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Select item 111388431.

Human and rodent type 1 11β-hydroxysteroid dehydrogenases are 7β-hydroxycholesterol dehydrogenases involved in oxysterol metabolism

M. Hult, B. Elleby, N. Shafqat, S. Svensson, A. Rane, H. Jörnvall, L. Abrahmsen, U. Oppermann

Cell Mol Life Sci. 2004 Apr; 61(7-8): 992–999. doi: 10.1007/s00018-003-3476-y

PMCID:: PMC11138843

Abstract Article PDF–218K

Select item 106264522.

Local glucocorticoid synthesis regulates house dust mite-induced airway hypersensitivity in mice

Verena M. Merk, Truong San Phan, Alice Wiedmann, Rowan S. Hardy, Gareth G. Lavery, Thomas Brunner

Front Immunol. 2023; 14: 1252874. Published online 2023 Oct 23. doi: 10.3389/fimmu.2023.1252874

PMCID:: PMC10626452

Abstract Article PDF–6.1M

Select item 103675503.

11β-Hydroxysteroid Dehydrogenase Type 1 Facilitates Osteoporosis by Turning on Osteoclastogenesis through Hippo Signaling

Hanwen Li, Sihan Hu, Runze Wu, Hongyou Zhou, Kai Zhang, Ke Li, Wenzheng Lin, Qin Shi, Hao Chen, Shan Lv

Int J Biol Sci. 2023; 19(11): 3628–3639. Published online 2023 Jul 15. doi: 10.7150/ijbs.82933

PMCID:: PMC10367550

Abstract Article PDF–8.3M

Select item 102444604.

Hyperglycemia-activated 11β-hydroxysteroid dehydrogenase type 1 increases endoplasmic reticulum stress and skin barrier dysfunction

Young Bin Lee, Hyun Jee Hwang, Eunjung Kim, Sung Ha Lim, Choon Hee Chung, Eung Ho Choi

Sci Rep. 2023; 13: 9206. Published online 2023 Jun 6. doi: 10.1038/s41598-023-36294-y

PMCID:: PMC10244460

Abstract Article PDF–4.3M

Select item 101724635.

Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS

Rahul Y. Mahida, Siân Lax, Christopher R. Bassford, Aaron Scott, Dhruv Parekh, Rowan S. Hardy, Babu Naidu, Michael A. Matthay, Paul M. Stewart, Mark C. Cooper, Gavin D. Perkins, David R. Thickett

Front Immunol. 2023; 14: 1159831. Published online 2023 Apr 27. doi: 10.3389/fimmu.2023.1159831

PMCID:: PMC10172463

Abstract Article PDF–3.5M

Select item 100270826.

11β-HSD1 determines the extent of muscle atrophy in a model of acute exacerbation of COPD

Justine M. Webster, Kelsy Waaijenberg, Wouter R. P. H. van de Worp, Marco C. J. M. Kelders, Sara Lambrichts, Claire Martin, Frank Verhaegen, Brent Van der Heyden, Charlotte Smith, Gareth G. Lavery, Annemie M. W. J. Schols, Rowan S. Hardy, Ramon C. J. Langen

Am J Physiol Lung Cell Mol Physiol. 2023 Apr 1; 324(4): L400–L412. Published online 2023 Feb 21. doi: 10.1152/ajplung.00009.2022

PMCID:: PMC10027082

Abstract Article

Select item 95780887.

11β-HSD1 contributes to age-related metabolic decline in male mice

Stuart A Morgan, Laura L Gathercole, Zaki K Hassan-Smith, Jeremy Tomlinson, Paul M Stewart, Gareth G Lavery

J Endocrinol. 2022 Dec 1; 255(3): 117–129. Published online 2022 Oct 7. doi: 10.1530/JOE-22-0169

PMCID:: PMC9578088

Abstract Article PDF–1.0M

Select item 95568378.

Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice

Elina Akalestou, Livia Lopez-Noriega, Ioannis Christakis, Ming Hu, Alexander D. Miras, Isabelle Leclerc, Guy A. Rutter

Front Endocrinol (Lausanne) 2022; 13: 1020576. Published online 2022 Sep 29. doi: 10.3389/fendo.2022.1020576

PMCID:: PMC9556837

Abstract Article PDF–6.7M

Select item 93277379.

Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice

Esteban Salazar-Petres, Daniela Pereira-Carvalho, Jorge Lopez-Tello, Amanda Nancy Sferruzzi-Perri

Biol Reprod. 2022 Jun; 106(6): 1292–1311. Published online 2022 Mar 16. doi: 10.1093/biolre/ioac056

PMCID:: PMC9327737

Abstract Article PDF–3.0M

Select item 913490810.

The GR-gp78 Pathway is involved in Hepatic Lipid Accumulation Induced by Overexpression of 11β-HSD1

Mengliang Hu, Tingting Han, Qiyu Pan, Dongsheng Ni, Fengyi Gao, Liying Wang, Hangjiang Ren, Xiaoyi Zhang, Haoyun Jiao, Yuefeng Wang, Dapeng Dai, Yong Man, Weiqing Tang, Yue Sun, Wei Li, Jian Li, Guoping Li

Int J Biol Sci. 2022; 18(8): 3107–3121. Published online 2022 Apr 30. doi: 10.7150/ijbs.42376

PMCID:: PMC9134908

Abstract Article PDF–3.2M

Select item 879007211.

