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Select item 99369781.

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio

Hepatology. 2023 Mar; 77(3): 874–887. Published online 2023 Feb 17. doi: 10.1002/hep.32581

PMCID:: PMC9936978

Abstract Article PDF–990K

Select item 93810402.

MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation

Rafael Romero-Becerra, Alfonso Mora, Elisa Manieri, Ivana Nikolic, Ayelén Melina Santamans, Valle Montalvo-Romeral, Francisco Miguel Cruz, Elena Rodríguez, Marta León, Luis Leiva-Vega, Laura Sanz, Víctor Bondía, David Filgueiras-Rama, Luis Jesús Jiménez-Borreguero, José Jalife, Barbara Gonzalez-Teran, Guadalupe Sabio

eLife. 2022; 11: e75250. Published online 2022 Aug 16. doi: 10.7554/eLife.75250

PMCID:: PMC9381040

Abstract Article PDF–8.2M

Select item 92039323.

NR2F1 is a barrier to dissemination of early stage breast cancer cells

Carolina Rodriguez-Tirado, Nupura Kale, Maria J. Carlini, Nitisha Shrivastava, Alcina A. Rodrigues, Bassem Khalil, Jose J. Bravo-Cordero, Yan Hong, Melissa Alexander, Jiayi Ji, Fariba Behbod, Maria S. Sosa

Cancer Res. Author manuscript; available in PMC 2022 Dec 15.

Published in final edited form as: Cancer Res. 2022 Jun 15; 82(12): 2313–2326. doi: 10.1158/0008-5472.CAN-21-4145

PMCID:: PMC9203932

Abstract Article PDF–2.1M

Select item 88441164.

Receptor for advanced glycation end products aggravates cognitive deficits in type 2 diabetes through binding of C‐terminal AAs 2‐5 to mitogen‐activated protein kinase kinase 3 (MKK3) and facilitation of MEKK3‐MKK3‐p38 module assembly

Xiao‐Yan Zhou, Chang‐Jiang Ying, Bin Hu, Yu‐Sheng Zhang, Tian Gan, Yan‐Dong Zhu, Nan Wang, An‐An Li, Yuan‐Jian Song

Aging Cell. 2022 Feb; 21(2): e13543. Published online 2022 Jan 26. doi: 10.1111/acel.13543

PMCID:: PMC8844116

Abstract Article PDF–4.0M

Select item 79387705.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 74145896.

Heme induces rapid endothelial barrier dysfunction via the MKK3/p38MAPK axis

Joel James, Anup Srivastava, Mathews Valuparampil Varghese, Cody A. Eccles, Marina Zemskova, Olga Rafikova, Ruslan Rafikov

Blood. 2020 Aug 6; 136(6): 749–754. Prepublished online 2020 Jun 16. doi: 10.1182/blood.2019003986

PMCID:: PMC7414589

Abstract Article

Select item 67776837.

Incremental load training improves renal fibrosis by regulating the TGF-β1/TAK1/MKK3/p38MAPK signaling pathway and inducing the activation of autophagy in aged mice

Chuncha Bao, Zhong Yang, Qiyan Cai, Qian Li, Hongli Li, Bin Shu

Int J Mol Med. 2019 Nov; 44(5): 1677–1686. Published online 2019 Sep 17. doi: 10.3892/ijmm.2019.4344

Correction in:: Int J Mol Med. 2023 Aug; 52(2): 71.

PMCID:: PMC6777683

Abstract Article PDF–741K

Select item 58428898.

Genetic Analyses Reveal Functions for MAP2K3 and MAP2K6 in Mouse Testis Determination

Nick Warr, Pam Siggers, Gwenn-Aël Carré, Sara Wells, Andy Greenfield

Biol Reprod. Author manuscript; available in PMC 2018 Mar 8.

Published in final edited form as: Biol Reprod. 2016 May; 94(5): 103. Published online 2016 Mar 23. doi: 10.1095/biolreprod.115.138057

PMCID:: PMC5842889

Abstract Article PDF–1.1M

Select item 55425799.

Cardiac Fibroblast-Specific Activating Transcription Factor 3 Protects Against Heart Failure by Suppressing MAP2K3-p38 Signaling

Yulin Li, Zhenya Li, Congcong Zhang, Ping Li, Yina Wu, Chunxiao Wang, Wayne Bond Lau, Xin-liang Ma, Jie Du

Circulation. Author manuscript; available in PMC 2018 May 23.

Published in final edited form as: Circulation. 2017 May 23; 135(21): 2041–2057. Published online 2017 Mar 1. doi: 10.1161/CIRCULATIONAHA.116.024599

PMCID:: PMC5542579

Abstract Article PDF–1.5M

Select item 493548610.

p38 MAPK α and β isoforms differentially regulate plasma membrane localization of MRP2

Christopher M. Schonhoff, Se Won Park, Cynthia R.L. Webster, M. Sawkat Anwer

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1; 310(11): G999–G1005. Published online 2016 Mar 24. doi: 10.1152/ajpgi.00005.2016

PMCID:: PMC4935486

Abstract Article

Select item 486497011.

Exendin-4 induces myocardial protection through MKK3 and Akt-1 in infarcted hearts

Jianfeng Du, Ling Zhang, Zhengke Wang, Naohiro Yano, Yu Tina Zhao, Lei Wei, Patrycja Dubielecka-Szczerba, Paul Y. Liu, Shougang Zhuang, Gangjian Qin, Ting C. Zhao

Am J Physiol Cell Physiol. 2016 Feb 15; 310(4): C270–C283. Published online 2016 Jan 6. doi: 10.1152/ajpcell.00194.2015

PMCID:: PMC4864970

Abstract Article

Select item 444185212.

