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Select item 113724431.

Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within interleukin-6 family cytokines

Anne Huber, Amr H. Allam, Christine Dijkstra, Stefan Thiem, Jennifer Huynh, Ashleigh R. Poh, Joshua Konecnik, Saumya P. Jacob, Rita Busuttil, Yang Liao, David Chisanga, Wei Shi, Mariah G. Alorro, Stephen Forrow, Daniele V.F. Tauriello, Eduard Batlle, Alex Boussioutas, David S. Williams, Michael Buchert, Matthias Ernst, Moritz F. Eissmann

Cell Rep. 2024 Aug 27; 43(8): 114616. Published online 2024 Aug 9. doi: 10.1016/j.celrep.2024.114616

PMCID:: PMC11372443

Abstract Article

Select item 109283292.

Inhibiting IL11RA to mitigate hepatic metastasis in skin cutaneous melanoma: Comprehensive insights from in vitro and in vivo investigations

Zhen‐Guo Zhang, Hong‐Mei Zhu, Huai‐Kang Hua

Skin Res Technol. 2024 Mar; 30(3): e13618. Published online 2024 Mar 11. doi: 10.1111/srt.13618

PMCID:: PMC10928329

Abstract Article PDF–2.2M

Select item 101251303.

IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome

Benjamin Ng, Chen Xie, Liping Su, Fathima F. Kuthubudeen, Xiu-Yi Kwek, Daryl Yeong, Chee Jian Pua, Stuart A. Cook, Wei-Wen Lim

Arterioscler Thromb Vasc Biol. 2023 May; 43(5): 739–754. Published online 2023 Apr 27. doi: 10.1161/ATVBAHA.122.318802

PMCID:: PMC10125130

Abstract Article PDF–6.9M

Select item 98529344.

Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice

Takashi Nishina, Yutaka Deguchi, Mika Kawauchi, Chen Xiyu, Soh Yamazaki, Tetuo Mikami, Hiroyasu Nakano

iScience. 2023 Feb 17; 26(2): 105934. Published online 2023 Jan 5. doi: 10.1016/j.isci.2023.105934

PMCID:: PMC9852934

Abstract Article PDF–4.0M

Select item 97231205.

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease

Anissa A. Widjaja, Sivakumar Viswanathan, Shamini G. Shekeran, Eleonora Adami, Wei-Wen Lim, Sonia Chothani, Jessie Tan, Joyce Wei Ting Goh, Hui Mei Chen, Sze Yun Lim, Carine M. Boustany-Kari, Julie Hawkins, Enrico Petretto, Norbert Hübner, Sebastian Schafer, Thomas M. Coffman, Stuart A. Cook

Nat Commun. 2022; 13: 7497. Published online 2022 Dec 5. doi: 10.1038/s41467-022-35306-1

PMCID:: PMC9723120

Abstract Article PDF–7.9M

Select item 97222656.

Interleukin-11 receptor subunit α-1 is required for maximal airway responsiveness to methacholine after acute exposure to ozone

Richard A. Johnston, Constance L. Atkins, Saad R. Siddiqui, William T. Jackson, Nicholas C. Mitchell, Chantal Y. Spencer, Albert W. Pilkington, 4th, Michael L. Kashon, Ikram U. Haque

Am J Physiol Regul Integr Comp Physiol. 2022 Dec 1; 323(6): R921–R934. Published online 2022 Oct 25. doi: 10.1152/ajpregu.00213.2022

PMCID:: PMC9722265

Abstract Article

Select item 85606417.

Interleukin-11 receptor expression on monocytes is dispensable for their recruitment and pathogen uptake during Leishmania major infection

Iris Baars, Juliane Lokau, Ina Sauerland, Andreas J. Müller, Christoph Garbers

Cytokine. 2021 Dec; 148: None. doi: 10.1016/j.cyto.2021.155699

PMCID:: PMC8560641

Abstract Article

Select item 83132398.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 82668139.

