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Items: 1 to 20 of 25

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function
Hao Sun, Ho-Sup Lee, Sarah Hyun-Ji Kim, Mikhael Fernandes de Lima, Alexandre R. Gingras, Qinyi Du, Wilma McLaughlin, Jailail Ablack, Miguel A. Lopez-Ramirez, Frederic Lagarrigue, Zhichao Fan, John T. Chang, Derek VanDyke, Jamie B. Spangler, Mark H. Ginsberg
Cell Rep. Author manuscript; available in PMC 2023 Oct 10.
Published in final edited form as: Cell Rep. 2023 Aug 29; 42(8): 112996. Published online 2023 Aug 21. doi: 10.1016/j.celrep.2023.112996
PMCID:
PMC10564087
AbstractArticlePDF–2.7M
3.
Direct Binding of Rap1 to Talin1 and to MRL Proteins Promotes Integrin Activation in CD4+ T Cells
Frederic Lagarrigue, Boyang Tan, Qinyi Du, Zhichao Fan, Miguel A. Lopez-Ramirez, Alexandre R. Gingras, Hsin Wang, Weiwei Qi, Hao Sun
J Immunol. Author manuscript; available in PMC 2023 Mar 15.
Published in final edited form as: J Immunol. 2022 Mar 15; 208(6): 1378–1388. Published online 2022 Feb 23. doi: 10.4049/jimmunol.2100843
PMCID:
PMC9644409
AbstractArticlePDF–1.9M
4.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
5.
Distinct integrin activation pathways for effector and regulatory T cell trafficking and function
Hao Sun, Frederic Lagarrigue, Hsin Wang, Zhichao Fan, Miguel Alejandro Lopez-Ramirez, John T. Chang, Mark H. Ginsberg
J Exp Med. 2021 Feb 1; 218(2): e20201524. Published online 2020 Oct 26. doi: 10.1084/jem.20201524
PMCID:
PMC7590511
AbstractArticlePDF–4.4M
6.
Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation
Frederic Lagarrigue, Alexandre R. Gingras, David S. Paul, Andrew J. Valadez, Monica N. Cuevas, Hao Sun, Miguel A. Lopez-Ramirez, Benjamin T. Goult, Sanford J. Shattil, Wolfgang Bergmeier, Mark H. Ginsberg
Blood Adv. 2018 Sep 25; 2(18): 2358–2368. Published online 2018 Sep 21. doi: 10.1182/bloodadvances.2018020487
PMCID:
PMC6156890
AbstractArticlePDF–2.0M
7.
Loss of T Cell RIAM Precludes Conjugate Formation with Antigen-Presenting Cells and Prevents Immune-mediated Diabetes
Frederic Lagarrigue, Frank B. Gertler, Mark H. Ginsberg, Joseph M. Cantor
J Immunol. Author manuscript; available in PMC 2018 May 16.
Published in final edited form as: J Immunol. 2017 May 1; 198(9): 3410–3415. Published online 2017 Mar 27. doi: 10.4049/jimmunol.1601743
PMCID:
PMC5954999
AbstractArticlePDF–852K
8.
Structural and functional analysis of a talin triple domain module suggests an alternative talin autoinhibitory configuration
Hao Zhang, Yu-Chung Chang, Qingqiu Huang, Mark L. Brennan, Jinhua Wu
Structure. Author manuscript; available in PMC 2017 May 3.
Published in final edited form as: Structure. 2016 May 3; 24(5): 721–729. Published online 2016 Apr 14. doi: 10.1016/j.str.2016.02.020
PMCID:
PMC4860257
AbstractArticlePDF–820K
9.
The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism
Hao Zhang, Yu-Chung Chang, Mark L. Brennan, Jinhua Wu
J Mol Cell Biol. 2014 Apr; 6(2): 128–139. Published online 2013 Nov 28. doi: 10.1093/jmcb/mjt044
PMCID:
PMC4817127
AbstractArticlePDF–1.6M
10.
Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice
Sarah Klapproth, Markus Sperandio, Elaine M. Pinheiro, Monika Prünster, Oliver Soehnlein, Frank B. Gertler, Reinhard Fässler, Markus Moser
Blood. 2015 Dec 17; 126(25): 2704–2712. Prepublished online 2015 Sep 3. doi: 10.1182/blood-2015-05-647453
PMCID:
PMC4683331
AbstractArticle
11.
Rap1 and its effector RIAM are required for lymphocyte trafficking
Wenjuan Su, Joseph Wynne, Elaine M. Pinheiro, Marianne Strazza, Adam Mor, Emilie Montenont, Jeffrey Berger, David S. Paul, Wolfgang Bergmeier, Frank B. Gertler, Mark R. Philips
Blood. 2015 Dec 17; 126(25): 2695–2703. Prepublished online 2015 Aug 31. doi: 10.1182/blood-2015-05-644104
PMCID:
PMC4683330
AbstractArticle
12.
Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion
Jun Yang, Liang Zhu, Hao Zhang, Jamila Hirbawi, Koichi Fukuda, Pallavi Dwivedi, Jianmin Liu, Tatiana Byzova, Edward F. Plow, Jinhua Wu, Jun Qin
Nat Commun. Author manuscript; available in PMC 2015 Jun 18.
Published in final edited form as: Nat Commun. 2014; 5: 5880. Published online 2014 Dec 18. doi: 10.1038/ncomms6880
PMCID:
PMC4432866
AbstractArticlePDF–2.0M
13.
Rap1-GTP–interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice
Simon Stritt, Karen Wolf, Viola Lorenz, Timo Vögtle, Shuchi Gupta, Michael R. Bösl, Bernhard Nieswandt
Blood. 2015 Jan 8; 125(2): 219–222. Prepublished online 2014 Oct 21. doi: 10.1182/blood-2014-08-597542
PMCID:
PMC4347307
AbstractArticle
14.
Structural and Mechanistic Insights into the Recruitment of Talin by RIAM in Integrin Signaling
Yu-Chung Chang, Hao Zhang, Janusz Franco-Barraza, Mark L. Brennan, Tejash Patel, Edna Cukierman, Jinhua Wu
Structure. Author manuscript; available in PMC 2015 Dec 2.
Published in final edited form as: Structure. 2014 Dec 2; 22(12): 1810–1820. Published online 2014 Nov 20. doi: 10.1016/j.str.2014.09.020
PMCID:
PMC4255149
AbstractArticlePDF–2.0M
15.
The Vertebrate Genome Annotation browser 10 years on
Jennifer L. Harrow, Charles A. Steward, Adam Frankish, James G. Gilbert, Jose M. Gonzalez, Jane E. Loveland, Jonathan Mudge, Dan Sheppard, Mark Thomas, Stephen Trevanion, Laurens G. Wilming
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D771–D779. Published online 2013 Dec 6. doi: 10.1093/nar/gkt1241
PMCID:
PMC3964964
AbstractArticlePDF–11M
16.
RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover
Benjamin T. Goult, Thomas Zacharchenko, Neil Bate, Ricky Tsang, Fiona Hey, Alexandre R. Gingras, Paul R. Elliott, Gordon C. K. Roberts, Christoph Ballestrem, David R. Critchley, Igor L. Barsukov
J Biol Chem. 2013 Mar 22; 288(12): 8238–8249. Published online 2013 Feb 6. doi: 10.1074/jbc.M112.438119
PMCID:
PMC3605642
AbstractArticlePDF–3.8M
17.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
18.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
19.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M
20.
αvβ3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration
Daniel C. Worth, Kairbaan Hodivala-Dilke, Stephen D. Robinson, Samantha J. King, Penny E. Morton, Frank B. Gertler, Martin J. Humphries, Maddy Parsons
J Cell Biol. 2010 Apr 19; 189(2): 369–383. doi: 10.1083/jcb.200912014
PMCID:
PMC2856911
AbstractArticlePDF–3.2M

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