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Items: 1 to 20 of 220

1.
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
Mengqi Li, Yu Wang, Xiaoyan Wei, Wei-Feng Cai, Jianfeng Wu, Mingxia Zhu, Yongliang Wang, Yan-Hui Liu, Jinye Xiong, Qi Qu, Yan Chen, Xiao Tian, Luming Yao, Renxiang Xie, Xiaomin Li, Siwei Chen, Xi Huang, Cixiong Zhang, Changchuan Xie, Yaying Wu, Zheni Xu, Baoding Zhang, Bin Jiang, Zhi-Chao Wang, Qinxi Li, Gang Li, Shu-Yong Lin, Li Yu, Hai-Long Piao, Xianming Deng, Jiahuai Han, Chen-Song Zhang, Sheng-Cai Lin
Cell Res. 2024 Oct; 34(10): 683–706. Published online 2024 Jun 19. doi: 10.1038/s41422-024-00985-6
PMCID:
PMC11442470
AbstractArticlePDF–6.2M
2.
血小板特异性Rictor敲除抑制小鼠血小板生成和活化及血栓形成
龙 清, 杨 峻, 刘 安玲
Nan Fang Yi Ke Da Xue Xue Bao. 2024 Aug 20; 44(8): 1605–1611. Chinese. doi: 10.12122/j.issn.1673-4254.2024.08.20
PMCID:
PMC11378050
AbstractArticlePDF–2.0M
3.
Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss
Erin R Cullen, Mona Safari, Isabelle Mittelstadt, Matthew C Weston
eLife. 2024; 12: RP91323. Published online 2024 Mar 6. doi: 10.7554/eLife.91323
PMCID:
PMC10942640
AbstractArticlePDF–13M
4.
Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung
Kelly Kersten, Ran You, Sophia Liang, Kevin M. Tharp, Joshua Pollack, Valerie M. Weaver, Matthew F. Krummel, Mark B. Headley
Cell Rep. Author manuscript; available in PMC 2023 Oct 23.
Published in final edited form as: Cell Rep. 2023 Jun 27; 42(6): 112582. Published online 2023 May 31. doi: 10.1016/j.celrep.2023.112582
PMCID:
PMC10592447
AbstractArticlePDF–1.1M
5.
mTORC2 regulates auditory hair cell structure and function
Maurizio Cortada, Soledad Levano, Michael N. Hall, Daniel Bodmer
iScience. 2023 Sep 15; 26(9): 107687. Published online 2023 Aug 19. doi: 10.1016/j.isci.2023.107687
PMCID:
PMC10484995
AbstractArticlePDF–4.9M
6.
mTORC2–NDRG1–CDC42 axis couples fasting to mitochondrial fission
Nuria Martinez-Lopez, Pamela Mattar, Miriam Toledo, Henrietta Bains, Manu Kalyani, Marie Louise Aoun, Mridul Sharma, Laura Beth J. McIntire, Leslie Gunther-Cummins, Frank P. Macaluso, Jennifer T. Aguilan, Simone Sidoli, Mathieu Bourdenx, Rajat Singh
Nat Cell Biol. 2023; 25(7): 989–1003. Published online 2023 Jun 29. doi: 10.1038/s41556-023-01163-3
PMCID:
PMC10344787
AbstractArticlePDF–23M
7.
Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells
Weiwei Xu, M.M. Fahd Qadir, Daniela Nasteska, Paula Mota de Sa, Caroline M. Gorvin, Manuel Blandino-Rosano, Charles R. Evans, Thuong Ho, Evgeniy Potapenko, Rajakrishnan Veluthakal, Fiona B. Ashford, Stavroula Bitsi, Jia Fan, Manika Bhondeley, Kejing Song, Venkata N. Sure, Siva S.V.P. Sakamuri, Lina Schiffer, Wandy Beatty, Rachael Wyatt, Daniel E. Frigo, Xiaowen Liu, Prasad V. Katakam, Wiebke Arlt, Jochen Buck, Lonny R. Levin, Tony Hu, Jay Kolls, Charles F. Burant, Alejandra Tomas, Matthew J. Merrins, Debbie C. Thurmond, Ernesto Bernal-Mizrachi, David J. Hodson, Franck Mauvais-Jarvis
Cell Rep. Author manuscript; available in PMC 2023 Jun 30.
Published in final edited form as: Cell Rep. 2023 May 30; 42(5): 112529. Published online 2023 May 17. doi: 10.1016/j.celrep.2023.112529
PMCID:
PMC10312392
AbstractArticlePDF–3.8M
8.
Natural γδT17 cell development and functional acquisition is governed by the mTORC2-c-Maf-controlled mitochondrial fission pathway
Yunke Wang, Hui Qin, Yihua Cai, Xu Chen, Hong Li, Diego Elias Montoya-Durango, Chuanlin Ding, Xiaoling Hu, Julia H. Chariker, Harshini Sarojini, Sufan Chien, Eric C. Rouchka, Huang-Ge Zhang, Jie Zheng, Fuming Qiu, Jun Yan
iScience. 2023 May 19; 26(5): 106630. Published online 2023 Apr 10. doi: 10.1016/j.isci.2023.106630
PMCID:
PMC10182300
AbstractArticlePDF–8.7M
9.
mTORC1 Deficiency Prevents the Development of MC903-Induced Atopic Dermatitis through the Downregulation of Type 2 Inflammation
Anupriya Gupta, Keunwook Lee, Kwonik Oh
Int J Mol Sci. 2023 Mar; 24(6): 5968. Published online 2023 Mar 22. doi: 10.3390/ijms24065968
PMCID:
PMC10054228
AbstractArticlePDF–2.0M
10.
