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Select item 110774291.

Diacylglycerol kinase alpha is a proliferation marker of intrahepatic cholangiocarcinoma associated with the prognosis

Shunsuke Shichi, Ko Sugiyama, Yoh Asahi, Chisato Shirakawa, Hiroki Nakamoto, Saori Kimura, Kazuki Wakizaka, Takeshi Aiyama, Akihisa Nagatsu, Tatsuya Orimo, Tatsuhiko Kakisaka, Akinobu Taketomi

Cancer Med. 2024 May; 13(9): e7238. Published online 2024 May 8. doi: 10.1002/cam4.7238

PMCID:: PMC11077429

Abstract Article PDF–2.5M

Select item 108762062.

Multiomics analysis reveals metabolic subtypes and identifies diacylglycerol kinase α (DGKA) as a potential therapeutic target for intrahepatic cholangiocarcinoma

Weiren Liu, Huqiang Wang, Qianfu Zhao, Chenyang Tao, Weifeng Qu, Yushan Hou, Run Huang, Zimei Sun, Guiqi Zhu, Xifei Jiang, Yuan Fang, Jun Gao, Xiaoling Wu, Zhixiang Yang, Rongyu Ping, Jiafeng Chen, Rui Yang, Tianhao Chu, Jian Zhou, Jia Fan, Zheng Tang, Dong Yang, Yinghong Shi

Cancer Commun (Lond) 2024 Feb; 44(2): 226–250. Published online 2023 Dec 24. doi: 10.1002/cac2.12513

PMCID:: PMC10876206

Abstract Article PDF–7.6M

Select item 101511393.

Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3

Dong Zhou, Tao Liu, Xinrui Rao, Xiaohua Jie, Yunshang Chen, Zilong Wu, Huilin Deng, Dan Zhang, Jian Wang, Gang Wu

Thorac Cancer. 2023 May; 14(13): 1179–1191. Published online 2023 Mar 25. doi: 10.1111/1759-7714.14851

PMCID:: PMC10151139

Abstract Article PDF–9.3M

Select item 86418044.

Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling

Pawan Sharma, Santosh K. Yadav, Sushrut D. Shah, Elham Javed, John M. Lim, Shi Pan, Ajay P. Nayak, Reynold A. Panettieri, Jr., Raymond B. Penn, Taku Kambayashi, Deepak A. Deshpande

Am J Respir Cell Mol Biol. 2021 Dec; 65(6): 658–671. Published online 2021 Mar 30. doi: 10.1165/rcmb.2021-0106OC

PMCID:: PMC8641804

Abstract Article PDF–1.5M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 73677576.

DGKA provides platinum resistance in ovarian cancer through activation of cJUN-WEE1 signaling

Jie Li, Chaoyun Pan, Austin C. Boese, JiHoon Kang, Anna D. Umano, Kelly R. Magliocca, Wenqing Yang, Yu Zhang, Sagar Lonial, Lingtao Jin, Sumin Kang

Clin Cancer Res. Author manuscript; available in PMC 2021 Jan 15.

Published in final edited form as: Clin Cancer Res. 2020 Jul 15; 26(14): 3843–3855. Published online 2020 Apr 27. doi: 10.1158/1078-0432.CCR-19-3790

PMCID:: PMC7367757

Abstract Article PDF–2.0M

Select item 72940957.

Diacylglycerol kinases regulate TRPV1 channel activity

Luyu Liu, Yevgen Yudin, Tibor Rohacs

J Biol Chem. 2020 Jun 12; 295(24): 8174–8185. Published online 2020 Apr 28. doi: 10.1074/jbc.RA119.012505

PMCID:: PMC7294095

Abstract Article PDF–3.9M

Select item 68877908.

DGKα in Neutrophil Biology and Its Implications for Respiratory Diseases

Gianluca Baldanzi, Mario Malerba

Int J Mol Sci. 2019 Nov; 20(22): 5673. Published online 2019 Nov 13. doi: 10.3390/ijms20225673

PMCID:: PMC6887790

Abstract Article PDF–1.6M

Select item 64237259.