Benjamin Ng, Anissa A. Widjaja, Sivakumar Viswanathan, Jinrui Dong, Sonia P. Chothani, Stella Lim, Shamini G. Shekeran, Jessie Tan, Narelle E. McGregor, Emma C. Walker, Natalie A. Sims, Sebastian Schafer, Stuart A. Cook

Sci Rep. 2021; 11: 14088. Published online 2021 Jul 8. doi: 10.1038/s41598-021-93623-9

PMCID:: PMC8266813

Abstract Article PDF–7.3M

Select item 808677110.

Colitis-induced IL11 promotes colon carcinogenesis

Hong Wang, David H Wang, Xu Yang, Yuhai Sun, Chung S Yang

Carcinogenesis. 2021 Apr; 42(4): 557–569. Published online 2020 Nov 16. doi: 10.1093/carcin/bgaa122

PMCID:: PMC8086771

Abstract Article PDF–1.3M

Select item 805240811.

Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer

Takashi Nishina, Yutaka Deguchi, Daisuke Ohshima, Wakami Takeda, Masato Ohtsuka, Shigeyuki Shichino, Satoshi Ueha, Soh Yamazaki, Mika Kawauchi, Eri Nakamura, Chiharu Nishiyama, Yuko Kojima, Satomi Adachi-Akahane, Mizuho Hasegawa, Mizuho Nakayama, Masanobu Oshima, Hideo Yagita, Kazutoshi Shibuya, Tetuo Mikami, Naohiro Inohara, Kouji Matsushima, Norihiro Tada, Hiroyasu Nakano

Nat Commun. 2021; 12: 2281. Published online 2021 Apr 16. doi: 10.1038/s41467-021-22450-3

PMCID:: PMC8052408

Abstract Article PDF–4.3M

Select item 778250412.

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Brijesh K. Singh, Sonia P. Chothani, Benjamin Ng, Wei Wen Lim, Jin Zhou, Madhulika Tripathi, Nicole S. J. Ko, Shamini G. Shekeran, Jessie Tan, Sze Yun Lim, Mao Wang, Pei Min Lio, Paul M. Yen, Sebastian Schafer, Stuart A. Cook, Anissa A. Widjaja

Nat Commun. 2021; 12: 66. Published online 2021 Jan 4. doi: 10.1038/s41467-020-20303-z

PMCID:: PMC7782504

Abstract Article PDF–10M

Select item 757612313.

Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models

Wei-Wen Lim, Ben Corden, Benjamin Ng, Konstantinos Vanezis, Giuseppe D’Agostino, Anissa A. Widjaja, Wei-Hua Song, Chen Xie, Liping Su, Xiu-Yi Kwek, Nicole G. Z. Tee, Jinrui Dong, Nicole S. J. Ko, Mao Wang, Chee Jian Pua, Muhammad H. Jamal, Beeyong Soh, Sivakumar Viswanathan, Sebastian Schafer, Stuart A. Cook

Sci Rep. 2020; 10: 17853. Published online 2020 Oct 20. doi: 10.1038/s41598-020-74944-7

PMCID:: PMC7576123

Abstract Article PDF–14M

Select item 621973314.

Peyer’s patch myeloid cells infection by Listeria signals through gp38⁺ stromal cells and locks intestinal villus invasion

Olivier Disson, Camille Blériot, Jean-Marie Jacob, Nicolas Serafini, Sophie Dulauroy, Grégory Jouvion, Cindy Fevre, Grégoire Gessain, Pierre Thouvenot, Gérard Eberl, James P. Di Santo, Lucie Peduto, Marc Lecuit

J Exp Med. 2018 Nov 5; 215(11): 2936–2954. doi: 10.1084/jem.20181210

PMCID:: PMC6219733

Abstract Article PDF–3.7M

Select item 580708215.