Maternal hyperglycemia inhibits pulmonary vasculogenesis during mouse fetal lung development by promoting GβL Ubiquitination-dependent mammalian target of Rapamycin assembly
Qingqing Luo, Xinqun Chai, Xiaoyan Xin, Weixiang Ouyang, Feitao Deng
Diabetol Metab Syndr. 2023; 15: 49. Published online 2023 Mar 17. doi: 10.1186/s13098-022-00974-y
PMCID:
PMC10021989
AbstractArticlePDF–1.5M
11.
mTORC2 Inhibition Improves Morphological Effects of PTEN Loss, But Does Not Correct Synaptic Dysfunction or Prevent Seizures
Erin R. Cullen, Kamran Tariq, Amy N. Shore, Bryan W. Luikart, Matthew C. Weston
J Neurosci. 2023 Feb 1; 43(5): 827–845. doi: 10.1523/JNEUROSCI.1354-22.2022
PMCID:
PMC9899090
AbstractArticlePDF–7.5M
12.
mTORC2 Loss in Oligodendrocyte Progenitor Cells Results in Regional Hypomyelination in the Central Nervous System
Kristin D. Dahl, Adam R. Almeida, Hannah A. Hathaway, Jennifer Bourne, Tanya L. Brown, Lisbet T. Finseth, Teresa L. Wood, Wendy B. Macklin
J Neurosci. 2023 Jan 25; 43(4): 540–558. doi: 10.1523/JNEUROSCI.0010-22.2022
PMCID:
PMC9888514
AbstractArticlePDF–9.9M
13.
Dietary glucosamine overcomes the defects in αβ-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis
Guy Werlen, Mei-Ling Li, Luca Tottone, Victoria da Silva-Diz, Xiaoyang Su, Daniel Herranz, Estela Jacinto
Nat Commun. 2022; 13: 7404. Published online 2022 Dec 1. doi: 10.1038/s41467-022-35014-w
PMCID:
PMC9715696
AbstractArticlePDF–4.3M
14.
Impact of Raptor and Rictor deletion on hippocampal pathology following status epilepticus
Christin M. Godale, Emma V. Parkins, Christina Gross, Steve C. Danzer
J Mol Neurosci. Author manuscript; available in PMC 2023 Mar 1.
Published in final edited form as: J Mol Neurosci. 2022 Jun; 72(6): 1243–1258. Published online 2022 May 27. doi: 10.1007/s12031-022-02030-w
PMCID:
PMC9571976
AbstractArticlePDF–1.5M
15.
Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice
Teayoun Kim, Shelly Nason, Jessica Antipenko, Brian Finan, Anath Shalev, Richard DiMarchi, Kirk M. Habegger
Diabetes. 2022 Oct; 71(10): 2123–2135. Published online 2022 Jul 25. doi: 10.2337/db21-1018
PMCID:
PMC9501720
AbstractArticlePDF–83M
16.
Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex
Vasiliki Karalis, Franklin Caval-Holme, Helen S. Bateup
Nat Commun. 2022; 13: 4665. Published online 2022 Aug 9. doi: 10.1038/s41467-022-31961-6
PMCID:
PMC9363483
AbstractArticlePDF–9.8M
17.
mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation
Calvin Wong, Omer Barkai, Feng Wang, Carolina Thörn Perez, Shaya Lev, Weihua Cai, Shannon Tansley, Noosha Yousefpour, Mehdi Hooshmandi, Kevin C. Lister, Mariam Latif, A. Claudio Cuello, Masha Prager-Khoutorsky, Jeffrey S. Mogil, Philippe Séguéla, Yves De Koninck, Alfredo Ribeiro-da-Silva, Alexander M. Binshtok, Arkady Khoutorsky
J Clin Invest. 2022 Aug 1; 132(15): e152635. Published online 2022 Aug 1. doi: 10.1172/JCI152635
PMCID:
PMC9337825
AbstractArticlePDF–6.7M
18.
Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
Polina Kosillo, Kamran M Ahmed, Erin E Aisenberg, Vasiliki Karalis, Bradley M Roberts, Stephanie J Cragg, Helen S Bateup
eLife. 2022; 11: e75398. Published online 2022 Jul 26. doi: 10.7554/eLife.75398
PMCID:
PMC9328766
AbstractArticlePDF–15M
19.
Tsc1 Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum
Ines Serra, Ana Stravs, Catarina Osório, Maria Roa Oyaga, Martijn Schonewille, Christian Tudorache, Aleksandra Badura
Front Mol Neurosci. 2022; 15: 831687. Published online 2022 May 13. doi: 10.3389/fnmol.2022.831687
PMCID:
PMC9137405
AbstractArticlePDF–4.0M
20.
IL-1β-activated mTORC2 promotes accumulation of IFN-γ+ γδ T cells by upregulating CXCR3 to restrict hepatic fibrosis
Qihui Liu, Quanli Yang, Zengfeng Wu, Yanfang Chen, Miaomiao Xu, Hua Zhang, Jiliang Zhao, Zonghua Liu, Zerong Guan, Jing Luo, Zhi-yong Li, Guodong Sun, Qiong Wen, Yan Xu, Zhenhua Li, Kebing Chen, Xiaosong Ben, Wanchun He, Xueshi Li, Zhinan Yin, Jianlei Hao, Ligong Lu
Cell Death Dis. 2022 Apr; 13(4): 289. Published online 2022 Apr 1. doi: 10.1038/s41419-022-04739-3
PMCID:
PMC8971410
AbstractArticlePDF–7.0M

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