Crystal structure and calcium‐induced conformational changes of diacylglycerol kinase α EF‐hand domains

Daisuke Takahashi, Kano Suzuki, Taiichi Sakamoto, Takeo Iwamoto, Takeshi Murata, Fumio Sakane

Protein Sci. 2019 Apr; 28(4): 694–706. Published online 2019 Feb 4. doi: 10.1002/pro.3572

PMCID:: PMC6423725

Abstract Article PDF–1.2M

Select item 502296010.

Decreased LIPF expression is correlated with DGKA and predicts poor outcome of gastric cancer

Yi Kong, Yan Zheng, Yanfei Jia, Ping Li, Yunshan Wang

Oncol Rep. 2016 Oct; 36(4): 1852–1860. Published online 2016 Aug 1. doi: 10.3892/or.2016.4989

PMCID:: PMC5022960

Abstract Article PDF–630K

Select item 479295811.

Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis

Christoph Weigel, Marlon R. Veldwijk, Christopher C. Oakes, Petra Seibold, Alla Slynko, David B. Liesenfeld, Mariona Rabionet, Sabrina A. Hanke, Frederik Wenz, Elena Sperk, Axel Benner, Christoph Rösli, Roger Sandhoff, Yassen Assenov, Christoph Plass, Carsten Herskind, Jenny Chang-Claude, Peter Schmezer, Odilia Popanda

Nat Commun. 2016; 7: 10893. Published online 2016 Mar 11. doi: 10.1038/ncomms10893

PMCID:: PMC4792958

Abstract Article PDF–743K

Select item 464468212.

Molecular Pathways: Targeting Diacylglycerol Kinase Alpha in Cancer

Benjamin Purow

Clin Cancer Res. Author manuscript; available in PMC 2016 Nov 15.

Published in final edited form as: Clin Cancer Res. 2015 Nov 15; 21(22): 5008–5012. Published online 2015 Sep 29. doi: 10.1158/1078-0432.CCR-15-0413

PMCID:: PMC4644682

Abstract Article PDF–258K

Select item 431849213.

A Molecular Defect in Intracellular Lipid Signaling in Human Neutrophils in Localized Aggressive Periodontal Tissue Damage

Karsten Gronert, Alpdogan Kantarci, Bruce D. Levy, Clary B. Clish, Sabine Odparlik, Hatice Hasturk, John A. Badwey, Sean P. Colgan, Thomas E. Van Dyke, Charles N. Serhan

J Immunol. Author manuscript; available in PMC 2015 Feb 5.

Published in final edited form as: J Immunol. 2004 Feb 1; 172(3): 1856–1861. doi: 10.4049/jimmunol.172.3.1856

PMCID:: PMC4318492

Abstract Article PDF–795K

Select item 423167014.

Diacylglycerol Kinase α Regulates Tubular Recycling Endosome Biogenesis and Major Histocompatibility Complex Class I Recycling

Shuwei Xie, Naava Naslavsky, Steve Caplan

J Biol Chem. 2014 Nov 14; 289(46): 31914–31926. Published online 2014 Sep 23. doi: 10.1074/jbc.M114.594291

PMCID:: PMC4231670

Abstract Article PDF–4.4M

Select item 404166215.

The Diacylglycerol Kinase α/Atypical PKC/β1 Integrin Pathway in SDF-1α Mammary Carcinoma Invasiveness

Elena Rainero, Cristina Cianflone, Paolo Ettore Porporato, Federica Chianale, Valeria Malacarne, Valentina Bettio, Elisa Ruffo, Michele Ferrara, Fabio Benecchia, Daniela Capello, Wolfgang Paster, Irene Locatelli, Alessandra Bertoni, Nicoletta Filigheddu, Fabiola Sinigaglia, Jim C. Norman, Gianluca Baldanzi, Andrea Graziani

PLoS One. 2014; 9(6): e97144. Published online 2014 Jun 2. doi: 10.1371/journal.pone.0097144

PMCID:: PMC4041662

Abstract Article PDF–1.5M

Select item 382958816.