MKK3 mediates inflammatory response through modulation of mitochondrial function

Anup Srivastava, Amanda S. Shinn, Patty J. Lee, Praveen Mannam

Free Radic Biol Med. Author manuscript; available in PMC 2016 Jun 1.

Published in final edited form as: Free Radic Biol Med. 2015 Jun; 83: 139–148. Published online 2015 Feb 17. doi: 10.1016/j.freeradbiomed.2015.01.035

PMCID:: PMC4441852

Abstract Article PDF–2.4M

Select item 438645913.

Regulation of the Death-Associated Protein Kinase 1 Expression and Autophagy via ATF6 Requires Apoptosis Signal-Regulating Kinase 1

Padmaja Gade, Srikanta B. Manjegowda, Shreeram C. Nallar, Uday B. Maachani, Alan S. Cross, Dhananjaya V. Kalvakolanu

Mol Cell Biol. 2014 Nov; 34(21): 4033–4048. doi: 10.1128/MCB.00397-14

PMCID:: PMC4386459

Abstract Article PDF–4.1M

Select item 428173214.

p38α MAPK Is Required for Tooth Morphogenesis and Enamel Secretion

Matthew B. Greenblatt, Jung-Min Kim, Hwanhee Oh, Kwang Hwan Park, Min-Kyung Choo, Yasuyo Sano, Coralee E. Tye, Ziedonis Skobe, Roger J. Davis, Jin Mo Park, Marianna Bei, Laurie H. Glimcher, Jae-Hyuck Shim

J Biol Chem. 2015 Jan 2; 290(1): 284–295. Published online 2014 Nov 18. doi: 10.1074/jbc.M114.599274

PMCID:: PMC4281732

Abstract Article PDF–4.5M

Select item 419391915.

Specific calcineurin targeting in macrophages confers resistance to inflammation via MKP-1 and p38

Amelia Escolano, Sara Martínez-Martínez, Arántzazu Alfranca, Katia Urso, Helena M Izquierdo, Mario Delgado, Francisco Martín, Guadalupe Sabio, David Sancho, Pablo Gómez-del Arco, Juan Miguel Redondo

EMBO J. 2014 May 16; 33(10): 1117–1133. Published online 2014 Mar 4. doi: 10.1002/embj.201386369

PMCID:: PMC4193919

Abstract Article PDF–1.7M

Select item 407349416.

The Central Role of EED in the Orchestration of Polycomb Group Complexes

Qi Cao, Xiaoju Wang, Meng Zhao, Rendong Yang, Rohit Malik, Yuanyuan Qiao, Anton Poliakov, Anastasia K. Yocum, Yong Li, Wei Chen, Xuhong Cao, Xia Jiang, Arun Dahiya, Clair Harris, Felix Y. Feng, Sundeep Kalantry, Zhaohui S. Qin, Saravana M. Dhanasekaran, Arul M. Chinnaiyan

Nat Commun. Author manuscript; available in PMC 2014 Jul 24.

Published in final edited form as: Nat Commun. 2014; 5: 3127. doi: 10.1038/ncomms4127

PMCID:: PMC4073494

Abstract Article PDF–2.1M

Select item 396262817.

MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury

Praveen Mannam, Amanda S. Shinn, Anup Srivastava, Radu F. Neamu, Wendy E. Walker, Michael Bohanon, Jane Merkel, Min-Jong Kang, Charles S. Dela Cruz, Amy M. Ahasic, Margaret A. Pisani, Mark Trentalange, A. Phillip West, Gerald S. Shadel, Jack A. Elias, Patty J. Lee

Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1; 306(7): L604–L619. Published online 2014 Jan 31. doi: 10.1152/ajplung.00272.2013

PMCID:: PMC3962628

Abstract Article

Select item 391664918.

Novel Protein Interactions with Endoglin and Activin Receptor-like Kinase 1: Potential Role in Vascular Networks

Guoxiong Xu, Miriam Barrios-Rodiles, Mirjana Jerkic, Andrei L. Turinsky, Robert Nadon, Sonia Vera, Despina Voulgaraki, Jeffrey L. Wrana, Mourad Toporsian, Michelle Letarte

Mol Cell Proteomics. 2014 Feb; 13(2): 489–502. Published online 2013 Dec 7. doi: 10.1074/mcp.M113.033464

PMCID:: PMC3916649

Abstract Article PDF–4.1M

Select item 388225919.

Differential Roles of MAPK Kinases MKK3 and MKK6 in Osteoclastogenesis and Bone Loss

David L. Boyle, Deepa Hammaker, Meghan Edgar, Mario M. Zaiss, Stefan Teufel, Jean Pierre David, Georg Schett, Gary S. Firestein

PLoS One. 2014; 9(1): e84818. Published online 2014 Jan 6. doi: 10.1371/journal.pone.0084818

Correction in:: PLoS One. 2014; 9(1): 10.1371/annotation/4fbfa4f0-cb27-4ec4-80d6-3b0ed5e9e8b8.

PMCID:: PMC3882259

Abstract Article PDF–964K

Select item 369784120.

Translational control of NKT cell cytokine production by p38 MAP kinase

Viswas K. Nagaleekar, Guadalupe Sabio, Idil Aktan, Alan Chant, Isaac W. Howe, Tina M. Thornton, Patrick J. Benoit, Roger J. Davis, Mercedes Rincon, Jonathan E. Boyson

J Immunol. Author manuscript; available in PMC 2013 Jul 1.

Published in final edited form as: J Immunol. 2011 Apr 1; 186(7): 4140–4146. Published online 2011 Mar 2. doi: 10.4049/jimmunol.1002614

PMCID:: PMC3697841

Abstract Article PDF–1.3M

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