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Items: 1 to 20 of 136

1.
TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer
Yanting Lin, Rui Gao, Dongquan Jing, Yiming Liu, Huijuan Da, Lutz Birnbaumer, Yong Yang, Xinghua Gao, Zhenhua Gao, Qiuhua Cao
Front Pharmacol. 2024; 15: 1392328. Published online 2024 May 21. doi: 10.3389/fphar.2024.1392328
PMCID:
PMC11148282
AbstractArticlePDF–5.1M
2.
The mouse retinal pigment epithelium mounts an innate immune defense response following retinal detachment
Steven F. Abcouwer, Bruna Miglioranza Scavuzzi, Phillip E. Kish, Dejuan Kong, Sumathi Shanmugam, Xuan An Le, Jingyu Yao, Heather Hager, David N Zacks
J Neuroinflammation. 2024; 21: 74. Published online 2024 Mar 25. doi: 10.1186/s12974-024-03062-2
PMCID:
PMC10964713
AbstractArticlePDF–9.1M
3.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
4.
TRPV4 Channels Promote Pathological, but Not Physiological, Cardiac Remodeling through the Activation of Calcineurin/NFAT and TRPC6
Laia Yáñez-Bisbe, Mar Moya, Antonio Rodríguez-Sinovas, Marisol Ruiz-Meana, Javier Inserte, Marta Tajes, Montserrat Batlle, Eduard Guasch, Aleksandra Mas-Stachurska, Elisabet Miró, Nuria Rivas, Ignacio Ferreira González, Anna Garcia-Elias, Begoña Benito
Int J Mol Sci. 2024 Feb; 25(3): 1541. Published online 2024 Jan 26. doi: 10.3390/ijms25031541
PMCID:
PMC10855372
AbstractArticlePDF–3.7M
5.
Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs
Guang Li, Lujing Chen, Zheng Jiang, King-Wai Yau
Proc Natl Acad Sci U S A. 2023 Dec 26; 120(52): e2315282120. Published online 2023 Dec 18. doi: 10.1073/pnas.2315282120
PMCID:
PMC10756192
AbstractArticlePDF–4.0M
6.
TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes
Yohei Yamaguchi, Gentaro Iribe, Toshiyuki Kaneko, Ken Takahashi, Takuro Numaga-Tomita, Motohiro Nishida, Lutz Birnbaumer, Keiji Naruse
J Physiol Sci. 2018 Mar; 68(2): 153–164. Published online 2017 Jan 19. doi: 10.1007/s12576-016-0519-3
PMCID:
PMC10718017
AbstractArticlePDF–1.2M
7.
TRPC6 Deletion Enhances eNOS Expression and Reduces LPS—Induced Acute Lung Injury
Mengyuan Wang, Xingfang Zhang, Juan Guo, Shangze Yang, Fang Yang, Xingjuan Chen
Int J Mol Sci. 2023 Dec; 24(23): 16756. Published online 2023 Nov 25. doi: 10.3390/ijms242316756
PMCID:
PMC10706254
AbstractArticlePDF–8.9M
8.
Trpc6 knockout protects against renal fibrosis by restraining the CN‑NFAT2 signaling pathway in T2DM mice
Ran Sun, Min Han, Yan Liu, Yong Su, Qifeng Shi, Lei Huang, Liangliang Kong, Weizu Li, Weiping Li
Mol Med Rep. 2024 Jan; 29(1): 13. Published online 2023 Nov 27. doi: 10.3892/mmr.2023.13136
PMCID:
PMC10704556
AbstractArticlePDF–7.0M
9.
Molecular Modification of Transient Receptor Potential Canonical 6 Channels Modulates Calcium Dyshomeostasis in a Mouse Model Relevant to Malignant Hyperthermia
Jose Rafael Lopez, Arkady Uryash, Jose Adams, Philip M. Hopkins, Paul D. Allen
Anesthesiology. Author manuscript; available in PMC 2023 Jan 12.
Published in final edited form as: Anesthesiology. 2021 Feb 1; 134(2): 234–247. doi: 10.1097/ALN.0000000000003635
PMCID:
PMC9836077
AbstractArticlePDF–741K
10.
Deletion of classical transient receptor potential 1, 3 and 6 alters pulmonary vasoconstriction in chronic hypoxia-induced pulmonary hypertension in mice
Kathrin Malkmus, Monika Brosien, Fenja Knoepp, Lisa Schaffelhofer, Friedrich Grimminger, Christoph Rummel, Thomas Gudermann, Alexander Dietrich, Lutz Birnbaumer, Norbert Weissmann, Simone Kraut
Front Physiol. 2022; 13: 1080875. Published online 2022 Dec 7. doi: 10.3389/fphys.2022.1080875
PMCID:
PMC9768328
AbstractArticlePDF–2.4M
11.
Analysis of hyperforin (St. John’s wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs
Yamina El Hamdaoui, Fang Zheng, Nikolas Fritz, Lian Ye, Mai Anh Tran, Kevin Schwickert, Tanja Schirmeister, Albert Braeuning, Dajana Lichtenstein, Ute A. Hellmich, Dorothee Weikert, Markus Heinrich, Giulia Treccani, Michael K. E. Schäfer, Gabriel Nowak, Bernd Nürnberg, Christian Alzheimer, Christian P. Müller, Kristina Friedland
Mol Psychiatry. 2022; 27(12): 5070–5085. Published online 2022 Oct 12. doi: 10.1038/s41380-022-01804-3
PMCID:
PMC9763113
AbstractArticlePDF–3.7M
12.
TRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca2+ leakage
Na Tang, Wen Tian, Guang-Yuan Ma, Xiong Xiao, Lei Zhou, Ze-Zhi Li, Xiao-Xiao Liu, Chong-Yao Li, Ke-Han Wu, Wenjuan Liu, Xue-Ying Wang, Yuan-Yuan Gao, Xin Yang, Jianzhao Qi, Ding Li, Yang Liu, Wen-Sheng Chen, Jinming Gao, Xiao-Qiang Li, Wei Cao
Nat Commun. 2022; 13: 7455. Published online 2022 Dec 2. doi: 10.1038/s41467-022-35242-0
PMCID:
PMC9718841
AbstractArticlePDF–4.7M
13.
Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling
Henning Hagmann, Naghmeh Hassanzadeh Khayyat, Cem Oezel, Antonios Papadakis, Alexander Kuczkowski, Thomas Benzing, Erich Gulbins, Stuart Dryer, Paul T. Brinkkoetter
Cells. 2022 Nov; 11(22): 3625. Published online 2022 Nov 16. doi: 10.3390/cells11223625
PMCID:
PMC9688324
AbstractArticlePDF–2.7M
14.
Pharmacological TRPC6 inhibition improves survival and muscle function in mice with Duchenne muscular dystrophy
Brian L. Lin, Joseph Y. Shin, William P.D. Jeffreys, Nadan Wang, Clarisse A. Lukban, Megan C. Moorer, Esteban Velarde, Olivia A. Hanselman, Seoyoung Kwon, Suraj Kannan, Ryan C. Riddle, Christopher W. Ward, Steven S. Pullen, Antonio Filareto, David A. Kass
JCI Insight. 2022 Oct 10; 7(19): e158906. Published online 2022 Oct 10. doi: 10.1172/jci.insight.158906
PMCID:
PMC9675567
AbstractArticlePDF–6.1M
15.
New Positive TRPC6 Modulator Penetrates Blood–Brain Barrier, Eliminates Synaptic Deficiency and Restores Memory Deficit in 5xFAD Mice
Nikita Zernov, Alexander V. Veselovsky, Vladimir V. Poroikov, Daria Melentieva, Anastasia Bolshakova, Elena Popugaeva
Int J Mol Sci. 2022 Nov; 23(21): 13552. Published online 2022 Nov 4. doi: 10.3390/ijms232113552
PMCID:
PMC9653995
AbstractArticlePDF–2.3M
16.
Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors
Sayaka Oda, Kazuhiro Nishiyama, Yuka Furumoto, Yohei Yamaguchi, Akiyuki Nishimura, Xiaokang Tang, Yuri Kato, Takuro Numaga-Tomita, Toshiyuki Kaneko, Supachoke Mangmool, Takuya Kuroda, Reishin Okubo, Makoto Sanbo, Masumi Hirabayashi, Yoji Sato, Yasuaki Nakagawa, Koichiro Kuwahara, Ryu Nagata, Gentaro Iribe, Yasuo Mori, Motohiro Nishida
Nat Commun. 2022; 13: 6374. Published online 2022 Oct 26. doi: 10.1038/s41467-022-34194-9
PMCID:
PMC9606288
AbstractArticlePDF–4.6M
17.
Store-operated Ca2+ entry and Ca2+ responses to hypothalamic releasing hormones in anterior pituitary cells from Orai1−/− and heptaTRPC knockout mice
Lucía Núñez, Gary S. Bird, Elena Hernando-Pérez, Enrique Pérez-Riesgo, James W. Putney, Jr, Carlos Villalobos
Biochim Biophys Acta Mol Cell Res. Author manuscript; available in PMC 2022 Oct 17.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2019 Jul; 1866(7): 1124–1136. Published online 2018 Nov 17. doi: 10.1016/j.bbamcr.2018.11.006
PMCID:
PMC9574777
AbstractArticlePDF–1.8M
18.
Gain-of-function, focal segmental glomerulosclerosis Trpc6 mutation minimally affects susceptibility to renal injury in several mouse models
Brittney J. Brown, Kimber L. Boekell, Brian R. Stotter, Brianna E. Talbot, Johannes S. Schlondorff
PLoS One. 2022; 17(8): e0272313. Published online 2022 Aug 1. doi: 10.1371/journal.pone.0272313
PMCID:
PMC9342776
AbstractArticlePDF–2.8M
19.
A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia
Tsukasa Shimauchi, Takuro Numaga-Tomita, Yuri Kato, Hiroyuki Morimoto, Kosuke Sakata, Ryosuke Matsukane, Akiyuki Nishimura, Kazuhiro Nishiyama, Atsushi Shibuta, Yutoku Horiuchi, Hitoshi Kurose, Sang Geon Kim, Yasuteru Urano, Takashi Ohshima, Motohiro Nishida
Cells. 2022 Jul; 11(13): 2041. Published online 2022 Jun 27. doi: 10.3390/cells11132041
PMCID:
PMC9266111
AbstractArticlePDF–3.1M
20.
Trpc6 gain-of-function disease mutation enhances phosphatidylserine exposure in murine platelets
Kimber L. Boekell, Brittney J. Brown, Brianna E. Talbot, Johannes S. Schlondorff
PLoS One. 2022; 17(6): e0270431. Published online 2022 Jun 24. doi: 10.1371/journal.pone.0270431
PMCID:
PMC9231752
AbstractArticlePDF–3.6M

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