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Items: 1 to 20 of 39

1.
WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells
Arindam Datta, Kajal Biswas, Joshua A. Sommers, Haley Thompson, Sanket Awate, Claudia M. Nicolae, Tanay Thakar, George-Lucian Moldovan, Robert H. Shoemaker, Shyam K. Sharan, Robert M. Brosh, Jr
Nat Commun. 2021; 12: 6561. Published online 2021 Nov 12. doi: 10.1038/s41467-021-26811-w
PMCID:
PMC8590011
AbstractArticlePDF–6.8M
2.
Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A
So-mi Kang, Min-Ho Yoon, Su-Jin Lee, Jinsook Ahn, Sang Ah Yi, Ki Hong Nam, Soyoung Park, Tae-Gyun Woo, Jung-Hyun Cho, Jaecheol Lee, Nam-Chul Ha, Bum-Joon Park
Sci Rep. 2021; 11: 9122. Published online 2021 Apr 27. doi: 10.1038/s41598-021-88325-1
Correction in:
Sci Rep. 2021; 11: 17776.
PMCID:
PMC8079706
AbstractArticlePDF–3.6M
3.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
4.
Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein
Lucie Aumailley, Marie Julie Dubois, Tracy A. Brennan, Chantal Garand, Eric R. Paquet, Robert J. Pignolo, André Marette, Michel Lebel
FASEB J. 2018 Jul; 32(7): 3623–3640. Published online 2018 Feb 8. doi: 10.1096/fj.201701176R
PMCID:
PMC5998970
AbstractArticle
5.
Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein
Lucie Aumailley, Florence Roux-Dalvai, Isabelle Kelly, Arnaud Droit, Michel Lebel
PLoS One. 2018; 13(3): e0193170. Published online 2018 Mar 1. doi: 10.1371/journal.pone.0193170
PMCID:
PMC5832228
AbstractArticlePDF–5.4M
6.
Global genetic analysis in mice unveils central role for cilia in congenital heart disease
You Li, Nikolai T. Klena, George C Gabriel, Xiaoqin Liu, Andrew J. Kim, Kristi Lemke, Yu Chen, Bishwanath Chatterjee, William Devine, Rama Rao Damerla, Chien-fu Chang, Hisato Yagi, Jovenal T. San Agustin, Mohamed Thahir, Shane Anderton, Caroline Lawhead, Anita Vescovi, Herbert Pratt, Judy Morgan, Leslie Haynes, Cynthia L. Smith, Janan T. Eppig, Laura Reinholdt, Richard Francis, Linda Leatherbury, Madhavi K. Ganapathiraju, Kimimasa Tobita, Gregory J. Pazour, Cecilia W. Lo
Nature. Author manuscript; available in PMC 2015 Nov 28.
Published in final edited form as: Nature. 2015 May 28; 521(7553): 520–524. Published online 2015 Mar 25. doi: 10.1038/nature14269
PMCID:
PMC4617540
AbstractArticlePDF–518K
7.
Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice
Lucie Aumailley, Chantal Garand, Marie Julie Dubois, F. Brad Johnson, André Marette, Michel Lebel
PLoS One. 2015; 10(10): e0140292. Published online 2015 Oct 8. doi: 10.1371/journal.pone.0140292
PMCID:
PMC4598085
AbstractArticlePDF–3.1M
8.
BLM helicase facilitates telomere replication during leading strand synthesis of telomeres
William C. Drosopoulos, Settapong T. Kosiyatrakul, Carl L. Schildkraut
J Cell Biol. 2015 Jul 20; 210(2): 191–208. doi: 10.1083/jcb.201410061
PMCID:
PMC4508891
AbstractArticlePDF–3.9M
9.
DNA damage-induced type I interferon promotes senescence and inhibits stem cell function
Qiujing Yu, Yuliya V. Katlinskaya, Christopher J. Carbone, Bin Zhao, Kanstantsin V. Katlinski, Hui Zheng, Manti Guha, Ning Li, Qijun Chen, Ting Yang, Christopher J. Lengner, Roger A. Greenberg, F. Brad Johnson, Serge Y. Fuchs
Cell Rep. Author manuscript; available in PMC 2016 May 5.
Published in final edited form as: Cell Rep. 2015 May 5; 11(5): 785–797. Published online 2015 Apr 23. doi: 10.1016/j.celrep.2015.03.069
PMCID:
PMC4426031
AbstractArticlePDF–1.6M
10.
The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers
Lin Chung, David Onyango, Zhigang Guo, Pingping Jia, Huifang Dai, Songbai Liu, Mian Zhou, Weiqiang Lin, Insun Pang, Hongzhi Li, Yate-Ching Yuan, Qin Huang, Li Zheng, Judith Lopes, Alain Nicolas, Weihang Chai, Dan Raz, Karen L. Reckamp, Binghui Shen
Oncogene. Author manuscript; available in PMC 2015 Aug 12.
