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Items: 1 to 20 of 180

1.
Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
Johanna Kliche, Leandro Simonetti, Izabella Krystkowiak, Hanna Kuss, Marcel Diallo, Emma Rask, Jakob Nilsson, Norman E Davey, Ylva Ivarsson
Mol Syst Biol. 2024 Sep; 20(9): 1025–1048. Published online 2024 Jul 15. doi: 10.1038/s44320-024-00055-4
PMCID:
PMC11369174
AbstractArticlePDF–2.7M
2.
The histone methyltransferase KMT2D maintains cellular glucocorticoid responsiveness by shielding the glucocorticoid receptor from degradation
Chuan-Jin Wu, Ferenc Livak, Jonathan D. Ashwell
J Biol Chem. 2024 Aug; 300(8): 107581. Published online 2024 Jul 25. doi: 10.1016/j.jbc.2024.107581
PMCID:
PMC11350265
AbstractArticlePDF–2.3M
3.
Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinoma
Wei Liu, Hongchao Cao, Jing Wang, Areeg Elmusrati, Bing Han, Wei Chen, Ping Zhou, Xiyao Li, Stephen Keysar, Antonio Jimeno, Cun-Yu Wang
Nat Commun. 2024; 15: 6755. Published online 2024 Aug 8. doi: 10.1038/s41467-024-50861-5
PMCID:
PMC11310337
AbstractArticlePDF–5.7M
4.
DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples
Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang
J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.
Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832
PMCID:
PMC11296914
AbstractArticlePDF–1.7M
5.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
AbstractArticlePDF–3.0M
6.
SETting up the genome: KMT2D and KDM6A genomic function in the Kabuki syndrome craniofacial developmental disorder
Karl B. Shpargel, Gabrielle Quickstad
Birth Defects Res. 2023 Dec 1; 115(20): 1885–1898. Published online 2023 Oct 6. doi: 10.1002/bdr2.2253
PMCID:
PMC11190966
AbstractArticlePDF–2.3M
7.
PI 3-Kinase and the Histone Methyl-Transferase KMT2D Collaborate to Induce Arp2/3-Dependent Migration of Mammary Epithelial Cells
Karina D. Rysenkova, Julia Gaboriaud, Artem I. Fokin, Raphaëlle Toubiana, Alexandre Bense, Camil Mirdass, Mélissa Jin, Minh Chau N. Ho, Elizabeth Glading, Sophie Vacher, Laura Courtois, Ivan Bièche, Alexis M. Gautreau
Cells. 2024 May; 13(10): 876. Published online 2024 May 19. doi: 10.3390/cells13100876
PMCID:
PMC11119607
AbstractArticlePDF–3.0M
8.
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors
Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer
Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740
PMCID:
PMC11109483
AbstractArticlePDF–2.9M
9.
Macular dystrophy in Kabuki syndrome due to de novo KMT2D variants: refining the phenotype with multimodal imaging and follow-up over 10 years: insight into pathophysiology
Veronika Vaclavik, Aurelie Navarro, Alain Jacot-Guillarmod, Armand Bottani, Young Joo Sun, Joel A. Franco, Vinit B. Mahajan, Vasily Smirnov, Isabelle Bouvet-Drumare
Graefes Arch Clin Exp Ophthalmol. 2024; 262(6): 1737–1744. Published online 2024 Jan 11. doi: 10.1007/s00417-023-06345-1
PMCID:
PMC11105987
AbstractArticlePDF–6.5M
10.
Interaction network of human early embryonic transcription factors
Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo
EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0
PMCID:
PMC10933267
AbstractArticlePDF–2.9M
11.
Molecular insights of KMT2D and clinical aspects of Kabuki Syndrome Type 1
Carly S. Golden, Saylor Williams, Maria A. Serrano
Birth Defects Res. Author manuscript; available in PMC 2024 Feb 6.
Published in final edited form as: Birth Defects Res. 2023 Nov 15; 115(19): 1809–1824. Published online 2023 May 9. doi: 10.1002/bdr2.2183
PMCID:
PMC10845236
AbstractArticlePDF–911K
12.
KMT2D Deficiency Causes Sensorineural Hearing Loss in Mice and Humans
Allison J. Kalinousky, Teresa R. Luperchio, Katrina M. Schrode, Jacqueline R. Harris, Li Zhang, Valerie B. DeLeon, Jill A. Fahrner, Amanda M. Lauer, Hans T. Bjornsson
Genes (Basel) 2024 Jan; 15(1): 48. Published online 2023 Dec 28. doi: 10.3390/genes15010048
PMCID:
PMC10815913
AbstractArticlePDF–1.9M
13.
EBF2 Links KMT2D‐Mediated H3K4me1 to Suppress Pancreatic Cancer Progression via Upregulating KLLN
Bing Yao, Mengying Xing, Shixin Meng, Shang Li, Jingwan Zhou, Ming Zhang, Chen Yang, Shuang Qu, Yucui Jin, Hongyan Yuan, Ke Zen, Changyan Ma
Adv Sci (Weinh) 2024 Jan; 11(2): 2302037. Published online 2023 Nov 28. doi: 10.1002/advs.202302037
PMCID:
PMC10787067
AbstractArticlePDF–18M
14.