IL-11 is a crucial determinant of cardiovascular fibrosis

Sebastian Schafer, Sivakumar Viswanathan, Anissa A. Widjaja, Wei-Wen Lim, Aida Moreno-Moral, Daniel M. DeLaughter, Benjamin Ng, Giannino Patone, Kingsley Chow, Ester Khin, Jessie Tan, Sonia P. Chothani, Lei Ye, Owen J. L. Rackham, Nicole S. J. Ko, Norliza E. Sahib, Chee Jian Pua, Nicole T. G. Zhen, Chen Xie, Mao Wang, Henrike Maatz, Shiqi Lim, Kathrin Saar, Susanne Blachut, Enrico Petretto, Sabine Schmidt, Tracy Putoczki, Nuno Guimarães-Camboa, Hiroko Wakimoto, Sebastiaan van Heesch, Kristmundur Sigmundsson, See L. Lim, Jia L. Soon, Victor T. T. Chao, Yeow L. Chua, Teing E. Tan, Sylvia M. Evans, Yee J. Loh, Muhammad H. Jamal, Kim K. Ong, Kim C. Chua, Boon-Hean Ong, Mathew J. Chakaramakkil, Jonathan G. Seidman, Christine E. Seidman, Norbert Hubner, Kenny Y. K. Sin, Stuart A. Cook

Nature. Author manuscript; available in PMC 2018 Feb 9.

Published in final edited form as: Nature. 2017 Dec 7; 552(7683): 110–115. Published online 2017 Nov 13. doi: 10.1038/nature24676

PMCID:: PMC5807082

Abstract Article PDF–5.3M

Select item 521768016.

Critical Contribution of Nuclear Factor Erythroid 2-related Factor 2 (NRF2) to Electrophile-induced Interleukin-11 Production

Takashi Nishina, Yutaka Deguchi, Ryosuke Miura, Soh Yamazaki, Yasuhiro Shinkai, Yuko Kojima, Ko Okumura, Yoshito Kumagai, Hiroyasu Nakano

J Biol Chem. 2017 Jan 6; 292(1): 205–216. Published online 2016 Nov 21. doi: 10.1074/jbc.M116.744755

PMCID:: PMC5217680

Abstract Article PDF–2.5M

Select item 412329517.

Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms

Shuang Zhang, Shuangbo Kong, Bingyan Wang, Xiaohong Cheng, Yongjie Chen, Weiwei Wu, Qiang Wang, Junchao Shi, Ying Zhang, Shumin Wang, Jinhua Lu, John P Lydon, Francesco DeMayo, Warren S Pear, Hua Han, Haiyan Lin, Lei Li, Hongmei Wang, Yan-ling Wang, Bing Li, Qi Chen, Enkui Duan, Haibin Wang

Cell Res. 2014 Aug; 24(8): 925–942. Published online 2014 Jun 27. doi: 10.1038/cr.2014.82

PMCID:: PMC4123295

Abstract Article PDF–4.7M

Select item 411746518.

Optimal Attenuation of Experimental Autoimmune Encephalomyelitis by Intravenous Immunoglobulin Requires an Intact Interleukin-11 Receptor

Carlyn A. Figueiredo, Paulina C. Drohomyrecky, Stephen D. S. McCarthy, Danila Leontyev, Xue-Zhong Ma, Donald R. Branch, Shannon E. Dunn

PLoS One. 2014; 9(7): e101947. Published online 2014 Jul 31. doi: 10.1371/journal.pone.0101947

Correction in:: PLoS One. 2014; 9(11): e113001.

PMCID:: PMC4117465

Abstract Article PDF–1.4M

Select item 357241019.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 356183220.

mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice

Stefan Thiem, Thomas P. Pierce, Michelle Palmieri, Tracy L. Putoczki, Michael Buchert, Adele Preaudet, Ryan O. Farid, Chris Love, Bruno Catimel, Zhengdeng Lei, Steve Rozen, Veena Gopalakrishnan, Fred Schaper, Michael Hallek, Alex Boussioutas, Patrick Tan, Andrew Jarnicki, Matthias Ernst

J Clin Invest. 2013 Feb 1; 123(2): 767–781. Published online 2013 Jan 16. doi: 10.1172/JCI65086

PMCID:: PMC3561832

Abstract Article PDF–7.3M

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