Published in final edited form as: Oncogene. 2015 Feb 12; 34(7): 902–911. Published online 2014 Mar 10. doi: 10.1038/onc.2014.19
PMCID:
PMC4160428
AbstractArticlePDF–1.9M
11.
Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis
Tracy A. Brennan, Kevin P. Egan, Carter M. Lindborg, Qijun Chen, Mariya T. Sweetwyne, Kurt D. Hankenson, Sharon X. Xie, Frederick B. Johnson, Robert J. Pignolo
Dis Model Mech. 2014 May; 7(5): 583–592. Published online 2014 Mar 13. doi: 10.1242/dmm.014928
PMCID:
PMC4007409
AbstractArticle
12.
R-Spondin 1 promotes vibration-induced bone formation in mouse models of osteoporosis
Haitao Wang, Tracy A. Brennan, Elizabeth Russell, Jung-Hoon Kim, Kevin P. Egan, Qijun Chen, Craig Israelite, David C. Schultz, Frederick B. Johnson, Robert J. Pignolo
J Mol Med (Berl) Author manuscript; available in PMC 2014 Dec 1.
Published in final edited form as: J Mol Med (Berl). 2013 Dec; 91(12): 10.1007/s00109-013-1068-3. Published online 2013 Aug 24. doi: 10.1007/s00109-013-1068-3
PMCID:
PMC3834172
AbstractArticlePDF–1.5M
13.
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency
Russell Moser, Masafumi Toyoshima, Kristin Robinson, Kay E. Gurley, Heather L. Howie, Jerry Davison, Martin Morgan, Christopher J. Kemp, Carla Grandori
Mol Cancer Res. Author manuscript; available in PMC 2013 Jul 10.
Published in final edited form as: Mol Cancer Res. 2012 Apr; 10(4): 535–545. Published online 2012 Feb 1. doi: 10.1158/1541-7786.MCR-11-0508
PMCID:
PMC3707802
AbstractArticlePDF–2.0M
14.
Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage
Radhakrishnan Kanagaraj, Prasanna Parasuraman, Boris Mihaljevic, Barbara van Loon, Kamila Burdova, Christiane König, Antonia Furrer, Vilhelm A. Bohr, Ulrich Hübscher, Pavel Janscak
Nucleic Acids Res. 2012 Sep; 40(17): 8449–8459. Published online 2012 Jun 29. doi: 10.1093/nar/gks648
PMCID:
PMC3458577
AbstractArticlePDF–5.8M
15.
Impairment of Osteoblast Differentiation Due to Proliferation-independent Telomere Dysfunction in Mouse Models of Accelerated Aging
Haitao Wang, Qijun Chen, Seoung-Hoon Lee, Yongwon Choi, F. Brad Johnson, Robert J. Pignolo
Aging Cell. Author manuscript; available in PMC 2013 Aug 1.
Published in final edited form as: Aging Cell. 2012 Aug; 11(4): 704–713. Published online 2012 Jun 11. doi: 10.1111/j.1474-9726.2012.00838.x
PMCID:
PMC3400025
AbstractArticlePDF–2.2M
16.
Loss of p16Ink4a Function Rescues Cellular Senescence Induced by Telomere Dysfunction
Xiufeng Zhang, Xiaoming Wu, Wenru Tang, Ying Luo
Int J Mol Sci. 2012; 13(5): 5866–5877. Published online 2012 May 16. doi: 10.3390/ijms13055866
PMCID:
PMC3382785
AbstractArticlePDF–465K
17.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
18.
The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold Attachment Factor B1 deficient mice
Sophie Lachapelle, Steffi Oesterreich, Michel Lebel
Aging (Albany NY) 2011 Mar; 3(3): 277–290. Published online 2011 Mar 20. doi: 10.18632/aging.100300
PMCID:
PMC3091521
AbstractArticlePDF–4.6M
19.
BCR/ABL stimulates WRN to promote survival and genomic instability
Artur Slupianek, Tomasz Poplawski, Stanislaw K. Jozwiakowski, Kimberly Cramer, Dariusz Pytel, Ewelina Stoczynska, Michal O. Nowicki, Janusz Blasiak, Tomasz Skorski
Cancer Res. Author manuscript; available in PMC 2012 Feb 1.
Published in final edited form as: Cancer Res. 2011 Feb 1; 71(3): 842–851. Published online 2010 Dec 1. doi: 10.1158/0008-5472.CAN-10-1066
PMCID:
PMC3032814
AbstractArticlePDF–1.4M
20.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M

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