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Items: 1 to 20 of 131

1.
GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension
Maggie M. Zhu, Jingbo Dai, Zhiyu Dai, Yi Peng, You-Yang Zhao
JCI Insight. 2024 Oct 22; 9(20): e177926. Published online 2024 Sep 24. doi: 10.1172/jci.insight.177926
PMCID:
PMC11530134
AbstractArticlePDF–21M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
GCN2 is required to maintain core body temperature in mice during acute cold
Jordan L. Levy, Emily T. Mirek, Esther M. Rodriguez, Brian Zalma, Jeffrey Burns, William O. Jonsson, Harini Sampath, Kirk A. Staschke, Ronald C. Wek, Tracy G. Anthony
Am J Physiol Endocrinol Metab. 2023 Nov 1; 325(5): E624–E637. Published online 2023 Oct 4. doi: 10.1152/ajpendo.00181.2023
PMCID:
PMC10864021
AbstractArticle
4.
The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages
Phoenix Toboz, Mehdi Amiri, Negar Tabatabaei, Catherine R. Dufour, Seung Hyeon Kim, Carine Fillebeen, Charles E. Ayemoba, Arkady Khoutorsky, Manfred Nairz, Lijian Shao, Kostandin V. Pajcini, Ki-Wook Kim, Vincent Giguère, Regiana L. Oliveira, Marco Constante, Manuela M. Santos, Carlos R. Morales, Kostas Pantopoulos, Nahum Sonenberg, Sandra Pinho, Soroush Tahmasebi
Proc Natl Acad Sci U S A. 2022 Aug 30; 119(35): e2121251119. Published online 2022 Aug 22. doi: 10.1073/pnas.2121251119
PMCID:
PMC9436309
AbstractArticlePDF–2.3M
5.
The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1)
Zeenat Farooq, Fedho Kusuma, Phillip Burke, Catherine R. Dufour, Duckgue Lee, Negar Tabatabaei, Phoenix Toboz, Ernest Radovani, Jack F. Greenblatt, Jalees Rehman, Jacob Class, Arkady Khoutorsky, Bruno D. Fonseca, Justin M. Richner, Eloi Mercier, Guillaume Bourque, Vincent Giguère, Arvind R. Subramaniam, Jaeseok Han, Soroush Tahmasebi
J Biol Chem. 2022 Sep; 298(9): 102277. Published online 2022 Jul 19. doi: 10.1016/j.jbc.2022.102277
PMCID:
PMC9396407
AbstractArticlePDF–2.9M
6.
Activation and execution of the hepatic integrated stress response by dietary essential amino acid deprivation is amino acid specific
William O. Jonsson, Emily T. Mirek, Ronald C. Wek, Tracy G. Anthony
FASEB J. 2022 Jul; 36(7): e22396. Published online 2022 Jun 12. doi: 10.1096/fj.202200204RR
PMCID:
PMC9204950
AbstractArticlePDF–704K
7.
PERK is a critical metabolic hub for immunosuppressive function in macrophages
Lydia N. Raines, Haoxin Zhao, Yuzhu Wang, Heng-Yi Chen, Hector Gallart-Ayala, Pei-Chun Hsueh, Wei Cao, Yeojung Koh, Ana Alamonte-Loya, Pu-Ste Liu, Julijana Ivanisevic, Chan-Wang Jerry Lio, Ping-Chih Ho, Stanley Ching-Cheng Huang
Nat Immunol. Author manuscript; available in PMC 2023 Mar 1.
Published in final edited form as: Nat Immunol. 2022 Mar; 23(3): 431–445. Published online 2022 Feb 28. doi: 10.1038/s41590-022-01145-x
PMCID:
PMC9112288
AbstractArticlePDF–2.4M
8.
The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery
Kiren Baines, Kazuaki Yoshioka, Yoh Takuwa, Jon D. Lane
Autophagy Rep. 2022; 1(1): 88–118. Published online 2022 Apr 7. doi: 10.1080/27694127.2022.2042054
PMCID:
PMC9015699
AbstractArticlePDF–3.3M
9.
GCN2 adapts protein synthesis to scavenging-dependent growth
Michel Nofal, Tim Wang, Lifeng Yang, Connor S.R. Jankowski, Sophia Hsin-Jung Li, Seunghun Han, Lance Parsons, Alexander N. Frese, Zemer Gitai, Tracy G. Anthony, Martin Wühr, David M. Sabatini, Joshua D. Rabinowitz
Cell Syst. Author manuscript; available in PMC 2022 Aug 16.
Published in final edited form as: Cell Syst. 2022 Feb 16; 13(2): 158–172.e9. Published online 2021 Oct 26. doi: 10.1016/j.cels.2021.09.014
PMCID:
PMC8961722
AbstractArticlePDF–2.6M
10.
The integrated stress response contributes to tRNA synthetase-associated peripheral neuropathy
E. L. Spaulding, T. J. Hines, P. Bais, A. L. D. Tadenev, R. Schneider, D. Jewett, B. Pattavina, S. L. Pratt, K. H. Morelli, M. G. Stum, D. P. Hill, C. Gobet, M. Pipis, M. M. Reilly, M. J. Jennings, R. Horvath, Y. Bai, M. E. Shy, B. Alvarez-Castelao, E. M. Schuman, L. P. Bogdanik, E. Storkebaum, R. W. Burgess
Science. Author manuscript; available in PMC 2022 Sep 3.
