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Select item 112082961.

Loss of Dnmt3a increases self-renewal and resistance to pegIFN-α in JAK2-V617F–positive myeloproliferative neoplasms

Marc Usart, Jan Stetka, Damien Luque Paz, Nils Hansen, Quentin Kimmerlin, Tiago Almeida Fonseca, Melissa Lock, Lucia Kubovcakova, Riikka Karjalainen, Hui Hao-Shen, Anastasiya Börsch, Athimed El Taher, Jessica Schulz, Jean-Christophe Leroux, Stefan Dirnhofer, Radek C. Skoda

Blood. 2024 Jun 13; 143(24): 2490–2503. Published online 2024 Mar 18. doi: 10.1182/blood.2023020270

PMCID:: PMC11208296

Abstract Article

Select item 111706852.

AIM2 inflammasome regulated by the IFN‐γ/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease

Yue Zhao, Bin Liang, Shuyang Sheng, Chen Wang, Bingyu Jin, Xiaokang Zhang, Yating Cheng, Changxin Shen, Fang Zheng

Immun Inflamm Dis. 2024 Jun; 12(6): e1317. Published online 2024 Jun 13. doi: 10.1002/iid3.1317

PMCID:: PMC11170685

Abstract Article PDF–3.7M

Select item 111637963.

Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia

Tobias Ronny Haage, Emmanouil Charakopoulos, Vikas Bhuria, Conny K. Baldauf, Mark Korthals, Juliane Handschuh, Peter Müller, Juan Li, Kunjan Harit, Gopala Nishanth, Stephanie Frey, Martin Böttcher, Klaus-Dieter Fischer, Jan Dudeck, Anne Dudeck, Daniel B. Lipka, Burkhart Schraven, Anthony R. Green, Andreas J. Müller, Dimitrios Mougiakakos, Thomas Fischer

J Hematol Oncol. 2024; 17: 43. Published online 2024 Jun 9. doi: 10.1186/s13045-024-01562-5

PMCID:: PMC11163796

Abstract Article PDF–10M

Select item 111598784.

Co‐overexpression of Janus kinase 2 and signal transducer and activator of transcription 5a promotes differentiation of mammary cancer cells through reversal of epithelial–mesenchymal transition

Ahmed S. Sultan, Hassan Brim, Zaki A. Sherif

Cancer Sci. 2008 Feb; 99(2): 272–279. Published online 2008 Feb 6. doi: 10.1111/j.1349-7006.2007.00685.x

PMCID:: PMC11159878

Abstract Article PDF–299K

Select item 111075745.

Mechanosensor polycystin-1 potentiates differentiation of human osteoblastic cells by upregulating Runx2 expression via induction of JAK2/STAT3 signaling axis

Georgia Dalagiorgou, Christina Piperi, Christos Adamopoulos, Urania Georgopoulou, Antonios N. Gargalionis, Anastasia Spyropoulou, Ilianna Zoi, Marjan Nokhbehsaim, Anna Damanaki, James Deschner, Efthimia K. Basdra, Athanasios G. Papavassiliou

Cell Mol Life Sci. 2017 Mar; 74(5): 921–936. Published online 2016 Oct 3. doi: 10.1007/s00018-016-2394-8

PMCID:: PMC11107574

Abstract Article PDF–5.7M

Select item 110448676.

KIAA0040 enhances glioma growth by controlling the JAK2/STAT3 signalling pathway

Jie He, Kaming Xue, Fei Fan, Lin Li, Xinyu Rao, Wei Liu, Chuansheng Nie

J Cell Mol Med. 2024 Apr; 28(8): e18332. Published online 2024 Apr 25. doi: 10.1111/jcmm.18332

PMCID:: PMC11044867

Abstract Article PDF–15M

Select item 110226937.

Targeting C21orf58 is a Novel Treatment Strategy of Hepatocellular Carcinoma by Disrupting the Formation of JAK2/C21orf58/STAT3 Complex

Hao Jiang, Yang Wang, Doudou Wen, Rongji Yu, Sayed S Esa, Kefeng Lv, Qing Feng, Jing Liu, Faxiang Li, Lan He, Xiaotang Di, Shubing Zhang

Adv Sci (Weinh) 2024 Apr; 11(15): 2306623. Published online 2024 Feb 11. doi: 10.1002/advs.202306623

PMCID:: PMC11022693

Abstract Article PDF–13M

Select item 109235188.

Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling

Bobin George Abraham, Teemu Haikarainen, Joni Vuorio, Mykhailo Girych, Anniina T. Virtanen, Antti Kurttila, Christos Karathanasis, Mike Heilemann, Vivek Sharma, Ilpo Vattulainen, Olli Silvennoinen

Sci Adv. 2024 Mar 8; 10(10): eadl2097. Published online 2024 Mar 8. doi: 10.1126/sciadv.adl2097

PMCID:: PMC10923518

Abstract Article PDF–4.4M

Select item 109184069.

Impact of CALR and JAK2V617F Mutations on Clinical Course and Disease Outcomes in Essential Thrombocythemia: A Multicenter Retrospective Study in Turkish Patients

Zehra Narlı Özdemir, Yıldız İpek, Püsem Patır, Gözde Ermiş, Rafiye Çiftçiler, Deniz Özmen, Mehmet Baysal, Vildan Gürsoy, Esra Yıldızhan, Serkan Güven, Tarık Ercan, Tayfun Elibol, Sinan Mersin, Eylem Genç, Eren Arslan Davulcu, Volkan Karakuş, Nergiz Erkut, Gürsel Güneş, Reyhan Diz Küçükkaya, Ahmet Emre Eşkazan

Turk J Haematol. 2024 Mar; 41(1): 26–36. Published online 2024 Mar 1. doi: 10.4274/tjh.galenos.2024.2023.0430

PMCID:: PMC10918406

Abstract Article PDF–777K

Select item 1087486310.

Proinflammatory phenotype of iPS cell-derived JAK2 V617F megakaryocytes induces fibrosis in 3D in vitro bone marrow niche

Niclas Flosdorf, Janik Böhnke, Marcelo A.S. de Toledo, Niklas Lutterbach, Vanesa Gómez Lerma, Martin Graßhoff, Kathrin Olschok, Siddharth Gupta, Vithurithra Tharmapalan, Susanne Schmitz, Katrin Götz, Herdit M. Schüler, Angela Maurer, Stephanie Sontag, Caroline Küstermann, Kristin Seré, Wolfgang Wagner, Ivan G. Costa, Tim H. Brümmendorf, Steffen Koschmieder, Nicolas Chatain, Miguel Castilho, Rebekka K. Schneider, Martin Zenke

Stem Cell Reports. 2024 Feb 13; 19(2): 224–238. Published online 2024 Jan 25. doi: 10.1016/j.stemcr.2023.12.011

PMCID:: PMC10874863

Abstract Article PDF–5.7M

Select item 1086223511.

PF4 activates the c-Mpl–Jak2 pathway in platelets

Richard J. Buka, Samantha J. Montague, Luis A. Moran, Eleyna M. Martin, Alexandre Slater, Steve P. Watson, Phillip L. R. Nicolson

Blood. 2024 Jan 4; 143(1): 64–69. Published online 2023 Oct 29. doi: 10.1182/blood.2023020872

PMCID:: PMC10862235

Abstract Article

Select item 1085081612.

A newly identified 45‐kDa JAK2 variant with an altered kinase domain structure represents a novel mode of JAK2 kinase inhibitor resistance

Sivahari Prasad Gorantla, Tony Andreas Mueller, Corinna Albers‐Leischner, Martina Rudelius, Nikolas von Bubnoff, Justus Duyster

Mol Oncol. 2024 Feb; 18(2): 415–430. Published online 2023 Dec 20. doi: 10.1002/1878-0261.13566

PMCID:: PMC10850816

Abstract Article PDF–7.3M

Select item 1084165813.

Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria

Jonathan Bohlen, Qinhua Zhou, Quentin Philippot, Masato Ogishi, Darawan Rinchai, Tea Nieminen, Simin Seyedpour, Nima Parvaneh, Nima Rezaei, Niloufar Yazdanpanah, Mana Momenilandi, Clément Conil, Anna-Lena Neehus, Carltin Schmidt, Carlos Andres Arango Franco, Tom Le Voyer, Taushif Khan, Rui Yang, Julia Puchan, Lucia Erazo, Mykola Roiuk, Taja Vatovec, Zarah Janda, Ivan Bagaric, Marie Materna, Adrian Gervais, Hailun Li, Jérémie Rosain, Jessica Peel, Yoann Seeleuthner, Ji Eun Han, Anne-Sophie L’Honneur, Marcela Moncada-Vélez, Marta Martin-Fernandez, Michael Espino Horesh, Tatiana Kochetkov, Monika Schmidt, Mohammed A. AlShehri, Eeva Salo, Saxen Harri, Gehad ElGhazali, Ahmad Yatim, Camille Soudée, Federica Sallusto, Armin Ensser, Nico Marr, Peng Zhang, Dusan Bogunovic, Aurélie Cobat, Mohammad Shahrooei, Vivien Béziat, Laurent Abel, Xiaochuan Wang, Stéphanie Boisson-Dupuis, Aurelio A. Teleman, Jacinta Bustamante, Qian Zhang, Jean-Laurent Casanova

Cell. Author manuscript; available in PMC 2024 Feb 5.

