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Select item 112476861.

Inpp5d haplodeficiency alleviates tau pathology in the PS19 mouse model of Tauopathy

Disha M. Soni, Peter Bor‐Chian Lin, Audrey Lee‐Gosselin, Christopher D. Lloyd, Emily Mason, Cynthia M. Ingraham, Abigail Perkins, Miguel Moutinho, Bruce T. Lamb, Shaoyou Chu, Adrian L. Oblak

Alzheimers Dement. 2024 Jul; 20(7): 4985–4998. Published online 2024 Jun 26. doi: 10.1002/alz.14078

PMCID:: PMC11247686

Abstract Article PDF–7.8M

Select item 108837742.

SHIP1 deficiency causes inflammation-dependent retardation in skeletal growth

Fatemeh Safari, Wen Jie Yeoh, Saskia Perret-Gentil, Frank Klenke, Silvia Dolder, Willy Hofstetter, Philippe Krebs

Life Sci Alliance. 2024 May; 7(5): e202302297. Published online 2024 Feb 22. doi: 10.26508/lsa.202302297

PMCID:: PMC10883774

Abstract Article PDF–13M

Select item 106033043.

Regulation of microglial responses after pediatric traumatic brain injury: exploring the role of SHIP-1

Erskine Chu, Richelle Mychasiuk, Tabitha R. F. Green, Akram Zamani, Larissa K. Dill, Rishabh Sharma, April L. Raftery, Evelyn Tsantikos, Margaret L. Hibbs, Bridgette D. Semple

Front Neurosci. 2023; 17: 1276495. Published online 2023 Oct 13. doi: 10.3389/fnins.2023.1276495

PMCID:: PMC10603304

Abstract Article PDF–27M

Select item 105768364.

The Alzheimer’s disease risk factor INPP5D restricts neuroprotective microglial responses in amyloid beta-mediated pathology

Joshua D. Samuels, Katelyn A. Moore, Hannah E. Ennerfelt, Alexis M. Johnson, Adeline E. Walsh, Richard J. Price, John R. Lukens

Alzheimers Dement. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: Alzheimers Dement. 2023 Nov; 19(11): 4908–4921. Published online 2023 Apr 15. doi: 10.1002/alz.13089

PMCID:: PMC10576836

Abstract Article PDF–2.2M

Select item 105717955.

Regulation of Microglial Signaling by Lyn and SHIP-1 in the Steady-State Adult Mouse Brain

Erskine Chu, Richelle Mychasiuk, Evelyn Tsantikos, April L. Raftery, Elan L’Estrange-Stranieri, Larissa K. Dill, Bridgette D. Semple, Margaret L. Hibbs

Cells. 2023 Oct; 12(19): 2378. Published online 2023 Sep 28. doi: 10.3390/cells12192378

PMCID:: PMC10571795

Abstract Article PDF–11M

Select item 104813446.

Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer’s disease

Emilie L. Castranio, Philip Hasel, Jean-Vianney Haure-Mirande, Angie V. Ramirez Jimenez, B. Wade Hamilton, Rachel D. Kim, Charles G. Glabe, Minghui Wang, Bin Zhang, Sam Gandy, Shane A. Liddelow, Michelle E. Ehrlich

Alzheimers Dement. Author manuscript; available in PMC 2023 Sep 6.

Published in final edited form as: Alzheimers Dement. 2023 Jun; 19(6): 2239–2252. Published online 2022 Nov 30. doi: 10.1002/alz.12821

PMCID:: PMC10481344

Abstract Article PDF–2.1M

Select item 100741527.

INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model

Akihiro Iguchi, Sho Takatori, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Genta Ito, Haruaki Sato, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C. Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita

iScience. 2023 Apr 21; 26(4): 106375. Published online 2023 Mar 13. doi: 10.1016/j.isci.2023.106375

PMCID:: PMC10074152

Abstract Article PDF–7.1M

Select item 99296088.

Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment

Sandra Fernandes, Neetu Srivastava, Chiara Pedicone, Raki Sudan, Elizabeth A. Luke, Otto M. Dungan, Angela Pacherille, Shea T. Meyer, Shawn Dormann, Stéphane Schurmans, Benedict J. Chambers, John D. Chisholm, William G. Kerr

iScience. 2023 Feb 17; 26(2): 106071. Published online 2023 Jan 28. doi: 10.1016/j.isci.2023.106071

PMCID:: PMC9929608

Abstract Article PDF–2.4M

Select item 98608189.

SHIP1 Controls Internal Platelet Contraction and α_IIbβ₃ Integrin Dynamics in Early Platelet Activation

Sonia Severin, Alessandra Consonni, Gaëtan Chicanne, Sophie Allart, Bernard Payrastre, Marie-Pierre Gratacap

Int J Mol Sci. 2023 Jan; 24(2): 958. Published online 2023 Jan 4. doi: 10.3390/ijms24020958

PMCID:: PMC9860818

Abstract Article PDF–2.6M

Select item 904771410.

Non-Muscle Myosin II Is Essential for the Negative Regulation of B-Cell Receptor Signaling and B-Cell Activation

Margaret K. Seeley-Fallen, Michelle Lazzaro, Chaohong Liu, Quan-Zhen Li, Arpita Upadhyaya, Wenxia Song

Front Immunol. 2022; 13: 842605. Published online 2022 Apr 14. doi: 10.3389/fimmu.2022.842605

PMCID:: PMC9047714

Abstract Article PDF–19M

Select item 846181111.

Inhibition of lipid phosphatase SHIP1 expands myeloid-derived suppressor cells and attenuates rheumatoid arthritis in mice

Eui-Young So, Changqi Sun, Keith Q. Wu, Patrycja M. Dubielecka, Anthony M. Reginato, Olin D. Liang

Am J Physiol Cell Physiol. 2021 Sep 1; 321(3): C569–C584. Published online 2021 Jul 21. doi: 10.1152/ajpcell.00433.2020

PMCID:: PMC8461811

Abstract Article

Select item 831323912.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 808251513.

INPP5D expression is associated with risk for Alzheimer’s disease and induced by plaque-associated microglia

Andy P. Tsai, Lin Peter Bor-Chian, Chuanpeng Dong, Miguel Moutinho, Brad T. Casali, Yunlong Liu, Bruce T. Lamb, Gary E. Landreth, Adrian L. Oblak, Kwangsik Nho

Neurobiol Dis. Author manuscript; available in PMC 2021 Jun 1.

Published in final edited form as: Neurobiol Dis. 2021 Jun; 153: 105303. Published online 2021 Feb 22. doi: 10.1016/j.nbd.2021.105303

PMCID:: PMC8082515

Abstract Article PDF–1.5M

Select item 808060714.

Selective deletion of SHIP-1 in hematopoietic cells in mice leads to severe lung inflammation involving ILC2 cells

Xujun Ye, Fengrui Zhang, Li Zhou, Yadong Wei, Li Zhang, Lihui Wang, Haiying Tang, Zi Chen, William G. Kerr, Tao Zheng, Zhou Zhu

Sci Rep. 2021; 11: 9220. Published online 2021 Apr 28. doi: 10.1038/s41598-021-88677-8

PMCID:: PMC8080607

Abstract Article PDF–4.4M

Select item 793877015.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 758277216.

The Role of SHIP1 on Apoptosis and Autophagy in the Adipose Tissue of Obese Mice

Jae Hun Jeong, Eun Bee Choi, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Gyeongah Park, Eun Ae Jeong, Hyun Joo Shin, Jaewoong Lee, Kyung Eun Kim, Gu Seob Roh

Int J Mol Sci. 2020 Oct; 21(19): 7225. Published online 2020 Sep 30. doi: 10.3390/ijms21197225