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Items: 1 to 20 of 223

1.
Lymphocyte-specific kinase expression is a prognostic indicator in ovarian cancer and correlates with a prominent B cell transcriptional signature
Emily Hinchcliff, Cherie Paquette, Jason Roszik, Sarah Kelting, Mark H. Stoler, Samuel C. Mok, Tsz-Lun Yeung, Qian Zhang, Melinda Yates, Weiyi Peng, Patrick Hwu, Amir Jazaeri
Cancer Immunol Immunother. 2019 Sep; 68(9): 1515–1526. Published online 2019 Sep 12. doi: 10.1007/s00262-019-02385-x
PMCID:
PMC11028084
AbstractArticlePDF–1.5M
2.
Combined Immunodeficiency Caused by a Novel Nonsense Mutation in LCK
Baerbel Keller, Shlomit Kfir-Erenfeld, Paul Matusewicz, Frederike Hartl, Atar Lev, Yu Nee Lee, Amos J. Simon, Tali Stauber, Orly Elpeleg, Raz Somech, Polina Stepensky, Susana Minguet, Burkhart Schraven, Klaus Warnatz
J Clin Immunol. 2024; 44(1): 4. Published online 2023 Dec 19. doi: 10.1007/s10875-023-01614-4
PMCID:
PMC10730691
AbstractArticlePDF–7.3M
3.
A Novel Biallelic LCK Variant Resulting in Profound T-Cell Immune Deficiency and Review of the Literature
Anna-Lisa Lanz, Serife Erdem, Alper Ozcan, Gulay Ceylaner, Murat Cansever, Serdar Ceylaner, Raffaele Conca, Thomas Magg, Oreste Acuto, Sylvain Latour, Christoph Klein, Turkan Patiroglu, Ekrem Unal, Ahmet Eken, Fabian Hauck
J Clin Immunol. 2024; 44(1): 1. Published online 2023 Dec 15. doi: 10.1007/s10875-023-01602-8
Correction in:
J Clin Immunol. 2024; 44(1): 41.
PMCID:
PMC10724324
AbstractArticlePDF–1.6M
4.
Identification of Breast Cancer LCK Proto-Oncogene as a Master Regulator of TNBC Neutrophil Enrichment and Polarization
Fatma Al Qutami, Walaa Al Halabi, Mahmood Y. Hachim
Int J Mol Sci. 2023 Sep; 24(17): 13269. Published online 2023 Aug 26. doi: 10.3390/ijms241713269
PMCID:
PMC10487917
AbstractArticlePDF–7.8M
5.
Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex
Islam E. Elkholi, Jonathan Boulais, Marie-Pier Thibault, Hong-Duc Phan, Amélie Robert, Lien B. Lai, Denis Faubert, Matthew J. Smith, Venkat Gopalan, Jean-Franҫois Côté
J Biol Chem. 2023 Sep; 299(9): 105123. Published online 2023 Aug 1. doi: 10.1016/j.jbc.2023.105123
PMCID:
PMC10480535
AbstractArticlePDF–2.4M
6.
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer
Goutam Dey, Rashmi Bharti, Chad Braley, Ravi Alluri, Emily Esakov, Katie Crean-Tate, Keith McCrae, Amy Joehlin-Price, Peter G. Rose, Justin Lathia, Zihua Gong, Ofer Reizes
J Ovarian Res. 2023; 16: 122. Published online 2023 Jun 27. doi: 10.1186/s13048-023-01194-2
PMCID:
PMC10294509
AbstractArticlePDF–8.5M
7.
Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis
Jieqiong Zhang, Zhenhua Hu, Hwa Hwa Chung, Yun Tian, Kah Weng Lau, Zheng Ser, Yan Ting Lim, Radoslaw M. Sobota, Hwei Fen Leong, Benjamin Jieming Chen, Clarisse Jingyi Yeo, Shawn Ying Xuan Tan, Jian Kang, Dennis Eng Kiat Tan, Ieng Fong Sou, Urszula Lucja McClurg, Manikandan Lakshmanan, Thamil Selvan Vaiyapuri, Anandhkumar Raju, Esther Sook Miin Wong, Vinay Tergaonkar, Ravisankar Rajarethinam, Elina Pathak, Wai Leong Tam, Ern Yu Tan, Wee-Wei Tee
Nat Commun. 2023; 14: 2439. Published online 2023 Apr 28. doi: 10.1038/s41467-023-38132-1
PMCID:
PMC10147683
AbstractArticlePDF–7.7M
8.
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong
Mol Cell. Author manuscript; available in PMC 2023 Apr 4.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015
PMCID:
PMC10072906
AbstractArticlePDF–4.2M
9.
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia
Qi Jin, Blanca Gutierrez Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Von Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L. Safgren, Yi-Chien Tsai, Beat Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D. Crispino, Aristotelis Tsirigos, Panagiotis Ntziachristos
Sci Adv. 2022 Dec; 8(49): eabq8437. Published online 2022 Dec 9. doi: 10.1126/sciadv.abq8437
PMCID:
PMC9733937
AbstractArticlePDF–2.2M
10.