Hearing characteristics and otoradiological abnormalities in three patients with novel pathogenic variants of KMT2D‐related Kabuki syndrome
Zhoushu Zheng, Lu Ding, Meihong Wang, Yinghui Zhang, Yihui Yang, Ming Tang, Jun Xu, Liangjiong Wang, Junhua Wu, Haibo Li
Mol Genet Genomic Med. 2024 Jan; 12(1): e2306. Published online 2023 Nov 3. doi: 10.1002/mgg3.2306
PMCID:
PMC10767598
AbstractArticlePDF–1.3M
15.
Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
Ezgi Ozyerli-Goknar, Ezgi Yagmur Kala, Ali Cenk Aksu, Ipek Bulut, Ahmet Cingöz, Sheikh Nizamuddin, Martin Biniossek, Fidan Seker-Polat, Tunc Morova, Can Aztekin, Sonia H. Y. Kung, Hamzah Syed, Nurcan Tuncbag, Mehmet Gönen, Martin Philpott, Adam P. Cribbs, Ceyda Acilan, Nathan A. Lack, Tamer T. Onder, H. T. Marc Timmers, Tugba Bagci-Onder
Cell Commun Signal. 2023; 21: 328. Published online 2023 Nov 16. doi: 10.1186/s12964-023-01335-6
PMCID:
PMC10652464
AbstractArticlePDF–8.0M
16.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
17.
KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
Yuanwang Pan, Han Han, Hai Hu, Hua Wang, Yueqiang Song, Yuan Hao, Xinyuan Tong, Ayushi S Patel, Selim Misirlioglu, Sittinon Tang, Hsin-Yi Huang, Ke Geng, Ting Chen, Angeliki Karatza, Fiona Sherman, Kristen E Labbe, Fan Yang, Alison Chafitz, Chengwei Peng, Chenchen Guo, Andre L Moreira, Vamsidhar Velcheti, Sally CM Lau, Pengfei Sui, Haiquan Chen, J Alan Diehl, Anil K Rustgi, Adam J Bass, John T Poirier, Xiaoyang Zhang, Hongbin Ji, Hua Zhang, Kwok-Kin Wong
Cancer Cell. Author manuscript; available in PMC 2024 Jan 9.
Published in final edited form as: Cancer Cell. 2023 Jan 9; 41(1): 88–105.e8. Published online 2022 Dec 15. doi: 10.1016/j.ccell.2022.11.015
PMCID:
PMC10388706
AbstractArticlePDF–3.8M
18.
MLL4 Regulates the Progression of Non–Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis
Yang Yang, Rongfang Qiu, Qiaoyou Weng, Ziwei Xu, Jingjing Song, Siyu Zhao, Miaomiao Meng, Dengke Zhang, Chunli Kong, Hailin Wang, Min Xu, Zhongwei Zhao, Jiansong Ji
Cancer Res Treat. 2023 Jul; 55(3): 778–803. Published online 2023 Jan 26. doi: 10.4143/crt.2022.1042
PMCID:
PMC10372590
AbstractArticlePDF–4.8M
19.
KMT2D Links TGF-β Signalling to Non-Canonical Activin Pathway and Regulates Pancreatic Cancer Cell Plasticity
Shuang Lu, Hong Sun Kim, Yubo Cao, Karan Bedi, Lili Zhao, Ishwarya Venkata Narayanan, Brian Magnuson, Yumei Gu, Jing Yang, Zhujun Yi, Sepideh Babaniamansour, Sargis Shameon, Chang Xu, Michelle T. Paulsen, Ping Qiu, Sivakumar Jeyarajan, Mats Ljungman, Dafydd Thomas, Yali Dou, Howard Crawford, Marina Pasca di Magliano, Kai Ge, Bo Yang, Jiaqi Shi
Int J Cancer. Author manuscript; available in PMC 2024 Aug 1.
Published in final edited form as: Int J Cancer. 2023 Aug 1; 153(3): 552–570. Published online 2023 May 4. doi: 10.1002/ijc.34528
PMCID:
PMC10330100
AbstractArticlePDF–1.5M
20.
The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression
Jin Wei, Mia Madel Alfajaro, Wesley L. Cai, Vincent R. Graziano, Madison S. Strine, Renata B. Filler, Scott B. Biering, Sylvia A. Sarnik, Sonam Patel, Bridget L. Menasche, Susan R. Compton, Silvana Konermann, Patrick D. Hsu, Robert C. Orchard, Qin Yan, Craig B. Wilen
PLoS Pathog. 2023 Jul; 19(7): e1011351. Published online 2023 Jul 6. doi: 10.1371/journal.ppat.1011351
PMCID:
PMC10325096
AbstractArticlePDF–2.9M

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