A miR-297/hypoxia/DGK-α axis regulating glioblastoma survival

Benjamin Kefas, Desiree H. Floyd, Laurey Comeau, Alyse Frisbee, Charli Dominguez, Charles G. diPierro, Fadila Guessous, Roger Abounader, Benjamin Purow

Neuro Oncol. 2013 Dec; 15(12): 1652–1663. Published online 2013 Oct 24. doi: 10.1093/neuonc/not118

PMCID:: PMC3829588

Abstract Article PDF–679K

Select item 347780417.

A Census of Human Soluble Protein Complexes

Pierre C. Havugimana, G. Traver Hart, Tamás Nepusz, Haixuan Yang, Andrei L. Turinsky, Zhihua Li, Peggy I. Wang, Daniel R. Boutz, Vincent Fong, Sadhna Phanse, Mohan Babu, Stephanie A. Craig, Pingzhao Hu, Cuihong Wan, James Vlasblom, Vaqaarun-Nisa Dar, Alexander Bezginov, Gregory W. Clark, Gabriel C. Wu, Shoshana J. Wodak, Elisabeth R.M. Tillier, Alberto Paccanaro, Edward M. Marcotte, Andrew Emili

Cell. Author manuscript; available in PMC 2013 Aug 31.

Published in final edited form as: Cell. 2012 Aug 31; 150(5): 1068–1081. doi: 10.1016/j.cell.2012.08.011

PMCID:: PMC3477804

Abstract Article PDF–7.7M

Select item 337781418.

Biosynthesis of Alkyl Lysophosphatidic Acid by Diacylglycerol Kinases

Amanda M. Gellett, Yugesh Kharel, Manjula Sunkara, Andrew J. Morris, Kevin R. Lynch

Biochem Biophys Res Commun. Author manuscript; available in PMC 2013 Jun 15.

Published in final edited form as: Biochem Biophys Res Commun. 2012 Jun 15; 422(4): 758–763. Published online 2012 May 22. doi: 10.1016/j.bbrc.2012.05.077

PMCID:: PMC3377814

Abstract Article PDF–768K

Select item 328878519.

Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases

Jinwook Shin, Thomas F. O’Brien, Jason M. Grayson, Xiao-Ping Zhong

J Immunol. Author manuscript; available in PMC 2013 Mar 1.

Published in final edited form as: J Immunol. 2012 Mar 1; 188(5): 2111–2117. Published online 2012 Jan 23. doi: 10.4049/jimmunol.1102265

PMCID:: PMC3288785

Abstract Article PDF–2.8M

Select item 322189020.

SAP-MEDIATED INHIBITION OF DIACYLGLYCEROL KINASE ALPHA REGULATES TCR-INDUCED DIACYLGLYCEROL SIGNALING

Gianluca Baldanzi, Andrea Pighini, Valentina Bettio, Elena Rainero, Sara Traini, Federica Chianale, Paolo Porporato, Nicoletta Filigheddu, Riccardo Mesturini, Shuping Song, Tamas Schweighoffer, Laura Patrussi, Cosima Tatiana Baldari, Xiao-Ping Zhong, Wim J. van Blitterswijk, Fabiola Sinigaglia, Kim E. Nichols, Ignacio Rubio, Ornella Parolini, Andrea Graziani

J Immunol. Author manuscript; available in PMC 2012 Dec 1.

Published in final edited form as: J Immunol. 2011 Dec 1; 187(11): 5941–5951. Published online 2011 Nov 2. doi: 10.4049/jimmunol.1002476

PMCID:: PMC3221890

Abstract Article PDF–1.7M

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