Nie

Cell Death Dis. 2017 Oct; 8(10): e3151. Published online 2017 Oct 26. doi: 10.1038/cddis.2017.559

Correction in:: Cell Death Dis. 2018 Nov; 9(11): 1127.

PMCID:: PMC5680924

Abstract Article PDF–2.0M

Select item 553161113.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 526093914.

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease

Felipe Roberti Teixeira, Suzanne J. Randle, Shachi P. Patel, Tycho E.T. Mevissen, Grasilda Zenkeviciute, Tie Koide, David Komander, Heike Laman

Biochem J. 2016 Oct 15; 473(20): 3563–3580. Prepublished online 2016 Aug 8. Published online 2016 Oct 11. doi: 10.1042/BCJ20160387

PMCID:: PMC5260939

Abstract Article PDF–1.1M

Select item 467168315.

The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells

Thomas C. Whisenant, Eigen R. Peralta, Lauren D. Aarreberg, Nina J. Gao, Steven R. Head, Phillip Ordoukhanian, Jamie R. Williamson, Daniel R. Salomon

PLoS One. 2015; 10(12): e0144409. Published online 2015 Dec 7. doi: 10.1371/journal.pone.0144409

PMCID:: PMC4671683

Abstract Article PDF–6.2M

Select item 461163516.

Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins

Arun K. Haldar, Clémence Foltz, Ryan Finethy, Anthony S. Piro, Eric M. Feeley, Danielle M. Pilla-Moffett, Masaki Komatsu, Eva-Maria Frickel, Jörn Coers

Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41): E5628–E5637. Published online 2015 Sep 28. doi: 10.1073/pnas.1515966112