Published in final edited form as: Cell. 2023 Nov 9; 186(23): 5114–5134.e27. Published online 2023 Oct 23. doi: 10.1016/j.cell.2023.09.024

PMCID:: PMC10841658

Abstract Article PDF–3.5M

Select item 1083745814.

Calreticulin and JAK2V617F driver mutations induce distinct mitotic defects in myeloproliferative neoplasms

Kristin Holl, Nicolas Chatain, Susanne Krapp, Julian Baumeister, Tiago Maié, Sarah Schmitz, Anja Scheufen, Nathalie Brock, Steffen Koschmieder, Daniel Moreno-Andrés

Sci Rep. 2024; 14: 2810. Published online 2024 Feb 2. doi: 10.1038/s41598-024-53240-8

PMCID:: PMC10837458

Abstract Article PDF–3.9M

Select item 1083603715.

Knockdown of liver cancer cell‐secreted exosomal PSMA5 controls macrophage polarization to restrain cancer progression by blocking JAK2/STAT3 signaling

Shujie Xie, Xiang Li, Jia Yan, Hua Yu, Shuhuai Chen, Kana Chen

Immun Inflamm Dis. 2024 Feb; 12(2): e1146. Published online 2024 Feb 2. doi: 10.1002/iid3.1146

PMCID:: PMC10836037

Abstract Article PDF–6.0M

Select item 1082487316.

Identification and validation of the association of Janus kinase 2 mutations with the response to immune checkpoint inhibitor therapy

Peipei Chen, Junyu Long, Jiayang Zhang, Fucun Xie, Wei Wu, Zhuang Tian, Shuyang Zhang, Kang Yu

Inflamm Res. 2024; 73(2): 263–276. Published online 2024 Jan 10. doi: 10.1007/s00011-023-01833-w

PMCID:: PMC10824873

Abstract Article PDF–8.0M

Select item 1074375317.

Exploiting Synthetic Lethality between Germline BRCA1 Haploinsufficiency and PARP Inhibition in JAK2V617F-Positive Myeloproliferative Neoplasms

Max Bermes, Maria Jimena Rodriguez, Marcelo Augusto Szymanski de Toledo, Sabrina Ernst, Gerhard Müller-Newen, Tim Henrik Brümmendorf, Nicolas Chatain, Steffen Koschmieder, Julian Baumeister

Int J Mol Sci. 2023 Dec; 24(24): 17560. Published online 2023 Dec 16. doi: 10.3390/ijms242417560

PMCID:: PMC10743753

Abstract Article PDF–8.2M

Select item 1073482718.

The impact of JAK2V617F mutation on Philadelphia-negative myeloproliferative neoplasms

Ezgi ŞAHİN, İpek YÖNAL-HİNDİLERDEN, Fehmi HİNDİLERDEN, Aynur ADAY, Meliha NALÇACI

Turk J Med Sci. 2022; 52(1): 150–165. Published online 2021 Sep 4. doi: 10.3906/sag-2103-247

PMCID:: PMC10734827

Abstract Article PDF–386K

Select item 1072669519.

JAK2, CALR, and MPL Mutation Profiles in Colombian patients with BCR-ABL Negative Myeloproliferative Neoplasms

Ana Isabel Giraldo-Rincón, Sara Naranjo Molina, Natalia Gomez-Lopera, Daniel Aguirre Acevedo, Andrea Ucroz Benavidez, Kenny Gálvez Cárdenas, Francisco Cuellar Ambrosí, Jose Domingo Torres, Sigifredo Ospina, Katherine Palacio, Lina Gaviria Jaramillo, Carlos Mario Muñeton, Gonzalo Vasquez Palacio

Colomb Med (Cali) 2023 Jul-Sep; 54(3): e2035353. Published online 2023 Sep 30. doi: 10.25100/cm.v54i3.5353

PMCID:: PMC10726695

Abstract Article PDF–841K

Select item 1072006820.

JAK2 as a surface marker for enrichment of human pluripotent stem cells-derived ventricular cardiomyocytes

Lee Chuen Liew, Boon Min Poh, Omer An, Beatrice Xuan Ho, Christina Ying Yan Lim, Jeremy Kah Sheng Pang, Leslie Y. Beh, Henry He Yang, Boon-Seng Soh

Stem Cell Res Ther. 2023; 14: 367. Published online 2023 Dec 13. doi: 10.1186/s13287-023-03610-2

PMCID:: PMC10720068

Abstract Article PDF–4.3M

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