A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling
Annika Schultz, Marvin Schnurra, Ali El-Bizri, Nadine M. Woessner, Sara Hartmann, Roland Hartig, Susana Minguet, Burkhart Schraven, Luca Simeoni
Cells. 2022 Sep; 11(17): 2723. Published online 2022 Sep 1. doi: 10.3390/cells11172723
PMCID:
PMC9455082
AbstractArticlePDF–1.7M
11.
Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling
Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser
Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151
PMCID:
PMC9105235
AbstractArticlePDF–5.8M
12.
Role of Programmed Cell Death Protein-1 and Lymphocyte Specific Protein Tyrosine Kinase in the Aryl Hydrocarbon Receptor- Mediated Impairment of the IgM Response in Human CD5+ Innate-Like B Cells
Jiajun Zhou, Lance K. Blevins, Robert B. Crawford, Norbert E. Kaminski
Front Immunol. 2022; 13: 884203. Published online 2022 Apr 26. doi: 10.3389/fimmu.2022.884203
PMCID:
PMC9088000
AbstractArticlePDF–5.7M
13.
Fluctuations in AKT and PTEN Activity Are Linked by the E3 Ubiquitin Ligase cCBL
Manuel Olazábal-Morán, Miriam Sánchez-Ortega, Laura Martínez-Muñoz, Carmen Hernández, Manuel S. Rodríguez, Mario Mellado, Ana C. Carrera
Cells. 2021 Nov; 10(11): 2803. Published online 2021 Oct 20. doi: 10.3390/cells10112803
PMCID:
PMC8616390
AbstractArticlePDF–4.6M
14.
Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified
Koen Debackere, Lukas Marcelis, Sofie Demeyer, Marlies Vanden Bempt, Nicole Mentens, Olga Gielen, Kris Jacobs, Michael Broux, Gregor Verhoef, Lucienne Michaux, Carlos Graux, Iwona Wlodarska, Philippe Gaulard, Laurence de Leval, Thomas Tousseyn, Jan Cools, Daan Dierickx
Nat Commun. 2021; 12: 3705. Published online 2021 Jun 17. doi: 10.1038/s41467-021-24037-4
PMCID:
PMC8211700
AbstractArticlePDF–5.6M
15.
Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation
Jonas Weiße, Julia Rosemann, Lisa Müller, Matthias Kappler, Alexander W. Eckert, Markus Glaß, Danny Misiak, Stefan Hüttelmaier, Wolfgang G. Ballhausen, Mechthild Hatzfeld, Monika Haemmerle, Tony Gutschner
Mol Cancer. 2021; 20: 88. Published online 2021 Jun 11. doi: 10.1186/s12943-021-01384-w
Correction in:
Mol Cancer. 2023; 22: 50.
PMCID:
PMC8194179
AbstractArticlePDF–5.0M
16.
Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling
Frederike A. Hartl, Jatuporn Ngoenkam, Esmeralda Beck-Garcia, Liz Cerqueira, Piyamaporn Wipa, Pussadee Paensuwan, Prapat Suriyaphol, Pankaj Mishra, Burkhart Schraven, Stefan Günther, Sutatip Pongcharoen, Wolfgang W. A. Schamel, Susana Minguet
Cells. 2021 Apr; 10(4): 834. Published online 2021 Apr 7. doi: 10.3390/cells10040834
PMCID:
PMC8068026
AbstractArticlePDF–1.4M
17.
Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1
Xiahui Li, Shujing Li, Bowen Li, Yanan Li, Sattout Aman, Kangkai Xia, Yuxi Yang, Bashir Ahmad, Huijian Wu
NPJ Precis Oncol. 2021; 5: 20. Published online 2021 Mar 19. doi: 10.1038/s41698-021-00158-3
PMCID:
PMC7979705
AbstractArticlePDF–6.8M
18.
A Novel, LAT/Lck Double Deficient T Cell Subline J.CaM1.7 for Combined Analysis of Early TCR Signaling
Inmaculada Vico-Barranco, Mikel M. Arbulo-Echevarria, Isabel Serrano-García, Alba Pérez-Linaza, José M. Miranda-Sayago, Arkadiusz Miazek, Isaac Narbona-Sánchez, Enrique Aguado
Cells. 2021 Feb; 10(2): 343. Published online 2021 Feb 6. doi: 10.3390/cells10020343
PMCID:
PMC7915312
AbstractArticlePDF–2.3M
19.
The Activity and Stability of p56Lck and TCR Signaling Do Not Depend on the Co-Chaperone Cdc37
Sarah Kowallik, Andreas Kritikos, Matthias Kästle, Christoph Thurm, Burkhart Schraven, Luca Simeoni
Int J Mol Sci. 2021 Jan; 22(1): 126. Published online 2020 Dec 24. doi: 10.3390/ijms22010126
PMCID:
PMC7795971
AbstractArticlePDF–1.7M
20.
Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56Lck regulates T-cell activation independently of Lck/CD45 interactions
Matthias Kästle, Camilla Merten, Roland Hartig, Thilo Kaehne, Ardiyanto Liaunardy-Jopeace, Nadine M. Woessner, Wolfgang W. Schamel, John James, Susana Minguet, Luca Simeoni, Burkhart Schraven
Cell Commun Signal. 2020; 18: 183. Published online 2020 Nov 23. doi: 10.1186/s12964-020-00673-z
PMCID:
PMC7682018
AbstractArticlePDF–3.7M

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