Enhanced Angiogenesis by 11βHSD1 Blockage Is Insufficient to Improve Reperfusion Following Hindlimb Ischaemia

Junxi Wu, Eileen Miller, Callam Davidson, Brian R. Walker, Patrick W. F. Hadoke

Front Cardiovasc Med. 2021; 8: 795823. Published online 2022 Jan 12. doi: 10.3389/fcvm.2021.795823

PMCID:: PMC8790072

Abstract Article PDF–1.3M

Select item 849232612.

Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization

Yan Yin, Meade E. Haller, Sangappa B. Chadchan, Ramakrishna Kommagani, Liang Ma

JCI Insight. 2021 Sep 8; 6(17): e150254. Published online 2021 Sep 8. doi: 10.1172/jci.insight.150254

PMCID:: PMC8492326

Abstract Article PDF–3.4M

Select item 819857913.

Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 Contributes to Epidermal Permeability Barrier Dysfunction in Aged Skin

Beom Jun Kim, Noo Ri Lee, Chung Hyeok Lee, Young Bin Lee, Sung Jay Choe, Solam Lee, Hyun Jee Hwang, Eunjung Kim, Gareth G. Lavery, Kyong-Oh Shin, Kyungho Park, Eung Ho Choi

Int J Mol Sci. 2021 Jun; 22(11): 5750. Published online 2021 May 27. doi: 10.3390/ijms22115750

PMCID:: PMC8198579

Abstract Article PDF–2.1M

Select item 781563714.

Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids

Chloe Fenton, Claire Martin, Rachel Jones, Adam Croft, Joana Campos, Amy J Naylor, Angela E Taylor, Myriam Chimen, Mark Cooper, Gareth G Lavery, Karim Raza, Rowan S Hardy

Ann Rheum Dis. 2021 Feb; 80(2): 250–260. Published online 2020 Nov 8. doi: 10.1136/annrheumdis-2020-218493

PMCID:: PMC7815637

Abstract Article PDF–9.1M

Select item 767886415.

Role of 11β-hydroxysteroid dehydrogenase type 1 in the development of atopic dermatitis

Noo Ri Lee, Beom Jun Kim, Chung Hyeok Lee, Young Bin Lee, Solam Lee, Hyun Jee Hwang, Eunjung Kim, Sung Hee Kim, Min-Geol Lee, Sang Eun Lee, Gareth G. Lavery, Eung Ho Choi

Sci Rep. 2020; 10: 20237. Published online 2020 Nov 19. doi: 10.1038/s41598-020-77281-x

PMCID:: PMC7678864

Abstract Article PDF–3.3M

Select item 667315116.

Enhanced Hippocampal Long-Term Potentiation and Spatial Learning in Aged 11β-Hydroxysteroid Dehydrogenase Type 1 Knock-Out Mice

Joyce L. W. Yau, Kara M. McNair, June Noble, David Brownstein, Carina Hibberd, Nik Morton, John J. Mullins, Richard G. M. Morris, Stuart Cobb, Jonathan R. Seckl

J Neurosci. 2007 Sep 26; 27(39): 10487–10496. doi: 10.1523/JNEUROSCI.2190-07.2007

PMCID:: PMC6673151

Abstract Article PDF–458K

Select item 644303917.

Liver-Selective Transgene Rescue of Hypothalamic-Pituitary-Adrenal Axis Dysfunction in 11βHydroxysteroid Dehydrogenase Type 1-Deficient Mice

Janice M. Paterson, Megan C. Holmes, Christopher J. Kenyon, Roderick Carter, John J. Mullins, Jonathan R. Seckl

Endocrinology. Author manuscript; available in PMC 2019 Apr 1.

Published in final edited form as: Endocrinology. 2007 Mar; 148(3): 961–966. Published online 2006 Dec 14. doi: 10.1210/en.2006-0603

PMCID:: PMC6443039

Abstract Article PDF–1.2M

Select item 606661118.

11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis

R.S. Hardy, C. Fenton, A.P. Croft, A.J. Naylor, R. Begum, G. Desanti, C.D. Buckley, G. Lavery, M.S. Cooper, K. Raza

J Autoimmun. 2018 Aug; 92: 104–113. doi: 10.1016/j.jaut.2018.05.010

PMCID:: PMC6066611

Abstract Article PDF–3.4M

Select item 587139519.

11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation

Manu Verma, Tiina M.J. Kipari, Zhenguang Zhang, Tak Yung Man, Thorsten Forster, Natalie Z.M. Homer, Jonathan R. Seckl, Megan C. Holmes, Karen E. Chapman

Brain Behav Immun. 2018 Mar; 69: 223–234. doi: 10.1016/j.bbi.2017.11.015

PMCID:: PMC5871395

Abstract Article PDF–1.6M

Select item 578005920.

Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion

Nicholas H.F. Fine, Craig L. Doig, Yasir S. Elhassan, Nicholas C. Vierra, Piero Marchetti, Marco Bugliani, Rita Nano, Lorenzo Piemonti, Guy A. Rutter, David A. Jacobson, Gareth G. Lavery, David J. Hodson

Diabetes. 2018 Feb; 67(2): 278–290. Published online 2017 Dec 4. doi: 10.2337/db16-1356