Published in final edited form as: Science. 2021 Sep 3; 373(6559): 1156–1161. Published online 2021 Sep 1. doi: 10.1126/science.abb3414
PMCID:
PMC8908546
AbstractArticlePDF–1.4M
11.
Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation
Juntao Yuan, Zhuoran Yu, Junling Gao, Kai Luo, Xiyue Shen, Bingqing Cui, Zhongbing Lu
Redox Biol. 2022 Feb; 49: 102224. Published online 2021 Dec 22. doi: 10.1016/j.redox.2021.102224
PMCID:
PMC8718669
AbstractArticlePDF–17M
12.
The eIF2 kinase GCN2 directs keratinocyte collective cell migration during wound healing via coordination of reactive oxygen species and amino acids
Rebecca R. Miles, Parth H. Amin, Miguel Barriera Diaz, Jagannath Misra, Erica Aukerman, Amitava Das, Nandini Ghosh, Tanner Guith, Michael D. Knierman, Sashwati Roy, Dan F Spandau, Ronald C. Wek
J Biol Chem. 2021 Nov; 297(5): 101257. Published online 2021 Sep 29. doi: 10.1016/j.jbc.2021.101257
PMCID:
PMC8554533
AbstractArticlePDF–4.0M
13.
The Role of Indoleamine 2,3-Dioxygenase in Renal Tubular Epithelial Cells Senescence under Anoxia or Reoxygenation
Theodoros Eleftheriadis, Georgios Pissas, Georgios Filippidis, Vassilios Liakopoulos, Ioannis Stefanidis
Biomolecules. 2021 Oct; 11(10): 1522. Published online 2021 Oct 15. doi: 10.3390/biom11101522
PMCID:
PMC8533884
AbstractArticlePDF–3.5M
14.
Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress
Jagannath Misra, Michael J Holmes, Emily T. Mirek, Michael Langevin, Hyeong-Geug Kim, Kenneth R Carlson, Malcolm Watford, X Charlie Dong, Tracy G Anthony, Ronald C Wek
Nucleic Acids Res. 2021 Jun 4; 49(10): 5726–5742. Published online 2021 May 22. doi: 10.1093/nar/gkab362
PMCID:
PMC8191763
AbstractArticlePDF–7.5M
15.
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
Deyang Yu, Nicole E. Richardson, Cara L. Green, Alexandra B. Spicer, Michaela E. Murphy, Victoria Flores, Cholsoon Jang, Ildiko Kasza, Maria Nikodemova, Matthew H. Wakai, Jay L. Tomasiewicz, Shany E. Yang, Blake R. Miller, Heidi H. Pak, Jacqueline A. Brinkman, Jennifer M. Rojas, William J. Quinn, III, Eunhae P. Cheng, Elizabeth N. Konon, Lexington R. Haider, Megan Finke, Michelle Sonsalla, Caroline M. Alexander, Joshua D. Rabinowitz, Joseph A. Baur, Kristen C. Malecki, Dudley W. Lamming
Cell Metab. Author manuscript; available in PMC 2022 May 4.
Published in final edited form as: Cell Metab. 2021 May 4; 33(5): 905–922.e6. Published online 2021 Apr 21. doi: 10.1016/j.cmet.2021.03.025
PMCID:
PMC8102360
AbstractArticlePDF–3.3M
16.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
17.
Maternal Immune Activation in Mice Disrupts Proteostasis in the Fetal Brain
Brian T. Kalish, Eunha Kim, Benjamin Finander, Erin E. Duffy, Hyunju Kim, Casey K. Gilman, Yeong Shin Yim, Lilin Tong, Randal J. Kaufman, Eric C. Griffith, Gloria B. Choi, Michael E. Greenberg, Jun R. Huh
Nat Neurosci. Author manuscript; available in PMC 2021 Jun 23.
Published in final edited form as: Nat Neurosci. 2021 Feb; 24(2): 204–213. Published online 2020 Dec 23. doi: 10.1038/s41593-020-00762-9
PMCID:
PMC7854524
AbstractArticlePDF–5.7M
18.
GCN2 Deficiency Enhances Protective Effects of Exercise on Hepatic Steatosis
Xueting Luo, Xiaowei Shi, Zhongguang Sun, Jing Xiao, Hui Song, Guo Lu, Xin Xu
Biomed Res Int. 2020; 2020: 1454396. Published online 2020 Nov 24. doi: 10.1155/2020/1454396
PMCID:
PMC7707946
AbstractArticlePDF–1.0M
19.
The Amino Acid Sensor Eif2ak4/GCN2 Is Required for Proliferation of Osteoblast Progenitors in Mice
Guoli Hu, Yilin Yu, Yuning J Tang, Colleen Wu, Fanxin Long, Courtney M Karner
J Bone Miner Res. Author manuscript; available in PMC 2020 Dec 9.
Published in final edited form as: J Bone Miner Res. 2020 Oct; 35(10): 2004–2014. Published online 2020 Jul 6. doi: 10.1002/jbmr.4091
PMCID:
PMC7688563
AbstractArticlePDF–2.3M
20.
GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis
Markus Terrey, Scott I Adamson, Alana L Gibson, Tianda Deng, Ryuta Ishimura, Jeffrey H Chuang, Susan L Ackerman
eLife. 2020; 9: e62731. Published online 2020 Nov 13. doi: 10.7554/eLife.62731
Correction in:
eLife. 2021; 10: e70785.
PMCID:
PMC7665888
AbstractArticlePDF–5.6M

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