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Select item 112149751.

FGF21 overexpression alleviates VSMC senescence in diabetic mice by modulating the SYK-NLRP3 inflammasome-PPARγ-catalase pathway: FGF21 alleviates high glucose-induced VSMC senescence

Yanyan Heng, Wei Wei, Linzhong Cheng, Feifei Wu, Haoyu Dong, Jingxia Li, Jianing Fu, Bingjie Yang, Xinyue Liang, Chunyan Liu, Haiju Li, Haihua Liu, Pengfei Zhang

Acta Biochim Biophys Sin (Shanghai) 2024 Jun 25; 56(6): 892–904. Published online 2024 May 10. doi: 10.3724/abbs.2024032

PMCID:: PMC11214975

Abstract Article PDF–3.5M

Select item 110777652.

FGF21 attenuates neuroinflammation following subarachnoid hemorrhage through promoting mitophagy and inhibiting the cGAS-STING pathway

Yue Ma, Zhiqin Liu, Lele Deng, Jingjing Du, Zenghui Fan, Tian Ma, Jing Xiong, Xue Xiuyun, Naibing Gu, Zhengli Di, Yu Zhang

J Transl Med. 2024; 22: 436. Published online 2024 May 8. doi: 10.1186/s12967-024-05239-y

PMCID:: PMC11077765

Abstract Article PDF–13M

Select item 109674743.

Lipodystrophy in methylmalonic acidemia associated with elevated FGF21 and abnormal methylmalonylation

Irini Manoli, Justin R. Sysol, PamelaSara E. Head, Madeline W. Epping, Oksana Gavrilova, Melissa K. Crocker, Jennifer L. Sloan, Stefanos A. Koutsoukos, Cindy Wang, Yiouli P. Ktena, Sophia Mendelson, Alexandra R. Pass, Patricia M. Zerfas, Victoria Hoffmann, Hilary J. Vernon, Laura A. Fletcher, James C. Reynolds, Maria G. Tsokos, Constantine A. Stratakis, Stephan D. Voss, Kong Y. Chen, Rebecca J. Brown, Ada Hamosh, Gerard T. Berry, Xiaoyuan Shawn Chen, Jack A. Yanovski, Charles P. Venditti

JCI Insight. 2024 Feb 22; 9(4): e174097. Published online 2024 Feb 22. doi: 10.1172/jci.insight.174097

PMCID:: PMC10967474

Abstract Article PDF–4.5M

Select item 109366144.

FGF21 and autophagy coordinately counteract kidney disease progression during aging and obesity

Satoshi Minami, Shinsuke Sakai, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Atsushi Takahashi, Jun Matsuda, Hiroaki Yonishi, Jun Nakamura, Shihomi Maeda, Sho Matsui, Isao Matsui, Yoshitaka Isaka

Autophagy. 2024; 20(3): 489–504. Published online 2023 Sep 18. doi: 10.1080/15548627.2023.2259282

PMCID:: PMC10936614

Abstract Article PDF–7.5M

Select item 108532835.

Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R

Camilla Lund, Pablo Ranea-Robles, Sarah Falk, Dylan M. Rausch, Grethe Skovbjerg, Victoria Kamma Vibe-Petersen, Nathalie Krauth, Jacob Lercke Skytte, Vasiliki Vana, Urmas Roostalu, Tune H. Pers, Jens Lund, Christoffer Clemmensen

Nat Commun. 2024; 15: 1192. Published online 2024 Feb 8. doi: 10.1038/s41467-024-45223-0

PMCID:: PMC10853283

Abstract Article PDF–2.2M

Select item 108477436.

Transplantation of committed pre-adipocytes from brown adipose tissue improves whole-body glucose homeostasis

Revati S. Dewal, Felix T. Yang, Lisa A. Baer, Pablo Vidal, Diego Hernandez-Saavedra, Nickolai P. Seculov, Adhideb Ghosh, Falko Noé, Olivia Togliatti, Lexis Hughes, Megan K. DeBari, Michael D. West, Richard Soroko, Hal Sternberg, Nafees N. Malik, Estella Puchulu-Campanella, Huabao Wang, Pearlly Yan, Christian Wolfrum, Rosalyn D. Abbott, Kristin I. Stanford

iScience. 2024 Feb 16; 27(2): 108927. Published online 2024 Jan 17. doi: 10.1016/j.isci.2024.108927

PMCID:: PMC10847743

Abstract Article PDF–6.4M

Select item 108442977.

Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21

Thomas Agius, Raffaella Emsley, Arnaud Lyon, Michael R. MacArthur, Kevin Kiesworo, Anna Faivre, Louis Stavart, Martine Lambelet, David Legouis, Sophie de Seigneux, Déla Golshayan, Francois Lazeyras, Heidi Yeh, James F. Markmann, Korkut Uygun, Alejandro Ocampo, Sarah J. Mitchell, Florent Allagnat, Sébastien Déglise, Alban Longchamp

Nat Commun. 2024; 15: 1073. Published online 2024 Feb 5. doi: 10.1038/s41467-024-44866-3

PMCID:: PMC10844297

Abstract Article PDF–6.7M

Select item 108084138.

Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice

Alejandro Delgado-Anglés, Albert Blasco-Roset, Francisco J. Godoy-Nieto, Montserrat Cairó, Francesc Villarroya, Marta Giralt, Joan Villarroya

J Physiol Biochem. 2024; 80(1): 41–51. Published online 2023 Nov 2. doi: 10.1007/s13105-023-00977-x

PMCID:: PMC10808413

Abstract Article PDF–3.1M

Select item 107969149.

ATF4 expression in thermogenic adipocytes is required for cold-induced thermogenesis in mice via FGF21-independent mechanisms

Sarah H. Bjorkman, Alex Marti, Jayashree Jena, Luis Miguel García-Peña, Eric T. Weatherford, Kevin Kato, Jivan Koneru, Jason Chen, Ayushi Sood, Matthew J. Potthoff, Christopher M. Adams, E. Dale Abel, Renata O. Pereira

Sci Rep. 2024; 14: 1563. Published online 2024 Jan 18. doi: 10.1038/s41598-024-52004-8

PMCID:: PMC10796914

Abstract Article PDF–2.5M

Select item 1079633010.

Non-alcoholic fatty liver disease promotes breast cancer progression through upregulated hepatic fibroblast growth factor 21

Yue Sui, Qingqing Liu, Cong Xu, Kumar Ganesan, Zhen Ye, Yan Li, Jianmin Wu, Bing Du, Fei Gao, Cailu Song, Jianping Chen

Cell Death Dis. 2024 Jan; 15(1): 67. Published online 2024 Jan 18. doi: 10.1038/s41419-023-06386-8

PMCID:: PMC10796330

Abstract Article PDF–5.8M

Select item 1069049311.

FGF21 Modulates Hippocampal Cold-Shock Proteins and CA2-Subregion Proteins in Neonatal Mice with Hypoxia-Ischemia

Jeremy R. Herrmann, Patrick M. Kochanek, Vincent A. Vagni, Keri Janesko-Feldman, Jason Stezoski, Kiersten Gorse, Travis C. Jackson

Pediatr Res. Author manuscript; available in PMC 2024 Apr 1.

Published in final edited form as: Pediatr Res. 2023 Oct; 94(4): 1355–1364. Published online 2023 May 16. doi: 10.1038/s41390-023-02652-9

PMCID:: PMC10690493

Abstract Article PDF–2.1M

Select item 1058317412.

Hepatic sialic acid synthesis modulates glucose homeostasis in both liver and skeletal muscle

Jun Peng, Liming Yu, Linzhang Huang, Vivian A. Paschoal, Haiyan Chu, Camila O. de Souza, Joseph V. Varre, Da Young Oh, Jennifer J. Kohler, Xue Xiao, Lin Xu, William L. Holland, Philip W. Shaul, Chieko Mineo

Mol Metab. 2023 Dec; 78: 101812. Published online 2023 Sep 28. doi: 10.1016/j.molmet.2023.101812

PMCID:: PMC10583174

Abstract Article PDF–4.0M

Select item 1057386713.

Hepatic-Specific FGF21 Knockout Abrogates Ovariectomy-Induced Obesity by Reversing Corticosterone Production

Jiayu Xu, Xinyu Shao, Haozhe Zeng, Chengxi Wang, Jiayi Li, Xiaoqin Peng, Yong Zhuo, Lun Hua, Fengyan Meng, Xingfa Han

Int J Mol Sci. 2023 Oct; 24(19): 14922. Published online 2023 Oct 5. doi: 10.3390/ijms241914922

PMCID:: PMC10573867

Abstract Article PDF–3.3M

Select item 1056110514.

The roles of FGF21 and GDF15 in mediating the mitochondrial integrated stress response

Jayashree Jena, Luis Miguel García-Peña, Renata O. Pereira

Front Endocrinol (Lausanne) 2023; 14: 1264530. Published online 2023 Sep 25. doi: 10.3389/fendo.2023.1264530

PMCID:: PMC10561105

Abstract Article PDF–763K

Select item 1049779115.

FGF21 alleviates adipose stem cell senescence via CD90 glycosylation-dependent glucose influx in remodeling healthy white adipose tissue

Zixin Zhou, Huiying Zhang, Yan Tao, Jinhao Zang, Jingyuan Zhao, Huijie Li, Yalin Wang, Tianci Wang, Hui Zhao, Fuwu Wang, Chun Guo, Faliang Zhu, Haiting Mao, Fengming Liu, Lining Zhang, Qun Wang

Redox Biol. 2023 Nov; 67: 102877. Published online 2023 Sep 9. doi: 10.1016/j.redox.2023.102877

PMCID:: PMC10497791

Abstract Article PDF–13M

Select item 1040174416.

Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?

Wouter Vankrunkelsven, Steven Thiessen, Sarah Derde, Ellen Vervoort, Inge Derese, Isabel Pintelon, Hanne Matheussen, Alexander Jans, Chloë Goossens, Lies Langouche, Greet Van den Berghe, Ilse Vanhorebeek

Skelet Muscle. 2023; 13: 12. Published online 2023 Aug 4. doi: 10.1186/s13395-023-00320-4